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Hypercard tablets are used to treat primary hypertrophic cardiomyopathy in cats. This is a condition which results in the heart becoming abnormally large and thickened. If patients are left untreated, the heart muscle gradually declines and the affected cat goes into heart failure. Hypercard acts to slow the heart down and allows the muscle to relax more. Blood vessels are opened up slightly, especially those supplying the heart. This improves the circulation of blood to the heart muscle, and makes it easier to pump blood around the body, reducing the work load on the heart muscle. Life span and quality of life are improved.
Hypercard side effects can include lethargy and anorexia, though these tend to pass in a few days as the patient gets used to the medication. A few cats will show vomiting or constipation, and possibly skin reactions and rashes. In a few cats the heart rate slows down too much and the blood pressure gets too low, so medication has to be stopped.
All prices include VAT where applicable.
Each tablet contains: Active substance:
Diltiazem 9.20 mg (equivalent to 10 mg of Diltiazem hydrochloride)
Excipients: Tartrazine (E102) 0.11 mg, Titanium dioxide (E171) 1.1 mg.
Coated tablet. A yellow coated biconvex tablet.
For the therapeutic treatment of feline primary hypertrophic cardiomyopathy.
Do not use in animals suffering from AV block (2nd or 3rd), hypotension or sick sinus syndrome.
Diltiazem should not be given to animals suffering from hepatic disease.
Do not use in animals suffering from renal disease.
Do not use in cats less than 12 months old.
Do not use in cats weighing less than 3 kg.
Do not use in animals that are hypersensitive to diltiazem.
Do not use in cats with severe bradycardia or arterial hypotension.
Do not use in conjunction with β blockers, digitalis or digoxin.
Do not use in pregnant or lactating females.
Hepatic failure may increase the plasma concentration of diltiazem.
Monitor glucose levels carefully in diabetic animals.
Use with caution in cats suffering from congestive heart failure.
Cats with possible pre-existing thyroid problems or hyperthyroidism should be treated for this first and then reassessed, prior to commencing treatment with Diltiazem.
Clinical examination to assess the effectiveness of treatment should be performed after 8 weeks.
Cardiac rate should be monitored prior to treatment commencing and at every follow up visit.
Wash hands after use as tartrazine in the colour coating may cause allergic reaction in people who are susceptible.
In case of accidental ingestion, seek medical advice immediately and show the package insert to the physician.
Do not break tablets.
Some lethargy can occur at the beginning of treatment.
Diltiazem may cause gastrointestinal problems, e.g. constipation, vomiting and anorexia.
Rashes, skin reactions and erythema are potential side effects of diltiazem.
Bradycardia, dyspnoea, hypotension and conduction abnormalities may occasionally occur. In such cases treatment should be suspended.
Do not use in pregnant or lactating females. Studies in laboratory animals have shown evidence of teratogenic and embryotoxic effects.
Use with caution in conjunction with other calcium channel blockers, anticonvulsant drugs, immunosuppressant drugs, lithium, neuromuscular blocking agents and aminoglycoside antibiotics.
Concurrent use with Cimetidine or any other Histamine 2 receptor antagonists may cause an increase in plasma Diltiazem concentrations.
Gaseous anaesthetics such as halothane, isoflurane or enflurane have synergistic or additive effects with Diltiazem, which may lead to hypotension, depressed myocardial contractile function, slow junctional rhythm and AV block. Therefore, animals treated with HyperCard 10 mg and undergoing gaseous anaesthesia should be monitored closely.
1 tablet per cat (weighing 3.0-6.25 kg body weight) every eight hours (equivalent to 1.6-3.3 mg diltiazem hydrochloride per kg every 8 hours).
Treatment should be given for the life of the animal.
Carry out gastric lavage and dose with activated charcoal.
For bradycardia and heart block, treat with normal saline infusion and vasopressors (Atropine, Dopamine or Isoprenaline).
Observations in humans have indicated that treatment with calcium may be useful in treating toxicity from calcium channel blocker overdose.
Pharmacotherapeutic group: Diltizem hydrochloride. Diltiazem hydrochloride is a benzothiazepine derivative, which acts as a calcium channel blocker.
ATCvet code: QC08DB01
This group of compounds exert their effect by interacting with the slow L-type calcium channels, thereby selectively inhibiting the inward movement of Ca ions across the cell membrane into vascular smooth muscle cells and myocardial cells.
With hypertrophic cardiomyopathy (HCM) the heart generally has a diminished capacity to restore low, resting levels of calcium during diastole. It appears that Diltiazem ameliorates HCM by decreasing calcium levels in the heart enabling proper relaxation of the muscle and halting or reversing the progression of the disease. It reduces cardiac work by moderating the heart rate and by reducing systemic vascular resistance thus reducing oxygen demand.
Diltiazem is rapidly absorbed following oral administration. Oral bioavailability in cats (71 %) is higher than in other species and is most likely to be the result of a reduced first pass effect. Following administration of HyperCard 10 mg to cats, the average time to obtain maximum plasma concentration (Tmax) is approximately 90 minutes, with only low levels remaining after eight hours. No effect of feeding was observed on the absorption of Diltiazem from the gastrointestinal tract. There is no evidence of accumulation. In most species, Diltiazem is metabolised by the liver and little of the unchanged drug is excreted in the urine.
Plasma protein binding in cats is 50 - 60 %.
Diltiazem is a significant hepatic microsomal enzyme inhibitor (especially of CYP3A4) and, therefore, will affect the pharmacokinetics and consequently possibly the efficacy and tolerance of some substances used in veterinary medicine (see Interactions).
Shelf life of the veterinary medicinal product as packaged for sale: 30 months.
Do not store above 25°C.
Keep the blister strips in the outer carton.
Tablets are located in a preformed low density polyethylene base containing 10 tablets and sealed with PC 100 laminate comprising of aluminium foil and a heat seal lacquer. Once sealed, 3 blisters of 10 tablets (30 tablets) are placed in a cardboard box.
Any unused product or waste material should be disposed of in accordance with national requirements.
Dechra Limited, Snaygill Industrial Estate, Keighley Road, Skipton, North Yorkshire, BD23 2RW, United Kingdom.
16 August 2000
For animal treatment only. To be supplied only on veterinary prescription. Keep out of sight and reach of children.
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Due to restrictions aerosols can't be sent by Royal Mail. We appreciate your understanding.
Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.
Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.
To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.
*For full details on returns, see our terms and conditions page.
Below are some recent questions we've received regarding HyperCard tablets for Cats, including answers from our team.
cats hypercard tablet
Missed dose what to do?
Give a dose as soon as you can, then give the remaining doses for the day spread evenly through the rest of the day, as long as there is at least about 4 hours between each dose. If there is not time to do that, then just forget the missed dose and give the others as normal, it is unlikely to be serious
My cat is on these 3 times daily. Wat if I missed one day will it affect him.
It is not ideal to miss a day, but in fact cats are so difficult with tablets that this can often happen. It does not seem to be a problem to miss a day or so occasionally.
Does HyperCard have to be given on an empty stomach and how long before giving the meds do you have to starve?
There are no particular requirements with Hypercard regarding giving with or without food. The absorption of the drug from the gut is not affected by the presence or absence of food (unlike some drugs) so you can feed when you want. It is advised that Hypercard tablets are best swallowed whole though, which can be difficult with many cats.