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Microbex Shampoo is used to treat skin conditions in dogs associated with bacterial or fungal overgrowth. This particularly includes proliferation of the yeast Malassezia pachydermatis and the bacterium Staphylococcus intermedius, which are commonly found in excessive numbers on dogs with itchy or sore skin. Microbex shampoo can help to control these clinical signs and restore the skin to good health.
Pink to orange clear solution, each ml of shampoo contains as active substance: chlorhexidine digluconate 31.2mg
For use in dogs for the treatment of Malassezia pachydermatis surface proliferation and the control of associated clinical signs.
Administer the shampoo topically three times a week for 2 weeks then, if necessary, twice a week for 2 weeks and finally on a weekly basis. If necessary, further use may be required in accordance with the directions of and a risk:benefit assessment by the prescribing veterinary surgeon.
Wet the animal thoroughly with clean water and apply the product to the animal at several points. Apply a quantity of product according to the dog’s weight and hair-coat length in order to develop lather. Distribute the product uniformly all over the surface of the hair and ensure that it is applied around the lips, under the tail and between the toes. Massage the animal’s body to develop lather and rinse immediately. Repeat the operation a second time but allow a 10-minute contact period before rinsing the hair coat with clean water. Leave the dog to dry naturally in a warm draught-free environment.
The following provides a guide to suitable volumes; however, the amount of the product to be administered has to be adapted to both, the size of the dog and the hair-coat length. The volume of the product applied should be sufficient to develop lather.
Bodyweight Volume of product
<4.9 kg 10 ml x 2 baths
5.0 to 10.9 kg 15 ml x 2 baths
11.0 to 15.9 kg 20 ml x 2 baths
16.0 to 20.9 kg 25 ml x 2 baths
21.0 to 30.9 kg 30 ml x 2 baths
31.0 to 45.9 kg 40 ml x 2 baths
>46.0 kg 50 ml x 2 baths
Special precautions for use in animals
For external use only.
In case of accidental contact with eyes, rinse with plenty of water.
This product should not be used in dogs that are known to be hypersensitive to chlorhexidine or any of the other ingredients. Safety of the product has not been demonstrated in animals of less than five months of age.
Do not allow the animal to lick itself during shampooing and rinsing or before it is dried. Take care to avoid the animal inhaling the product or getting it into the eyes, nose or mouth during shampooing.
Safety of the product has not been demonstrated beyond six weeks of use.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
Handle this product with care if you know you are sensitised or if you have been advised not to work with such preparations. Avoid contact with eyes. In case of accidental eye contact, rinse with abundant quantities of water. In case of eye irritation, seek medical advice. Wash hands after use. Do not eat, drink or smoke while handling this product. In the event of accidental ingestion, seek medical advice and show the package insert or the label to the physician.
Adverse reactions (frequency and seriousness)
In a clinical trial, pruritus and erythematous reactions were common observations after shampooing with this product. In most cases, these reactions did not necessitate the cessation of treatment and clinical signs resolved completely without any specific therapy. However, if signs persist, the veterinary surgeon should re-evaluate the treatment.
Conjunctival inflammation may occur and usually resolves without treatment.
Use during pregnancy, lactation or lay
Laboratory studies in rats and dogs have not produced any evidence of teratogenic, foetotoxic or maternotoxic effects due to chlorhexidine. However, the safety of the product in dogs has not been investigated during pregnancy and lactation. Therefore, use in accordance with a benefit/risk assessment by the responsible veterinarian.
Puppies should not come into contact with nursing females after treatment until the coat has dried.
Interaction with other medicinal products and other forms of interaction
Frequent shampooing may reduce the efficacy of other topically-applied products, e.g. ectoparasiticides.
No data are available to evaluate interactions with other topically-applied products.
Overdose (symptoms, emergency procedures, antidotes), if necessary
A tolerance study performed in dogs receiving up to five times the recommended therapeutic dose, three days a week for four consecutive weeks, showed on occasions slight cutaneous reactions only. These reactions were transient, although they could last for several days when shampooing was ongoing. They did not require any specific treatment.
Keep out of the reach and sight of children.
Shelf life of the veterinary medicinal product as packaged for sale: 3 years.
Shelf life after first opening the immediate packaging: 2 months.
Special precautions for storage
This veterinary medicinal product does not require any special storage condition.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
Carton box containing one 200-ml white high-density polyethylene bottle closed by a polypropylene disc top screw and an overcap.
Chlorhexidine digluconate is an antiseptic agent of the biguanine group with a broad-spectrum bactericidal activity against gram-positive and gram-negative bacteria as well as a fungicidal activity against yeasts.
The mode of action of chlorhexidine (i.e. whether it is bactericidal or bacteriostatic) depends on the concentration used. Chlorhexidine alters the permeability of the bacterial-cell wall. At low concentrations, low molecular-weight substances leak out without the cell being irreversibly damaged. At higher concentrations, chlorhexidine enters the cell, causes precipitation of the cytoplasm, prevents repair to the bacterial-cell membrane and causes the destruction of the bacterial cell.
Typical MIC values found in clinical Malassezia pachydermatis isolates are 2-4 µg/ml (2008).
To date (2009) no resistance to chlorhexidine has been shown for Malassezia pachydermatis.
Resistance to chlorhexidine is uncommon in Gram (+) bacteria but some resistant Gram (-) isolates have been described in human hospital environments (Proteus spp., Pseudomonas spp.).
When used in accordance with the recommended dose regimen the development of resistance to chlorhexidine is not expected.
After topical administration of the product to dogs, there was little or no systemic absorption of chlorhexidine digluconate. Absorption of chlorhexidine after oral administration is also very low. The efficacy of the product is due to the high concentrations of chlorhexidine digluconate achieved on the body surface for the 10-minute period of shampooing.
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