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Frontline Spot On Combo for Dogs & Cats

Frontline Spot On Combo for Dogs & Cats
Cats » Pack of 3 Pipettes
Dogs 2-10kg Small » Pack of 3 Pipettes
Dogs 10-20kg Medium » Pack of 3 Pipettes
Dogs 10-20kg Medium » Pack of 6 Pipettes
Dogs 20-40kg Large » Pack of 3 Pipettes
Dogs 40-60kg Extra Large » Pack of 3 Pipettes

  • Cats » Pack of 3 Pipettes £16.99
  • Cats » Pack of 6 Pipettes £19.34
  • Dogs 2-10kg Small » Pack of 3 Pipettes £21.49
  • Dogs 2-10kg Small » Pack of 6 Pipettes £22.01
  • Dogs 10-20kg Medium » Pack of 3 Pipettes £23.50
  • Dogs 10-20kg Medium » Pack of 6 Pipettes £24.85
  • Dogs 20-40kg Large » Pack of 3 Pipettes £25.99
  • Dogs 20-40kg Large » Pack of 6 Pipettes £26.20
  • Dogs 40-60kg Extra Large » Pack of 3 Pipettes £29.99
  • Dogs 40-60kg Extra Large » Pack of 6 Pipettes £30.58

Selection of 10 products from

£16.99 to £30.58

Description

Frontline Combo is the prescription-only form of Frontline Spot On, the most popular Flea and Tick treatment available. Combo has an extra ingredient which is particularly helpful for flea control if you forget to re-apply Frontline as frequently as you should. The extra ingredient has a more persistent action on the skin and coat of dogs and cats. This additional ingredient does not kill fleas, but in effect it sterilizes female fleas so that they cannot breed. Each individual flea does not live for long anyway, so that preventing them breeding can be an effective form of control in itself. Just like Frontline Spot On, Frontline Combo is supplied in small pipettes which are emptied onto the back of the neck of the cat or dog to be treated.

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All prices include VAT where applicable.

Medication Datasheets

Dogs 10-20kg Medium » Pack of 6 Pipettes

Frontline Combo Spot-On Dog S, M, L, XL

Qualitative and quantitative composition

Each pipette contains:

For the full list of excipients, see below.

Pharmaceutical form

Spot-on solution. Clear amber solution.

Clinical particulars

Target species

Dogs.

Indications for use

The product can be used as part of a treatment strategy for the control of Flea Allergy Dermatitis (FAD).

Contra-indications

In the absence of available data, the product should not be used on puppies less than 8 weeks old and/or weighing less than 2 kg.

Do not use on sick (e.g. systemic diseases, fever) or convalescent animals.

Do not use in rabbits, as adverse drug reactions, even mortality, could occur.

In absence of studies, the use of the product is not recommended in non-target species. This product is specifically developed for dogs. Do not use in cats and ferrets, as this could lead to overdosing.

Special warnings for each target species

Bathing/immersion in water within 2 days after application of the product and more frequent bathing than once a week should be avoided, as no study has been performed to investigate how this affects the efficacy of the product. Emollient shampoos can be used prior to treatment, but reduce the duration of protection against fleas to approximately 5 weeks when used weekly after application of the product. Weekly bathing with a 2% chlorhexidine medicated shampoo did not affect efficacy against fleas during a 6 week long study.

Dogs should not be allowed to swim in watercourses for 2 days after application. There may be an attachment of a few ticks. For this reason transmission of infectious diseases cannot be completely excluded if conditions are unfavourable. Fleas from pets often infest the animal’s basket, bedding and regular resting areas such as carpets and soft furnishings which should be treated, in case of massive infestation and at the beginning of the control measures, with a suitable insecticide and vacuumed regularly.

Special precautions for use in animals

Avoid contact with the animal’s eyes. It is important to make sure that the product is applied to an area where the animal cannot lick it off and to make sure that animals do not lick each other following treatment.

Special precautions to be taken by the person administering the product to animals

This product can cause mucous membrane, skin and eye irritation. Therefore, contact of the product with mouth, skin and eyes should be avoided. Animals or operators with a known hypersensitivity to insecticides or alcohol should avoid contact with the product.

