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Mycinor contains the antibiotic clindamycin made by Norbook. It is particularly effective against certain types of bacteria and can penetrate into particular tissues within the body much better than many other antibiotics. Vets will often choose this antibiotic based on these characteristics (and ideally culture and sensitivity testing). It is licensed in particular for the treatment of infected wounds and abscesses, and infections involving the mouth, bone and skin. Treatment can be given once or twice daily for a period of 4 days up to a month or more, depending on the particular case.
Mycinor Tablets are white to off-white circular tablets that can be divided into equal halves for oral administration to dogs
Each Mycinor Tablet contains:
25, 75, 150 or 300mg Clindamycin (as Clindamycin Hydrochloride)
Mycinor Tablets are indicated for use in dogs as follows:
For the treatment of infected wounds and abscesses, and infected mouth cavity and dental infections, caused by or associated with Staphylococcus spp, Streptococcus spp (except Streptococcus faecalis), Bacteroides spp, Fusobacterium necrophorum, and Clostridium perfringens. To help provide antimicrobial cover during dental procedures.
For the treatment of superficial pyoderma associated with Staphylococcus intermedius.
For the treatment of osteomyelitis, caused by Staphylococcus aureus.
Before Clindamycin therapy is initiated, the involved pathogens should be identified and sensitivity to clindamycin established.
For oral administration only.
1. For the treatment of infected wounds and abscesses, and infected mouth cavity and dental infections in dogs, administer either:
• 5.5 mg/kg of bodyweight every 12 hours for 7-10 days, or
• 11 mg/kg of bodyweight every 24 hours for 7-10 days
If no clinical response is seen within 4 days, redetermine the diagnosis. To help provide antimicrobial cover during dental procedures, a 10 day course is recommended. This should be initiated five days before dental therapy and continued for five days thereafter. In dogs, treatment may be extended to a maximum of 28 days based on clinical judgement.
2. For the treatment of superficial pyoderma in dogs, administer either:
• 5.5 mg/kg of bodyweight every 12 hours, or
• 11 mg/kg of bodyweight every 24 hours
Therapy of canine superficial pyoderma is usually recommended for 21 days, with extension of therapy based on clinical judgement.
3. For the treatment of osteomyelitis in dogs, administer:
• 11 mg/kg of bodyweight every 12 hours for a minimum of 28 days
If no clinical response is seen within 14 days, the treatment should be stopped and the diagnosis redetermined.
Bodyweight Superficial pyoderma, dental infections, wounds and abscesses, Osteomyelitis
For Dosing Guide Visit:
Do not use in animals that are hypersensitive to preparations containing clindamycin or lincomycin.
Do not administer to rabbits, hamsters, guinea pigs, chinchillas, horses or ruminants because ingestion of clindamycin by these species may result in severe gastrointestinal disturbance.
Clindamycin and erythromycin show parallel resistance. Partial cross-resistance has been demonstrated between clindamycin, erythromycin and other macrolides antibiotics.
During prolonged therapy of one month or greater, periodic liver and kidney function tests and blood counts should be performed.
Animals with severe renal and/or very severe hepatic disturbances accompanied by severe metabolic aberrations should be dosed with caution and should be monitored by serum examination during high-dose clindamycin therapy.
Vomiting and diarrhoea have occasionally been observed.
Clindamycin sometimes causes the overgrowth of non-sensitive organisms such as resistant clostridia and yeasts. In cases of superinfection, appropriate measures must be taken according to the clinical situation.
While high dose studies in rats suggest that clindamycin is not a teratogen and does not significantly affect the breeding performance of males and females, safety in gestating bitches or breeding male dogs has not been established.
Clindamycin hydrochloride has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Mycinor Tablets should be used with caution in animals receiving such agents.
Clindamycin should not be used concomitantly with chloramphenicol or macrolides as they antagonise each other at their site of action at the 50S ribosomal sub-unit.
Do not store above 25°C.
Store in a dry place.
Wash hands after handling tablets.
Care should be taken to avoid accidental ingestion.
In case of accidental ingestion, particularly by children, seek medical advice immediately and show the package leaflet or label to the doctor
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
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