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Advantage Flea Control

  • 40 Cats/Dogs/Rabbits Up To 4kg » 4 Pipettes £9.10
  • 80 Large Cats & Pet Rabbits » 4 Pipettes £9.40
  • 100 Medium Dogs 4-10kg » 4 Pipettes £9.45
  • 250 Large Dogs 10-25kg » 4 Pipettes £10.29
  • 400 Extra Large Dogs Over 25kg » 4 Pipettes £10.65

Description

Advantage is one of the most effective and safe treatments to treat fleas on dogs, cats and rabbits.

Available as a spot on, it is easy to apply and treats the whole animal. Advantage can be used on cats and dogs from 8 weeks of age, and on rabbits from 10 weeks. It is safe to apply to lactating females and doing this will treat the puppies or kittens as well as the adult.

In addition to this flea treatment you may require an additional household spray to combat fleas which may not have yet hatched or dormant fleas in and around the house. Please click here to see the range of household sprays available.

Please take care not to let the product come into contact with varnished or other household surfaces. The alcohol carrier in the product may have adverse effects on these surfaces. Allow the products to fully dry before allowing the animal contact with these surfaces and do not put used pipettes on them.

Presentation

A clear yellow to slightly brownish solution containing as active substance imidacloprid. Each tube contains 0.4 ml (40 mg imidacloprid), 0.8 ml (80 mg imidacloprid), 1 ml (100 mg imidacloprid), 2.5 ml (250 mg imidacloprid) and 4.0 ml (400 mg imidacloprid) respectively as listed above. The product also contains benzyl alcohol and butylhydroxytoluene (E321) as an antioxidant.

Uses

For the prevention and treatment of flea infestations on cats and dogs, and for the treatment of biting lice (Trichodectes canis) on dogs.

For the treatment of flea infestations on pet rabbits.

Fleas are killed within one day following treatment. One treatment prevents further flea infestation for up to four weeks on dogs, three to four weeks on cats and up to one week on pet rabbits. The product can be used as part of a treatment strategy for Flea Allergy Dermatitis (FAD) in the cat and the dog, where this has been previously diagnosed by a veterinary surgeon.

Dosage and administration

Please refer to Table 1

Dosage and Treatment Schedule

TABLE 1

Species

Product

No. of Pipettes

Imidacloprid (mg/kg bw)

Cats

Less than 4 kg bodyweight

Advantage 40 mg Spot-On Solution for Small Cats, Small Dogs and Pet Rabbits

1 x 0.4 ml

Minimum of 10

4 kg and greater

Advantage 80 mg Spot-On Solution for Large Cats and Pet Rabbits

1 x 0.8 ml

Maximum of 20

Dogs

Less than 4 kg bodyweight

Advantage 40 mg Spot-On Solution for Small Cats, Small Dogs and Pet Rabbits

1 x 0.4 ml

Minimum of 10

4 kg to less than 10 kg

Advantage 100 Spot-On Solution for Dogs

1 x 1.0 ml

Minimum of 10

10 kg to less than 25 kg

Advantage 250 Spot-On Solution for Dogs

1 x 2.5 ml

Minimum of 10

25 kg to less than 40 kg

Advantage 400 Spot-On Solution for Dogs

1 x 4.0 ml

Minimum of 10

40 kg and greater

Advantage 400 Spot-On Solution for Dogs

2 x 4.0 ml

Minimum of 10

Rabbit

Adult less than 4 kg bodyweight (older than 10 weeks)

4 kg and greater

Advantage 40 mg Spot-On Solution for Small Cats, Small Dogs and Pet Rabbits

Advantage 80 mg Spot-On Solution for Large Cats and Pet Rabbits

1 x 0.4 ml 1x 0.8 ml

Minimum of 10 Maximum of 20

Treatment should be repeated after four weeks. Treatment of nursing bitches and queens controls flea infestations on both dam and offspring.

Fleas are killed within one day following treatment. One treatment prevents further flea infestation on dogs and cats for up to four weeks and on rabbits for up to one week. Should re-treatment be necessary earlier than four weeks, do not treat more frequently than weekly.