Avoid contents coming into contact with the fingers. If this occurs, wash hands with soap and water. After accidental ocular exposure the eye should be rinsed carefully with pure water. Wash hands after use.

Treated animals should not be handled until the application site is dry, and children should not be allowed to play with treated animals until the application site is dry. It is therefore recommended that animals are not treated during the day, but should be treated during the early evening, and that recently treated animals are not allowed to sleep with owners, especially children.

Do not smoke, drink or eat during application.

Adverse reactions

Among the very rare suspected reactions, transient skin reactions at the application site (skin discoloration, local hair loss, itching, redness) and general itching or hair loss have been reported after use. Excessive salivation, reversible nervous signs (increased sensitivity to stimulation, depression, other nervous signs), vomiting or respiratory symptoms have also been observed after use. If licking occurs, a brief period of excessive salivation may be observed due mainly to the nature of the carrier. Do not overdose.

Use during pregnancy, lactation or lay

The product can be used during pregnancy and lactation.

Interactions

None known.

Amounts to be administered and administration route

By topical application to the skin. In the absence of safety studies, the minimum treatment interval is 4 weeks.

Weight (kg) Dosage
1 x 0.67 ml pipette
10 - 20 1 x 1.34 ml pipette
20 - 40 1 x 2.68 ml pipette
>40 1 x 4.02 ml pipette

Method of administration:

Hold the pipette upright. Tap the narrow part of the pipette to ensure the contents remain within the main body of the pipette. Snap back the tip. Part the coat on the back of the animal at the base of the neck in front of the shoulder blades until the skin is visible. Place the tip of the pipette on the skin and squeeze the pipette several times to empty its contents completely and directly onto the skin in one spot.

Temporary changes to the coat (clumped/greasy hair) may be noted at the application site.

Overdose

No adverse effects were observed in target animal safety studies in 8 week old puppies, growing dogs and dogs weighing about 2 kg treated once at five times the recommended dose. The risk of experiencing adverse effects may however increase when overdosing, so animals should always be treated with the correct pipette size according to bodyweight.

Pharmacological particulars

The product is an insecticidal and acaricidal solution for topical use, containing an association of an adulticidal active ingredient, fipronil, in combination with an ovicidal and larvicidal active ingredient, (S)-methoprene.

ATCvet code: QP53AX65

Pharmacodynamic properties

Fipronil is an insecticide and acaricide belonging to the phenylpyrazole family. It acts by interacting with ligand-gated chloride channels, in particular those gated by the neurotransmitter gamma-aminobutyric acid (GABA), thereby blocking pre- and post-synaptic transfer of chloride ions across cell membranes. This results in uncontrolled activity of the central nervous system and death of insects or acarines. Fipronil kills fleas within 24 hours and ticks (Dermacentor reticulatus, Dermacentor variabilis, Rhipicephalus sanguineus, Ixodes scapularis, Ixodes ricinus, Haemaphysalis longicornis, Haemaphysalis flava, Haemaphysalis campanulata) and lice within 48 hours post-exposure.

(S)-methoprene is an insect growth regulator (IGR) of the class of compounds known as juvenile hormone analogues that inhibit the development of immature stages of insects. This compound mimics the action of juvenile hormone and causes impaired development and death of the developing stages of fleas. The on-animal ovicidal activity of (S)-methoprene results from either direct penetration of the eggshell of newly laid eggs or from absorption through the cuticle of the adult fleas. (S)-methoprene is also effective in preventing flea larvae and pupae from developing, which prevents contamination of the environment of treated animals with the immature stages of fleas.

Pharmaceutical particulars

Excipients

Butylhydroxyanisole (E320), Butylhydroxytoluene (E321), Ethanol, Polysorbate 80 (E433), Polyvidone, Diethylene glycol monoethyl ether.

Major incompatibilities

None known.

Shelf life

Shelf life of the product as packaged for sale: 3 years.

Special precautions for storage

Do not store above 30 °C. Store in the original package.

Immediate packaging

Box containing 1 or 2 blister card(s) of 3 x 0.67 ml (S), 1.34 ml (M), 2.68 ml (L), or 4.02 ml (XL) green pipettes with a scored tip.

