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Hy-50 (Hy 50) Vet 17mg/ml

  • 3ml dose £88.55


Hy-50 Vet is an injection for use in horses. It is used to treat joint problems where there is no infection involved and can be injected directly into the joint, or into the blood stream.

Qualitative and quantitative composition

Active substance:

Sodium hyaluronate 17 mg/ml.

Excipients: For a full list of excipients, see Excipients.

Pharmaceutical form

Solution for injection. Clear, colourless, viscous solution.

Clinical particulars

Target species


Indications for use

For intra-articular and intravenous treatment of lameness caused by joint dysfunction associated with non-infectious synovitis.


Do not use in cases of joint infection.

Special precautions for use in animals

Radiographic evaluation should be carried out in cases of acute, severe lameness to ensure that the joints are free from serious fractures.

Special precautions to be taken by the person administering the veterinary medicinal product to animals

Not applicable.

Adverse reactions

Transient mild swelling and/or heat has been reported in treated joints (2.7%). These self-limiting local signs resolve spontaneously within 48 hours, and do not negate a successful therapeutic outcome.

Use during pregnancy and lactation

Safety in pregnant and lactating mares has not been documented. Use only according to the benefit/risk assessment by the responsible veterinarian.


No data available.

Amounts to be administered and administration route

Intravenous use: 3 ml intravenously repeated at weekly intervals for a total of three treatments.

For single intra-articular injection: 3 ml (51 mg) intra-articularly into medium sized and large joints. Smaller joints such as intertarsal, tarsometatarsal and interphalangeal joints can be treated with a 1.5 ml dose (25.5 mg).

More than one joint may be treated at the same time.

Excess synovial fluid should be removed whenever possible prior to injection.

Remove product from refrigerator approximately 10 minutes before performing injection. The injection should be administered under strict aseptic conditions. Ensure removal of dirt, hair, topical medicaments and soap/antiseptic residues. Intra-articular injections should not be made through overlying skin that is infected, blistered, scurfed or otherwise compromised. A sterile dressing and clean bandage should be applied after injection, as appropriate for the particular joint treated.

Single dose syringes made ready for injection shall be used immediately. Any unused portion of a syringe is to be discarded.


Not reported.

Withdrawal period

Meat and offal: zero days.

Pharmacological particulars

Pharmacotherapeutic group: Sodium hyaluronate (hyaluronic acid).

ATC Vet code: QM09AX01

Pharmacodynamic properties

The active substance in HY-50 Vet, sodium hyaluronate, is produced by a bacterial fermentation process. Sodium hyaluronate is the sodium salt of hyaluronic acid, a non-sulphated acid mucopolysaccharide or glycosaminoglycan of high molecular weight composed of equimolar amounts of D-glucuronic acid and N-acetylglucosamine linked together by glycosidic bonds.

Hyaluronic acid is a natural constituent of connective tissues in all mammals and its chemical structure is the same in all species. Vitreous humour, umbilical cord and synovial fluid are especially rich in hyaluronic acid. Hyaluronic acid is also found in the articular cartilage matrix.

Hyaluronic acid has biochemical activities which are distinct from its physical and rheological properties. It is an effective free radical scavenger, a potent inhibitor of leucocyte and macrophage migration and aggregation, and enhances healing of connective tissue.

Intra-articularly administered sodium hyaluronate alleviates aseptic joint inflammation and enhances joint function. The mechanism of action involved in the beneficial effects of sodium hyaluronate is not fully understood.

Pharmacokinetic properties

Studies with radiolabelled hyaluronic acid in rabbit and sheep indicate that after intra-articular injection, hyaluronic acid is cleared from the joint within 4 to 5 days. Uptake is primarily via the lymphatics. Hyaluronate is metabolised in the liver.

Pharmacokinetic properties of intravenously administered sodium hyaluronate have not been studied.

Pharmaceutical particulars


Sodium chloride 7.57 mg/ml, disodium phosphate heptahydrate 3.78 mg/ml, sodium dihydrogen phosphate monohydrate 0.45 mg/ml, water for injection qs to 1 ml.


Do not mix with any other product.

Shelf life

Shelf life of the veterinary medicinal product as packaged for sale: 3 years.

Single dose syringes made ready for injection shall be used immediately. Any unused portion of a syringe is to be discarded.

Special precautions for storage

Store in a refrigerator (2°C-8°C). Do not freeze. Keep out of the reach and sight of children.

Immediate packaging

Pre-loaded 3 ml single-dose glass syringes. Each syringe is packaged in an individual heat-sealed tray and carton. Available in single cartons or boxes containing 12 cartons. Not all pack sizes may be marketed.


Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed in accordance with national requirements.

Marketing authorisation holder (if different from distributor)

Dechra Limited, Dechra House, Jamage Industrial Estate, Talke Pits, Stoke-on-Trent, Staffordshire, ST7 1XW.

Marketing authorisation number

Vm 10434/4078.

Date of the first authorisation and date of renewal

Date of first authorisation: 12.06.1998

Date of last renewal: 12.06.2008

Any other information

For animal treatment only. To be supplied only on veterinary prescription.

Date of revision of the text


Legal category


GTIN (Global Trade Item No)

HY-50 Vet. 17 mg/ml Solution for Injection


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