Re-infestation from emergence of new fleas in the environment may continue to occur for six weeks or longer after treatment is initiated. More than one treatment may therefore be required, depending on the level of fleas in the environment. To aid reduction in environmental challenge, the additional use of a suitable environmental treatment against adult fleas and developing stages is recommended. In order to reduce further the environmental challenge, it is recommended that all cats, dogs and rabbits in the household are treated.

The product remains effective if the animal becomes wet, for example after exposure to heavy rain or after swimming (dogs). However, re-treatment may become necessary, depending on the presence of fleas in the environment. In these cases do not treat more frequently than once weekly.

In the case of biting louse infestation in dogs, a veterinary examination 30 days after treatment is recommended as some animals may require a second treatment.

Method of Administration

Remove one tube from the package. Hold the tube in an upright position, twist and pull off cap. Use reversed cap to twist and remove seal from tube. See Figure 1.

Advantage - Opening pipette

Figure 1: Opening a tube

Administration to the Cat/Rabbit

Part the hair on the pet’s neck at the base of the skull until the skin is visible. Place the tip of the tube on the skin and squeeze firmly several times to empty the contents directly onto the skin. See Figure 2. Correct application will minimise the opportunity for the animal to lick off the product. Apply only to undamaged skin. Do not allow recently treated animals to groom each other.

Advantage - Application to cat and rabbit

Figure 2: Administration to the cat/rabbit

For dogs of less than 25kg body weight

With the dog in the standing position, part the coat between the shoulder blades until the skin is visible. Place the tip of the tube on the skin and squeeze firmly several times to empty the contents directly onto the skin. See Figure 3.

Advantage - Application to dog (1)

Figure 3: Administration to dogs up to 25kg

For dogs of 25 kg body weight and greater

The dog should be standing for easy application. The entire contents of the tube should be applied evenly to 3 or 4 spots all located at different application sites along the dog's backline from the shoulder to the base of the tail. At each spot, part the coat until the skin is visible. Place the tip of the tube on the skin and gently squeeze the tube to expel a portion of its contents directly onto the skin. Do not apply an excessive amount of solution at any one spot, as that could cause some of the product to run down the animal's side. See Figure 4.

Advantage - Application to big dog (1)

Figure 4: Administration to dogs over 25kg

For all dogs

Do not apply an excessive amount of solution at any one spot that could cause some of the solution to run down the side of the dog. The product is bitter tasting and salivation may occasionally occur if the dog licks the application site immediately after treatment. This is not a sign of intoxication and disappears within some minutes without treatment. Correct application will minimize the opportunity for the dog to lick the product. Apply only to undamaged skin. Do not allow recently treated animals to groom each other.

Use During Pregnancy and Lactation

No reproductive toxic effects have been observed in rats and no primary embryotoxic or teratogenic toxic effects have been observed during the studies on rats and rabbits. Studies on pregnant and lactating bitches, queens and does together with their offspring are limited. Evidence so far indicates that no adverse effects are to be expected in these animals.

Contra-indications, warnings, etc

Do not treat unweaned puppies or kittens of less than 8 weeks of age.

Do not use on pet rabbits of less than 10 weeks of age.

Do not use in animals that are known to be hypersensitive to the active substance or any of the excipients.

Apply only to undamaged skin.

This product is for topical use and should not be administered orally.

Care should be taken to avoid the contents of the tube coming into contact with the eyes or mouth of the recipient animal.

Do not allow recently treated animals to groom each other.

For external use only.

The product is bitter tasting and salivation may occasionally occur if the animal licks the application site immediately after treatment. This is not a sign of intoxication and disappears within a few minutes without treatment (see dosage and administration).

On very rare occasions skin reactions such as hair loss, redness, itching and skin lesions may occur. Agitation and disorientation has also been reported.

Excessive salivation and nervous signs such as incoordination, tremors and depression have been reported exceptionally in dogs.

No incompatibility has been observed between this product at twice the recommended dose and the following commonly used veterinary products: fenthion, lufenuron, milbemycin, febantel, pyrantel and praziquantel (dogs) and lufenuron, pyrantel and praziquantel (cats).

The compatibility of the product was also demonstrated with a wide range of routine treatments under field conditions including vaccination.

