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Ketofen contains the anti-inflammatory drug ketoprofen. Ketofen talets are normally used to treat pain and inflammation associated with injuries in dogs and cats as well as for the long term treatment of arthritis in dogs. A higher dose rate (1mg/kg) is used following injury for a period up to 5 days. A lower dose rate (0.25mg/kg) is used for treating arthritis which maybe maintained for a month or longer upon the advice of the veterinary surgeon.
Ketofen injection can be used in dogs and cats, or at a higher strength in horses, cattle and pigs.
Active substance: Ketoprofen 100 mg/ml
Preservative: Benzyl alcohol 10 mg/ml
For the full list of excipients, see below.
Solution for injection.
Horses, cattle and pigs.
In the horse, Ketofen 10% is indicated for:
-The alleviation of inflammation and pain associated with musculoskeletal disorders;
-The alleviation of visceral pain associated with colic.
In cattle, Ketofen 10% is indicated for:
-The supportive treatment of parturient paresis associated with calving;
-Reducing the pyrexia and distress associated with bacterial respiratory disease when used in conjunction with antimicrobial therapy as appropriate;
-Improving the recovery rate in acute clinical mastitis, including acute endotoxin mastitis, caused by gram negative micro-organisms, in conjunction with antimicrobial therapy;
-Reducing oedema of the udder associated with calving;
-Reducing pain associated with lameness
In pigs, Ketofen 10% is indicated for:
-Reducing the pyrexia and respiratory rate associated with bacterial or viral respiratory disease when used in conjunction with antimicrobial therapy as appropriate;
-The supportive treatment of Mastitis Metritis Agalactia Syndrome in sows, in conjunction with antimicrobial therapy as appropriate.
Do not administer to horses, cattle or pigs that have previously shown a hypersensitivity to ketoprofen. Do not administer other non-steroidal anti-inflammatory drugs (NSAIDs) concurrently or within 24 hours of each other. Use is contraindicated in animals suffering from cardiac, hepatic or renal disease, where there is the possibility of gastrointestinal ulceration or bleeding, where there is evidence of a blood dyscrasia or hypersensitivity to the product.
Use in any animal less than 6 weeks of age or in aged animals may involve additional risk. If such use cannot be avoided animals may require a reduced dosage and careful management. Avoid use in any dehydrated, hypovolaemic or hypotensive animals as there is a potential risk of increased renal toxicity.
Avoid intra-arterial injection. Do not exceed the stated dose or duration of treatment.
In case of accidental self-injection seek medical advice. Wash hands after use. Avoid splashes on the skin and eyes. Irrigate thoroughly with water should this occur. If irritation persists seek medical advice.
In common with all NSAIDs, due to their action of inhibition of prostaglandin synthesis, there can be the possibility in certain individuals of gastric or renal intolerance.
As the effects of ketoprofen on fertility, pregnancy or foetal health of horses have not been determined, Ketofen 10% should not be administered to pregnant mares. Ketofen 10% may be given to pregnant and lactating cattle. It is indicated for use in lactating sows.
Some NSAIDs may be highly bound to plasma proteins and compete with other highly bound drugs which can lead to toxic effects. Concurrent administration with nephrotoxic drugs should be avoided.
For use in musculoskeletal conditions, the recommended dosage is 2.2 mg ketoprofen/kg i.e. 1 ml/45 kg bodyweight, administered by intravenous injection once daily for up to 3 to 5 days.
For use in equine colic, the recommended dosage is 2.2 mg/kg (1 ml/45 kg) bodyweight, given by intravenous injection for immediate effect. A second injection may be given if colic recurs.
The recommended dose is 3 mg ketoprofen/kg bodyweight, i.e. 1 ml/33 kg bodyweight, administered by intravenous or deep intramuscular injection once daily for up to 3 days.
The recommended dose is 3 mg ketoprofen/kg bodyweight, i.e. 1 ml/33 kg bodyweight, administered once by deep intramuscular injection.
No clinical signs were observed when Ketofen 10% was administered to horses at 5 times the recommended dose for 15 days, to cattle at 5 times the recommended dose for 5 days, or to pigs at 3 times the recommended dose for 3 days.
Horses have been found to tolerate intravenous dosages of ketoprofen of 2.2, 6.6 and 11.0 mg/kg once daily for 15 consecutive days (i.e. up to 5 times the recommended dose for three times the recommended duration) with no evidence of toxic effects.
Ketoprofen is similarly well-tolerated in cattle, where doses of up to 15 mg/kg/day (5 times the recommended dose) for 5 consecutive days have been given without significant adverse effects. The product has been safely given to calves as young as 3 days of age, and to pregnant and lactating cattle. Ketoprofen is well tolerated in pigs. Doses of 9 mg/kg/day (3 times the recommended dose) for 3 consecutive days have been given with no significant adverse effects.
Horses, cattle and pigs must not be slaughtered for human consumption during treatment. Animals may be slaughtered for human consumption only after the following periods from the last treatment:
Horses – 1 day
Cattle – following intravenous administration: 1 day
– following intramuscular administration: 4 days
Pigs – 4 days
There is no withholding period necessary for the milk of treated cattle.
L Arginine, Benzyl Alcohol, Citric Acid Monohydrate, Water for injections.
Shelf life of the product as packaged for sale: 2 years. Following withdrawal of the first dose, use the product within 28 days.
Do not store above 25 °C. Protect from light. Discard unused material safely.
50 ml, 100 ml and 250 ml glass bottles.
Any unused product or waste materials derived from such products should be disposed of in accordance with local requirements.
Ketofen 10% solution for injection 50 ml
Ketofen 10% solution for injection 100 ml
Ketofen 10% solution for injection 250 ml
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