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Program Plus is a unique product which controls fleas and worms from one tablet. Different size tablets are available and are used according to the bodyweight of the dog to be treated. In areas where heartworm is found, or for dogs travelling to Euprope on the Pet Travel Scheme, monthly dosing will control heartworm too. The tablet has to be given with or just after food, for full absorption to occur. Puppies weighing over 1kg can be dosed from 2 weeks of age. Program Plus is believed to be safe to use on pregnant and lactating bitches, though treatment with any drug is best avoided during early pregnancy if possible.
All prices include VAT where applicable.
Each tablet contains:
Milbemycin oxime 11.5 mg
Lufenuron 230.0 mg
Titanium dioxide (E171) 3.7 mg
White, pentagonal, biconvex, bevel-edged, coated tablets with “GLG” on one side and “CGV” on the reverse.
Indications for use, specifying the target species
PROGRAM Plus is used for the prevention of fleas (Ct. felis, Ct. canis, preadult stages), and for the concurrent prevention of heartworm (elimination of L3/L4 larval stages of Dirofilaria immitis) and/or treatment of adult stages of gastrointestinal nematodes such as hookworms (Ancylostoma caninum),
roundworms (Toxocara canis) and whipworms (Trichuris vulpis).
Do not use in case of hypersensitivity to the active substance, to the adjuvants or to any of the excipients.
Ideally, tablets are administered on the same day each month. If an interval is greater than 6 weeks, treatment should be resumed immediately and be continued at monthly intervals and, in case of heartworm prevention, a veterinarian should be consulted.
Special precautions for use
i)Special precautions for use in animals
In heartworm risk regions, or in case it is known that a dog has been travelling to and from heartworm risk regions, before commencing PROGRAM Plus treatment as with any other heartworm preventive,
a veterinary consultation is advised to exclude the presence of any concurrent infestation of Dirofilaria immitis. In the case of a positive diagnosis, adulticidal therapy is indicated before administering PROGRAM Plus.
ii)Special precautions to be taken by the person administering the veterinary medicinal product to animals
In the case of accidental ingestion seek medical advice immediately and show the package leaflet or the label to the physician.
Adverse reactions (frequency and seriousness)
Pale mucous membranes, increased intestinal peristalsis, lethargy, diarrhea have been observed very rarely after treatment. The treatment of dogs with a high number of circulating microfilariae can sometimes lead to the appearance of moderate and transitory hypersensitivity reactions, such as pale mucous membranes, vomiting, laboured breathing, or excessive salivation. These reactions are associated with the release of proteins from dead or dying microfilariae and are not a direct toxic effect of the product.
Use during pregnancy, lactation or lay
Can be used during pregnancy.
Can be used during lactation.
Interaction with other medicinal products and other forms of interaction
During treatment with PROGRAM Plus, no other antiparasitic macrocyclic lactones should be administered.
Amounts to be administered and administration route
PROGRAM Plus tablets, available in four sizes, are given according to the weight of the dog, consistent with the administration of a minimum dose of 0.5 mg milbemycin oxime and 10 mg lufenuron per kg body weight.
PROGRAM Plus should be administered in the following situations:
To prevent flea infestations with concurrent heartworm prevention and/or gastrointestinal nematode infection treatment should start from 2 weeks of age, or from a minimum weight of 1 kg.
Dogs in a non-heartworm region:
Program Plus can be used as part of the seasonal prevention of fleas replacing lufenuron mono (PROGRAM tablets) in cases with diagnosed concurrent gastrointestinal nematode infection. After elimination of the nematode infection confirmed by faecal examination, prevention of fleas should continue with PROGRAM tablets if indicated.
In puppies, treatment with Program Plus is recommended up to one month after weaning. Thereafter, prevention of fleas can be continued with lufenuron mono (Program).
Dogs travelling to a heartworm region:
To prevent flea infestations with concurrent heartworm prevention, dogs travelling to a heartworm risk region should begin medication within one month after arrival. Treatment should continue monthly, with the last administration given after the dog has left the region.
Dogs in a heartworm region:
To prevent flea infestations and to prevent heartworm, medication should begin within one month after the appearance of mosquitoes, or one month before the appearance of fleas, and continue throughout the risk period with the last dose given within one month after the mosquito and flea season finishes.
