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Frontline Spot On Combo for Dogs & Cats

  • Cats » Pack of 3 Pipettes £14.05
  • Cats » Pack of 6 Pipettes £19.34
  • Dogs 2-10kg Small » Pack of 3 Pipettes £17.60
  • Dogs 2-10kg Small » Pack of 6 Pipettes £22.01
  • Dogs 10-20kg Medium » Pack of 3 Pipettes £19.32
  • Dogs 10-20kg Medium » Pack of 6 Pipettes £24.85
  • Dogs 20-40kg Large » Pack of 3 Pipettes £21.09
  • Dogs 20-40kg Large » Pack of 6 Pipettes £26.20
  • Dogs 40-60kg Extra Large » Pack of 3 Pipettes £24.45
  • Dogs 40-60kg Extra Large » Pack of 6 Pipettes £30.58

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Description

Frontline Combo is the prescription-only form of Frontline Spot On, the most popular Flea and Tick treatment available. Combo has an extra ingredient which is particularly helpful for flea control if you forget to re-apply Frontline as frequently as you should. The extra ingredient has a more persistent action on the skin and coat of dogs and cats. This additional ingredient does not kill fleas, but in effect it sterilizes female fleas so that they cannot breed. Each individual flea does not live for long anyway, so that preventing them breeding can be an effective form of control in itself. Just like Frontline Spot On, Frontline Combo is supplied in small pipettes which are emptied onto the back of the neck of the cat or dog to be treated.

Frontline Combo Spot-On Dog S, M, L, XL

Presentation

Spot-on solution.

Small: 1 pipette of 0.67 ml contains fipronil 67 mg, (S)-methoprene 60.30 mg.

Medium: 1 pipette of 1.34 ml contains fipronil 134 mg, (S)-methoprene 120.60 mg.

Large: 1 pipette of 2.68 ml contains fipronil 268 mg, (S)-methoprene 241.20 mg.

XL: 1 pipette of 4.02 ml contains fipronil 402 mg, (S)-methoprene 361.80 mg.

Also contains butylhydroxyanisole (E320) and butylhydroxytoluene (E321).

Uses

To be used against infestations with fleas, ticks and/or biting lice.

- Treatment of flea infestations (Ctenocephalides spp.) and insecticidal efficacy against new infestations with adult fleas persists for 8 weeks.

- Prevention of the multiplication of fleas by inhibiting the development of eggs (ovicidal activity) and larvae and pupae (larvicidal activity) originating from eggs laid by adult fleas for 8 weeks after application.

- Treatment of tick infestations (Ixodes ricinus, Dermacentor variabilis, Dermacentor reticulatus, Rhipicephalus sanguineus). The product has persistent acaricidal efficacy for up to 4 weeks against ticks.

- Treatment of infestations with biting lice (Trichodectes canis).

The product can be used as part of a treatment strategy for the control of Flea Allergy Dermatitis (FAD).

Dosage and administration

Dosage

1 pipette of 0.67 ml (S) per dog weighing over 2 and up to 10 kg;

1 pipette of 1.34 ml (M) per dog weighing over 10 kg and up to 20 kg;

1 pipette of 2.68 ml (L) per dog weighing over 20 kg and up to 40 kg;

1 pipette of 4.02 ml (XL) per dog weighing over 40 kg;

corresponding to a minimum recommended dose of 6.7 mg/kg for fipronil and 6 mg/kg for (S)-methoprene, by topical application to the skin.

In the absence of safety studies the minimum treatment interval is 4 weeks.

Method of administration

Hold the pipette upright. Tap the narrow part of the pipette to ensure the contents remain within the main body of the pipette. Snap back the tip. Part the coat on the back of the animal at the base of the neck in front of the shoulder blades until the skin is visible. Place the tip of the pipette on the skin and squeeze the pipette several times to empty its contents completely and directly onto the skin in one spot.

Temporary changes to the coat (clumped/greasy hair) may be noted at the application site.

Contra-indications, warnings, etc

For animal treatment only.

In the absence of available data, the product should not be used on puppies less than 8 weeks old and/or weighing less than 2 kg. No adverse effects were observed in target animal safety studies in 8 week-old puppies, growing dogs and dogs weighing about 2 kg treated once at five times the recommended dose. The risk of experiencing adverse effects may however increase when overdosing, so animals should always be treated with the correct pipette size according to bodyweight.

