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Phenoleptil Tablets for Dogs

Phenoleptil Tablets for Dogs

  • 12.5mg » Priced per Tablet £0.09
  • 50mg » Priced per Tablet £0.19

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£0.09 to £0.19


Phenoleptil Tablets are used in dogs to control epileptic fits (seizures). They need to be given twice daily. Finding the correct dose to use involves monitoring for further fits, any undesirable side effects and the performance of blood tests. Most dogs will require treatment for the rest of their lives. Periodic blood tests to monitor for signs of liver trouble are recommended.

Below is the product datasheet. This has been provided by the manufacturer and should always be provided with the medication.


Company name: Animalcare Limited
Address: Common Road
York YO19 5RU
Telephone: 01904 487687
Fax: 01904 487611
Email: [email protected]


White to off white biconvex tablets with brown speckles and a score line on one side. Each tablet contains 12.5 mg or 50 mg phenobarbital. 50mg tablets can be divided into equal halves.


Prevention of seizures due to generalised epilepsy in dogs.

Dosage and administration

For oral administration. The recommended initial dosage is 2.5 mg phenobarbital per kg body weight twice daily. Tablets must be given at the same time each day to achieve successful therapy. Eventual adjustments of this dosage should be made on the basis of clinical efficacy, blood levels and the occurrence of undesirable side effects.
The serum phenobarbital concentrations should be measured after steady state has been achieved. The ideal therapeutic range for serum phenobarbital concentration is between 15 and 40 g/ml. If serum phenobarbital concentration is less than 15 g/ml or the seizures are not controlled the dose may be increased by 20% at a time, with associated monitoring of serum phenobarbital levels up to a maximum serum concentration 45 g/ml. The ultimate doses may vary considerably (ranging from 1 mg to 15 mg per kg body weight twice daily) because of the differences in phenobarbital excretion and differences in sensitivity among patients.
If the seizures are not being satisfactorily controlled and if the maximum level concentration is about 40g/ml, then the diagnosis should be reconsidered and/or a second antiepileptic product (such as bromides) should be added to the treatment protocol.
In stabilised epileptic patients, it is not recommended to switch from other phenobarbital formulations to Phenoleptil 12.5 mg or 50 mg Tablets. However, if this can not be avoided then additional caution should be taken. It is recommended to try to achieve as similar dosages as possible compared with the previous formulation used taking into consideration current plasma concentration measurements. Stabilisation protocols as for initiating treatments should be followed. See special warnings.
For accuracy of dosing, dogs under 10 kg should commence therapy with Phenoleptil 12.5 mg Tablets.

