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Enacard tablets are used to treat dogs with mild, moderate or severe heart failure. It has been shown to increase the ability to take exercise as well as life expectancy in affected dogs. It is particularly intended for dogs with leaking valves (mitral incompetence). This causes the heart to be less efficient as a pump, due to the reflux back through the valve when it is supposed to be closed. This condition develops most commonly in older, small breed dogs, often with no former history of heart trouble. Enacard also helps if there is a weakness of the heart muscle itself, causing it to stretch too much, making the heart wall weak and thin (dilated cardiomyopathy). Enacard is often combined with other heart medications, especially diuretics (which clear excess fluid from the body).
ENACARD Tablets for Dogs (enalapril maleate) are presented as round non-scored biconvex uncoated tablets, colour coded according to dosage strength: 1.0 mg - green; 2.5 mg - blue; 5.0 mg - pink; 10.0 mg - yellow and 20.0 mg – white.
For the treatment of mild, moderate and severe congestive heart failure in dogs caused by mitral regurgitation or dilated cardiomyopathy as an adjunctive therapy with diuretics. For improved exercise tolerance and increased survival in dogs with mild, moderate and severe heart failure.
ENACARD Tablets for Dogs should be administered orally at a recommended dose rate of 0.5 mg/kg once daily. Individual dosages should be administered on the basis of bodyweight using the appropriate tablet or combination of tablet sizes.
In the absence of a clinical response within 2 weeks following initiation of therapy with the product, the dose should be increased, depending on the patient's response, up to a maximum of 0.5 mg/kg bodyweight administered twice daily. This dose titration may be performed over a two to four week period, or more rapidly if indicated by the presence of continuing signs of congestive heart failure. Dogs should be observed closely for 48 hours following initial dosing or an increase in dose.
Therapy with diuretics should be initiated at least one day prior to starting treatment with the product. Evaluation of the patient should include assessment of renal function prior to initiation of therapy and for 2 to 7 days after treatment with the product.
For animal treatment only.
Renal function impairment in the target species.
Pre-renal azotaemia is usually a result of hypotension induced by impaired cardio-vascular performance. On occasion substances that deplete blood volume, such as diuretics, or which vasodilate, such as angiotensin-converting enzyme (ACE) inhibitors may contribute to lowering systemic blood pressure. This may create a hypotensive state or exacerbate an existing hypotensive situation and result in pre-renal azotaemia. Dogs with no detectable renal disease may develop minor and transient increases in blood urea nitrogen or serum creatinine when the product is administered concomitantly with a diuretic. Renal function should be monitored both before and 2 to 7 days after starting the treatment with the product. The dose of the diuretic and/or the product should be reduced or their use should be discontinued if signs of hypotension or azotaemia develop or if the concentrations of blood urea nitrogen and/or serum creatinine increase significantly over pre-treatment levels. Periodic monitoring of renal function should be continued. Should clinical signs of overdosage occur (e.g. azotaemia) after the dose is increased from once daily to twice daily, the dose should be decreased to once daily.
Whilst all clinical data were generated in conjunction with frusemide, the product may be administered to dogs being treated with thiazide diuretics.
Do not use in any dog that has evidence of cardiac output failure e.g. aortic stenosis.
The product is not recommended for use in pregnant bitches. Safety in breeding dogs has not been established.
Do not use with potassium-sparing diuretics.
The product has been demonstrated to be generally well tolerated. In clinical studies, the overall incidence of side effects was not significantly greater with the product than with vehicle tablets. For the most part side effects have been mild and transient in nature and have not required discontinuation of therapy. Clinical signs reported include azotaemia, lethargy, drowsiness, hypotension, disorientation and incoordination.
ENACARD Tablets for Dogs given at the recommended dose level has been shown to have an adequate margin of safety in dogs with heart failure. The safety of the product has been thoroughly investigated in several animal species including man to assess its general toxicity. Normal dogs given 15 mg per kg per day for up to one year showed no adverse effects or changes.
In case of accidental ingestion, seek urgent medical attention showing the product label to the doctor or nurse. Physicians should contact a Poison Control Centre for advice concerning cases of human consumption.
Wash hands after use.
Keep out of the reach and sight of children.
Do not store above 25°C, and avoid transient temperatures above 50°C.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
Cartons containing four blister strips each containing seven tablets.
All prices include VAT where applicable.
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For UK delivery, we charge the following:
Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.
For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.
We can deliver most items to all around the world, but prices do vary. The majority of light weight orders (less than 1.5kg) can be delivered for a flat rate of £10. For an accurate estimate of the delivery charge, please put the items you require in your basket and use the "Estimate Delivery" system on the shopping basket page (you only need to enter your country and postal/zip code) for a quick quote. For deliveries to the USA you may need to go to the checkout page and enter your full address to get a quote (as some services need your state in order to quote too). For more information on international deliveries, please see our delivery information page.
Due to air freight restrictions aerosols cannot ever be sent abroad by Royal Mail. We appreciate your understanding.
Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.
Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.
To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.
*For full details on returns, see our terms and conditions page.
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