The product can be used during pregnancy and lactation.

Do not use on sick (systemic diseases, fever…) or convalescent animals.

Do not use in rabbits, as adverse reactions and even death could occur.

In absence of studies, the use of the product is not recommended in non-target species.

This product is specifically developed for dogs. Do not use in cats and ferrets, as this could lead to overdosing.

Do not overdose.

It is important to make sure that the product is applied to an area where the animal cannot lick it off and to make sure that animals do not lick each other following treatment. If licking occurs, a brief period of hypersalivation may be observed due mainly to the nature of the carrier.

Bathing/immersion in water within 2 days after application of the product and more frequent bathing than once a week should be avoided, as no study has been performed to investigate how this affects the efficacy of the product. Emollient shampoos can be used prior to treatment, but reduce the duration of protection against fleas to approximately 5 weeks when used weekly after application of the product. Weekly bathing with a 2% chlorhexidine medicated shampoo did not affect efficacy against fleas during a 6 week long study.

Dogs should not be allowed to swim in watercourses for 2 days after application.

There may be an attachment of a few ticks. For this reason transmission of infectious diseases cannot be completely excluded if conditions are unfavourable.

Fleas from pets often infest the animal's basket, bedding and regular resting areas such as carpets and soft furnishings which should be treated, in case of massive infestation and at the beginning of the control measures, with a suitable insecticide and vacuumed regularly.

There are no known interactions with other medications.

Among the very rare suspected adverse reactions, transient skin reactions at the application site (skin discolouration, local hair loss, itching, redness) and general itching or hair loss have been reported after use. Excessive salivation, reversible neurological signs (increased sensitivity to stimulation, depression, other nervous signs), vomiting or respiratory signs have also been observed after use.

Avoid contact with the animal's eyes.

Animals with a known hypersensitivity to insecticides or alcohol should avoid contact with FRONTLINE Combo Spot-On Dog.

Operator safety:

Operators with a known hypersensitivity to insecticides or alcohol should avoid contact with FRONTLINE Combo Spot-On Dog.

This product can cause mucous membrane, skin and eye irritation. Therefore, contact of the product with mouth, skin and eyes should be avoided. After accidental ocular exposure the eye should be rinsed carefully with pure water.

Avoid contents coming into contact with the fingers. If this occurs, wash hands with soap and water.

Treated animals should not be handled until the application site is dry, and children should not be allowed to play with treated animals until the application site is dry. It is therefore recommended that animals are not treated during the day, but should be treated during the early evening, and that recently treated animals are not allowed to sleep with owners, especially children.

Wash hands after use.

Do not smoke, drink or eat during application.

Pharmaceutical precautions

Keep out of the reach and sight of children.

Do not store above 30°C. Store in the original package.

Any unused product or waste material should be disposed of in accordance with national requirements.

Fipronil and (S)-methoprene may adversely affect aquatic organisms. Do not contaminate ponds, waterways or ditches with the product or empty containers.

Legal category

POM-V

Packaging Quantities

Blister card of 1 × 0.67 ml (S) pipette with a scored tip.

Box of 1 or 2 blister card(s) of 3 × 0.67 ml (S), 1.34 ml (M), 2.68 ml (L), 4.02 ml (XL) pipettes with a scored tip.

Further information

The product is an insecticidal and acaricidal solution for topical use, containing an association of an adulticidal active ingredient, fipronil, in combination with an ovicidal and larvicidal active ingredient, (S)-methoprene.

Fipronil is an insecticide and acaricide belonging to the phenylpyrazole family. It acts by interacting with ligand-gated chloride channels, in particular those gated by the neurotransmitter gamma-aminobutyric acid (GABA), thereby blocking pre- and post-synaptic transfer of chloride ions across cell membranes. This results in uncontrolled activity of the central nervous system and death of insects or acarines. Fipronil kills fleas within 24 hours and ticks (Dermacentor reticulatus, Dermacentor variabilis, Rhipicephalus sanguineus, Ixodes scapularis, Ixodes ricinus, Haemaphysalis longicornis, Haemaphysalis flava, Haemaphysalis campanulata) and lice within 48 hours post-exposure.

