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Loxicom is supplied as a liquid to add to food or as tablets. It contains the well known and trusted veterinary drug meloxicam. This is a non-steroidal anti-inflammatory drug which is used to provide relief from the stiffness and discomfort associated with osteoarthritis in the dog and cat. It is also used for other painful, inflammatory conditions, especially of the musculo-skeletal system, such as injuries. It can be given for a short course in acute conditions, or can be given for long periods of time in chronic conditions.
Alleviation of inflammation and pain in both acute and chronic musculo-skeletal disorders in dogs Do not use in pregnant or lactating animals.
Initial treatment is a single dose of 0.2mg meloxicam/kg bodyweight (i.e.1.33ml/10 kg bodyweight) on the first day. Treatment is to be continued once daily by oral administration (at 24 hour interval) at a maintenance dose of 0.1mg meloxicam/kg bodyweight (i.e. 0.667ml/10kg bodyweight).
For longer term treatment, once clinical response has been observed (after 4 days), the dose can be adjusted to the lowest effective individual dose reflecting that the degree of pain and inflammation associated with chronic musculo-skeletal disorders may vary over time.
Particular care should be taken with regard to the accuracy of dosing. Please carefully follow the instructions of the veterinarian.
For oral use. To be administered with food or directly into the mouth. shake well before use.
The suspension can be given using either of the two measuring syringes provided in the package. The syringes fit onto the bottle and have a kg-bodyweight scale which corresponds to the maintenance dose (i.e. 0.1mg meloxicam/kg bodyweight). Thus for initiation of the therapy on the first day, twice the maintenance volume will be required.
A clinical response is normally seen within 3-4 days. Treatment should be discontinued after 10 days at the latest if no clinical improvement is apparent. Avoid introduction of contamination during use.
Each ml contains: Meloxicam 1.5mg/ml Sodium benzoate 1.5mg
Do not use in pregnant or lactating animals. Do not use in animals suffering from gastrointestinal disorders such as irritation and haemorrhage, impared hepatic, cardiac or renal function and haemorrhagic disorders. Do not use in case of hypersensitivity to the active substance or to any of the excipients. Do not use in dogs less than 6 weeks of age. Typical adverse reactions of non-steroidal anti-inflammatory drugs (NSAIDs) such as loss of appetite, vomiting, diarrhoea, faecal occult blood, apathy and renal failure have occasionally been reported. These adverse reactions occur generally within the first treatment week and are in most cases transient and disappear following termination of the treatment but in very rare cases may be serious or fatal. If adverse reactions occur, treatment shoud be discontinued and the advice of a veterinarian should be sought. Avoid use in any dehydrated, hypovolaemic or hypotensive animal, as there is a potential risk of renal toxicity. Other NSAIDs, diuretics, anticoagulants, aminoglycoside antibiotics and substances with high protein binding may compete for binding and thus lead to toxic effects. Loxicom must not be administered in conjunction with other NSAIDs or glucocorticosteroids. Pre-treatment with anti-inflammatory substances may result in additional or increased adverse effects and accordingly a treatment-free period with such veterinary medicinal products should be observed for at least 24 hours before commencement of treatment. The treatment-free period, however, should take into account the pharmacokinetic properties of the products used previously. In the case of overdose symptomatic treatment should be initiated.
All prices include VAT where applicable.
Each ml contains:
Active Substance: Meloxicam 1.5 mg
Excipients: Sodium Benzoate 1.5 mg
Pale yellow oral suspension.
Indications for use, specifying the target species
Alleviation of inflammation and pain in both acute and chronic musculo-skeletal disorders in dogs.
Do not use in pregnant or lactating animals.
Do not use in animals suffering from gastrointestinal disorders such as irritation and haemorrhage, impaired hepatic, cardiac or renal function and haemorrhagic disorders.
Do not use in case of hypersensitivity to the active substance or to any of the excipients.
Do no use in dogs less than 6 weeks of age.
Special warnings for each target species
Special precautions for use
Special precautions for use in animals
If adverse reactions occur, treatment should be discontinued and the advice of a veterinarian should be sought.
Avoid use in any dehydrated, hypovolaemic or hypotensive animal, as there is a potential risk of renal toxicity.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
People with known hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs) should avoid contact with the veterinary medicinal product.
In case of accidental ingestion, seek medical advice immediately and show the package leaflet or the label to the physician.
