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Program Plus is a unique product which controls fleas and worms from one tablet. Different size tablets are available and are used according to the bodyweight of the dog to be treated. In areas where heartworm is found, or for dogs travelling to Euprope on the Pet Travel Scheme, monthly dosing will control heartworm too. The tablet has to be given with or just after food, for full absorption to occur. Puppies weighing over 1kg can be dosed from 2 weeks of age. Program Plus is believed to be safe to use on pregnant and lactating bitches, though treatment with any drug is best avoided during early pregnancy if possible.
Active ingredients: milbemycin oxime and lufenuron.
Film-coated tablets are available in 4 different sizes:
Red outer pack, tablets contain: 2.3mg milbemycin oxime and 46mg lufenuron
Green outer pack, tablets contain: 5.75mg milbemycin oxime and 115mg lufenuron
Yellow outer pack, tablets contain: 11.5mg milbemycin oxime and 230mg lufenuron
White outer pack, tablets contain: 23mg milbemycin oxime and 460mg lufenuron
PROGRAM PLUS tablets are indicated for the prevention of fleas (Ct. felis, Ct. canis, preadult stages), and for the concurrent prevention of heartworm disease (elimination of 3rd and 4th larval stages of Dirofilaria immitis) and/or treatment of adult stages of gastrointestinal nematodes such as hookworms (Ancylostoma caninum), roundworms (Toxocara canis) and whipworms (Trichuris vulpis) in dogs.
PROGRAM PLUS tablets are administered at a minimum dose of 0.5 mg milbemycin oxime and 10 mg lufenuron per kg body weight.
PROGRAM PLUS tablets are available in four sizes and are given according to the weight of the dog.
Colour code of outer pack
up to 4.5 kg
from 5 to 11 kg
from 12 to 22 kg
from 23 to 45 kg
For dogs greater than 45 kg, a combination of tablets is given, consistent with the recommended minimum dose.
PROGRAM PLUS tablets should be administered in the following situations:
To prevent flea infestations with concurrent heartworm prevention and/or gastrointestinal nematode infection medication should start from 2 weeks of age, or from a minimum weight of 1 kg.
PROGRAM PLUS can be used as part of the seasonal prevention of fleas replacing lufenuron mono (PROGRAM tablets) in cases with diagnosed concurrent gastrointestinal nematode infection. After elimination of the nematode infection confirmed by faecal examination, prevention of fleas should continue with PROGRAM tablets if indicated.
In puppies, medication with PROGRAM PLUS is recommended up to one month after weaning. Thereafter, prevention of fleas can be continued with lufenuron mono (PROGRAM).
To prevent flea infestations and heartworm disease at the same time, dogs travelling to a heartworm risk region should begin medication within one month after arrival. Treatment should continue monthly, with the last administration given after the dog has left the region.
Dogs in a heartworm region:To prevent flea infestations and heartworm disease at the same time, medication should begin within one month after the appearance of mosquitoes, or one month before the appearance of fleas, and continue throughout the risk period with the last dose given within one month after the mosquito and flea season finishes.
If dogs have a high level of flea infestation at the start of treatment, it may be necessary to apply a flea adulticide during the first one to two months. It is important to treat all dogs and cats in the household for fleas. Cats in the same household should be treated with PROGRAM oral or injectable suspension.
To ensure adequate drug absorption, PROGRAM PLUS tablets must be administered with food (for example mixed with the daily feed) or placed directly in the mouth after feeding.
Treatment with PROGRAM PLUS tablets may begin at any time of the year. In geographic areas where the presence of fleas and mosquitoes (heartworm vector) is seasonal, depending on ambient temperature, treatment should be started one month prior to the appearance of the insects and then repeated monthly throughout the risk period. In environments with year-round flea infestations and concurrent heartworm risk, treatment may be continued throughout the year without interruption.
Ideally, tablets are administered on the same day each month. If an interval is greater than 6 weeks, treatment should be resumed immediately and be continued at monthly intervals and, in case of heartworm prevention, a veterinarian should be consulted.
PROGRAM PLUS tablets immediately block the reproductive cycle of fleas by inhibiting the development of eggs and larvae. Pre-existing generations (e.g. pupae) present in the environment can, however, continue to develop and emerge for several weeks after the start of treatment.
In heartworm risk regions, or if it is known that a dog has been travelling to and from heartworm risk regions, before commencing PROGRAM PLUS treatment as with any other heartworm preventive, a veterinary consultation is advised to exclude the presence of any concurrent infestation of Dirofilaria immitis. In the case of a positive diagnosis, adulticidal therapy is indicated before administering PROGRAM PLUS.
Pale mucous membranes and increased intestinal peristalsis have been observed in some dogs after treatment. The treatment of dogs with a high number of circulating microfilariae can sometimes lead to the appearance of moderate and transitory hypersensitivity reactions, such as pale mucous membranes, vomiting, laboured breathing, or excessive salivation. These reactions are associated with the release of proteins from dead or dying microfilariae and are not a direct toxic effect of the product.
If you notice any other side effects, please inform your veterinary surgeon.
For animal treatment only.
Special Precautions for the Disposal of Unused Veterinary Medicinal Product or Waste Materials Derived from such Veterinary Medicinal Products.
Any unused PROGRAM PLUS tablets or waste materials derived from them should be disposed of in accordance with local requirements.
Keep out of the reach and sight of children.
Do not store above 25°C.
Keep the blister strips in the outer carton.
Plastic blister packs each containing 6 tablets.
Milbemycin oxime, which belongs to the group of macrocyclic lactones, is active against mites, against larval and adult stages of nematodes as well as against larvae of Dirofilaria immitis.
Novartis Animal Health S.p.A
Largo U Boccioni 1
21040 Origgio (Varese)
Milbemycin oxime/lufenuron 2.3 mg/46 mg
Milbemycin oxime/lufenuron 5.75 mg/115 mg
Milbemycin oxime/lufenuron 11.5 mg/230 mg
Milbemycin oxime/lufenuron 23 mg/460 mg
All prices include VAT where applicable.
Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.
For UK delivery, we charge the following:
Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.
For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.
We can deliver most items to all around the world, but prices do vary. The majority of light weight orders (less than 1.5kg) can be delivered for a flat rate of £10. For an accurate estimate of the delivery charge, please put the items you require in your basket and use the "Estimate Delivery" system on the shopping basket page (you only need to enter your country and postal/zip code) for a quick quote. For deliveries to the USA you may need to go to the checkout page and enter your full address to get a quote (as some services need your state in order to quote too). For more information on international deliveries, please see our delivery information page.
Due to air freight restrictions aerosols cannot ever be sent abroad by Royal Mail. We appreciate your understanding.
Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.
Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.
To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.
*For full details on returns, see our terms and conditions page.
Below are some recent questions we've received regarding Program Plus Tablets for Dogs, including answers from our team.
Does this all in one tablet include treatment and prevention of ticks please?
Ticks are one of the most difficult parasites to control and this product has no activity against them at all. It works very well for fleas and for worms living in the gut, which are the main parasites able to affect most dogs. If ticks are a concern in your area, then a topical treatment is needed for them, usually applied in the form of a spot-on. (Frontline Spot-on is the classic example. It is also effective against fleas, but not against any worms.)