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Equilis Vaccine For Horses

  • Strep E » 1ml Dose (Pack of 10) £196.37



One dose (0.2 ml) contains a live, modified strain of Streptococcus equi TW928 109.0 to 109.4 cfu*.

*Colony forming units.


For the immunisation of horses against Streptococcus equi to reduce clinical signs and occurrence of lymph node abscesses. The onset of immunity is established at two weeks after basic vaccination. The duration of immunity is up to 3 months.

A priming response is maintained for up to six months after basic vaccination. Therefore only a single dose of vaccine is needed to restore immunity.

The vaccine is intended for use in horses for which a risk of Streptococcus equi infection has been clearly identified, due to contact with horses from areas where this pathogen is known to be present, e.g. stables with horses that travel to shows and/or competitions in such areas, or stables that obtain or have livery horses from such areas.

The vaccine strain is deletion mutant with a limited growth potential in mammalian tissue. It is able to multiply locally at the submucosal injection site for a short period and is shed into the oro-nasal cavity over a few days, but the vaccine strain does not survive on the oro-nasal mucosa and does not disseminate systemically at the recommended dose.

Dosage and administration

Dosage: 0.2 ml of reconstituted vaccine by submucosal vaccination.

Basic vaccination: Horses from 4 months of age onwards receive two vaccinations of one dose with a 4 week interval.

Revaccination: Revaccinate every three months to maintain immunity.

A priming response is maintained for up to six months after basic vaccination. Therefore only a single dose of vaccine is needed to restore immunity.

It is recommended that all horses stabled together are vaccinated. Allow the solvent to reach room temperature (15 - 25°C). Aseptically reconstitute the freeze-dried vaccine with 0.3 ml of the sterile solvent provided. Do NOT shake and wait 1 minute after addition of the solvent. Withdraw 0.2 ml of the reconstituted vaccine into the syringe provided with the vaccine (see Figure 1) and connect the applicator to the needle (see Figure 2). Restrain the animal’s head, lift the upper lip and insert the needle into the inside of the upper lip until the applicator rests on the lip. Administer the whole content of the syringe into the inside of the upper lip (see Figure 3).

Figure 1:

equilis_strepE1 (1)

Figure 2:

equilis_strepE2 (1)

Figure 3:

equilis_strepE3 (1)

Contra-indications, warnings, etc

Do not use in pregnant or lactating mares.

Shedding of the vaccine strain from the injection site can be observed for a period of four days after vaccination.

From literature, it is known that a very low number of horses may develop purpura haemorrhagica if they are vaccinated shortly after infection. Purpura haemorrhagica has not been observed in any of the safety studies performed during development of Equilis StrepE. As the incidence of purpura haemorrhagica is very low, its occurrence cannot be ruled out completely. Only healthy horses should be vaccinated. Ensure that the lyophilisate is completely reconstituted before use. Basic vaccination performed during an outbreak is not efficacious, because immunity is insufficient until basic vaccination has been completed.

Adverse reactions

After vaccination a diffusely swollen reaction, which may be warm or painful, develops at the injection site within 4 hours. The reaction is maximal at 2-3 days post vaccination with a maximum area of 3 cm by 8 cm. This swelling resolves completely within 3 weeks and normally has no effect on the appetite of the vaccinated animal and causes no apparent discomfort. The vaccine organism may establish a small suppurative inflammation locally at the injection site, leading to a disruption of the overlaying lip mucosa and subsequent discharge of fluid and inflammatory cells. A slight cloudy discharge commonly occurs from the mucosal injection site at 3 or 4 days post vaccination.

Slight enlargements, which may be transiently painful, of the retropharyngeal and mandibular lymph nodes may occur for a few days after vaccination. In very rare cases an abscess may develop at the injection site or in the regional lymph nodes.

Further, an increase in rectal temperature up to 2°C may occur on the day of vaccination. In rare cases, inappetence, fever and shivering may be observed. In very rare cases depression may develop.

In addition to the clinical signs given above, vaccination with a ten times overdose may induce an abscess in one of the submandibular lymph nodes. The abscesses drain purulent material from 2 weeks after vaccination, but heal without intervention within a month thereafter. Furthermore, an increase in rectal temperature up to 2.5 °C may occur on the day of vaccination. Slight apathy may occasionally be observed one day after vaccination.

Special precautions to be taken by the person administering the vaccine

Special care must be taken when connecting the applicator to the needle to avoid needle-stick injuries. In case of accidental self injection, seek medical advice immediately and show the package insert or the label to the physician.

To the user: This product contains a live bacterial deletion mutant with a limited growth potential in mammalian tissue. Accidental self injection may result in an inflammatory reaction with severe pain and swelling. If you are accidentally injected with this product seek prompt medical advice even if only a very small amount is injected and take the package leaflet with you.

To the physician: This product contains a live auxotrophic deletion mutant Streptococcus equi vaccine with attenuated virulence. However, the bacterial compounds of this product can cause an inflammatory reaction with intense and painful swelling after accidental injection. Anti-inflammatory therapy is indicated even if only a very small amount of the product is injected. An additional antibiotic treatment should be considered for safety reasons. The sensitivity of the vaccine is listed in Section Interactions below.


Limited information is available on the safety and efficacy from the use of this vaccine with any other. It is therefore recommended that no other vaccines should be administered concurrently or simultaneously. The vaccine strain is sensitive to penicillins, tetracyclines, macrolides and lincomycin. The vaccine strain is resistant to aminoglycosides, sulphonamides, flumequine, and trimethoprim-sulfa combinations. Do not use antibiotics within one week after vaccination. Do not mix with any other veterinary medicinal products except the solvent supplied for use with the vaccine.

Withdrawal period

Zero days.

For animal treatment only. Keep out of reach and sight of children.

Pharmaceutical precautions

Lyophilisate: Store refrigerated (+2°C to +8°C). Protect from light.

Solvent: This medicinal product does not require any special storage conditions.

Reconstituted vials should be used within 4 hours.

Dispose of waste material by boiling, incineration or immersion in an appropriate disinfectant approved for use by the competent authorities.

Legal category


Packaging Quantities

1 pack contains 10 vials with lyophilisate and 10 vials of 0.5 ml solvent, 10 applicators, 10 syringes with needles.

Further information

In the challenge studies performed by Intervet 75% of horses showed a significant reduction in clinical signs and abscess formation at the recommended dose. For any information about this veterinary medicinal product, please contact the local representative of the Marketing Authorisation Holder.

Marketing authorisation number


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