(S)-Methoprene is an insect growth regulator (IGR) of the class of compounds known as juvenile hormone analogues that inhibit the development of immature stages of insects. This compound mimics the action of juvenile hormone and causes impaired development and death of the developing stages of fleas. The on-animal ovicidal activity of (S)-methoprene results from either direct penetration of the eggshell of newly laid eggs or from absorption through the cuticle of the adult fleas. (S)-methoprene is also effective in preventing flea larvae and pupae from developing, which prevents contamination of the environment of treated animals with the immature stages of fleas.

Both (S)-methoprene and fipronil are well-distributed in the haircoat of a dog within one day after application. The concentrations of fipronil and (S)-methoprene in the haircoat decrease with time and are detectable for at least 60 days after dosing. Parasites are killed through contact rather than systemic exposure.

No pharmacological interaction between fipronil and (S)-methoprene was noted.

Marketing authorisation number

Vm 08327/4211-4.

Frontline Combo Spot-On Cat

Presentation

Pipette of 0.5 ml spot on solution containing fipronil 50 mg, (S)-methoprene 60 mg. Also contains butylhydroxyanisole (E320) and butylhydroxytoluene (E321).

Uses

Cats and Ferrets

In Cats:

- Elimination of fleas (Ctenocephalides spp.) and insecticidal efficacy against new infestations with adult fleas persists for 4 weeks.

- Prevention of the multiplication of fleas by inhibiting the development of eggs (ovicidal activity), larvae and pupae (larvicidal activity) originating from eggs laid by adult fleas for 6 weeks after application.

- Elimination of ticks (Ixodes ricinus, Dermacentor variabilis, Rhipicephalus sanguineus). The product has a persistent acaricidal efficacy for up to 2 weeks against ticks (based on experimental data).

- Elimination of biting lice (Felicola subrostratus).

Can be used as part of a treatment strategy for the control of Flea Allergy Dermatitis (FAD).

In Ferrets:

-To be used against infestations with fleas, alone or in association with ticks.

-Elimination of fleas (Ctenocephalides spp.). Insecticidal efficacy against new infestations with adult fleas persistent for 4 weeks. Prevention of the multiplication of fleas by inhibiting the development of eggs (ovicidal activity), larvae and pupae (larvicidal activity) originating from eggs laid by adult fleas.

-Elimination of ticks (Ixodes ricinus,). The product has a persistent acaricidal efficacy for 4 weeks against ticks (based on experimental data).

Dosage and administration

Dosage

One pipette of 0.5 ml per cat, corresponding to a minimum recommended dose of 5 mg/kg for fipronil and 6 mg/kg for (S)-methoprene, by topical application to the skin.

In the absence of safety studies, the minimum treatment interval is 4 weeks.

One pipette of 0.5ml per ferret corresponding to a dose of 50 mg for fipronil and 60 mg for (S)-methoprene per ferret, by topical application to the skin.

The minimum treatment interval is 4 weeks.

Method of administration

Hold the pipette upright. Tap the narrow part of the pipette to ensure the contents remain within the main body of the pipette. Snap back the tip. Part the coat on the back of the animal at the base of the neck in front of the shoulder blades until the skin is visible. Place the tip of the pipette on the skin and squeeze the pipette several times to empty its contents completely and directly onto the skin in one spot.

Contra-indications, warnings, etc

For animal treatment only.

The risks of experiencing adverse effects may increase with overdosing.

In the absence of available data, the product should not be used on kittens less than 8 weeks old and/or weighing less than 1 kg. The product should not be used on ferrets less than 6 months old.

It is important to make sure that the product is applied to an area where the animal cannot lick it off and to make sure that animals do not lick each other following treatment.

No data on the effect of bathing/shampooing on the efficacy of the product in cats and ferrets are available. However, based on information available for dogs shampooed from 2 days after application of the product, it is not recommended to bath animals within 2 days after application of the product.

There may be an attachment of single ticks. For this reason transmission of infectious diseases cannot be completely excluded if conditions are unfavourable.

Fleas from pets often infest the animal's basket, bedding and regular resting areas such as carpets and soft furnishings which should be treated, in case of massive infestation and at the beginning of the control measures, with a suitable insecticide and vacuumed regularly.

The potential toxicity of the product for kittens of less than 8 weeks of age in contact with a treated queen is not documented. Special care should be taken in this case.