Adverse reactions (frequency and seriousness)
Typical adverse reactions of NSAIDs such as loss of appetite, vomiting, diarrhoea, faecal occult blood, apathy and renal failure have occasionally been reported. In very rare cases haemorrhagic diarrhoea, haematemesis, gastrointestinal ulceration and elevated liver enzymes have been reported. These adverse reactions occur generally within the first treatment week and are in most cases transient and disappear following termination of the treatment but in very rare cases may be serious or fatal.
Use during pregnancy, lactation or lay
The safety of the veterinary medicinal product has not been established during pregnancy and lactation
Interaction with other medicinal products and other forms of interaction
Other NSAIDs, diuretics, anticoagulants, aminoglycoside antibiotics and substances with high protein binding may compete for binding and thus lead to toxic effects. Loxicom must not be administered in conjunction with other NSAIDs or glucocorticosteroids.
Pre-treatment with anti-inflammatory substances may result in additional or increased adverse effects and accordingly a treatment-free period with such veterinary medicinal products should be observed for at least 24 hours before commencement of treatment. The treatment-free period, however, should take into account the pharmacokinetic properties of the products used previously.
Amounts to be administered and administration route
To be administered with food or directly into the mouth.
Shake well before use.
Initial treatment is a single dose of 0.2 mg meloxicam/kg bodyweight (i.e. 1.33 ml/10 kg bodyweight) on the first day. Treatment is to be continued once daily by oral administration (at 24 hour intervals) at a maintenance dose of 0.1 mg meloxicam/kg bodyweight (i.e. 0.667 ml/10 kg bodyweight).
For longer term treatment, once clinical response has been observed (after ≥ 4 days), the dose can be adjusted to the lowest effective individual dose reflecting that the degree of pain and inflammation associated with chronic musculo-skeletal disorders may vary over time.
Particular care should be taken with regard to the accuracy of dosing.
The suspension can be given using either of the two measuring syringes provided in the package (depending on weight of dog). The syringes fit onto the bottle and have a kg-bodyweight scale which corresponds to the maintenance dose (i.e. 0.1 mg meloxicam/kg bodyweight). Thus for the first day, twice the maintenance volume will be required. Alternatively therapy may be initiated with Loxicom 5 mg/ml solution for injection.
A clinical response is normally seen within 3-4 days. Treatment should be discontinued after 10 days at the latest if no clinical improvement is apparent.
Avoid introduction of contamination during use.
Overdose (symptoms, emergency procedures, antidotes), if necessary
In the case of overdose, symptomatic treatment should be initiated.
Pharmacotherapeutic Group: Anti-inflammatory and anti-rheumatic products, non-steroids (oxicams).
ATCvet code: QM01AC06
Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) of the oxicam class which acts by inhibition of prostaglandin synthesis, thereby exerting anti-inflammatory, analgesic, anti-exudative and antipyretic effects. It reduces leukocyte infiltration into the inflamed tissue. To a minor extent it also inhibits collagen-induced thrombocyte aggregation. In vitro and in vivo studies demonstrated that meloxicam inhibits cyclooxygenase-2 (COX-2) to a greater extent than cyclooxygenase-1 (COX-1).
Meloxicam is completely absorbed following oral administration and maximal plasma concentrations are obtained after approximately 4.5 hours. When the product is used according to the recommended dosage regime, steady state concentrations of meloxicam in plasma are reached on the second day of treatment.
There is a linear relationship between the dose administered and plasma concentration observed in the therapeutic dose range in dogs. Approximately 97 % of meloxicam is bound to plasma proteins. The volume of distribution is 0.3 l/kg.
Meloxicam is predominantly found in plasma and is also a major biliary excretion product whereas urine contains only traces of the parent compound. Meloxicam is metabolised to an alcohol, an acid derivative and to several polar metabolites. All major metabolites have been shown to be pharmacologically inactive.
Meloxicam is eliminated with a half-life of 24 hours. Approximately 75 % of the administered dose is eliminated via faeces and the remainder via urine.
List of Excipients
Disodium Phosphate Dihydrate
Sodium Dihydrogen Phosphate Dihydrate
Citric Acid Anhydrous
Shelf-life of the veterinary medicinal product as packaged for sale: 18 months
Shelf-life after first opening the immediate packaging: 6 months
Special precautions for storage
This veterinary medicinal product does not require any special storage conditions.
Nature and composition of immediate packaging
The veterinary medicinal product is presented in 10 ml, 32 ml, 100 ml and 2 x100ml polyethylene screw bottles with HDPE/LDPE child resistant caps. Two polyethylene/polypropylene measuring syringes, a 1 ml and 5 ml syringe, are supplied with each bottle to ensure accurate dosing of small and large dogs.
