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  • 5mg Tablets » Pack of 50 £28.60
  • 20mg Tablets » Pack of 50 £88.83
  • Injection (10%) » 50ml Bottle £48.65
  • Injection (10%) » 100ml Bottle £90.32
  • Injection (10%) » 250ml Bottle £203.20

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£28.60 to £203.20

Description

Ketofen contains the anti-inflammatory drug ketoprofen. Ketofen talets are normally used to treat pain and inflammation associated with injuries in dogs and cats as well as for the long term treatment of arthritis in dogs. A higher dose rate (1mg/kg) is used following injury for a period up to 5 days. A lower dose rate (0.25mg/kg) is used for treating arthritis which maybe maintained for a month or longer upon the advice of the veterinary surgeon.

Ketofen injection can be used in dogs and cats, or at a higher strength in horses, cattle and pigs.

Ketofen 5mg, 20mg Tablets

Qualitative and quantitative composition

Active substance: Ketoprofen 5 mg per tablet

Ketoprofen 20 mg per tablet

For the full list of excipients, see below.

Pharmaceutical form

White uncoated tablets with a break line on one side. The score line is intended to facilitate ease of swallowing and not to divide into equal doses.

Clinical particulars

Target species

Dogs and cats.

Indications for use

For the relief of acute pain and inflammation associated with musculo-skeletal and other painful disorders in the dog and cat. For the relief of pain in dogs associated with chronic osteoarthritic conditions.

Contra-indications

Do not administer with diuretics or anti-coagulants. Do not administer other non-steroidal anti-inflammatory drugs (NSAIDs) concurrently or within 24 hours of each other. Use is contraindicated in animals suffering from cardiac, hepatic or renal disease, where there is a possibility of gastrointestinal ulceration or bleeding, where there is evidence of a blood dyscrasia or hypersensitivity to the product.

Special warnings for each target species

Avoid use in any dehydrated, hypovolaemic or hypotensive animals as there is a potential risk of increased renal toxicity.

Use in any animal less than 6 weeks of age or in aged animals may involve additional risk. If such use cannot be avoided animals may require a reduced dosage and careful clinical management.

Special precautions for use in animals

When treating acute pain or inflammation, do not exceed the stated dose of 1 mg/kg or 5 day duration of treatment.

Special precautions to be taken by the person administering the product to animals

Wash hands after use. In the event of accidental ingestion, seek medical advice and show the doctor what has been taken.

Adverse reactions

Vomiting and diarrhoea rarely but occasionally occur following treatment. These signs disappear rapidly when treatment is discontinued.

Use during pregnancy, lactation or lay

Do not administer to pregnant animals.

Interactions

Some NSAIDs may be highly bound to plasma proteins and compete with other highly bound drugs which can lead to toxic effects. Concurrent administration with nephrotoxic drugs should be avoided.

Amounts to be administered and administration route

For acute indications in dogs and cats, the recommended dosage is 1 mg of ketoprofen per kg bodyweight administered orally once daily for up to 5 days. Ketofen tablets may be given on the day following administration of Ketofen 1% injection to maintain treatment for up to a total of 5 days.

For chronic pain in dogs, the recommended dosage is 0.25 mg of ketoprofen per kg bodyweight administered once daily. The recommended duration of treatment is up to 30 days. If continued treatment is indicated beyond the thirty days, the animal should first be re-examined by the veterinarian.

Overdose

The product is well tolerated by dogs and cats at three times the recommended dose of 1 mg/kg, i.e., at 3 mg/kg. Ketoprofen is well tolerated in dogs at five times the recommended dose of 0.25 mg/kg for up to 90 days, i.e., at 1.25 mg/kg.

Pharmaceutical particulars

Excipients

Microcrystalline cellulose, Maltodextrine saccharose, Magnesium stearate, Lactose monohydrate.

Major incompatibilities

None observed.

Shelf life

Shelf life of the product as packaged for sale: 3 years.

Special precautions for storage

Do not store above 25 °C.

Immediate packaging

10 tablets per blister, packed in boxes of 5 or 10 blisters.

Disposal

Any unused product or waste materials derived from such products should be disposed of in accordance with local requirements.

Marketing authorisation numbers

Vm 80327/4074.

Vm 08327/4076.

Legal category

POM-V

GTIN (Global Trade Item No)

Ketofen 5 mg Tablets

03661103000105

Ketofen 20 mg Tablets

03661103000112

Ketofen 10% solution for injection

Qualitative and quantitative composition

Active substance: Ketoprofen 100 mg/ml

Preservative: Benzyl alcohol 10 mg/ml

For the full list of excipients, see below.

Pharmaceutical form

Solution for injection.

Clinical particulars

Target species

Horses, cattle and pigs.

Indications for use

In the horse, Ketofen 10% is indicated for:

-The alleviation of inflammation and pain associated with musculoskeletal disorders;

-The alleviation of visceral pain associated with colic.

In cattle, Ketofen 10% is indicated for:

-The supportive treatment of parturient paresis associated with calving;

-Reducing the pyrexia and distress associated with bacterial respiratory disease when used in conjunction with antimicrobial therapy as appropriate;

-Improving the recovery rate in acute clinical mastitis, including acute endotoxin mastitis, caused by gram negative micro-organisms, in conjunction with antimicrobial therapy;

-Reducing oedema of the udder associated with calving;

-Reducing pain associated with lameness

In pigs, Ketofen 10% is indicated for:

-Reducing the pyrexia and respiratory rate associated with bacterial or viral respiratory disease when used in conjunction with antimicrobial therapy as appropriate;

-The supportive treatment of Mastitis Metritis Agalactia Syndrome in sows, in conjunction with antimicrobial therapy as appropriate.