In cats, no adverse clinical signs were produced using doses of five times the therapeutic level for eight consecutive weeks.

In dogs, no adverse clinical signs were produced by individual doses of up to 200 mg/kg body weight (five to eight times the therapeutic dose), daily treatments at 100 mg/kg body weight for five consecutive days or weekly treatments at five times the maximum dose rate for eight consecutive weeks.

In rabbits, no adverse clinical signs were seen using doses of up to 45 mg/kg body weight (4 times the therapeutic level) weekly for 4 consecutive weeks.

Dogs: In rare cases of overdose or licking of treated fur, nervous system disorders (such as twitching, tremors, ataxia, mydriasis, miosis, lethargy) can occur.

Poisoning following inadvertent oral uptake in either man or animals is unlikely. In this event, treatment should be symptomatic.

There is no known specific antidote but administration of activated charcoal may be beneficial.

The solvent in this product may stain certain materials including leather, fabrics, plastics and finished surfaces. Allow the application site to dry before permitting contact with such materials.

Withdrawal period(s)

Do not use on rabbits intended for human consumption.

User Safety

Wash hands thoroughly after use.

Wash off any skin contamination with soap and water.

After application do not stroke or groom animals until the application site is dry (typically within an hour or so). People with known skin sensitivity may be particularly sensitive to the product.

This product contains benzyl alcohol and may cause skin sensitisation or transient skin reactions (for example allergy, irritation, tingling).

Avoid contact between the product and the skin, eyes and mouth.

If the product gets into eyes accidentally, the eyes should be thoroughly flushed with water.

If skin or eye irritation persists, seek medical attention. If the product is accidentally swallowed, obtain medical attention immediately.

Do not eat, drink or smoke during application.

Store away from food, drink or animal feeding stuffs.

Environmental Safety

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local / national requirements.

Pharmaceutical precautions

No special precautions for storage. Store away from food, drink and animal feeding stuffs.

Shelf-life of the veterinary medicinal product as packaged for sale: 5 years

Legal category

NFA-VPS

Packaging Quantities

Blister pack, containing 4 white polypropylene pipettes with caps, filled as follows:

Advantage 40 mg Spot-On Solution for Small Cats, Small Dogs & Pet Rabbits

4 x 0.4 ml pipettes

Advantage 80 mg Spot-On Solution for Large Cats & Pet Rabbits

4 x 0.8 ml pipettes

Advantage 100 Spot-On Solution for Dogs

4 x 1.0 ml pipettes

Advantage 250 Spot-On Solution for Dogs

4 x 2.5 ml pipettes

Advantage 400 Spot-On Solution for Dogs

4 x 4.0 ml pipettes

Further information

Pharmacotherapeutic group: antiparasitic products, insecticides and repellents ATCvet code: QP53AX17 Imidacloprid, 1-(6-Chloro-3-pyridylmethyl)-N-nitro-imidazolidin-2-ylideneamine is an ectoparasiticide belonging to a new group of chloronicotinyl compounds. Chemically, it is more accurately described as a chloronicotinyl nitroguanidine

Imidacloprid is an ectoparasiticide belonging to a group of chloronicotinyl compounds. Chemically, it is more accurately described as a chloronicotinyl nitroguanidine.

The pharmacological properties of imidacloprid are novel. The substance has a high affinity for the nicotinergic acetylcholine receptors in the post-synaptic region of the central nervous system (CNS). The ensuing inhibition of cholinergic transmission in insects results in paralysis and death. Due to the weak nature of the interaction with mammalian nicotinergic receptor sites and the postulated poor penetration through the blood/brain barrier in mammals, it has virtually no effect on the mammalian CNS. The minimal pharmacological activity in mammals is supported by safety studies involving systemic administration of sub-lethal doses to rabbits, mice and rats.