Disposal

Any unused product or waste materials derived from such products should be disposed of in accordance with local requirements.

Fipronil and (S)-methoprene may adversely affect aquatic organisms. Do not contaminate ponds, waterways or ditches with the product or empty containers.

Marketing Authorisation Number

Vm 08327/4211-4

Legal category

Dogs 20-40kg Large » Pack of 6 Pipettes

Frontline Combo Spot-On Dog S, M, L, XL

Qualitative and quantitative composition

Each pipette contains:

For the full list of excipients, see below.

Pharmaceutical form

Spot-on solution. Clear amber solution.

Clinical particulars

Target species

Dogs.

Indications for use

The product can be used as part of a treatment strategy for the control of Flea Allergy Dermatitis (FAD).

Contra-indications

In the absence of available data, the product should not be used on puppies less than 8 weeks old and/or weighing less than 2 kg.

Do not use on sick (e.g. systemic diseases, fever) or convalescent animals.

Do not use in rabbits, as adverse drug reactions, even mortality, could occur.

In absence of studies, the use of the product is not recommended in non-target species. This product is specifically developed for dogs. Do not use in cats and ferrets, as this could lead to overdosing.

Special warnings for each target species

Bathing/immersion in water within 2 days after application of the product and more frequent bathing than once a week should be avoided, as no study has been performed to investigate how this affects the efficacy of the product. Emollient shampoos can be used prior to treatment, but reduce the duration of protection against fleas to approximately 5 weeks when used weekly after application of the product. Weekly bathing with a 2% chlorhexidine medicated shampoo did not affect efficacy against fleas during a 6 week long study.

Dogs should not be allowed to swim in watercourses for 2 days after application. There may be an attachment of a few ticks. For this reason transmission of infectious diseases cannot be completely excluded if conditions are unfavourable. Fleas from pets often infest the animal’s basket, bedding and regular resting areas such as carpets and soft furnishings which should be treated, in case of massive infestation and at the beginning of the control measures, with a suitable insecticide and vacuumed regularly.

Special precautions for use in animals

Avoid contact with the animal’s eyes. It is important to make sure that the product is applied to an area where the animal cannot lick it off and to make sure that animals do not lick each other following treatment.

Special precautions to be taken by the person administering the product to animals

This product can cause mucous membrane, skin and eye irritation. Therefore, contact of the product with mouth, skin and eyes should be avoided. Animals or operators with a known hypersensitivity to insecticides or alcohol should avoid contact with the product.

Avoid contents coming into contact with the fingers. If this occurs, wash hands with soap and water. After accidental ocular exposure the eye should be rinsed carefully with pure water. Wash hands after use.

Treated animals should not be handled until the application site is dry, and children should not be allowed to play with treated animals until the application site is dry. It is therefore recommended that animals are not treated during the day, but should be treated during the early evening, and that recently treated animals are not allowed to sleep with owners, especially children.

Do not smoke, drink or eat during application.

Adverse reactions

Among the very rare suspected reactions, transient skin reactions at the application site (skin discoloration, local hair loss, itching, redness) and general itching or hair loss have been reported after use. Excessive salivation, reversible nervous signs (increased sensitivity to stimulation, depression, other nervous signs), vomiting or respiratory symptoms have also been observed after use. If licking occurs, a brief period of excessive salivation may be observed due mainly to the nature of the carrier. Do not overdose.

Use during pregnancy, lactation or lay

The product can be used during pregnancy and lactation.

Interactions

None known.

Amounts to be administered and administration route

By topical application to the skin. In the absence of safety studies, the minimum treatment interval is 4 weeks.

Weight (kg) Dosage
1 x 0.67 ml pipette
10 - 20 1 x 1.34 ml pipette
20 - 40 1 x 2.68 ml pipette
>40 1 x 4.02 ml pipette

Method of administration:

Hold the pipette upright. Tap the narrow part of the pipette to ensure the contents remain within the main body of the pipette. Snap back the tip. Part the coat on the back of the animal at the base of the neck in front of the shoulder blades until the skin is visible. Place the tip of the pipette on the skin and squeeze the pipette several times to empty its contents completely and directly onto the skin in one spot.

