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Intervet Bravoxin 10

Intervet Bravoxin 10

  • 50ml Bottle £27.49
  • 100ml Bottle £45.49

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Description

Protects sheep and cattle against clostridial diseases. POM-VPS.

Below is the product datasheet. This has been provided by the manufacturer and should always be provided with the medication.

Introduction

MSD-AH
Company name: MSD Animal Health
Address: Walton Manor
Walton
Milton Keynes
MK7 7AJ
Telephone: 01908 685685 (Customer Support Centre)
Fax: 01908 685555
Email: [email protected]
Website: www.msd-animal-health.co.uk
 

Qualitative and quantitative composition

Each 1 ml dose of vaccine contains:

Active substance Potency per ml
Clostridium perfringens type A (α) toxoid ≥ 0.5 U#
C. perfringens type B & C (β) toxoid ≥ 18.2 IU*
C. perfringens type D (ε) toxoid ≥ 5.3 IU*
C. chauvoei whole culture ≥ 90% protection**
C. novyi type B toxoid ≥ 3.8 IU*
C. septicum toxoid ≥ 4.6 IU*
C. tetani toxoid ≥ 4.9 IU*
C. sordellii toxoid ≥ 4.4 U1
C. haemolyticum toxoid ≥ 17.4 U#

* ELISA According to PhEur
1 In House ELISA
** Guinea pig challenge test according to PhEur
# In vitro toxin neutralisation test based on haemolysis of sheep erythrocytes.

Adjuvant  
Aluminium potassium sulphate (alum) 3,026 - 4,094 ppm
   
Excipients  
Thiomersal 0.12 - 0.18 mg
Formaldehyde ≤ 0.05% w/v

For a full list of excipients, see section “Pharmaceutical particulars”.
 

 

Pharmaceutical form

Suspension for injection.
Light brown aqueous suspension that settles on storage.
 

Clinical particulars

Target species
Cattle and sheep from 2 weeks of age.
Indications for use
For the active immunisation of sheep and cattle against diseases caused by Clostridium perfringens type A; C. perfringens type B; C. perfringens type C; C. perfringens type D; C. chauvoei; C. novyi type B; C. septicum; C. sordellii; C. haemolyticum and against tetanus caused by C. tetani. For the passive immunisation of lambs and calves against infection caused by the above mentioned clostridial species (except C. haemolyticum in sheep).
The onset of immunity is two weeks after the primary course.
Duration of active immunity:
An anamnestic humoral immune response (immunological memory) to all components was demonstrated 12 months following the primary course of vaccination.

As demonstrated by serology/persistent antibody titre only:
Sheep: 12 months against C. perfringens types A, B, C and D; C. novyi type B; C. sordellii and C. tetani.
  < 6 months against C. septicum; C. haemolyticum and C. chauvoei.
Cattle: 12 months against C. tetani and C. perfringens type D.
  < 12 months against C. perfringens types A, B and C.
  < 6 months against C. novyi type B; C. septicum; C. sordellii; C. haemolyticum and C. chauvoei.

Duration of passive immunity as demonstrated by serology/persistent antibody titre only is:
For lambs: At least 2 weeks for C. septicum and C. chauvoei.
  At least 8 weeks for C. perfringens type B and C. perfringens type C, and
  at least 12 weeks for C. perfringens type A; C. perfringens type D; C. novyi type B; C. tetani and C. sordellii.
  No passive immunity was observed for C. haemolyticum.
For calves: At least 2 weeks for C. sordellii and C. haemolyticum.
  At least 8 weeks for C. septicum and C. chauvoei and
  at least 12 weeks for C. perfringens type A; C. perfringens type B; C. perfringens type C; C. perfringens type D; C. novyi type B and C. tetani.

Contra-indications
None.
Special warnings for each target species
The effectiveness of the vaccine in providing passive immunity to young lambs and calves depends on these animals ingesting adequate amounts of colostrum on the first day of life. Clinical trials have demonstrated that the presence of maternal antibodies (MDA), particularly against C. tetani, C. novyi type B, C. perfringens type A (calves only), C. chauvoei (lambs only) and C. perfringens type D may reduce the antibody response to vaccination in young lambs and calves. Therefore, to ensure an optimal response in young animals with high levels of MDA, the primary vaccination should be delayed until the levels wane (which is after about 8-12 weeks of age, see section “Indications for use”).
Special precautions for use
In the event of an anaphylactic reaction appropriate treatment such as adrenaline should be administered without delay. Do not vaccinate sick or immuno-deficient animals.
Operator warnings:
In the case of accidental self-injection, encourage bleeding and wash the area immediately with water. If a local reaction develops, seek medical advice showing the package leaflet or the label to the physician.
Adverse reactions
75 - 100% of animals vaccinated with Bravoxin 10 may experience reactions to vaccination.
Most commonly reported adverse reactions are localised swelling or in duration at the injection site but may also include mild hyperthermia, abscess or other reaction in the underlying tissues at the injection site.
Swelling at the injection site occurs in the majority of animals. This may reach up to a mean value of 6 cm in sheep and 15 cm diameter in cattle; occasionally reactions of up to 25 cm diameter may be seen in cattle. Most local reactions resolve within 3-6 weeks in sheep and in less than 10 weeks in cattle, but may persist longer in a minority of animals. An abscess may develop in some animals. Vaccination may give rise to reactions in the underlying tissues at the injection site.
Skin discolouration at the injection site (which returns to normal as the local reaction resolved) may occur. Localised pain at the injection site for 1-2 days post first vaccination may occur.
The local reactions do not affect the general health, demeanour, feeding or weight gain of the animals.
Use during pregnancy, lactation or lay
No side effects other than those described in section “Adverse Reactions” were seen when the vaccine was used in sheep and cattle between 8 and 2 weeks prior to parturition. In the absence of specific data, the use of the vaccine is not recommended during the first or second third of pregnancy. Avoid stress in pregnant ewes and cows.
Interactions
No information is available on the compatibility of this vaccine with any other. Therefore the safety and efficacy of this product when used with any other (either when used on the same day or at different times) has not been demonstrated.
Amounts to be administered and administration route
Sheep – from 2 weeks of age: Dose - 1 ml.