Do not overdose.

Cats: Among the very rare suspected adverse reactions, transient skin reactions at the application site (scaling, local hair loss, itching, redness) and general itching or hair loss have been reported after use. Excessive salivation, reversible nervous signs (increased sensitivity to stimulation, depression, other nervous signs) or vomiting have also been observed after use.

If licking occurs, a brief period of hypersalivation may be observed due mainly to the nature of the carrier.

Avoid contact with the animal’s eyes.

Animals with a known hypersensitivity to insecticides or alcohol should avoid contact with FRONTLINE Combo Spot-On Cat.

No undesirable effects were observed in target animal safety studies in cats and kittens aged 8 weeks and older and weighing about 1 kg treated once a month at five times the recommended dose for six consecutive months. Itching may occur following treatment. Overdose application of the product will cause a sticky appearance of hairs at the treatment spot. However, should this occur, it will disappear within 24 hours post application.

In ferrets aged 6 months and older and treated once every 2 weeks for four treatments, at five times the recommended dose, weight loss was observed in some animals.

Do not use on sick (systemic diseases, fever…) or convalescent animals.

Do not use in rabbits, as adverse reactions and even death could occur

In absence of studies, the use of the product is not recommended in non-target species.

Use in pregnancy:

Cats: The product can be used during pregnancy.

(For treatment during the lactating period, see contraindications sections)

Ferrets: Laboratory studies in cats have not produced any evidence of teratogenic, foetotoxic or maternotoxic effects. The safety of the veterinary medicinal product has not been established in ferrets during pregnancy and lactation. Use only according to the risk-benefit assessment by the responsible veterinarian.

Operator safety:

Operators with a known hypersensitivity to insecticides or alcohol should avoid contact with FRONTLINE Combo Spot-On Cat.

This product can cause mucous membrane, skin and eye irritation. Therefore, contact of the product with mouth, skin and eyes should be avoided. After accidental ocular exposure the eye should be rinsed carefully with pure water.

Avoid contents coming into contact with the fingers. If this occurs, wash hands with soap and water.

Treated animals should not be handled until the application site is dry, and children should not be allowed to play with treated animals until the application site is dry. It is therefore recommended that animals are not treated during the day, but should be treated during the early evening, and that recently treated animals are not allowed to sleep with owners, especially children.

Wash hands after use.

Do not smoke, drink or eat during application.

Pharmaceutical precautions

Keep out of the reach and sight of children.

Do not store above 30°C. Store in the original package.

Any unused product or waste material should be disposed of in accordance with national requirements.

Fipronil and (S)-methoprene may adversely affect aquatic organisms. Do not contaminate ponds, waterways or ditches with the product or empty containers.

Legal category

POM-V

Packaging Quantities

Box of 1 or 2 blister card(s) of 3 × 0.5 ml green pipettes with a scored tip.

Further information

The product is an insecticidal and acaricidal solution for topical use, containing an adulticidal active ingredient, fipronil, in combination with an ovicidal and larvicidal active ingredient, (S)-methoprene.

Fipronil is an insecticide and acaricide belonging to the phenylpyrazole family. It acts by interacting with ligand-gated chloride channels, in particular those gated by the neurotransmitter gamma-aminobutyric acid (GABA), thereby blocking pre- and post-synaptic transfer of chloride ions across cell membranes. This results in uncontrolled activity of the central nervous system and death of insects or acarines. Fipronil kills fleas within 24 hours, ticks (Dermacentor variabilis, Rhipicephalus sanguineus, Ixodes scapularis, Ixodes ricinus, Haemaphysalis longicornis, Haemaphysalis flava, Haemaphysalis campanulata) and lice within 48 hours post-exposure.

(S)-Methoprene is an insect growth regulator (IGR) of the class of compounds known as juvenile hormone analogues that inhibit the development of immature stages of insects. This compound mimics the action of juvenile hormone and causes impaired development and death of the developing stages of fleas. The on-animal ovicidal activity of (S)-methoprene results from either direct penetration of the eggshell of newly laid eggs or from absorption through the cuticle of the adult fleas. (S)-methoprene is also effective in preventing flea larvae and pupae from developing, which prevents contamination of the environment of treated animals with the immature stages of fleas.

