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PMSG (Intervet)
5000iu » 25ml Bottle

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  • 5000iu » 25ml Bottle £38.50

Description

PMSG is a hormone injection used to influence the breeding cycle in cows, sows, ewes and bitches. A veterinary prescription and treatment regime needs to be followed to ensure that treatment is effective.

PMSG is often used in conjunction with hormone-releasing Chronogest sponges. (Click to see them on VioVet.)

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  • Landline: 01582 842096
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  • Email: [email protected]

All prices include VAT where applicable.

Medication Datasheets

5000iu » 25ml Bottle

PMSG-Intervet 5000 iu powder and solvent for solution for injection

Presentation

PMSG-Intervet is presented as a white, freeze-dried crystalline plug containing 5000 iu Serum Gonadotrophin (PMSG) supplied together with solvent, which when reconstituted gives a solution containing 200 iu PMSG per ml.

Uses

PMSG is capable of supplementing and being substituted for both luteinising hormone and follicle stimulating gonadotrophin of the anterior pituitary gland in both the male and female, stimulating development of the ovarian follicle.

Dosage and administration

Make up immediately before use.

Reconstitute by dissolving the powder plug in about 5 ml of the solvent provided and then syringe the resulting solution into the solvent vial to mix with the remaining solvent. Administer by subcutaneous or intramuscular injection using normal aseptic precautions.

Cow

In conjunction with the use of progestagen treatment when used for oestrus control in non-cycling cattle:

400-700 iu

Superovulation:

1500-4000 iu - on day 9-13 of oestrous cycle.

Sow

Anoestrus post weaning (induction of oestrus is difficult until 40 days post partum):

1000 iu - s.c. or i.m. Fertile oestrus usually follows in 3 - 7 days.

Ewe

In conjunction with progestagen-releasing sponges when used out of the normal breeding season:

500 iu - s.c. or i.m. at time of sponge removal.

Bitch

Oestrus induction (subnormal oestrus with non-acceptance):

20 iu/kg - s.c. daily for 10 days. At day 10 injection of 500 iu hCG.

Superovulation in cattle

The product may be used for the superovulation of female donor cattle preparatory to embryo transfer. As an example, the following regime has been successfully applied:

A single dose of the product (1500 - 4000 iu) is injected on day 9 - 13 of a normal oestrous cycle (NB the exact dose of the product required to achieve effective superovulation will depend upon a number of factors particularly the breed, age, reproductive history, general health and nutritional status of the donor female and will be subject to individual variation). Forty-eight hours after the injection, luteolysis is induced by the injection of a prostaglandin analogue. Commonly one and a half times the normal luteolytic dose is administered. Oestrus normally occurs approximately 48 hours after the prostaglandin injection. Insemination is carried out at 60 and 72 hours after prostaglandin injection.

Collection of fertilised embryos (flushing) is carried out 6-8 days after insemination, suitable embryos being transferred to female recipient cattle whose oestrous cycles have previously been synchronised with that of the donor female.

(Experience has shown that oestrous cycles in donor and recipient females should be synchronised within ± 24 hours if reasonable success is to be expected.) A further prostaglandin treatment (commonly 1½ times the luteolytic dose) must be given at the time of collection.

Note:

PMSG is a protein hormone which acts on the ovary to stimulate the production of follicles. The number of follicles produced can be influenced by the dose of PMSG administered and this must be taken into account when calculating the dose for a particular flock of ewes. In general, the further out of season that breeding is attempted and the lower the normal prolificacy of the flock, the more PMSG that will be required. An average dose of 500 iu /ewe is recommended as a useful starting point but doses ranging from 200 - 750 iu have been used on occasion. It is therefore recommended that accurate flock records are kept of breed, dose given, time of injection and lambs produced so that in future seasons the amount can, if necessary, be adjusted for optimum results.

Contra-indications, warnings, etc

Where the possibility of multiple ovulations (due to exaggerated response from prolonged blood concentrations) has not been excluded by clinical examination following administration of PMSG to uniparous species (unless to induce superovulation in cattle), it is inadvisable to permit service or insemination during the first heat produced.

In rare cases, as with all protein preparations, anaphylactoid incidents may occur shortly after injection. Adrenaline injection (1:1000) given intravenously or intramuscularly when clinical signs appear is the standard treatment. The administration of corticosteroids may also be indicated.

Repeated administration can result in reduced efficacy due to immune-mediated antagonism.

Operator warnings

Care should be taken to avoid accidental self-injection.

Wash your hands after use.

Withdrawal periods

General indications

Milk (Cattle): Zero days.

Meat (Cattle, pigs, sheep): Zero days.

Superovulation in cattle

Milk: 48 hours after 2nd prostaglandin treatment.

Meat: 28 days.

For animal treatment only. Keep out of the sight and reach of children.

Pharmaceutical precautions

Store in a refrigerator (+2 °C to +8 °C). Protect from light. Reconstituted product should be stored in a refrigerator (2-8 °C), and reconstituted product remaining 24 hours after preparation should be discarded.

Any unused product or waste material should be disposed of in accordance with national requirements.

Legal category

Packaging quantities

Clear, glass Type I Vials containing 5000 iu Serum gonadotrophin with Type I Halogenated butyl rubber stoppers with aluminium crimp caps (used by The Netherlands site).

And

Clear, glass Type I Vials containing 5000 iu Serum gonadotrophin with Bromobutyl rubber stoppers with aluminium crimp caps (used by the Germany site).

Colourless glass vial containing 25 ml solvent for reconstitution.

Packaged in a carton containing 1 vial of powder and 1 vial of solvent.

Further information

Nil.

Marketing Authorisation Number

Vm 01708/4309.

Delivery Information

How quickly do you deliver?

Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.

What do you charge for delivery?

For UK delivery, we charge the following:

Order Total Weight Delivery
£0-£28.99 Under 2kg £2.99
2kg+ £4.99
£29-£38.99 Under 2kg Free
2kg+ £4.99
£39+ Under 2kg Free
2kg+ Free

Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.

For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.

We can deliver most items to all around the world, but prices do vary. To find the exact cost of shipping your item, and to see all options available, follow these steps:

  1. Put the items you wish to order in your basket
  2. Proceed to checkout and enter your delivery address, including country
  3. Delivery information including price will automatically update to what is available to you

Delivery of aerosols

Due to restrictions aerosols can't be sent by Royal Mail. We appreciate your understanding.

Delivery of temperature controlled items

Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.

How do I cancel or return an order?

Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.

To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.

*For full details on returns, see our terms and conditions page.

Reviews

Q & A

Below are some recent questions we've received regarding PMSG (Intervet), including answers from our team.

26 May 2015 at 11:53am

How many tyme i can use pmsg hormone in the same animal

moamer elfadil

Do the body imune system of ewe form antibodies against pmsg..and for that can I use it again ..if I can how many month I can use it again.

Thanks
Moamer elfadil

  • Non-Executive Director

The answer is not clear. The ewe will form antibodies to the product and this will tend to reduce its effectiveness with repeated use, but this does not usually completely prevent it from working at all in future. You should be OK to use it again at a suitable time for you. (Note that occasionally an anaphylactic response would be possible with repeated use and might require treatment.)