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Novartis Wormer Flukicide Combinex for Sheep

  • 2 x 5 litre & 2.2 litre Bottles £497.69
  • 800ml Bottle £58.11
  • 2.2 litre Bottle £123.56
  • 5 litre Bottle £230.65

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A combination worming product with a wholly effective flukicide. Contains levamisole and triclabendazole. POM-VPS.

Below is the product datasheet. This has been provided by the manufacturer and should always be provided with the medication.


Company name: Novartis Animal Health UK Ltd
Address: Frimley Business Park
GU16 7SR
Telephone: 01276 694402
Fax: 01276 694403


A cream coloured suspension containing 3.75% w/v levamisole hydrochloride and 5% w/v triclabendazole.


For the treatment and control of parasitic bronchitis, parasitic gastroenteritis and fasciolosis in sheep. When used at the recommended dose rate, Combinex Sheep is effective against mature and developing immature stages of levamisole sensitive Haemonchus, Ostertagia, Trichostrongylus, Cooperia, Nematodirus, Bunostomum, Chabertia and Oesophagostomum species in the gastrointestinal tract, and Dictyocaulus spp. in the lungs. It is also effective against all stages of triclabendazole susceptible Fasciola hepatica from 2 day old early immature to adult fluke and so is indicated against both acute and chronic fasciolosis.

Dosage and administration

Combinex Sheep is given as an oral drench and is suitable for use through most types of automatic drenching guns. It can be safely administered to young or pregnant sheep.
Recommended dose rate: 7.5 mg levamisole hydrochloride/kg bodyweight and 10 mg triclabendazole/kg bodyweight. This is equivalent to 1 ml Combinex Sheep per 5 kg bodyweight.

Examples: 10 kg 2 ml
11–15 kg 3 ml
16–20 kg 4 ml
21–30 kg 6 ml
31–40 kg 8 ml
41–50 kg 10 ml
51–60 kg
abd so on
12 ml

Contra-indications, warnings, etc

When the product is used at the recommended dose rate and animals are not overly stressed, side effects are rare. At higher dosages, transient side effects due to levamisole may occur (i.e. salivation and slight muscle tremors).
Assess bodyweight as accurately as possible before calculating the dosage. Intensive use or misuse can give rise to resistance. To reduce this risk, dosing programmes should be discussed with your Veterinary Advisor. Anthelmintics are agents that destroy or result in the expulsion of susceptible parasitic worms. Parasite resistance to a particular class of anthelmintic may develop following frequent, repeated use of an anthelmintic of that class. To reduce this risk, dosing programmes should be discussed with a veterinary surgeon. Combinex contains the anthelmintic Triclabendazole. Fluke (Fasciola hepatica) resistance to triclabendazole has been identified and losses associated with resistant strains of fluke in sheep flocks treated with triclabendazole can be significant. If signs of fascioliasis continue after treatment with COMBINEX SHEEP, DO NOT REPEAT THE DOSE and do not dose with other products containing triclabendazole. Seek veterinary advice. If resistance is suspected or confirmed, you should change the active ingredient on veterinary advice.
Efficacy of this product against roundworms is reduced if levamisole-resistant strains are present. Efficacy of this product against liver fluke is reduced if triclabendazole-resistant strains are present.
For animal treatment only. Keep out of the reach of children. When using do not eat, drink or smoke. Wash hands and exposed skin before meals and after work. Wash splashes from eyes and skin immediately. Take off immediately any contaminated clothing.
Dispose of used containers in accordance with guidance from your local waste regulation authority. Do not contaminate ponds, waterways or ditches with the products or used container.
Levamisole can cause idiosyncratic reactions and serious blood disorders in a very small number of people. If symptoms such as dizziness, nausea, vomiting or abdominal discomfort are experienced when using the product, or sore mouth/throat or fever occur shortly afterwards, then medical advice should be sought immediately.
Withdrawal Periods
Meat - Animals must not be slaughtered for human consumption during treatment.
Sheep should not be slaughtered for human consumption within 56 days of the last treatment.
Milk - Not to be administered to sheep producing milk intended for human consumption.

Pharmaceutical precautions

Protect from frost. Store in a dark place below 25°C. Shake container before use and use unaltered product from the original container. Following withdrawal of the first dose, use the product within 12 months. Clean drenching equipment before and after use.

Legal category


Packaging Quantities

0.8 litre, 2.2 litre and 5 litre collapsible backpacks.

Further information

Chemical group of anthelmintic 2-LM.

Marketing authorisation number

VM 12501/4020.

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