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Propalin is prescribed for bitches which tend to leak urine when relaxed or resting in their bed (sphincter mechanism incontinence or SME). This is a condition which is fairly common in spayed bitches of certain breeds (mostly tail-docked breeds) though it can occur in other situations. Often the incontinence develops a long while after spaying. Propalin acts to stimulate more tone in the muscles at the exit to the bladder, so that passive leaking is less likely to occur. Initially a full dose of Propalin needs to be given three times daily. This works best if given with a small amount of food on an empty tummy. Once the urine leaking has been brought under control, which can take a few days, many bitches remain continent even if the frequency and dose of Propalin is reduced.
Urinary incontinence can affect dogs of both sexes, at any age, and if you find that your dog is leaving behind “wet spots” in their bed or in random places in the house, then propalin could be the answer. This involuntary loss of ability to control urine can be very stressful for both dog and owner, but the condition is eminently treatable with propalin, which can be bought online at VioVet, your trusted online pet retailer.
Dogs affected by urinary incontinence will dribble or leak urine, often while asleep, and although there is no cure, the condition can be effectively managed. Propalin is safe and easy to use, and works by strengthening the muscle tone at the neck of the bladder to prevent the accidental leakage of urine. The treatment comes in the form of a chewable tablet or a syrup that can be disguised in your dog’s food. Results are seen fast, and improvements in your dog’s condition can usually be seen in the first week
Syrup. Clear colourless solution for oral use containing 40mg/ml phenylpropanolamine as phenylpropanolamine hydrochloride.
Treatment of urinary incontinence associated with urethral sphincter incompetence in the bitch. Efficacy has only been demonstrated in ovariohysterectomised bitches
The recommended dose is 0.8mg phenylpropanolamine/kg bodyweight (equivalent to 1mg/kg phenylpropanolamine hydrochloride/kg) 3 times daily in the feed, corresponding to 0.1 ml Propalin Syrup/5 kg bodyweight 3 times daily. The absorption rate is increased if the product is administered to fasted dogs.
The use of Propalin is not appropriate for the treatment of behavioural causes of inappropriate urination. Do not administer to patients treated with non-selective monoamine oxidase inhibitors.
Do not use in case of known hypersensitivity to active substance or to any of the excipients.
In the course of field clinical trials, loose stools, liquid diarrhoea, decrease in appetite, arrhythmia and collapse were reported in some dogs. Treatment was continued depending on the severity of the undesirable effect observed.
Sympathomimetics may produce a wide range of effects, most of which mimic the results of excessive stimulation of the sympathetic nervous system (e.g. effects on heart rate and blood pressure).
Dizziness and restlessness were also occasionally reported. Hypersensitivity may occur in very rare cases.
Phenylpropanolamine, a sympathomimetic drug, may affect the cardiovascular system, especially blood pressure and heart rate, and should be used with caution in animals with cardiovascular diseases.
Care should be exercised in treating animals with severe renal or hepatic insufficiency, diabetes mellitus, hyperadrenocorticism, glaucoma, hyperthyroidism or other metabolic disorders.
In bitches less than 1 year old the possibility of anatomical disorders contributing to incontinence should be considered prior to treatment.
Do not administer to pregnant or lactating bitches.
Care should be exercised in administering Propalin Syrup with other sympathomimetic drugs, anticholinergic drugs, tricyclic antidepressants or specific type B monoamine oxidase inhibitors. It should not be used in patients treated with non-selective monoamine oxidase inhibitors.
In healthy dogs, no side effects were observed at up to 5 times the recommended dosage. However, an overdose of phenylpropanolamine could produce symptoms of excessive stimulation of the sympathic nervous system. Treatment should be symptomatic. Alpha-adrenergic blockers may be appropriate in the case of severe overdose. However, no specific recommendation on drugs or dosages can be given.
Phenylpropanolamine Hydrochloride is toxic when overdoses are ingested. Adverse effects may include dizziness, headache, nausea, insomnia or restlessness, and increased blood pressure. High overdose may be fatal, especially in children.
To avoid accidental ingestion, the product must be used and kept out of reach of children. Always replace the cap securely after use. In the event of accidental ingestion, seek immediate medical attention showing the physician the package insert.
In the event of accidental skin contact, wash the contaminated area with soap and water. Wash hands after use of the product.
In the event of accidental eye contact, rinse the eye with clean water for about 15 minutes and seek medical advice.
Do not store above 25°C. Do not refrigerate.
Shelf life of the veterinary medicinal product as packaged for sale: 2 years
Shelf life after first opening the immediate packaging: 3 months
Any unused products or waste material should be disposed of in accordance with national requirements.
30ml and 100 ml: HDPE bottle with LDPE syringe adapter insert and a polypropylene child resistant closure; the package contains also one 1.5ml graduated syringe of LDPE/polystyrene.
Not all pack sizes may be marketed.
Pharmacological Immunological Properties
Phenylpropanolamine hydrochloride is a sympapathomimetic agent. It is an analogue of the endogenous sympathomimetic amines. ATC Vetcode: QG04BX91.
The clinical effect of phenylpropanolamine in urinary incontinence is based on its stimulation effect on α-adrenergic receptors. This causes an increase in, and a stabilisation of, the closure pressure in the urethra, which is innervated mainly by adrenergic nerves.
Phenylpropanolamine is a racemic mixture of D and L enantiomers.
In the dog, the mean half-life of phenylpropanolamine is approximately 3 hours with maximal plasma concentrations being found after approximately 1 hour. No accumulation of phenylpropanolamine has been observed after a dose of 1mg/phenylpropanolamine hydrochloride/kg 3 times daily over 15 days.
When the product is administered to a fasted dog, bioavailability is increased significantly.
Propalin Syrup 30ml
Propalin Syrup 100ml
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