Cattle – from 2 weeks of age: Dose – 2 ml.
Administration: By subcutaneous injection at a suitable site. The recommended site is the loose skin on the side of the neck.
The bottle should be well shaken before any vaccine is withdrawn. Syringes and needles should be sterile before use and the injection should be made through an area of clean, dry skin taking precautions against contamination.
Primary vaccination: Two doses should be administered, 4-6 weeks apart (see sections “Special warnings for each target species” and “Indications for use”).
Booster vaccination: A single dose should be administered at 6 to 12 month intervals (see also section “Indications for use”).
Use in pregnancy: To provide passive protection of the offspring, via the colostrum, a single booster dose should be administered between 8 and 2 weeks before parturition, provided that animals have received a full primary vaccination course before pregnancy.
Overdose
In calves and lambs, local reactions may increase slightly if twice the recommended dose is administered (refer to section “Adverse Reactions”).
Withdrawal periods
Zero days.
 

 

Pharmacological particulars

Immunological properties
ATCvet codes: QI02AB01 and QI04AB01
To stimulate active immunity in sheep and cattle against C. chauvoei and the toxins of Clostridium perfringens type A, C. perfringens type B, C. perfringens type C, C. perfringens type D, C. novyi, C. septicum, C. tetani, C. sordellii, and C. haemolyticum contained in the vaccine.
To provide passive immunity via the colostrum against the above clostridial infections in young lambs and calves.
 

Pharmaceutical particulars

Excipients
Aluminium potassium sulphate (alum), Thiomersal, Formaldehyde and Sodium Chloride (0.85% solution).
Major incompatibilities
Do not mix with any other vaccine, immunological and veterinary medicinal products.
Shelf life
Shelf-life of the veterinary medicinal product as packaged for sale: 30 months.
Shelf-life after first opening the immediate packaging: 8 hours.
Special precautions for storage
Store and transport refrigerated (2°C - 8°C). Protect from light. Do not freeze.
Immediate packaging
Cardboard box with 1 flexible low density polyethylene bottle of 20, 50 or 100 ml with a pharmaceutical grade rubber bung held in place with an aluminium seal. Not all pack sizes may be marketed.
Disposal
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
 

Marketing authorisation number

Vm 01708/4585.
 

Any other information

Nil
 

Legal category

POM-VPS
 

Need help or advice? Contact us:

  • Landline: 01582 842096
  • Mon - Fri: 8:30am - 5:00pm
  • Sat: 9:00am - 1:00pm (Collections only)
  • Email: [email protected]

All prices include VAT where applicable.

Delivery Information

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Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.

What do you charge for delivery?

For UK delivery, we charge the following:

Order Total Weight Delivery
£0-£28.99 Under 2kg £2.99
2kg+ £4.99
£29-£38.99 Under 2kg Free
2kg+ £4.99
£39+ Under 2kg Free
2kg+ Free

Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.

For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.

We can deliver most items to all around the world, but prices do vary. The majority of light weight orders (less than 1.5kg) can be delivered for a flat rate of £10. For an accurate estimate of the delivery charge, please put the items you require in your basket and use the "Estimate Delivery" system on the shopping basket page (you only need to enter your country and postal/zip code) for a quick quote. For deliveries to the USA you may need to go to the checkout page and enter your full address to get a quote (as some services need your state in order to quote too). For more information on international deliveries, please see our delivery information page.

Delivery of aerosols

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Delivery of temperature controlled items

Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.

How do I cancel or return an order?

Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.

To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.

*For full details on returns, see our terms and conditions page.

Reviews

Q & A

Below are some recent questions we've received regarding Intervet Bravoxin 10, including answers from our team.

22 June 2017 at 4:54pm

What dose should I give

Sue Smith

Is it just 1ml required to any size/weight of sheep/lamb?

  • Veterinary Advisor

Yes thats right. 1ml for any sheep/lamb over 2 weeks old.