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Program Plus Tablets for Dogs

  • Large Dogs 23-45kg » Pack of 6 £35.50
  • Medium Dogs 12-22kg » Pack of 6 £33.49
  • Small Dogs 5-11kg » Pack of 6 £32.50
  • Tiny Dogs 1-4.5kg » Pack of 6 £34.49

Selection of 4 products from

£32.50 to £35.50

Program Plus is a unique product which controls fleas and worms from one tablet. Different size tablets are available and are used according to the bodyweight of the dog to be treated. In areas where heartworm is found, or for dogs travelling to Euprope on the Pet Travel Scheme, monthly dosing will control heartworm too. The tablet has to be given with or just after food, for full absorption to occur. Puppies weighing over 1kg can be dosed from 2 weeks of age. Program Plus is believed to be safe to use on pregnant and lactating bitches, though treatment with any drug is best avoided during early pregnancy if possible.


Active ingredients: milbemycin oxime and lufenuron.

Film-coated tablets are available in 4 different sizes:

Red outer pack, tablets contain: 2.3mg milbemycin oxime and 46mg lufenuron

Green outer pack, tablets contain: 5.75mg milbemycin oxime and 115mg lufenuron

Yellow outer pack, tablets contain: 11.5mg milbemycin oxime and 230mg lufenuron

White outer pack, tablets contain: 23mg milbemycin oxime and 460mg lufenuron


PROGRAM PLUS tablets are indicated for the prevention of fleas (Ct. felis, Ct. canis, preadult stages), and for the concurrent prevention of heartworm disease (elimination of 3rd and 4th larval stages of Dirofilaria immitis) and/or treatment of adult stages of gastrointestinal nematodes such as hookworms (Ancylostoma caninum), roundworms (Toxocara canis) and whipworms (Trichuris vulpis) in dogs.

Dosage and administration

PROGRAM PLUS tablets are administered at a minimum dose of 0.5 mg milbemycin oxime and 10 mg lufenuron per kg body weight.

PROGRAM PLUS tablets are available in four sizes and are given according to the weight of the dog.

Colour code of outer pack

Body weight








up to 4.5 kg

from 5 to 11 kg

from 12 to 22 kg

from 23 to 45 kg

1 tab./month

1 tab./month

1 tab./month

1 tab./month

For dogs greater than 45 kg, a combination of tablets is given, consistent with the recommended minimum dose.

PROGRAM PLUS tablets should be administered in the following situations:


To prevent flea infestations with concurrent heartworm prevention and/or gastrointestinal nematode infection medication should start from 2 weeks of age, or from a minimum weight of 1 kg.

Dogs in a non-heartworm region

PROGRAM PLUS can be used as part of the seasonal prevention of fleas replacing lufenuron mono (PROGRAM tablets) in cases with diagnosed concurrent gastrointestinal nematode infection. After elimination of the nematode infection confirmed by faecal examination, prevention of fleas should continue with PROGRAM tablets if indicated.

In puppies, medication with PROGRAM PLUS is recommended up to one month after weaning. Thereafter, prevention of fleas can be continued with lufenuron mono (PROGRAM).

Dogs travelling to a heartworm region

To prevent flea infestations and heartworm disease at the same time, dogs travelling to a heartworm risk region should begin medication within one month after arrival. Treatment should continue monthly, with the last administration given after the dog has left the region.

Dogs in a heartworm region

Dogs in a heartworm region:To prevent flea infestations and heartworm disease at the same time, medication should begin within one month after the appearance of mosquitoes, or one month before the appearance of fleas, and continue throughout the risk period with the last dose given within one month after the mosquito and flea season finishes.

If dogs have a high level of flea infestation at the start of treatment, it may be necessary to apply a flea adulticide during the first one to two months. It is important to treat all dogs and cats in the household for fleas. Cats in the same household should be treated with PROGRAM oral or injectable suspension.

Advice on Correct Administration

To ensure adequate drug absorption, PROGRAM PLUS tablets must be administered with food (for example mixed with the daily feed) or placed directly in the mouth after feeding.

Treatment with PROGRAM PLUS tablets may begin at any time of the year. In geographic areas where the presence of fleas and mosquitoes (heartworm vector) is seasonal, depending on ambient temperature, treatment should be started one month prior to the appearance of the insects and then repeated monthly throughout the risk period. In environments with year-round flea infestations and concurrent heartworm risk, treatment may be continued throughout the year without interruption.

Ideally, tablets are administered on the same day each month. If an interval is greater than 6 weeks, treatment should be resumed immediately and be continued at monthly intervals and, in case of heartworm prevention, a veterinarian should be consulted.

PROGRAM PLUS tablets immediately block the reproductive cycle of fleas by inhibiting the development of eggs and larvae. Pre-existing generations (e.g. pupae) present in the environment can, however, continue to develop and emerge for several weeks after the start of treatment.

Contra-indications, warnings, etc

In heartworm risk regions, or if it is known that a dog has been travelling to and from heartworm risk regions, before commencing PROGRAM PLUS treatment as with any other heartworm preventive, a veterinary consultation is advised to exclude the presence of any concurrent infestation of Dirofilaria immitis. In the case of a positive diagnosis, adulticidal therapy is indicated before administering PROGRAM PLUS.

Pale mucous membranes and increased intestinal peristalsis have been observed in some dogs after treatment. The treatment of dogs with a high number of circulating microfilariae can sometimes lead to the appearance of moderate and transitory hypersensitivity reactions, such as pale mucous membranes, vomiting, laboured breathing, or excessive salivation. These reactions are associated with the release of proteins from dead or dying microfilariae and are not a direct toxic effect of the product.

If you notice any other side effects, please inform your veterinary surgeon.


For animal treatment only.

Special Precautions for the Disposal of Unused Veterinary Medicinal Product or Waste Materials Derived from such Veterinary Medicinal Products.

Any unused PROGRAM PLUS tablets or waste materials derived from them should be disposed of in accordance with local requirements.

Pharmaceutical precautions

Keep out of the reach and sight of children.

Do not store above 25°C.

Keep the blister strips in the outer carton.

Legal category


Packaging Quantities

Plastic blister packs each containing 6 tablets.

Further information

Milbemycin oxime, which belongs to the group of macrocyclic lactones, is active against mites, against larval and adult stages of nematodes as well as against larvae of Dirofilaria immitis.

Marketing Authoristion Holder (if different from distributor)

Novartis Animal Health S.p.A

Largo U Boccioni 1

21040 Origgio (Varese)


Marketing authorisation numbers

Milbemycin oxime/lufenuron 2.3 mg/46 mg

Vm 18352/4000

Milbemycin oxime/lufenuron 5.75 mg/115 mg

Vm 18352/4001

Milbemycin oxime/lufenuron 11.5 mg/230 mg

Vm 18352/4002

Milbemycin oxime/lufenuron 23 mg/460 mg

Vm 18352/4003

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Questions & Answers for Program Plus Tablets for Dogs

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Ticks as wel?

15th Oct 2013
Nicky Harvey

Does this all in one tablet include treatment and prevention of ticks please?


  • Non-Executive Director

Ticks are one of the most difficult parasites to control and this product has no activity against them at all. It works very well for fleas and for worms living in the gut, which are the main parasites able to affect most dogs. If ticks are a concern in your area, then a topical treatment is needed for them, usually applied in the form of a spot-on. (Frontline Spot-on is the classic example. It is also effective against fleas, but not against any worms.)