In further studies, in addition to the adulticide flea efficacy of imidacloprid, a larvicidal flea efficacy in the surroundings of the treated cat or dog has been demonstrated. Larval stages in the cat’s and dog's surroundings are killed following contact with a treated animal. Oral studies in the rat show imidacloprid to be absorbed rapidly from the gastro-intestinal tract. Almost complete absorption (95%) occurs within 48 hours. Peak plasma concentrations are observed within 2.5 hours following administration. Tissue distribution is also rapid with the lowest levels recorded in the brain. The active ingredient undergoes extensive metabolism with only 10-16% remaining as parent compound. Almost complete (96%) elimination occurs within 48 hours, approximately 75% being removed by the kidneys and 21% with the faeces. The solution is indicated for cutaneous administration. Following topical application, the product is quickly distributed over the animal. Acute dermal studies in the rat and target animal overdose and serum kinetic studies have established that systemic absorption is very low, transient and not relevant for clinical efficacy. This has been further demonstrated by a study in which fleas were not killed after having fed on previously treated animals once the animal’s skin and fur had been cleaned of all active material.

Marketing authorisation number

Advantage 40 mg Spot-On Solution for Small Cats, Small Dogs & Pet Rabbits

Vm 00010/4117

Advantage 80 mg Spot-On Solution for Large Cats & Pet Rabbits

Vm 00010/4134

Advantage 100 Spot-On Solution for Dogs

Vm 00010/4167

Advantage 250 Spot-On Solution for Dogs

Vm 00010/4166

Advantage 400 Spot-On Solution for Dogs

Vm 00010/4165

GTIN (Global Trade Item No)

Advantage 40 mg Spot-On Solution for Small Cats, Small Dogs & Pet Rabbits

04007221014676

Advantage 80 mg Spot-On Solution for Large Cats & Pet Rabbits

04007221014713

Advantage 100 Spot-On Solution for Dogs

04007221014645

Advantage 250 Spot-On Solution for Dogs

04007221014652

Advantage 400 Spot-On Solution for Dogs

04007221014669

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Reviews of Advantage Flea Control

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Questions & Answers for Advantage Flea Control

Below are some recent questions we've received regarding Advantage Flea Control, including answers from our team.

Ask Your Own Question

Ferret

7th Aug 2016
Neil

Can this be used on ferrets

Danielle Fletcher
  • Category Manager, Own Brand & E-SQP

Hi Neil,

A product called ClearSpot contains the same active ingredient as Advantage but they have a product developed and licensed for use on ferrets and rabbits. I would recommend using this, as Advantage is not licensed for use on ferrets.

Itchy skin

7th Jun 2016
Janet Towers

Can u recomend any other form of relief for my dogs skin, hes biting skin/tail, i was told he allergic to flea saliva but i flea him every 4wks but at moment hes constantly biting/itching, in past hes had steroids from vet. Thankyou.

John Cousins
  • Veterinary Surgeon

This does sound like an allergy. If this type of condition is investigated, there can be one or more allergies present at the same time, all contributing to the symptoms you notice. Fleas are probably the commonest cause and are probably involved even if you have been treating for them. It is very difficult to completely prevent any fleas from biting him and if he is very sensitive to the occasional bite, it is very difficult for you. There are a few things you can do to try and help the situation. The first is to maintain rigorous flea control 12 months of the year. It can seem like a waste of money to treat dogs like this over the winter, but if you do so it the results are usually very much better. Make sure you treat all dogs and cats at the same times, even if the others do not have skin trouble. The others can carry fleas otherwise. You should spray with an environmental flea spray around the house too, Indorex is a good example product. Then you can give a skin supplement such as Yumega as well. This will help to condition the skin and have a mild, anti-inflammatory effect in the skin. Other than that, there is not much I can advise other than visit your own vet and maybe have another steroid injection. That is not the ideal thing to do but if the skin problem has become bad enough, it is by far the quickest way of making it comfortable. Doing all the above might prevent the problem in future, but can be a bit slow at settling it down after it has got out of hand.

My jack russell is it safe to use, skin very itchy at min, on antihistimines

7th Jun 2016
Janet Towers

Is it ok trying different ones

John Cousins
  • Veterinary Surgeon

Advantage is very safe and very unlikely to interact adversely with other things you might give to control itchy skin. The only things you should not give are other topical parasite treatments which contain the same active ingredient (= imidacloprid). Check the labels for imidacloprid and avoid that along with Advantage. You should be fine to give antihistamines and fatty acid supplements are often helpful too. Something like Yumega can be very helpful, though it takes a few weeks to reach full effect. Do spray around the house with something like Indorex too, as well as treating any other pets for fleas even if they do not appear to have any trouble. They might carry them.

