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Program Plus Tablets for Dogs

Program Plus Tablets for Dogs
Large Dogs 23-45kg » Pack of 6

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  • Large Dogs 23-45kg » Pack of 6 £46.49
  • Medium Dogs 12-22kg » Pack of 6 £43.49
  • Small Dogs 5-11kg » Pack of 6 £41.99
  • Tiny Dogs 1-4.5kg » Pack of 6 £44.50

Selection of 4 products from

£41.99 to £46.49

Description

Program Plus is a unique product which controls fleas and worms from one tablet. Different size tablets are available and are used according to the bodyweight of the dog to be treated. In areas where heartworm is found, or for dogs travelling to Euprope on the Pet Travel Scheme, monthly dosing will control heartworm too. The tablet has to be given with or just after food, for full absorption to occur. Puppies weighing over 1kg can be dosed from 2 weeks of age. Program Plus is believed to be safe to use on pregnant and lactating bitches, though treatment with any drug is best avoided during early pregnancy if possible.

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All prices include VAT where applicable.

Medication Datasheets

Medium Dogs 12-22kg » Pack of 6

PROGRAM Plus film-coated tablets 11.5mg/230 mg

Qualitative and quantitative composition

Each tablet contains:

Active substances

Milbemycin oxime 11.5 mg

Lufenuron 230.0 mg

Excipient:

Titanium dioxide (E171) 3.7 mg

Pharmaceutical form

Film-coated tablets

White, pentagonal, biconvex, bevel-edged, coated tablets with “GLG” on one side and “CGV” on the reverse.

Clinical particulars

Target species

Dogs

Indications for use, specifying the target species

PROGRAM Plus is used for the prevention of fleas (Ct. felis, Ct. canis, preadult stages), and for the concurrent prevention of heartworm (elimination of L3/L4 larval stages of Dirofilaria immitis) and/or treatment of adult stages of gastrointestinal nematodes such as hookworms (Ancylostoma caninum),

roundworms (Toxocara canis) and whipworms (Trichuris vulpis).

Contraindications

Do not use in case of hypersensitivity to the active substance, to the adjuvants or to any of the excipients.

Special warnings

Ideally, tablets are administered on the same day each month. If an interval is greater than 6 weeks, treatment should be resumed immediately and be continued at monthly intervals and, in case of heartworm prevention, a veterinarian should be consulted.

Special precautions for use

i)Special precautions for use in animals

In heartworm risk regions, or in case it is known that a dog has been travelling to and from heartworm risk regions, before commencing PROGRAM Plus treatment as with any other heartworm preventive,

a veterinary consultation is advised to exclude the presence of any concurrent infestation of Dirofilaria immitis. In the case of a positive diagnosis, adulticidal therapy is indicated before administering PROGRAM Plus.

ii)Special precautions to be taken by the person administering the veterinary medicinal product to animals

None.

In the case of accidental ingestion seek medical advice immediately and show the package leaflet or the label to the physician.

Adverse reactions (frequency and seriousness)

Pale mucous membranes, increased intestinal peristalsis, lethargy, diarrhea have been observed very rarely after treatment. The treatment of dogs with a high number of circulating microfilariae can sometimes lead to the appearance of moderate and transitory hypersensitivity reactions, such as pale mucous membranes, vomiting, laboured breathing, or excessive salivation. These reactions are associated with the release of proteins from dead or dying microfilariae and are not a direct toxic effect of the product.

Use during pregnancy, lactation or lay

Pregnancy:

Can be used during pregnancy.

Lactation:

Can be used during lactation.

Interaction with other medicinal products and other forms of interaction

During treatment with PROGRAM Plus, no other antiparasitic macrocyclic lactones should be administered.

Amounts to be administered and administration route

PROGRAM Plus tablets, available in four sizes, are given according to the weight of the dog, consistent with the administration of a minimum dose of 0.5 mg milbemycin oxime and 10 mg lufenuron per kg body weight.

PROGRAM Plus should be administered in the following situations:

Puppies:

To prevent flea infestations with concurrent heartworm prevention and/or gastrointestinal nematode infection treatment should start from 2 weeks of age, or from a minimum weight of 1 kg.

Dogs in a non-heartworm region:

Program Plus can be used as part of the seasonal prevention of fleas replacing lufenuron mono (PROGRAM tablets) in cases with diagnosed concurrent gastrointestinal nematode infection. After elimination of the nematode infection confirmed by faecal examination, prevention of fleas should continue with PROGRAM tablets if indicated.

