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Pen & Strep Injection

Pen & Strep Injection

  • 100ml £16.99


A combination of Penicillin and Dihydrostreptomycin indicated in the treatment of conditions such as joint ill, enteritis and some forms of mastitis caused by bacteria sensitive to Penicillin and/or Streptomycin in cattle, horses, pigs and sheep.


1ml/25 kg bodyweight once daily by deep IM injection for up to 3 days.

Max dose at one site: cattle 6ml, sheep 3ml, pigs 1.5ml


Meat: cattle 23 days, sheep 31 days, pigs 18 days

Milk: cattle 60 hours.

Not for use in sheep producing milk for human consumption

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Medication Datasheets


Pen & Strep Suspension for Injection

Pen & Strep Suspension for Injection

Qualitative and quantitative composition

Active substance(s): Procaine Penicillin 200 mgDihydrostreptomycin Sulphate250 mgExcipients:The product also contains 1.5mg Hydroxybenzoate Esters (as Nipasept Sodium) as antimicrobial preservative and 1.25mg sodium formaldehyde sulphoxylate dihydrate as antioxidant.For a full list of excipients, see section Pharmaceutical Particulars

Active substance(s):

Procaine Penicillin

200 mg

Dihydrostreptomycin Sulphate

250 mg


The product also contains 1.5mg Hydroxybenzoate Esters (as Nipasept Sodium) as antimicrobial preservative and 1.25mg sodium formaldehyde sulphoxylate dihydrate as antioxidant.

For a full list of excipients, see section Pharmaceutical Particulars

Pharmaceutical form

Suspension for Injection.

A white to off-white aqueous suspension for injection.

Clinical particulars

Target species





Indications for use, specifying the target species

For the treatment of systemic infections in cattle, horses, sheep and pigs caused by or associated with organisms sensitive to penicillin and/or streptomycin including:

Arcanobacterium pyogenes

Erysipelothrix rhusiopathiae

Klebsiella pneumoniae

Listeria spp

Mannheimia haemolytica

Pasteurella multocida

Staphylococcus spp (non-penicillinase producing)

Streptococcus spp

Salmonella spp

and for the control of secondary bacterial infection with sensitive organisms in diseases primarily associated with viral infection.


Contraindicated in known cases of hypersensitivity to penicillins.

Special Warnings for Each Target Species

Use with care in animals known to have kidney disease or defective renal function.

Do not exceed the recommended dosage or duration of treatment.

Special Precautions for Use

Special precautions for use in animals:

Care should be taken not to exceed the recommended dosage. Aminoglycosides have a narrower margin of safety than beta lactam antibiotics.

Special precautions to be taken by the person administering the product to the animals:

Care should be taken to avoid accidental self-injection. In the case of accidental self-injection, seek medical advice immediately.

Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross-reactions to cephalosporins and vice versa. Allergic reaction to these substances may occasionally be serious.

Adverse reactions (frequency and seriousness)

Occasionally in sucking and fattening pigs, administration may cause a transient pyrexia, vomiting, shivering, listlessness and in-coordination.

A palpable but transient local reaction may occur at the site of intramuscularadministration in horses.

Use during pregnancy, lactation or lay

Pen & Strep can be safely administered to pregnant and lactating animals. However in pregnant sows and gilts a vulval discharge which could be associated with abortion has been reported.

Interactions with other medicinal products and other forms of interaction

Do not administer with other antibiotics such as tetracyclines or with other aminoglycosides.

Amount to be administered and administration route

Shake the vial before use.

Administer by deep intramuscular injection.

Recommended dosage rate is 8 mg/kg bodyweight procaine penicillin with 10 mg/kg bodyweight dihydrostreptomycin sulphate equivalent to 1 ml per 25 kg bodyweight. Treatment should be given once daily for up to 3 consecutive days. The maximum dose volume administered at one site should not exceed 15 ml for horses, 6 ml for cattle, 3 ml for sheep and 1.5 ml for pigs.

Overdose (symptoms, emergency procedures, antidotes) (if necessary)

No treatment specified.

Withdrawal periods

Animals must not be slaughtered for human consumption during treatment.


Not to be used in sheep producing milk for human consumption.

Sheep intended for human consumption should not be slaughtered until 31 days after the last treatment.


Milk for human consumption must not be taken during treatment.

Milk for human consumption may only be taken from cows after 60 hours from the last treatment.

Cattle intended for human consumption should not be slaughtered until 23 days after the last treatment.