Temporary changes to the coat (clumped/greasy hair) may be noted at the application site.

Overdose

No adverse effects were observed in target animal safety studies in 8 week old puppies, growing dogs and dogs weighing about 2 kg treated once at five times the recommended dose. The risk of experiencing adverse effects may however increase when overdosing, so animals should always be treated with the correct pipette size according to bodyweight.

Pharmacological particulars

The product is an insecticidal and acaricidal solution for topical use, containing an association of an adulticidal active ingredient, fipronil, in combination with an ovicidal and larvicidal active ingredient, (S)-methoprene.

ATCvet code: QP53AX65

Pharmacodynamic properties

Fipronil is an insecticide and acaricide belonging to the phenylpyrazole family. It acts by interacting with ligand-gated chloride channels, in particular those gated by the neurotransmitter gamma-aminobutyric acid (GABA), thereby blocking pre- and post-synaptic transfer of chloride ions across cell membranes. This results in uncontrolled activity of the central nervous system and death of insects or acarines. Fipronil kills fleas within 24 hours and ticks (Dermacentor reticulatus, Dermacentor variabilis, Rhipicephalus sanguineus, Ixodes scapularis, Ixodes ricinus, Haemaphysalis longicornis, Haemaphysalis flava, Haemaphysalis campanulata) and lice within 48 hours post-exposure.

(S)-methoprene is an insect growth regulator (IGR) of the class of compounds known as juvenile hormone analogues that inhibit the development of immature stages of insects. This compound mimics the action of juvenile hormone and causes impaired development and death of the developing stages of fleas. The on-animal ovicidal activity of (S)-methoprene results from either direct penetration of the eggshell of newly laid eggs or from absorption through the cuticle of the adult fleas. (S)-methoprene is also effective in preventing flea larvae and pupae from developing, which prevents contamination of the environment of treated animals with the immature stages of fleas.

Pharmaceutical particulars

Excipients

Butylhydroxyanisole (E320), Butylhydroxytoluene (E321), Ethanol, Polysorbate 80 (E433), Polyvidone, Diethylene glycol monoethyl ether.

Major incompatibilities

None known.

Shelf life

Shelf life of the product as packaged for sale: 3 years.

Special precautions for storage

Do not store above 30 °C. Store in the original package.

Immediate packaging

Box containing 1 or 2 blister card(s) of 3 x 0.67 ml (S), 1.34 ml (M), 2.68 ml (L), or 4.02 ml (XL) green pipettes with a scored tip.

Disposal

Any unused product or waste materials derived from such products should be disposed of in accordance with local requirements.

Fipronil and (S)-methoprene may adversely affect aquatic organisms. Do not contaminate ponds, waterways or ditches with the product or empty containers.

Marketing Authorisation Number

Vm 08327/4211-4

Legal category

Dogs 2-10kg Small » Pack of 6 Pipettes

Frontline Combo Spot-On Dog S, M, L, XL

Qualitative and quantitative composition

Each pipette contains:

For the full list of excipients, see below.

Pharmaceutical form

Spot-on solution. Clear amber solution.

Clinical particulars

Target species

Dogs.

Indications for use

The product can be used as part of a treatment strategy for the control of Flea Allergy Dermatitis (FAD).

Contra-indications

In the absence of available data, the product should not be used on puppies less than 8 weeks old and/or weighing less than 2 kg.

Do not use on sick (e.g. systemic diseases, fever) or convalescent animals.

Do not use in rabbits, as adverse drug reactions, even mortality, could occur.

In absence of studies, the use of the product is not recommended in non-target species. This product is specifically developed for dogs. Do not use in cats and ferrets, as this could lead to overdosing.

Special warnings for each target species

Bathing/immersion in water within 2 days after application of the product and more frequent bathing than once a week should be avoided, as no study has been performed to investigate how this affects the efficacy of the product. Emollient shampoos can be used prior to treatment, but reduce the duration of protection against fleas to approximately 5 weeks when used weekly after application of the product. Weekly bathing with a 2% chlorhexidine medicated shampoo did not affect efficacy against fleas during a 6 week long study.