Each syringe is graduated in bodyweight, the 1 ml syringe is graduated from 0.5 kg to 15 kg and the 5 ml syringe for 2.5 kg to 75 kg.
Special precautions for the disposal of unused veterinary medicinal product or waste material derived from the use of such products
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
Co Down, BT35 6JP
Date of first authorisation: 10/02/2009
Date of last renewal: 12/03/2014
Detailed information on this veterinary medicinal product is available on the website of the European
Medicines Agency http://www.ema.europa.eu/.
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For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.
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Below are some recent questions we've received regarding Loxicom Oral for Dogs & Cats, including answers from our team.
My 12 yr old staffie has been prescribed loxicom for arthritis, would joint supplements such as cod liver oil or similar help him at all and can they be taken together
Loxicom belongs to a group of drugs (the so called NSAIDs) which are often used alongside a joint supplement. It is widely believed that the combination is helpful, though scientific support for this is not totally conclusive. The most highly regarded joint supplements contain glucosamine, chondroitin and some other ingredients. Good examples would be Yumove and Joint Force. I would recommend you give one of these rather than cod liver oil. They need to be given for a few weeks before you can expect to see full results, because they are nutritional supplements rather than drugs, so their effects tend to take a while to build up. Some dogs do seem to respond remarkably well, others minimally, but you only find out by trying.
How do I get a prescription &how much will my vet charge
As soon as your vet has decided which medication is best for your pet, you can ask him or her to give you a written prescription for that medication. It is that piece of paper which we need a copy of before we can sell you the medication. It is entirely up to your vet how much they charge for writing it out. Most vets charge between £5 and £15, though a few vets do not charge at all. They are also able to write the prescription for just one small bottle, or multiple bottles to last you 6 months or a year if they feel the medication will be needed for that long. We can then keep a copy of the prescription and you can buy new bottles when you need them. That way you pay just one prescription fee for multiple bottles. It all depends how helpful your vet is - they vary a lot.
Is 0.1mg/kg the most a dog can have. My rotti has a osteosarcoma and is for palliative care. Currently taking 0.1mg/kg but was wondering if he can have more.
Some dogs can tolerate a higher dose, others will react badly (maybe after a while as the drug builds up in the body) and suffer serious side effects (usually gastro-intestinal upset with bleeding etc, but maybe liver/kidney trouble). I am afraid that the outlook for your dog is clearly not good anyway, so you will of course just want to do what you can to make things less uncomfortable. Usually this would be achieved by adding other classes of pain-relieving medication to the Loxicom, rather than pushing the dose of Loxicom to potentially problematic levels. Your vet could prescribe other medicines to add so I would definitely do that first. (If you can get a written prescription we sell many other things very economically, but they must be prescribed by your own vet.)
Hello my dog has renal problems and is managed on a special diet, recently he has developed joint problems, following x-rays he was prescribed loxicom, I am concerned about the effects this drug might have on his kidneys, I am aware that unfortunately wanting to keep him pain free means we have to give him something. Is this drug particularly tough on the kidneys? Thankyou for your help.
You are right to be mindful of the issues here, but there is not a perfect answer. Loxicom contains the drug meloxicam and this probably provides the best balance between good pain relief combined with minimal adverse effect on the kidneys. You should not exceed the recommended dose and if possible, judging on results, you might try to reduce the dose of Loxicom in time. Obviously talk to your own vet about this, but for many dogs in this situation, this is a perfectly reasonable choice. If your dog becomes ill in any way, especially if he goes off his food or shows vomiting or diarrhoea, then you should stop Loxicom until things are better.
my GSD just got spayed on Friday n my vet charged me £15 for 1.5 mg/ml bottle of loxicom and today I had to buy another one as she is still swollen, In future how would I go about askn for a prescription to buy online as its so much cheaper for me. ty x
You can at any time ask your vet for a written prescription from him/her in order to buy medication elsewhere. Your vet will be familiar with this sort of request. He/she is obliged to give you a prescription on request if the medication is suitable, but can and normally will charge you for the document (say £10 or £15). That can mean that it is not worth buying the medication elsewhere, but it depends how helpful your vet wants to be. Some do not charge at all. Usually the system works best for animals which are on long-term medication for arthritis or heart disease etc and you can buy 6 months worth of meds on one prescription.
how long t see improvement and
How long does it take t show improvement my dog has had injection and one dose but still squeling out in pain and cant move how long leave him before consulting vet again
It sounds as if your dog might be in severe pain and the treatment is not being effective. Some causes of pain do not respond well to this drug anyway, so I think you should go back to your vet and get things re-assessed.