Pigs intended for human consumption should not be slaughtered until 18 days after the last treatment.


Not to be used in horses intended for human consumption.

Treated horses may never be slaughtered for human consumption.

The horse must have been declared as not intended for human consumption under national horse passport legislation

Pharmacological particulars

Pharmacotherapeutic group: Antibacterials for intramammary use, Combination of antibacterials for intramammary use, Beta-lactam antibacterials, penicillins, combinations with other antibacterials

ATCvet Code: QJ51RC03

Pharmacodynamic properties

Penicillin G is a beta-lactam antibiotic and its structure contains the beta-lactam ring and thiazolidine ring common to all penicillins. Beta-lactam antibiotics prevent the bacterial cell wall of susceptible Gram-positive bacteria from forming by interfering with the final stage of peptidoglycan synthesis. They inhibit the activity of transpeptidase enzymes, which catalyse cross-linkage of the glycopeptide polymer units that form the cell wall. They exert a bactericidal action but cause lysis only of growing cells.

Dihydrostreptomycin is an aminoglycoside antibiotic active against gram-negative aerobes, which after penetration of the cell envelope binds to receptors on the 30S sub unit of the bacterial ribosome. It induces misreading of the genetic code on the messenger ribonucleic acid (mRNA) template, causing bacteriostasis. Aminoglycosides exert synergistic action in combination with beta-lactam antibiotics.

Pharmacokinetic properties

After injection of Pen & Strep, the procaine penicillin is rapidly absorbed from the site of injection, with maximum penicillin levels of between 1 and 2 µg/ml for horses, sheep and pigs and 0.5 µg/ml for cattle, being obtained within 2 hours of injection.

The penicillin elimination half-lives are approximately 2 hours for sheep and pigs, 5 hours for cattle and 11 hours for horses. Dihydrostreptomycin is absorbed at a similar rate, with maximum plasma levels of 23 µg/ml being obtained for cattle, sheep and pigs, and 15 µg/ml for horses. The elimination half-lives are approximately 2 hours for cattle, sheep and pigs and 4 hours for horses.

Pharmaceutical particulars

List of excipients

Hydroxybenzoate Esters (as Nipasept Sodium)

Sodium Formaldehyde Sulphoxylate Dihydrate

Povidone K12

Polysorbate 80

Sodium Citrate Dihydrate

Disodium Edetate Dihydrate


Citric Acid Anhydrous

Water for Injections


None known.


Shelf life of the veterinary medicinal product as packaged for sale:

Glass: 9 months, Plastic: 24 months

Shelf life after first opening the immediate packaging: 28 days.

Special precautions for storage

Glass: Do not store above 25°C.

Plastic: Store between 2 - 8°C

Protect from light.

Following withdrawal of the first dose, use the product within 28 days.

Discard unused material.

Nature and composition of immediate packaging

Clear type II multidose glass vials of 50 ml and 100 ml sealed with bromobutyl bungs and aluminium caps.

Clear polyethylene terephthalate plastic vials of 50 ml, 100 ml and 250 ml sealed with bromobutyl bungs and aluminium caps.

Not all pack sizes may be marketed.

Special precautions for the disposal of unused veterinary medicinal products or waste materials derived from the use of such products, if appropriate

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Marketing Authorisation Holder (if different from distributor)

Norbrook Laboratories Limited

Station Works

Camlough Road


Co. Down

BT35 6JP Northern Ireland

Marketing Authorisation Number

Vm 02000/4100

Date of the first authorisation or date of renewal

12th March 1991

Date of revision of the text

January 2012

Any other information


Legal category

Delivery Information

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Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.

What do you charge for delivery?

For UK delivery, we charge the following:

Order Total Weight Delivery
£0-£28.99 Under 2kg £2.99
2kg+ £4.99
£29-£38.99 Under 2kg Free
2kg+ £4.99
£39+ Under 2kg Free
2kg+ Free

Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.

For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.

We can deliver most items to all around the world, but prices do vary. The majority of light weight orders (less than 1.5kg) can be delivered for a flat rate of £10. For an accurate estimate of the delivery charge, please put the items you require in your basket and use the "Estimate Delivery" system on the shopping basket page (you only need to enter your country and postal/zip code) for a quick quote. For deliveries to the USA you may need to go to the checkout page and enter your full address to get a quote (as some services need your state in order to quote too). For more information on international deliveries, please see our delivery information page.

Delivery of aerosols

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Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.

How do I cancel or return an order?

Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.

To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.

*For full details on returns, see our terms and conditions page.


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