Dogs should not be allowed to swim in watercourses for 2 days after application. There may be an attachment of a few ticks. For this reason transmission of infectious diseases cannot be completely excluded if conditions are unfavourable. Fleas from pets often infest the animal’s basket, bedding and regular resting areas such as carpets and soft furnishings which should be treated, in case of massive infestation and at the beginning of the control measures, with a suitable insecticide and vacuumed regularly.

Special precautions for use in animals

Avoid contact with the animal’s eyes. It is important to make sure that the product is applied to an area where the animal cannot lick it off and to make sure that animals do not lick each other following treatment.

Special precautions to be taken by the person administering the product to animals

This product can cause mucous membrane, skin and eye irritation. Therefore, contact of the product with mouth, skin and eyes should be avoided. Animals or operators with a known hypersensitivity to insecticides or alcohol should avoid contact with the product.

Avoid contents coming into contact with the fingers. If this occurs, wash hands with soap and water. After accidental ocular exposure the eye should be rinsed carefully with pure water. Wash hands after use.

Treated animals should not be handled until the application site is dry, and children should not be allowed to play with treated animals until the application site is dry. It is therefore recommended that animals are not treated during the day, but should be treated during the early evening, and that recently treated animals are not allowed to sleep with owners, especially children.

Do not smoke, drink or eat during application.

Adverse reactions

Among the very rare suspected reactions, transient skin reactions at the application site (skin discoloration, local hair loss, itching, redness) and general itching or hair loss have been reported after use. Excessive salivation, reversible nervous signs (increased sensitivity to stimulation, depression, other nervous signs), vomiting or respiratory symptoms have also been observed after use. If licking occurs, a brief period of excessive salivation may be observed due mainly to the nature of the carrier. Do not overdose.

Use during pregnancy, lactation or lay

The product can be used during pregnancy and lactation.

Interactions

None known.

Amounts to be administered and administration route

By topical application to the skin. In the absence of safety studies, the minimum treatment interval is 4 weeks.

Weight (kg) Dosage
1 x 0.67 ml pipette
10 - 20 1 x 1.34 ml pipette
20 - 40 1 x 2.68 ml pipette
>40 1 x 4.02 ml pipette

Method of administration:

Hold the pipette upright. Tap the narrow part of the pipette to ensure the contents remain within the main body of the pipette. Snap back the tip. Part the coat on the back of the animal at the base of the neck in front of the shoulder blades until the skin is visible. Place the tip of the pipette on the skin and squeeze the pipette several times to empty its contents completely and directly onto the skin in one spot.

Temporary changes to the coat (clumped/greasy hair) may be noted at the application site.

Overdose

No adverse effects were observed in target animal safety studies in 8 week old puppies, growing dogs and dogs weighing about 2 kg treated once at five times the recommended dose. The risk of experiencing adverse effects may however increase when overdosing, so animals should always be treated with the correct pipette size according to bodyweight.

Pharmacological particulars

The product is an insecticidal and acaricidal solution for topical use, containing an association of an adulticidal active ingredient, fipronil, in combination with an ovicidal and larvicidal active ingredient, (S)-methoprene.

ATCvet code: QP53AX65

Pharmacodynamic properties

Fipronil is an insecticide and acaricide belonging to the phenylpyrazole family. It acts by interacting with ligand-gated chloride channels, in particular those gated by the neurotransmitter gamma-aminobutyric acid (GABA), thereby blocking pre- and post-synaptic transfer of chloride ions across cell membranes. This results in uncontrolled activity of the central nervous system and death of insects or acarines. Fipronil kills fleas within 24 hours and ticks (Dermacentor reticulatus, Dermacentor variabilis, Rhipicephalus sanguineus, Ixodes scapularis, Ixodes ricinus, Haemaphysalis longicornis, Haemaphysalis flava, Haemaphysalis campanulata) and lice within 48 hours post-exposure.