Both (S)-methoprene and fipronil are well-distributed in the haircoat of cats within 24 hours after application. The concentrations of fipronil and (S)-methoprene in the haircoat decrease with time and are detectable for at least 59 days after dosing. Parasites are killed through contact rather than by systemic exposure.

No pharmacological interaction between fipronil and (S)-methoprene was noted.

Marketing authorisation number

Vm 08327/4210.

Need help or advice? Contact us:

  • Landline: 01582 842096
  • Freephone*: 0800 084 2608
  • Mon - Fri: 8:30am - 6:00pm
  • Sat: 9:00am - 1:00pm
  • Email: support@viovet.co.uk

All prices include VAT where applicable. *The freephone number is free from most UK landlines only, mobiles are usually charged so we'd recommend calling our landline from your mobile or internationally.

Reviews of Frontline Spot On Combo for Dogs & Cats

Read our customers' reviews of Frontline Spot On Combo for Dogs & Cats

Questions & Answers for Frontline Spot On Combo for Dogs & Cats

Below are some recent questions we've received regarding Frontline Spot On Combo for Dogs & Cats, including answers from our team.

Ask Your Own Question

Suitable for puppies

29th Jan 2015
Lucianne

Are these okay for puppies?

Danielle Fletcher
  • Category Manager, Own Brand & E-SQP

Frontline Combo requires a prescription from your vet to purchase, so they will prescribe the pipettes for your puppies if they are suitable. The data sheet states that they are intended for puppies over 8 weeks of age and/or weighing over 2 kg. If you can send us the prescription, we would be able to supply you with Frontline Combo for your puppies.

You can buy standard Frontline Spot On without a prescription, and the same guidelines for use in puppies apply. You don't need a prescription for the standard Frontline, but you will need to provide a few simple details about the group being treated before we can supply them. You will be prompted to do this after you have completed the order, and it should only take a minute or two. Feel free to ring our customer services if you are unsure of anything.

Frontline spot-on and prescription Frontline

16th Dec 2013
Julia Barnes

What is the difference between Frontline spot-on and prescription Frontline?

John Cousins
  • Veterinary Surgeon

Frontline Spot-on

  • This contains one ingredient.
  • It coats the skin and hair after being applied and kills off fleas.
  • It persists on the coat even if the animal swims or is shampooed, as long as there is at least a 24 hour gap before and after applying the Frontline.

Prescription Frontline

  • This contains 2 ingredients.
  • The first one is exactly the same as in normal Spot-on.
  • The second one also coats the skin and coat, but does not kill fleas at all. Instead it sterilises fleas, so that they cannot breed.
  • The idea of it is that it persists longer on the coat than the killing ingredient.
  • Hence if people do not re-apply the frontline as often as they should, then the killing ingredient will no longer be effective (especially on animals at the top of the weight range of the product used). The other ingredient works for about twice as long as the main ingredient. The idea behind this is that if fleas cannot breed, you only get very small numbers of them and they are unlikely to be noticed or do any harm.

Re-applying Frontline

16th Dec 2013
Amanda Grimshaw

How soon to re-apply Frontline? I can still see fleas!

John Cousins
  • Veterinary Surgeon

As long as you applied the Frontline properly, it will be killing off the fleas. They take about 24 hours to die. While they are dying, they are very easy to spot on the animal. Healthy fleas are more difficult to see, because they hide better. As fleas are dying and dropping off, more "new" fleas are jumping on your cat from the environment. This is a very bad year for fleas. Most of the flea population affecting your cat is not on your cat, but is actually in carpets and nooks and crannies between floor boards etc. They replenish the fleas on your cat all the time.

You should wait 4 weeks between applications on your cat, but you should vacuum all carpets regularly and use "RIP Fleas" or something similar around the house. It still takes quite a few weeks for most people to get rid of all the fleas.

Where we get our products

19th Nov 2013
narisa chapman

Do your products come from abroad my vet doesnt want to give me a prescription if the frontline combo incase its been frozen on a plane being shiped over hear says it affects the performance of drugs thankyou narisa

  • Veterinary Nurse

All of our veterinary supplies come from UK wholesalers to the veterinary trade. We get the vast majority from Centaur Services Ltd, who supply many of the practices in the UK. We have used centaurs for many many years from when we first has out veterinary practice in 1987! Please call us if you have any further questions.