Contra-indications

Do not administer to horses, cattle or pigs that have previously shown a hypersensitivity to ketoprofen. Do not administer other non-steroidal anti-inflammatory drugs (NSAIDs) concurrently or within 24 hours of each other. Use is contraindicated in animals suffering from cardiac, hepatic or renal disease, where there is the possibility of gastrointestinal ulceration or bleeding, where there is evidence of a blood dyscrasia or hypersensitivity to the product.

Special warnings for each target species

Use in any animal less than 6 weeks of age or in aged animals may involve additional risk. If such use cannot be avoided animals may require a reduced dosage and careful management. Avoid use in any dehydrated, hypovolaemic or hypotensive animals as there is a potential risk of increased renal toxicity.

Special precautions for use in animals

Avoid intra-arterial injection. Do not exceed the stated dose or duration of treatment.

Special precautions to be taken by the person administering the product to animals

In case of accidental self-injection seek medical advice. Wash hands after use. Avoid splashes on the skin and eyes. Irrigate thoroughly with water should this occur. If irritation persists seek medical advice.

Adverse reactions

In common with all NSAIDs, due to their action of inhibition of prostaglandin synthesis, there can be the possibility in certain individuals of gastric or renal intolerance.

Use during pregnancy, lactation or lay

As the effects of ketoprofen on fertility, pregnancy or foetal health of horses have not been determined, Ketofen 10% should not be administered to pregnant mares. Ketofen 10% may be given to pregnant and lactating cattle. It is indicated for use in lactating sows.

Interactions

Some NSAIDs may be highly bound to plasma proteins and compete with other highly bound drugs which can lead to toxic effects. Concurrent administration with nephrotoxic drugs should be avoided.

Amounts to be administered and administration route

Horse:

For use in musculoskeletal conditions, the recommended dosage is 2.2 mg ketoprofen/kg i.e. 1 ml/45 kg bodyweight, administered by intravenous injection once daily for up to 3 to 5 days.

For use in equine colic, the recommended dosage is 2.2 mg/kg (1 ml/45 kg) bodyweight, given by intravenous injection for immediate effect. A second injection may be given if colic recurs.

Cattle:

The recommended dose is 3 mg ketoprofen/kg bodyweight, i.e. 1 ml/33 kg bodyweight, administered by intravenous or deep intramuscular injection once daily for up to 3 days.

Pigs:

The recommended dose is 3 mg ketoprofen/kg bodyweight, i.e. 1 ml/33 kg bodyweight, administered once by deep intramuscular injection.

Overdose

No clinical signs were observed when Ketofen 10% was administered to horses at 5 times the recommended dose for 15 days, to cattle at 5 times the recommended dose for 5 days, or to pigs at 3 times the recommended dose for 3 days.

Horses have been found to tolerate intravenous dosages of ketoprofen of 2.2, 6.6 and 11.0 mg/kg once daily for 15 consecutive days (i.e. up to 5 times the recommended dose for three times the recommended duration) with no evidence of toxic effects.

Ketoprofen is similarly well-tolerated in cattle, where doses of up to 15 mg/kg/day (5 times the recommended dose) for 5 consecutive days have been given without significant adverse effects. The product has been safely given to calves as young as 3 days of age, and to pregnant and lactating cattle. Ketoprofen is well tolerated in pigs. Doses of 9 mg/kg/day (3 times the recommended dose) for 3 consecutive days have been given with no significant adverse effects.

Withdrawal periods

Horses, cattle and pigs must not be slaughtered for human consumption during treatment. Animals may be slaughtered for human consumption only after the following periods from the last treatment:

Horses – 1 day

Cattle – following intravenous administration: 1 day

– following intramuscular administration: 4 days

Pigs – 4 days

There is no withholding period necessary for the milk of treated cattle.

Pharmaceutical particulars

Excipients

L Arginine, Benzyl Alcohol, Citric Acid Monohydrate, Water for injections.

Major incompatibilities

None known.

Shelf life

Shelf life of the product as packaged for sale: 2 years. Following withdrawal of the first dose, use the product within 28 days.

Special precautions for storage

Do not store above 25 °C. Protect from light. Discard unused material safely.

Immediate packaging

50 ml, 100 ml and 250 ml glass bottles.

Disposal

Any unused product or waste materials derived from such products should be disposed of in accordance with local requirements.

Marketing authorisation number

Vm 08327/4067.

Legal category

POM-V

GTIN (Global Trade Item No)

Ketofen 10% solution for injection 50 ml

03661103000266

Ketofen 10% solution for injection 100 ml

03661103000259

Ketofen 10% solution for injection 250 ml

03661103006763

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Questions & Answers for Ketofen

Below are some recent questions we've received regarding Ketofen, including answers from our team.

Ask Your Own Question

Does it work?

12th Dec 2014
Elizabeth Pryor

How does this drug work? My 6yr old horse has just started treatment with it for a low level osteosteoarthritis in his right front fetlock. Can he lead a normal riding club level type life? How many years will he be rideable for?

John Cousins
  • Veterinary Surgeon

Ketofen is an anti-inflammatory drug which provides some relief from pain. It will not cure the arthritis in any way, bit helps reduce the symptoms. However arthritis varies considerably between different individuals and it is very difficult to predict how it will progress over time. Lots of factors can influence it. General advice would be to keep exercise to a moderate level. Strenuous or prolonged periods of exercise should always be avoided. Ideally a similar daily routine should be maintained every day, rather than some days with minimal exercise and others which much more. Provide a gentle warm-up period at the start of exercise and very importantly keep the horse slightly lean. Many horses with arthritis are slightly overweight and many people find this appearance quite pleasing, but it puts a great deal more wear and tear for the joints to deal with. A lean horse will have much less trouble from arthritis. Your horse might do well for many years, but a level of weakness will remain.