Contra-indications, warnings, etc

Do not use in case of hypersensivity to the active substance. Do not use in animals with serious impaired hepatic function. Do not use in animals with serious renal or cardiovascular disorders. Do not use in dogs weighing less than 5 kg body weight.
Adverse reactions:. During start of therapy ataxia, sleepiness, slackness and dizziness can occur but these effects are usually transitory and disappear in most, but not all, patients with continued medication. Some animals can demonstrate a paradoxical hyperexcitability, particularly after first starting therapy. As this hyperexcitability is not linked to overdosage, no reduction of dosage is needed. Polyuria, polydipsia and polyphagia can occur at average or higher therapeutic active serum concentrations; these effects can be diminished by limiting intake of both food and water. Sedation and ataxia often become significant concerns as serum levels reach the higher ends of the therapeutic range. High plasma concentrations may be associated with hepatotoxicity.
Phenobarbital can have deleterious effects on stem cells from bone marrow. Consequences are immunotoxic pancytopenia and/or neutropenia. These reactions disappear after the treatments withdrawal. Treating dogs with phenobarbital may lower their TT4 or FT4 serum levels, however this may not be an indication of hypothyroidism. Treatment with thyroid hormone replacement should only be started if there are clinical signs of the disease. If adverse effects are severe, decrease in the administered dose should be recommended. If you notice any serious effects or any other effects not mentioned in this leaflet, please inform your veterinary surgeon.
Special precautions for use in animals: The decision to start antiepileptic drug therapy with phenobarbital should be evaluated for each individual case and depends on number, frequency, duration and severity of seizures in dogs. General recommendations for initiating therapy include a single seizure occurring more than once every 4-6 weeks, cluster seizure activity (i.e. more than one seizure within 24 h) or status epilepticus regardless of frequency. To achieve successful therapy, administration of tablets must be at the same time each day. Withdrawal or transition from other types of antiepileptic therapy should be made gradually to avoid precipitating an increase in the frequency of seizures. Some dogs are free of epileptic seizures during the treatment, some show only a seizure reduction, and some are considered to be non-responders. Doses for smaller dogs can not be adjusted in accordance with the 20% regimen, and therefore special care should be taken in monitoring these animals. 12.5mg tablets should not be divided.
Caution is recommended in animals with impaired hepatic and renal function, hypovolemia, anemia and cardiac or respiratory dysfunction. The chance of hepatotoxic side effects can be diminished or delayed using an effective dose that is as low as possible. Monitoring of hepatic parameters is recommended in case of a prolonged therapy. It is recommended to assess the clinical pathology of the patient 2-3 weeks after start of treatment and afterwards every 4-6 months, e.g. measurement of hepatic enzymes and serum bile acids. It is important to know that the effects of hypoxia etc. do cause increased levels of hepatic enzymes after a seizure. Phenobarbital may increase the activity of serum alkaline phosphatase and transaminases. These may demonstrate non-pathological changes, but could also represent hepatotoxicity. Therefore, in the case of suspected hepatotoxicity, liver function tests are recommended. Increased liver enzyme values do not require a dose reduction of Phenobarbital if the serum bile acids are in the normal range. Monitoring of hepatic parameters is recommended in case of a prolonged therapy, because of phenobarbitals hepatotoxicity. In stabilised epileptic patients, it is not recommended to switch from other phenobarbital formulations to Phenoleptil 12.5 mg or 50 mg Tablets. However, if this can not be avoided then additional caution should be taken. This includes more frequent plasma concentration sampling to ensure that therapeutic levels are maintained. Monitoring for increased side effects and for hepatic dysfunction should be conducted more regularly until stabilisation is confirmed.
Withdrawal of therapy with Phenobarbital formulations should be made gradually to avoid precipitating an increase in the frequency of seizures.
Use during pregnancy or lactation: Phenobarbital crosses the placental barrier and at higher doses (reversible) withdrawal symptoms in newborns cannot be excluded. Studies in laboratory animals have shown evidence of action of phenobarbital on prenatal growth, especially concerning sexual development. Neonatal bleeding tendencies have been associated with phenobarbital treatment during pregnancy. Administration of Vitamin K to the dam for 10 days before parturition may help to minimize these effects on the fetus.
The safety of the veterinary medicinal product has not been established during pregnancy of dogs. The benefits of treatment may be greater than the potential risks associated with epileptic seizures on the fetus (hypoxia and acidosis). Therefore, in case of pregnancy, termination of antiepileptic treatment is not recommended; however, the dose should be as low as possible. Phenobarbital is excreted in small amounts in breast milk and during nursing pups should be monitored carefully for undesired sedative effects. Weaning early may be an option. If somnolence/sedative effects (that could interfere with suckling) appear in nursing newborns, an artificial suckling method should be chosen. Use during pregnancy and lactation only according to the benefit/risk assessment by the responsible veterinarian.
Overdose: Symptoms of overdose are: depression of the central nervous system demonstrated by signs ranging from sleep to coma, respiratory problems, cardiovascular problems, hypotension and shock leading to renal failure and death. In case of overdose remove ingested product from the stomach, for example by lavage. Activated charcoal may be given. Offer respiratory support. There is no specific antidote, but CNS stimulants (like Doxapram) may stimulate the respiratory centre. Give oxygen support.
User warnings: People with known hypersensitivity to barbiturates should avoid contact with the veterinary medicinal product. Wash hands after use. In case of accidental ingestion seek medical advice immediately and show the package leaflet or the label to the doctor.