(S)-methoprene is an insect growth regulator (IGR) of the class of compounds known as juvenile hormone analogues that inhibit the development of immature stages of insects. This compound mimics the action of juvenile hormone and causes impaired development and death of the developing stages of fleas. The on-animal ovicidal activity of (S)-methoprene results from either direct penetration of the eggshell of newly laid eggs or from absorption through the cuticle of the adult fleas. (S)-methoprene is also effective in preventing flea larvae and pupae from developing, which prevents contamination of the environment of treated animals with the immature stages of fleas.

Pharmaceutical particulars

Excipients

Butylhydroxyanisole (E320), Butylhydroxytoluene (E321), Ethanol, Polysorbate 80 (E433), Polyvidone, Diethylene glycol monoethyl ether.

Major incompatibilities

None known.

Shelf life

Shelf life of the product as packaged for sale: 3 years.

Special precautions for storage

Do not store above 30 °C. Store in the original package.

Immediate packaging

Box containing 1 or 2 blister card(s) of 3 x 0.67 ml (S), 1.34 ml (M), 2.68 ml (L), or 4.02 ml (XL) green pipettes with a scored tip.

Disposal

Any unused product or waste materials derived from such products should be disposed of in accordance with local requirements.

Fipronil and (S)-methoprene may adversely affect aquatic organisms. Do not contaminate ponds, waterways or ditches with the product or empty containers.

Marketing Authorisation Number

Vm 08327/4211-4

Legal category

Dogs 40-60kg Extra Large » Pack of 6 Pipettes

Frontline Combo Spot-On Dog S, M, L, XL

Qualitative and quantitative composition

Each pipette contains:

For the full list of excipients, see below.

Pharmaceutical form

Spot-on solution. Clear amber solution.

Clinical particulars

Target species

Dogs.

Indications for use

The product can be used as part of a treatment strategy for the control of Flea Allergy Dermatitis (FAD).

Contra-indications

In the absence of available data, the product should not be used on puppies less than 8 weeks old and/or weighing less than 2 kg.

Do not use on sick (e.g. systemic diseases, fever) or convalescent animals.

Do not use in rabbits, as adverse drug reactions, even mortality, could occur.

In absence of studies, the use of the product is not recommended in non-target species. This product is specifically developed for dogs. Do not use in cats and ferrets, as this could lead to overdosing.

Special warnings for each target species

Bathing/immersion in water within 2 days after application of the product and more frequent bathing than once a week should be avoided, as no study has been performed to investigate how this affects the efficacy of the product. Emollient shampoos can be used prior to treatment, but reduce the duration of protection against fleas to approximately 5 weeks when used weekly after application of the product. Weekly bathing with a 2% chlorhexidine medicated shampoo did not affect efficacy against fleas during a 6 week long study.

Dogs should not be allowed to swim in watercourses for 2 days after application. There may be an attachment of a few ticks. For this reason transmission of infectious diseases cannot be completely excluded if conditions are unfavourable. Fleas from pets often infest the animal’s basket, bedding and regular resting areas such as carpets and soft furnishings which should be treated, in case of massive infestation and at the beginning of the control measures, with a suitable insecticide and vacuumed regularly.

Special precautions for use in animals

Avoid contact with the animal’s eyes. It is important to make sure that the product is applied to an area where the animal cannot lick it off and to make sure that animals do not lick each other following treatment.

Special precautions to be taken by the person administering the product to animals

This product can cause mucous membrane, skin and eye irritation. Therefore, contact of the product with mouth, skin and eyes should be avoided. Animals or operators with a known hypersensitivity to insecticides or alcohol should avoid contact with the product.

Avoid contents coming into contact with the fingers. If this occurs, wash hands with soap and water. After accidental ocular exposure the eye should be rinsed carefully with pure water. Wash hands after use.

Treated animals should not be handled until the application site is dry, and children should not be allowed to play with treated animals until the application site is dry. It is therefore recommended that animals are not treated during the day, but should be treated during the early evening, and that recently treated animals are not allowed to sleep with owners, especially children.

Do not smoke, drink or eat during application.