In puppies, treatment with Program Plus is recommended up to one month after weaning. Thereafter, prevention of fleas can be continued with lufenuron mono (Program).

Dogs travelling to a heartworm region:

To prevent flea infestations with concurrent heartworm prevention, dogs travelling to a heartworm risk region should begin medication within one month after arrival. Treatment should continue monthly, with the last administration given after the dog has left the region.

Dogs in a heartworm region:

To prevent flea infestations and to prevent heartworm, medication should begin within one month after the appearance of mosquitoes, or one month before the appearance of fleas, and continue throughout the risk period with the last dose given within one month after the mosquito and flea season finishes.

If dogs have a high level of flea infestation at the start of treatment, it may be necessary to apply a flea adulticide during the first one to two months. It is important to treat all dogs and cats in the household for fleas. Cats in the same household should be treated with PROGRAM oral or injectable suspension.

Overdose (symptoms, emergency procedures, antidotes), if necessary

At 10x recommended dose rate (i.e. 5 mg milbemycin oxime, 100 mg lufenuron per kg) and higher dose rates clinical signs such as transient ataxia, trembling, depression, salivation, and mydriasis may be observed. There is no specific antidote.

Withdrawal period(s)

Not applicable.

Pharmacological particulars

Pharmacotherapeutic group: Milbemycin oxime Anthelmintic, Lufenuron Insect Growth Regulator

ATC Vet Code: QP54AB51

Pharmacodynamic properties

Milbemycin belongs to the group of macrocyclic lactones, isolated from the fermentation of Streptomyces hygroscopicus var. aureolacrimosus. Out of the selected analogues, the one currently used for medicinal purposes is Milbemycin A3/A4 oxime (ratio ≤20 : ≥80). As one of the active

principles in Program Plus, it is effective against larval stages (L3, L4, and the microfilariae) of Dirofilaria immitis, and anthelmintic activity against the following nematodes: Toxocara canis, Trichuris vulpis, Ancylostoma caninum. The activity of milbemycin is correlated with its action on invertebrate neurotransmission: it potentiates GABA (gamma-amino-butyric acid), an inhibitor of neuromuscular transmission, leading to paralysis.

Lufenuron belongs to the chemical group of benzoylureas, and is considered an IGR (Insect Growth Regulator) or IDI (Insect Development Inhibitor). It inhibits the development of fleas by interfering with the normal synthesis, polymerisation and deposition of the chitin, the principal component of the

arthropod exoskeleton. The adult flea absorbs lufenuron via its bloodmeal. At therapeutic levels, lufenuron has no effect upon adult fleas, but passes transovarially to act upon certain stages of the development of the insect (egg and larva), thus interrupting the insect life cycle. Also, adult flea faeces containing lufenuron exert a larvicidal effect when ingested by the larvae directly.

Pharmacokinetic particulars

Milbemycin oxime is characterised by gastro-enteric absorption. It reaches peak plasma concentrations of about 200 - 300 ng/mL within about 2 to 5 hours after oral administration at recommended dose. Thereafter, milbemycin oxime concentrations decrease in plasma with a half life of about 1 to 3 days.

Following oral administration, lufenuron is distributed via the blood to the adipose tissue, from which, metabolically unmodified, it is constantly released above the minimum effective concentration for at least one month.

Pharmaceutical particulars

List of excipients

Titanium dioxide (E171)

Macrogol 8000

Cellulose, microcrystalline

Lactose monohydrate

Pregelatinised maize starch

Croscarmellose sodium

Hypromellose

Talc

Magnesium stearate

Incompatibilities

None known.

Shelf life

Shelf-life of the veterinary medicinal product as packaged for sale: 5 years.

Special precautions for storage

Do not store above 25°C

Keep the blister strips in the outer carton.

Nature and composition of immediate packaging

Carton containers, each containing 6 or 8 pentagonal tablets in PVDC/PVC blisters, thermosealed with aluminium foil, boxed in a free-opening, labelled carton.

Not all pack sizes may be marketed.

Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.

Marketing Authorisation Holder (if different from distributor)

NA

Marketing Authorisation Number

Vm 00879/4028

Date of the first authorisation or date of renewal

19 October 2000

Date of revision of the text

January 2016

Any other information

Legal category

Large Dogs 23-45kg » Pack of 6

PROGRAM Plus film-coated tablets 23mg/460 mg

Qualitative and quantitative composition

Each tablet contains:

Active substances

Milbemycin oxime 23.0 mg

Lufenuron 460.0 mg

Excipient:

Titanium dioxide (E171) 7.5 mg

Pharmaceutical form

Film-coated tablets

White, pentagonal, biconvex, bevel-edged, coated tablets with “GKG” on one side and “CGV” on the reverse.