Pharmaceutical precautions

Keep out of the reach and sight of children. Keep the container in the outer package in order to protect from light. Do not use after expiry date stated on the blister label and the carton. Any divided 50mg tablet portions remaining after 24 hours should be discarded. Divided tablets should be stored in the blister pack.
Disposal: Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Legal category

POM-V CD(Sch 3)

Packaging Quantities

Aluminum/PVC strips with 10 tablets packed in cardboard boxes with 5, 10, 25, 50 or 100 strips. Not all pack sizes may be marketed.

Further information

The antiepileptic effects of phenobarbital are probably the result of at least two mechanisms, being decreased monosynaptic transmission, which presumably results in reduced neuronal excitability and an increase in the motor cortex's threshold for electrical stimulation.
About 45% of the plasma concentration is protein bound. Metabolism is by aromatic hydroxylation of the phenyl group in the para position (p-hydroxyphenobarbital), and about 25% of the drug is excreted unchanged in the urine. Elimination half-lives vary considerably between individuals and range from about 40-90 hours.
A therapeutic dose of phenobarbital for antiepileptic therapy can significantly induce plasma protein (such as 1acid glycoprotein, AGP), which bind drugs. Therefore special attention must be paid to the pharmacokinetics and doses of drugs simultaneously administered. The plasmatic concentration of cyclosporine, thyroid hormones and theophylline is decreased in the case of concurrent administration of phenobarbital. The effectiveness of these substances is diminished too. Cimetidine and ketoconazole are inhibitors of hepatic enzymes: concurrent use with phenobarbital can induce an increase of serum concentration of phenobarbital. Concurrent use with potassium bromide increases the risk of pancreatitis. Concurrent use with other drugs having a central depressive action like narcotic analgesics, morphine derivates, phenothiazines, antihistamines, clomipramine and chloramphenicol can decrease the effect of phenobarbital. Phenobarbital may enhance the metabolism of, and therefore decrease the effect of, antiepileptics, chloramphenicol, corticosteroids, doxycycline, beta blockers and metronidazole. The reliability of oral contraceptives is lower. Phenobarbital may decrease the absorption of griseofulvin. The following drugs can decrease the convulsive threshold: quinolones, high doses of -lactam antibiotic, theophyllin, aminophyllin, cyclosporine and propofol for example). Medications which may alter the seizure threshold should only be used if really necessary and when no safer alternative exists.

Marketing authorisation number

Phenoleptil 12.5mg: Vm19994/4005
Phenoleptil 50mg: Vm19994/4006

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  • Landline: 01582 842096
  • Mon - Fri: 8:30am - 5:00pm
  • Sat: 9:00am - 1:00pm (Collections only)
  • Email: [email protected]

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Delivery Information

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Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.

What do you charge for delivery?

For UK delivery, we charge the following:

Order Total Weight Delivery
£0-£28.99 Under 2kg £2.99
2kg+ £4.99
£29-£38.99 Under 2kg Free
2kg+ £4.99
£39+ Under 2kg Free
2kg+ Free

Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.

For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.

We can deliver most items to all around the world, but prices do vary. The majority of light weight orders (less than 1.5kg) can be delivered for a flat rate of £10. For an accurate estimate of the delivery charge, please put the items you require in your basket and use the "Estimate Delivery" system on the shopping basket page (you only need to enter your country and postal/zip code) for a quick quote. For deliveries to the USA you may need to go to the checkout page and enter your full address to get a quote (as some services need your state in order to quote too). For more information on international deliveries, please see our delivery information page.

Delivery of aerosols

Due to restrictions aerosols can't be sent by Royal Mail. We appreciate your understanding.

Delivery of temperature controlled items

Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.

How do I cancel or return an order?

Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.

To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.

*For full details on returns, see our terms and conditions page.

Reviews (2)

Q & A

Below are some recent questions we've received regarding Phenoleptil Tablets for Dogs, including answers from our team.

17 December 2015 at 8:36pm


What if a dog has received one extra 12.5mg tablet by accident? Is this dangerous?

  • Non-Executive Director

This is very unlikely to be a problem at all, other than making your dog a little sleepy for a few hours. The only other thing to add is that a small percentage of dogs on this particular medication for a long time do go on to develop liver damage, which can be checked for on a blood test. If your dog has not been tested for a while, or ever, then this might be a sensible precaution if you are worried or your dog goes off its food or otherwise seems unwell.