If dogs have a high level of flea infestation at the start of treatment, it may be necessary to apply a flea adulticide during the first one to two months. It is important to treat all dogs and cats in the household for fleas. Cats in the same household should be treated with PROGRAM oral or injectable suspension.
Overdose (symptoms, emergency procedures, antidotes), if necessary
At 10x recommended dose rate (i.e. 5 mg milbemycin oxime, 100 mg lufenuron per kg) and higher dose rates clinical signs such as transient ataxia, trembling, depression, salivation, and mydriasis may be observed. There is no specific antidote.
Pharmacotherapeutic group: Milbemycin oxime Anthelmintic, Lufenuron Insect Growth Regulator
ATC Vet Code: QP54AB51
Milbemycin belongs to the group of macrocyclic lactones, isolated from the fermentation of Streptomyces hygroscopicus var. aureolacrimosus. Out of the selected analogues, the one currently used for medicinal purposes is Milbemycin A3/A4 oxime (ratio ≤20 : ≥80). As one of the active
principles in Program Plus, it is effective against larval stages (L3, L4, and the microfilariae) of Dirofilaria immitis, and anthelmintic activity against the following nematodes: Toxocara canis, Trichuris vulpis, Ancylostoma caninum. The activity of milbemycin is correlated with its action on invertebrate neurotransmission: it potentiates GABA (gamma-amino-butyric acid), an inhibitor of neuromuscular transmission, leading to paralysis.
Lufenuron belongs to the chemical group of benzoylureas, and is considered an IGR (Insect Growth Regulator) or IDI (Insect Development Inhibitor). It inhibits the development of fleas by interfering with the normal synthesis, polymerisation and deposition of the chitin, the principal component of the
arthropod exoskeleton. The adult flea absorbs lufenuron via its bloodmeal. At therapeutic levels, lufenuron has no effect upon adult fleas, but passes transovarially to act upon certain stages of the development of the insect (egg and larva), thus interrupting the insect life cycle. Also, adult flea faeces containing lufenuron exert a larvicidal effect when ingested by the larvae directly.
Milbemycin oxime is characterised by gastro-enteric absorption. It reaches peak plasma concentrations of about 200 - 300 ng/mL within about 2 to 5 hours after oral administration at recommended dose. Thereafter, milbemycin oxime concentrations decrease in plasma with a half life of about 1 to 3 days.
Following oral administration, lufenuron is distributed via the blood to the adipose tissue, from which, metabolically unmodified, it is constantly released above the minimum effective concentration for at least one month.
List of excipients
Titanium dioxide (E171)
Pregelatinised maize starch
Shelf-life of the veterinary medicinal product as packaged for sale: 5 years.
Special precautions for storage
Do not store above 25°C
Keep the blister strips in the outer carton.
Nature and composition of immediate packaging
Carton containers, each containing 6 or 8 pentagonal tablets in PVDC/PVC blisters, thermosealed with aluminium foil, boxed in a free-opening, labelled carton.
Not all pack sizes may be marketed.
Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.
19 October 2000
Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.
For UK delivery, we charge the following:
Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.
For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.
We can deliver most items to all around the world, but prices do vary. The majority of light weight orders (less than 1.5kg) can be delivered for a flat rate of £10. For an accurate estimate of the delivery charge, please put the items you require in your basket and use the "Estimate Delivery" system on the shopping basket page (you only need to enter your country and postal/zip code) for a quick quote. For deliveries to the USA you may need to go to the checkout page and enter your full address to get a quote (as some services need your state in order to quote too). For more information on international deliveries, please see our delivery information page.
Due to restrictions aerosols can't be sent by Royal Mail. We appreciate your understanding.
Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.
Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.
To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.
*For full details on returns, see our terms and conditions page.
Below are some recent questions we've received regarding Program Plus Tablets for Dogs, including answers from our team.
Does this all in one tablet include treatment and prevention of ticks please?
Ticks are one of the most difficult parasites to control and this product has no activity against them at all. It works very well for fleas and for worms living in the gut, which are the main parasites able to affect most dogs. If ticks are a concern in your area, then a topical treatment is needed for them, usually applied in the form of a spot-on. (Frontline Spot-on is the classic example. It is also effective against fleas, but not against any worms.)