Kittens

18th Jan 2016
donsb

My kittens are eight weeks,but when I treat the older cats they all get diaohrea, worried abt the babies x

John Cousins
  • Veterinary Surgeon

As long as you use the right size of Advantage, then it should be perfectly safe to use on kittens once they are 8 weeks old. (Use the Small Cat version for kittens of course.) I am not sure why your other cats seem to get diarrhoea when treated. Do they find it traumatic to be given flea treatment? Sometimes it can be a stress effect, rather than the medication itself.

I have a bullmastiff weight of 45kg+

9th Dec 2015
Tracy

What Advantage flea treatment size can I use for him pls.
Thanks

John Cousins
  • Veterinary Surgeon

The recommended dose for all dogs over 40kg is two pipettes at the same time of the Advantage 400 Extra Large Dog size. (You will see this on the manufacturer's data sheet which we show on the website. Scroll down past the main listing and then click on "Dosage and Administration".)

Breed of dog

8th Nov 2015
Gem

Can you please tell me if I can use advantage for a collie. I have read that collieshe cannot use all type of flea treatments. She is a rescue so we do not know breeding bit she looks like a border collie.

John Cousins
  • Veterinary Surgeon

Advantage contains the active ingredient imidacloprid. This is NOT one of the compounds which shows additional potential toxicity in collies so Advantage should be perfectly safe to give to your dog.

Active ingredient

6th Nov 2015
Nat c

What is the active ingredient for this product please? Many thanks

John Cousins
  • Veterinary Surgeon

Advantage is the original product containing imidacloprid. There are a number of generic, copy products now available too with the same ingredient.

Crawling dandruff

27th Sep 2015
Bella

Will this product treat crawling dandruff

John Cousins
  • Veterinary Surgeon

Advantage is not licensed to kill "Walking Dandruff" (Cheyletiella species of mites) so officially it does not. However the active ingredient of Advantage (imidacloprid) is known to have an effect against various mites including Cheyletiella, so my personal opinion is that it would be reasonable to try it on a dog, cat or rabbit with this diagnosis. (Usually it is seen on rabbits in fact.)

Does advantage protection disappear when dog is washed?

25th Aug 2015
Samantha Monnington
  • VioVet Customer Since: May 2015
  • From: north Warwickshire, United Kingdom

I have had to reapply after only two weeks when dogs were bathed. They are small, white and allowed in bedroom. Is there any other product that may be more suitable?

John Cousins
  • Veterinary Surgeon

Most fleas do not live on the dogs. They are found in nooks and crannies in the environment, then jump onto the dogs when they need to feed. The Advantage is as potent as anything else and is probably killing fleas off very well, but they are being replaced by others which also die after a while, but you will see them on your dogs as this happens. You just need to continue to use Advantage monthly and after a couple of months or so they will all be under control. To speed this up you need to treat the environment. This involves using a spray such as Indorex, as well as vacuum cleaning your carpets, washing pet bedding on a hot wash, etc. Applying even more stuff to your dogs will not help much at all. You can give a tablet such as Capstar to definitely kill all fleas on the dog in 24 hours, but the tablet will not have any effect after that.

Strange smell

11th Aug 2015
Marie

I've noticed after I've applied advantage flea drops to my dog there is a not so nice, pungent odour that comes off him for about 3 days after. This was also the case with my other dog I had for 16 years. Do u have any answers for this? My dogs moods etc don't change it's just the smell. I sometimes shower him 24hrs after applying the drops but smell is still strong. I'm starting to dread putting his flea drops on every month but know I have too. Thanks, marie

John Cousins
  • Veterinary Surgeon

Most people do not find this problem, so I am not sure quite why it is so bad for you. It is unlikely to have any other impications, but if you do not like the smell there is no getting away from that. You could try an alternative product with a different active ingredient. Frontline Spot-on would be the leading possible example. I doubt if you would notice the same problem with that.