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Oxytocin is given by injection at the time of parturition to help with the following situations:
-to stimulate of contraction of the muscles of the uterus, helping the passage of the foetus, as long as the cervix is already fully dilated- to facilitate contraction and involution of the uterus after birth is complete, therefore helping with the expulsion of a retained placenta- to aid in the control of bleeding after the birth has occurred- to promote milk `let-down' where this seems to be delayed or inadequate
Oxytocin injection can be used in all species of mammal under the direction of a veterinary surgeon. Oxytocin needs to be stored at fridge temperatures.
Clear, sterile, aqueous solution of oxytocin equivalent to 10 i.u. per ml (0.18 mg/ml). Chlorbutanol 5 mg/ml is included as a preservative.
Injections of Oxytocin-S will initiate strong, regular and purposeful contractions of the uterine muscle especially in the later stages of pregnancy and post-partum. Oxytocin-S evokes the `let down' of milk although it has no action on the smooth muscles of the gut or urinary bladder, nor is it effective in the treatment of diabetes insipidus. The absence of vasopressor and antidiuretic effects make Oxytocin-S particularly suitable for obstetric use (stimulation of parturition, promotion of uterine involution and control of post-partum haemorrhage) and the treatment of agalactia.
Oxytocin-S is indicated for:
- stimulation of uterine contraction to facilitate parturition in the presence of a fully dilated cervix
- to promote involution of the post-parturient uterus and thus aid the passage of retained placenta
- to aid in the control of post-partum haemorrhage
- promotion of milk `let-down' in cases of agalactia and to facilitate `stripping out' of infected quarters in the treatment of mastitis in cows.
Oxytocin-S should normally be given by deep intramuscular injection.
2–5 i.u. 0.2–0.5 ml
2–10 i.u. 0.2–1 ml
Ewe, goat, sow
2–10 i.u. 0.2–1 ml
10–40 i.u. 1–4 ml
Indications (see 'Uses' above) other than mastitis
10–40 i.u. 1–4 ml
Adjunct to mastitis treatment
A single dose of up to 80 i.u. (8 ml) prior to stripping out before the first mastitis treatment followed by repeated doses of 20 i.u. (2 ml) prior to each stripping out 2 or 3 times daily while mastitis treatment continues.
Where the intravenous route is used, these doses should be reduced to one-quarter of the intramuscular dose and the injection given slowly at a dilution of 1 in 10 Water for Injections PhEur.
Where speed of onset is not a priority, Oxytocin-S may be given by the subcutaneous route.
A low initial dosage is recommended by any route as repeat administration is permissible.
Large doses may be employed in post-parturient animals.
Use with aseptic precautions.
1. When Oxytocin-S is used as an aid to parturition, cervical dilation must be confirmed prior to administration to prevent the risk of foetal death and possible uterine rupture.
2. Oxytocin-S is contra-indicated in any form of obstructive dystocia.
3. Excessive doses of the product may delay parturition by producing incoordinated uterine contractions which interfere with the progress of the foetus especially in multiple pregnancies.
4. The effects of daily dosages of 100 i.u. or more (to facilitate `stripping out' of infected quarters in the treatment of mastitis in cows) on the oestrous cycle have not been fully investigated and the cycle length may be altered.
5. Adrenaline at physiological levels markedly reduces effect of oxytocin on the uterus or mammary gland. For this reason the animal should not be frightened when complete oxytocin effect is desired to cause either milk `let-down' or uterine contractions.
Care should be taken to avoid accidental self-injection. Should self-injection occur, medical advice should be sought immediately. Women, particularly during lactation or the later stages of pregnancy, should avoid handling the product as it could cause smooth muscle (e.g. uterine) contraction.
Cattle, horses, pigs, sheep and goats: Meat – zero days.
Cattle, sheep and goats: Milk – zero hours.
For animal treatment only. Keep out of reach and sight of children.
Store in a refrigerator (+2o and +8o C). Protect from light.
Keep container in outer carton.
Following withdrawal of the first dose, use the product within 28 days.
When the container is broached for the first time, the date on which any product remaining in the container should be discarded should be calculated. A statement of the in-use shelf life of the product is given on the packaging insert. This discard date should be written in the space provided on the label.
Dispose of any unused product and empty containers in accordance with guidance from your local waste regulation authority.
Do not use in late pregnancy unless the intention is to promote parturition.
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