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Eprinex Multi 5mg/ml pour-on for beef and dairy cattle, sheep and goats
All prices include VAT where applicable.
Each ml contains:
Eprinomectin...................................................................................... 5.0 mg
Butylhydroxytoluene (E321)............................................................ 0.1 mg
Alpha-tocopherol………………………………………………………….max. 0.06 mg
For the full list of excipients, see below
Pour-on solution. Clear slightly yellow solution.
Beef and dairy cattle, sheep and goats.
Treatment of infestation by the following parasites sensitive to eprinomectin:
Gastrointestinal Roundworms (Adult, L4 and Inhibited L4)
Gastrointestinal Roundworms (Adult and L4)
Gastrointestinal roundworms (Adult)
Lungworms (Adult and L4)
Warbles (parasitic stages)
Sarcoptes scabiei var bovis
Applied as recommended, the product prevents reinfestations with:ParasiteProlonged ActivityDictyocaulus viviparus Up to 28 daysOstertagia ostertagi Up to 28 daysOesophagostomum radiatum Up to 28 daysCooperia punctata Up to 28 daysCooperia surnabada Up to 28 daysCooperia oncophoraUp to 28 daysNematodirus helvetianus Up to 14 daysTrichostrongylus colubriformis Up to 21 daysTrichostrongylus axei Up to 21 daysHaemonchus placeiUp to 21 days
Up to 28 days
Up to 28 days
Up to 28 days
Up to 28 days
Up to 28 days
Up to 28 days
Up to 14 days
Up to 21 days
Up to 21 days
Up to 21 days
For best results Eprinex Multi should be part of a programme to control both internal and external parasites of cattle based on the epidemiology of these parasites.
Gastrointestinal roundworms (adults)
Teladorsagia circumcincta (pinnata/trifurcata)
Gastrointestinal roundworms (adult)
Teladorsagia circumcincta (pinnata/trifurcata)
This product is formulated only for topical application to cattle, sheep and goats including lactating dairy animals. Do not use in other animal species.Do not use in cases of hypersensitivity to the active substance or to any of the excipients.
For effective use, the product should not be applied to areas of the backline covered with mud or manure. The product should be applied only on healthy skin.
In cattle, rainfall before, during or after the application of the product, has been shown to have no impact on its efficacy. It also has been demonstrated that haircoat length has no impact on the product’s efficacy. The effect of rainfall and haircoat length on efficacy has not been evaluated in sheep and goats.
For cattle, in order to limit cross-transfer of eprinomectin, treated animals may be separated from untreated animals. Non-compliance with this recommendation may lead to residue violations in untreated animals.
Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately result in ineffective therapy:
− Too frequent and repeated use of anthelmintics from the same class, over an extended period of time.
− Underdosing, which may be due to underestimation of bodyweight, misadministration of the product, or lack of calibration of the dosing device (if any).
While mite and louse numbers decline rapidly following treatment, due to the feeding habits of some mites, in some cases several weeks may be required for complete eradication.
Do not smoke, eat or drink while handling the product.
Wash hands after use.
This product may be irritating to skin and eyes. Avoid contact with eyes and skin.
People with known hypersensitivity to the active substance or to any of the excipients should avoid contact with the product.
Operators should wear rubber gloves, boots and waterproof coat when applying the product.
Should clothing become contaminated, remove as soon as possible and launder before re-use.
If accidental skin contact occurs, wash the affected area immediately with soap and water.
Should accidental eye exposure occur, flush eyes immediately with plenty of clean water. Should irritation persist, seek medical advice.
Do not ingest.
In case of accidental ingestion, rinse out mouth thoroughly with water, seek medical advice immediately and show the package insert or the label to the physician.
Eprinomectin is very toxic to dung fauna and aquatic organisms, is persistent in soils and may accumulate in sediments. The risk to aquatic ecosystems and dung fauna can be reduced by avoiding repeated use of eprinomectin (and products of the same anthelmintic class). In order to reduce the risk to aquatic ecosystems, treated animals should not have direct access to water bodies for a minimum of two weeks after treatment.
In very rare cases, pruritus and alopecia have been observed after the use of the veterinary medicinal product.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
Laboratory studies (rat, rabbit) have not produced any evidence of a teratogenic or embryotoxic effects due to the use of eprinomectin at therapeutic doses. Laboratory studies in cattle have not produced any evidence of a teratogenic or foetotoxic effect at the recommended therapeutic dose. The product can be used in dairy cattle during pregnancy and lactation.
The safety of eprinomectin during pregnancy in sheep and goats has not been tested. Use only according to the benefit/risk assessment of the responsible veterinarian in these species.
No interactions with other medicines and no other forms of interactions are known. Since eprinomectin binds extensively to plasmatic proteins, this should be taken into account if it is used in association with other molecules having the same characteristics.
To ensure administration of a correct dose, bodyweight should be determined as accurately as possible; accuracy of the dosing device should be checked. If animals are to be treated collectively rather than individually, they should be grouped according to their bodyweight and dosed accordingly, in order to avoid under- and over- dosing.
The product should be applied topically by pouring along the backline in a narrow strip extending from the withers to the tailhead.
Administer by topical application at the dose rate of 0.5 mg eprinomectin per kg bodyweight, corresponding to the recommended dose rate of 1 ml per 10 kg bodyweight.