Adverse reactions

Among the very rare suspected reactions, transient skin reactions at the application site (skin discoloration, local hair loss, itching, redness) and general itching or hair loss have been reported after use. Excessive salivation, reversible nervous signs (increased sensitivity to stimulation, depression, other nervous signs), vomiting or respiratory symptoms have also been observed after use. If licking occurs, a brief period of excessive salivation may be observed due mainly to the nature of the carrier. Do not overdose.

Use during pregnancy, lactation or lay

The product can be used during pregnancy and lactation.

Interactions

None known.

Amounts to be administered and administration route

By topical application to the skin. In the absence of safety studies, the minimum treatment interval is 4 weeks.

Weight (kg) Dosage
1 x 0.67 ml pipette
10 - 20 1 x 1.34 ml pipette
20 - 40 1 x 2.68 ml pipette
>40 1 x 4.02 ml pipette

Method of administration:

Hold the pipette upright. Tap the narrow part of the pipette to ensure the contents remain within the main body of the pipette. Snap back the tip. Part the coat on the back of the animal at the base of the neck in front of the shoulder blades until the skin is visible. Place the tip of the pipette on the skin and squeeze the pipette several times to empty its contents completely and directly onto the skin in one spot.

Temporary changes to the coat (clumped/greasy hair) may be noted at the application site.

Overdose

No adverse effects were observed in target animal safety studies in 8 week old puppies, growing dogs and dogs weighing about 2 kg treated once at five times the recommended dose. The risk of experiencing adverse effects may however increase when overdosing, so animals should always be treated with the correct pipette size according to bodyweight.

Pharmacological particulars

The product is an insecticidal and acaricidal solution for topical use, containing an association of an adulticidal active ingredient, fipronil, in combination with an ovicidal and larvicidal active ingredient, (S)-methoprene.

ATCvet code: QP53AX65

Pharmacodynamic properties

Fipronil is an insecticide and acaricide belonging to the phenylpyrazole family. It acts by interacting with ligand-gated chloride channels, in particular those gated by the neurotransmitter gamma-aminobutyric acid (GABA), thereby blocking pre- and post-synaptic transfer of chloride ions across cell membranes. This results in uncontrolled activity of the central nervous system and death of insects or acarines. Fipronil kills fleas within 24 hours and ticks (Dermacentor reticulatus, Dermacentor variabilis, Rhipicephalus sanguineus, Ixodes scapularis, Ixodes ricinus, Haemaphysalis longicornis, Haemaphysalis flava, Haemaphysalis campanulata) and lice within 48 hours post-exposure.

(S)-methoprene is an insect growth regulator (IGR) of the class of compounds known as juvenile hormone analogues that inhibit the development of immature stages of insects. This compound mimics the action of juvenile hormone and causes impaired development and death of the developing stages of fleas. The on-animal ovicidal activity of (S)-methoprene results from either direct penetration of the eggshell of newly laid eggs or from absorption through the cuticle of the adult fleas. (S)-methoprene is also effective in preventing flea larvae and pupae from developing, which prevents contamination of the environment of treated animals with the immature stages of fleas.

Pharmaceutical particulars

Excipients

Butylhydroxyanisole (E320), Butylhydroxytoluene (E321), Ethanol, Polysorbate 80 (E433), Polyvidone, Diethylene glycol monoethyl ether.

Major incompatibilities

None known.

Shelf life

Shelf life of the product as packaged for sale: 3 years.

Special precautions for storage

Do not store above 30 °C. Store in the original package.

Immediate packaging

Box containing 1 or 2 blister card(s) of 3 x 0.67 ml (S), 1.34 ml (M), 2.68 ml (L), or 4.02 ml (XL) green pipettes with a scored tip.

Disposal

Any unused product or waste materials derived from such products should be disposed of in accordance with local requirements.

Fipronil and (S)-methoprene may adversely affect aquatic organisms. Do not contaminate ponds, waterways or ditches with the product or empty containers.

Marketing Authorisation Number

Vm 08327/4211-4

Legal category

Delivery Information

How quickly do you deliver?

Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.

What do you charge for delivery?

For UK delivery, we charge the following:

Order Total Weight Delivery
£0-£28.99 Under 2kg £2.99
2kg+ £4.99
£29-£38.99 Under 2kg Free
2kg+ £4.99
£39+ Under 2kg Free
2kg+ Free

Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.

