Estimated dispatch within 2 working days.
A combination of Penicillin and Dihydrostreptomycin indicated in the treatment of conditions such as joint ill, enteritis and some forms of mastitis caused by bacteria sensitive to Penicillin and/or Streptomycin in cattle, horses, pigs and sheep.
1ml/25 kg bodyweight once daily by deep IM injection for up to 3 days.
Max dose at one site: cattle 6ml, sheep 3ml, pigs 1.5ml
Meat: cattle 23 days, sheep 31 days, pigs 18 days
Milk: cattle 60 hours.
Not for use in sheep producing milk for human consumption
All prices include VAT where applicable.
Active substance(s): Procaine Penicillin 200 mgDihydrostreptomycin Sulphate250 mgExcipients:The product also contains 1.5mg Hydroxybenzoate Esters (as Nipasept Sodium) as antimicrobial preservative and 1.25mg sodium formaldehyde sulphoxylate dihydrate as antioxidant.For a full list of excipients, see section Pharmaceutical Particulars
The product also contains 1.5mg Hydroxybenzoate Esters (as Nipasept Sodium) as antimicrobial preservative and 1.25mg sodium formaldehyde sulphoxylate dihydrate as antioxidant.
For a full list of excipients, see section Pharmaceutical Particulars
Suspension for Injection.
A white to off-white aqueous suspension for injection.
For the treatment of systemic infections in cattle, horses, sheep and pigs caused by or associated with organisms sensitive to penicillin and/or streptomycin including:
Staphylococcus spp (non-penicillinase producing)
and for the control of secondary bacterial infection with sensitive organisms in diseases primarily associated with viral infection.
Contraindicated in known cases of hypersensitivity to penicillins.
Use with care in animals known to have kidney disease or defective renal function.
Do not exceed the recommended dosage or duration of treatment.
Special precautions for use in animals:
Care should be taken not to exceed the recommended dosage. Aminoglycosides have a narrower margin of safety than beta lactam antibiotics.
Special precautions to be taken by the person administering the product to the animals:
Care should be taken to avoid accidental self-injection. In the case of accidental self-injection, seek medical advice immediately.
Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross-reactions to cephalosporins and vice versa. Allergic reaction to these substances may occasionally be serious.
Occasionally in sucking and fattening pigs, administration may cause a transient pyrexia, vomiting, shivering, listlessness and in-coordination.
A palpable but transient local reaction may occur at the site of intramuscularadministration in horses.
Pen & Strep can be safely administered to pregnant and lactating animals. However in pregnant sows and gilts a vulval discharge which could be associated with abortion has been reported.
Do not administer with other antibiotics such as tetracyclines or with other aminoglycosides.
Shake the vial before use.
Administer by deep intramuscular injection.
Recommended dosage rate is 8 mg/kg bodyweight procaine penicillin with 10 mg/kg bodyweight dihydrostreptomycin sulphate equivalent to 1 ml per 25 kg bodyweight. Treatment should be given once daily for up to 3 consecutive days. The maximum dose volume administered at one site should not exceed 15 ml for horses, 6 ml for cattle, 3 ml for sheep and 1.5 ml for pigs.
No treatment specified.
Animals must not be slaughtered for human consumption during treatment.
Not to be used in sheep producing milk for human consumption.
Sheep intended for human consumption should not be slaughtered until 31 days after the last treatment.
Milk for human consumption must not be taken during treatment.
Milk for human consumption may only be taken from cows after 60 hours from the last treatment.
Cattle intended for human consumption should not be slaughtered until 23 days after the last treatment.
Pigs intended for human consumption should not be slaughtered until 18 days after the last treatment.
Not to be used in horses intended for human consumption.
Treated horses may never be slaughtered for human consumption.
The horse must have been declared as not intended for human consumption under national horse passport legislation
Pharmacotherapeutic group: Antibacterials for intramammary use, Combination of antibacterials for intramammary use, Beta-lactam antibacterials, penicillins, combinations with other antibacterials
ATCvet Code: QJ51RC03
Penicillin G is a beta-lactam antibiotic and its structure contains the beta-lactam ring and thiazolidine ring common to all penicillins. Beta-lactam antibiotics prevent the bacterial cell wall of susceptible Gram-positive bacteria from forming by interfering with the final stage of peptidoglycan synthesis. They inhibit the activity of transpeptidase enzymes, which catalyse cross-linkage of the glycopeptide polymer units that form the cell wall. They exert a bactericidal action but cause lysis only of growing cells.
Dihydrostreptomycin is an aminoglycoside antibiotic active against gram-negative aerobes, which after penetration of the cell envelope binds to receptors on the 30S sub unit of the bacterial ribosome. It induces misreading of the genetic code on the messenger ribonucleic acid (mRNA) template, causing bacteriostasis. Aminoglycosides exert synergistic action in combination with beta-lactam antibiotics.
After injection of Pen & Strep, the procaine penicillin is rapidly absorbed from the site of injection, with maximum penicillin levels of between 1 and 2 µg/ml for horses, sheep and pigs and 0.5 µg/ml for cattle, being obtained within 2 hours of injection.
The penicillin elimination half-lives are approximately 2 hours for sheep and pigs, 5 hours for cattle and 11 hours for horses. Dihydrostreptomycin is absorbed at a similar rate, with maximum plasma levels of 23 µg/ml being obtained for cattle, sheep and pigs, and 15 µg/ml for horses. The elimination half-lives are approximately 2 hours for cattle, sheep and pigs and 4 hours for horses.
Hydroxybenzoate Esters (as Nipasept Sodium)
Sodium Formaldehyde Sulphoxylate Dihydrate
Sodium Citrate Dihydrate
Disodium Edetate Dihydrate
Citric Acid Anhydrous
Water for Injections
Shelf life of the veterinary medicinal product as packaged for sale:
Glass: 9 months, Plastic: 24 months
Shelf life after first opening the immediate packaging: 28 days.
Glass: Do not store above 25°C.
Plastic: Store between 2 - 8°C
Protect from light.
Following withdrawal of the first dose, use the product within 28 days.
Discard unused material.
Clear type II multidose glass vials of 50 ml and 100 ml sealed with bromobutyl bungs and aluminium caps.
Clear polyethylene terephthalate plastic vials of 50 ml, 100 ml and 250 ml sealed with bromobutyl bungs and aluminium caps.
Not all pack sizes may be marketed.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
Norbrook Laboratories Limited
BT35 6JP Northern Ireland
12th March 1991
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