Sheep and goats:
Administer by topical application at the dose rate of 1.0 mg eprinomectin per kg bodyweight, corresponding to the recommended dose rate of 2 ml per 10 kg bodyweight.
When administering the product along the backline, part the fleece/coat and place applicator nozzle or bottle spout against the skin.
Method of administration
For 250 ml and 1 litre bottles:
• Attach the metering cup to the bottle.
• Set the dose by turning the top section of the cup to align the correct bodyweight with the pointer on the knurled cap. When bodyweight is between markings, use the higher setting.
• Hold the bottle upright and squeeze it to deliver a slight excess of the required dose. Release the pressure and tilt the bottle to deliver the dose. For the 1 litre bottle: when a 10 ml or 15 ml dose is required, turn the pointer to “STOP” before delivering the dose. The off (STOP) position will close the system between dosing.
• The dosing cup should not be stored attached to the bottle when not in use. Remove the cup after each use and replace with the bottle cap.
For 2.5 and 5 litre:
• Attach the open end of the draw-off tubing to an appropriate dosing gun.
• Attach draw-off tubing to the cap with the stem that is included in the pack. Replace shipping cap with the cap having the draw-off tubing. Tighten the draw-off cap.
• Gently prime the dosing gun, checking for leaks.
• Follow the dosing gun manufacturer’s directions for adjusting the dose.
No signs of toxicity were observed when 8-week old calves were treated at up to 5 times the therapeutic dose (2.5 mg eprinomectin/kg bodyweight.) 3 times at 7-day intervals.
One calf treated once at 10 times the therapeutic dose (5 mg/kg bodyweight.) in the tolerance study showed transient mydriasis. There were no other adverse reactions to the treatment.
No signs of toxicity were observed when 17-week old sheep were treated at doses up to 5 times the therapeutic dose (5 mg eprinomectin/kg bodyweight) 3 times at 14-day intervals.
No antidote has been identified.
Meat and offal: 15 days. Milk: zero hours.
Meat and offal: 2 days. Milk: zero hours
Meat and offal: 1 day. Milk: zero hours
Eprinomectin is a member of the macrocyclic lactone class of endectocides. Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve or muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite.
Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA).
The margin of safety for compounds of this class is attributable to the fact that mammals do not have glutamate-gated chloride channels; the macrocyclic lactones have a low affinity for other mammalian ligand-gated chloride channels, and they do not readily cross the blood-brain barrier.
Eprinomectin is bound extensively to plasma proteins (99%).
Pharmacokinetic studies have been conducted in lactating and non-lactating animals, administered topically at a single dosage of 0.5 mg/kg body weight in cattle and at 1 mg/kg bodyweight in sheep and goats.
For cattle, results from two representative studies found mean peak plasma concentrations of 9.7 and 43.8 ng/ml that were observed at 4.8 and 2.0 days post dose. The corresponding elimination half-lives in plasma were 5.2 and 2.0 days, and mean area-under-the-curve values of 124 and 241 ng*day/ml.
Eprinomectin is not extensively metabolized in cattle following topical administration.
Faeces was the major route of elimination of the drug in beef cattle and dairy cows.
For sheep, a mean peak plasma concentration (Cmax) of 6.20 ng/ml was observed following a topical dose of 1mg/kg. The half-life in plasma was 6.4 days with mean area under the curve (AUC last) value of 48.8 ng*day/ml.
For goats, peak mean plasma concentrations ranging from 3 to 13.1 ng/ml were observed from day 1 to day 2 post dose. The half life in plasma ranged from less than one day to 3 days with area under the curve mean values ranging from 15.7 to 39.1 ng-day/ml.
An in vitro microsomal metabolism study was conducted using liver microsomes isolated from cattle, sheep and goats. It showed that the differences in pharmacokinetics observed between cattle, sheep and goats do not result from differences in the rate or extent of metabolism but suggests more complete absorption of eprinomectin by cattle.
Butylhydroxytoluene (E321), Propylene glycol dicaprylocaprate, Alpha-tocopherol
In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products
Shelf life of the veterinary medicinal product as packaged for sale: 3 years.
Shelf life after first opening the immediate packaging: see expiry date.
Keep the container in the outer carton in order to protect from light. This veterinary medicinal product does not require any special temperature storage conditions. Store container upright.
250 ml and 1L HDPE bottle. 2.5 and 5L HDPE back pack. Sealed foil and tamper evident HDPE screw cap with polypropylene liner.
250 ml bottle with 2 measuring devices of 25 ml (1 for cattle, 1 for sheep/goat). 1L bottle with 2 measuring devices (1 of 60 ml for cattle, 1 of 25 ml for sheep/goat). 2.5L back-pack with a dispensing cap. 5L back-pack with a dispensing cap.
One bottle or one back-pack per cardboard box.
The 2.5 litre and 5 litre back-packs are designed for use with a suitable automatic dispensing gun. Not all pack sizes may be marketed.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements. Do not contaminate surface waters or ditches with the product or used container.
Like other macrocyclic lactones, eprinomectin has the potential to adversely affect non-target organisms. Following treatment, excretion of potentially toxic levels of eprinomectin may take place over a period of several weeks. Faeces containing eprinomectin excreted onto pasture by treated animals may reduce the abundance of dung feeding organisms which may impact on the dung degradation.
15 December 2016
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To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.
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