For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.

We can deliver most items to all around the world, but prices do vary. The majority of light weight orders (less than 1.5kg) can be delivered for a flat rate of £10. For an accurate estimate of the delivery charge, please put the items you require in your basket and use the "Estimate Delivery" system on the shopping basket page (you only need to enter your country and postal/zip code) for a quick quote. For deliveries to the USA you may need to go to the checkout page and enter your full address to get a quote (as some services need your state in order to quote too). For more information on international deliveries, please see our delivery information page.

Delivery of aerosols

Due to restrictions aerosols can't be sent by Royal Mail. We appreciate your understanding.

Delivery of temperature controlled items

Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.

How do I cancel or return an order?

Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.

To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.

*For full details on returns, see our terms and conditions page.

Reviews (21)

Q & A

Below are some recent questions we've received regarding Frontline Spot On Combo for Dogs & Cats, including answers from our team.

29 January 2015 at 5:44pm

Suitable for puppies

Lucianne

Are these okay for puppies?

  • Brand Manager

Frontline Combo requires a prescription from your vet to purchase, so they will prescribe the pipettes for your puppies if they are suitable. The data sheet states that they are intended for puppies over 8 weeks of age and/or weighing over 2 kg. If you can send us the prescription, we would be able to supply you with Frontline Combo for your puppies.

You can buy standard Frontline Spot On without a prescription, and the same guidelines for use in puppies apply. You don't need a prescription for the standard Frontline, but you will need to provide a few simple details about the group being treated before we can supply them. You will be prompted to do this after you have completed the order, and it should only take a minute or two. Feel free to ring our customer services if you are unsure of anything.

16 December 2013 at 12:04pm

Frontline spot-on and prescription Frontline

Julia Barnes

What is the difference between Frontline spot-on and prescription Frontline?

  • Non-Executive Director

Frontline Spot-on

  • This contains one ingredient.
  • It coats the skin and hair after being applied and kills off fleas.
  • It persists on the coat even if the animal swims or is shampooed, as long as there is at least a 24 hour gap before and after applying the Frontline.

Prescription Frontline

  • This contains 2 ingredients.
  • The first one is exactly the same as in normal Spot-on.
  • The second one also coats the skin and coat, but does not kill fleas at all. Instead it sterilises fleas, so that they cannot breed.
  • The idea of it is that it persists longer on the coat than the killing ingredient.
  • Hence if people do not re-apply the frontline as often as they should, then the killing ingredient will no longer be effective (especially on animals at the top of the weight range of the product used). The other ingredient works for about twice as long as the main ingredient. The idea behind this is that if fleas cannot breed, you only get very small numbers of them and they are unlikely to be noticed or do any harm.
16 December 2013 at 11:55am

Re-applying Frontline

Amanda Grimshaw

How soon to re-apply Frontline? I can still see fleas!

  • Non-Executive Director

As long as you applied the Frontline properly, it will be killing off the fleas. They take about 24 hours to die. While they are dying, they are very easy to spot on the animal. Healthy fleas are more difficult to see, because they hide better. As fleas are dying and dropping off, more "new" fleas are jumping on your cat from the environment. This is a very bad year for fleas. Most of the flea population affecting your cat is not on your cat, but is actually in carpets and nooks and crannies between floor boards etc. They replenish the fleas on your cat all the time.

You should wait 4 weeks between applications on your cat, but you should vacuum all carpets regularly and use "RIP Fleas" or something similar around the house. It still takes quite a few weeks for most people to get rid of all the fleas.

19 November 2013 at 5:26pm

Where we get our products

narisa chapman

Do your products come from abroad my vet doesnt want to give me a prescription if the frontline combo incase its been frozen on a plane being shiped over hear says it affects the performance of drugs thankyou narisa

  • Non-Executive Director

All of our veterinary supplies come from UK wholesalers to the veterinary trade. We get the vast majority from Centaur Services Ltd, who supply many of the practices in the UK. We have used centaurs for many many years from when we first has out veterinary practice in 1987! Please call us if you have any further questions.