Clinical particulars

Target species

Dogs

Indications for use, specifying the target species

PROGRAM Plus is used for the prevention of fleas (Ct. felis, Ct. canis, preadult stages), and for the concurrent prevention of heartworm (elimination of L3/L4 larval stages of Dirofilaria immitis) and/or treatment of adult stages of gastrointestinal nematodes such as hookworms (Ancylostoma caninum), roundworms (Toxocara canis) and whipworms (Trichuris vulpis).

Contraindications

Do not use in case of hypersensitivity to the active substance, to the adjuvants or to any of the excipients.

Special warnings

Ideally, tablets are administered on the same day each month. If an interval is greater than 6 weeks, treatment should be resumed immediately and be continued at monthly intervals and, in case of heartworm prevention, a veterinarian should be consulted.

Special precautions for use

i)Special precautions for use in animals

In heartworm risk regions, or in case it is known that a dog has been travelling to and from heartworm risk regions, before commencing PROGRAM Plus treatment as with any other heartworm preventive, a veterinary consultation is advised to exclude the presence of any concurrent infestation of Dirofilaria immitis. In the case of a positive diagnosis, adulticidal therapy is indicated before administering PROGRAM Plus.

ii)Special precautions to be taken by the person administering the veterinary medicinal product to animals

None.

In the case of accidental ingestion seek medical advice immediately and show the package leaflet or the label to the physician.

Adverse reactions (frequency and seriousness)

Pale mucous membranes, increased intestinal peristalsis, lethargy, diarrhea have been observed very rarely after treatment. The treatment of dogs with a high number of circulating microfilariae can sometimes lead to the appearance of moderate and transitory hypersensitivity reactions, such as pale

mucous membranes, vomiting, laboured breathing, or excessive salivation. These reactions are associated with the release of proteins from dead or dying microfilariae and are not a direct toxic effect of the product.

Use during pregnancy, lactation or lay

Pregnancy:

Can be used during pregnancy.

Lactation:

Can be used during lactation.

Interaction with other medicinal products and other forms of interaction

During treatment with PROGRAM Plus, no other antiparasitic macrocyclic lactones should be administered.

Amounts to be administered and administration route

PROGRAM Plus tablets, available in four sizes, are given according to the weight of the dog, consistent with the administration of a minimum dose of 0.5 mg milbemycin oxime and 10 mg lufenuron per kg body weight.

PROGRAM Plus should be administered in the following situations:

Puppies:

To prevent flea infestations with concurrent heartworm prevention and/or gastrointestinal nematode infection treatment should start from 2 weeks of age, or from a minimum weight of 1 kg.

Dogs in a non-heartworm region:

Program Plus can be used as part of the seasonal prevention of fleas replacing lufenuron mono (PROGRAM tablets) in cases with diagnosed concurrent gastrointestinal nematode infection. After elimination of the nematode infection confirmed by faecal examination, prevention of fleas should continue with PROGRAM tablets if indicated.

In puppies, treatment with Program Plus is recommended up to one month after weaning. Thereafter, prevention of fleas can be continued with lufenuron mono (Program).

Dogs travelling to a heartworm region:

To prevent flea infestations with concurrent heartworm prevention, dogs travelling to a heartworm risk region should begin medication within one month after arrival. Treatment should continue monthly, with the last administration given after the dog has left the region.

Dogs in a heartworm region:

To prevent flea infestations and to prevent heartworm, medication should begin within one month after the appearance of mosquitoes, or one month before the appearance of fleas, and continue throughout the risk period with the last dose given within one month after the mosquito and flea season finishes.

If dogs have a high level of flea infestation at the start of treatment, it may be necessary to apply a flea adulticide during the first one to two months. It is important to treat all dogs and cats in the household for fleas. Cats in the same household should be treated with PROGRAM oral or injectable suspension.

Overdose (symptoms, emergency procedures, antidotes), if necessary

At 10x recommended dose rate (i.e. 5 mg milbemycin oxime, 100 mg lufenuron per kg) and higher dose rates clinical signs such as transient ataxia, trembling, depression, salivation, and mydriasis may be observed. There is no specific antidote.

Withdrawal period(s)

Not applicable.

Pharmacological particulars

Pharmacotherapeutic group: Milbemycin oxime Anthelmintic, Lufenuron Insect Growth Regulator

ATC Vet Code: QP54AB51

Pharmacodynamic properties

Milbemycin belongs to the group of macrocyclic lactones, isolated from the fermentation of Streptomyces hygroscopicus var. aureolacrimosus. Out of the selected analogues, the one currently used for medicinal purposes is Milbemycin A3/A4 oxime (ratio ≤20 : ≥80). As one of the active principles in Program Plus, it is effective against larval stages (L3, L4, and the microfilariae) of Dirofilaria immitis, and anthelmintic activity against the following nematodes: Toxocara canis, Trichuris vulpis, Ancylostoma caninum. The activity of milbemycin is correlated with its action on invertebrate neurotransmission: it potentiates GABA (gamma-amino-butyric acid), an inhibitor of neuromuscular transmission, leading to paralysis.

Lufenuron belongs to the chemical group of benzoylureas, and is considered an IGR (Insect Growth Regulator) or IDI (Insect Development Inhibitor). It inhibits the development of fleas by interfering with the normal synthesis, polymerisation and deposition of the chitin, the principal component of the

arthropod exoskeleton. The adult flea absorbs lufenuron via its bloodmeal. At therapeutic levels, lufenuron has no effect upon adult fleas, but passes transovarially to act upon certain stages of the development of the insect (egg and larva), thus interrupting the insect life cycle. Also, adult flea faeces containing lufenuron exert a larvicidal effect when ingested by the larvae directly.

Pharmacokinetic particulars

Milbemycin oxime is characterised by gastro-enteric absorption. It reaches peak plasma concentrations of about 200 - 300 ng/mL within about 2 to 5 hours after oral administration at recommended dose. Thereafter, milbemycin oxime concentrations decrease in plasma with a half life of about 1 to 3 days.

Following oral administration, lufenuron is distributed via the blood to the adipose tissue, from which, metabolically unmodified, it is constantly released above the minimum effective concentration for at least one month.

Pharmaceutical particulars

List of excipients

Titanium dioxide (E171)

Macrogol 8000

Cellulose, microcrystalline

Lactose monohydrate

Pregelatinised maize starch

Croscarmellose sodium

Hypromellose

Talc

Magnesium stearate

Incompatibilities

None known.

Shelf life

Shelf-life of the veterinary medicinal product as packaged for sale: 5 years.

Special precautions for storage

Do not store above 25°C

Keep the blister strips in the outer carton.

Nature and composition of immediate packaging

Carton containers, each containing 6 or 8 pentagonal tablets in PVDC/PVC blisters, thermosealed with aluminium foil, boxed in a free-opening, labelled carton.

Not all pack sizes may be marketed.

Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.

Marketing Authorisation Holder (if different from distributor)

Elanco Europe Ltd

Lilly House

Priestley Road

Basingstoke

Hampshire

RG24 9NL

Marketing Authorisation Number

Vm 00879/4030

Date of the first authorisation or date of renewal

19 November 2000

Date of revision of the text

January 2016

Any other information

Legal category

Delivery Information

How quickly do you deliver?

Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.

What do you charge for delivery?

For UK delivery, we charge the following:

Order Total Weight Delivery
£0-£28.99 Under 2kg £2.99
2kg+ £4.99
£29-£38.99 Under 2kg Free
2kg+ £4.99
£39+ Under 2kg Free
2kg+ Free

Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.

For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.

We can deliver most items to all around the world, but prices do vary. To find the exact cost of shipping your item, and to see all options available, follow these steps:

  1. Put the items you wish to order in your basket
  2. Proceed to checkout and enter your delivery address, including country
  3. Delivery information including price will automatically update to what is available to you

Delivery of aerosols

Due to restrictions aerosols can't be sent by Royal Mail. We appreciate your understanding.

Delivery of temperature controlled items

Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.

How do I cancel or return an order?

Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.

To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.

*For full details on returns, see our terms and conditions page.

Reviews (4)

Q & A

Below are some recent questions we've received regarding Program Plus Tablets for Dogs, including answers from our team.

15 October 2013 at 9:22pm

Ticks as wel?

Nicky Harvey

Does this all in one tablet include treatment and prevention of ticks please?

Thanks

  • Non-Executive Director

Ticks are one of the most difficult parasites to control and this product has no activity against them at all. It works very well for fleas and for worms living in the gut, which are the main parasites able to affect most dogs. If ticks are a concern in your area, then a topical treatment is needed for them, usually applied in the form of a spot-on. (Frontline Spot-on is the classic example. It is also effective against fleas, but not against any worms.)