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Intestinal worms, whether Roundworms or Tapeworms, can pose a potentially serious health threat to your dogs if left untreated, so regular worming (every 3 months) is a necessity. In order to survive and multiply within the internal environment of your dog, worms will feed on the blood and content of the gut, with some laying dormant for up to a year within the muscle tissue, depositing an unprecedented number of eggs every day. This can lead to unpleasant symptoms of sickness, loss of appetite, diarrhoea and excessive bottom cleaning, however, sometimes worms are not accompanied by any diagnostic symptoms. Not only are worms a troublesome affliction for your dog, but they can be potentially hazardous for you if transferred through touching and licking, or picked up on your shoes and brought into the home. Drontal is an effective, economical worming treatment for dogs and cats, acting to safeguard your pet against the intrusion of harmful worms in the body, comprising an active ingredient that interferes with the energy metabolism of worms, causing them to die and pass out of the body. Drontal de-wormers are available in palatable flavours to encourage willing consumption and in a suitable form for puppies.
Drontal Flavour Dog tablets are now bone shaped. Please see below for the tablet dimensions.
Please note, Drontal Puppy Suspension is only suitable for dogs up to one year old.
| Product | Dosage | Tablet Size | |
| Cat Tablets | 1 tablet up to 4kg bodyweight | 13mm | |
| Cat XL Tablets | 1 tablet up to 6kg bodyweight | 13mm | |
| Dog Tablets (Bone Shaped) |
| 17mm | |
| Dog Tablets (Bone Shaped) | 1 tablet up to 6-10kg bodyweight | 17mm | |
| Dog XL Tablets | 1 tablet up to 35kg bodyweight | 24mm | |
| Puppy Suspension | 1ml suspension per 1kg bodyweight |
Please note, Drontal Puppy Suspension is only suitable for dogs up to one year old.
Even though the symptoms of worm infestation are not readily visible, most vets will advise you to de-worm your pet at least every 3 months. This will prevent a heavy worm burden building up, which could cause significant health problems for your dog or cat. Equally importantly, a regular Drontal dose will eradicate the one or two round worms (Toxocara species) often present in our pets but causing no apparent symptoms at all. These sub-clinical infections are important because these worms will be laying eggs which are passed out in the faeces and can remain dormant on the ground for long periods (or even on your pet's coat). If these microscopic eggs are accidentally ingested by children then they may start to develop inside the child's body. This development can result in microscopic worm larvae migrating into the brain, eye or other organs of the child with sometimes very serious consequences (visceral larva migrans). Regular worming with Drontal is therefore an important part of responsible pet ownership with regard to human health, besides being beneficial for your dog.Drontal dog wormer kills every type of intestinal worm that infects dogs in the UK. Drontal for dogs comes in flavoured tablets and are available in two sizes, with Drontal Plus for smaller dogs, which has a bone shaped tablet, and Drontal Plus XL for larger breeds. A single dose of Drontal is an effective treatment and dose not need to be repeated until more worms may have been picked up. The British Veterinary Association recommends treating adult dogs for worms every 3 months.
Drontal Cat comes in two sizes, with the standard tablet treating cats up to 4kg bodyweight, and Drontal Cat XL treating larger cats up to 6kg in weight. Drontal Cat is suitable for kittens over 6 weeks old.
All prices include VAT where applicable.
Drontal Cat Film-coated Tablets are white to yellowish, scored, coated tablets that can be divided into equal halves. Each tablet contains 230 mg pyrantel embonate and 20 mg praziquantel with 1.8 mg Titanium Dioxide (E171).
Drontal Cat XL Film-coated Tablets are unscored coated white to yellowish, ellipsoid, biconvex tablets, each containing 345 mg pyrantel embonate and 30 mg praziquantel with 2.6 mg Titanium Dioxide (E171).
For the treatment of gastrointestinal roundworms and tapeworms of cats: Toxocara cati, Toxascaris leonina, Dipylidium caninum, Taenia taeniaeformis (see ‘Further information’).
Dosage:
The recommended dose rates are 57.5 mg/kg pyrantel embonate and 5 mg/kg praziquantel. This is equivalent to one Drontal Cat Film-coated Tablet per 4 kg body weight and 1 Drontal Cat XL Film-coated Tablet per 6 kg body weight.
See dosage chart below for examples:
| Weight of Cat | No of Drontal Cat Film-coated Tablets | No of Drontal Cat XL Film-coated Tablets | |
|---|---|---|---|
| 2 kg | ½ | ||
| 4 kg | 1 | ||
| 6 kg | 1½ | or | 1 |
| 8 kg | 2 | ||
| 10 kg | 1 | plus | 1 |
For single oral administration. The tablets should be given directly to the animal, but if necessary can be disguised in food.
Not to be used during pregnancy but may be used during lactation.
Not intended for use in kittens less than 6 weeks of age.
Do not use simultaneously with piperazine compounds.
Until sufficient studies have been performed with this combination, do not use during pregnancy.
Mild and transient digestive tract disorders such as hypersalivation and/or vomiting and mild and transient neurological disorders such as ataxia may occur in extremely rare cases.
In the interests of good hygiene, persons administering the tablets directly to a cat, or by adding them to the cat’s food, should wash their hands afterwards.
For animal treatment only. Keep out of the reach of children.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
Do not store above 25°C.
Do not remove tablets from strip packing until required for use.
Any part-used tablets should be discarded.
Drontal Cat Film-coated Tablets: Shelf-life of the veterinary medicinal product as packaged for sale: 5 years.
Drontal Cat XL Film-coated Tablets: Shelf-life of the veterinary medicinal product as packaged for sale: 4 years.
| Drontal® Cat Film-coated Tablets: | Cardboard cartons with polyethylene-coated aluminium foil blisters containing 2, 24 or 96 tablets in strips of 2 or 8 tablets. |
|---|---|
| Drontal® Cat XL Film-coated Tablets : | Cardboard cartons with polyethylene-coated aluminium foil blisters containing 2, 8, or 48 tablets in strips of 2 or 8 tablets. |
An anthelmintic active against gastrointestinal roundworms and tapeworms. ATC VetCode: QP52 AA51. Pharmacotherapeutic Group: Anthelmintics, Praziquantel combinations. The product contains two active ingredients, pyrantel embonate (pamoate) a tetrahydropyrimidine derivative and praziquantel a partially hydrogenated pyrazino-isoquinoline derivative, used widely as an anthelmintic for both human and veterinary use.
Pyrantel acts as a cholinergic agonist. Its mode of action is to stimulate nicotinic cholinergic receptors of the parasite, induce spastic paralysis and thereby allow expulsion from the gastrointestinal (GI) system by peristalsis.
Praziquantel is very rapidly absorbed and distributed throughout the parasite. Both in vivo and in vitro studies have shown that praziquantel causes severe damage to the parasite integument, resulting in contraction and paralysis. There is an almost instantaneous tetanic contraction of the parasite musculature and a rapid vacuolisation of the syncytial tegument. This rapid contraction has been explained by changes in divalent cation fluxes, especially calcium.
In this fixed combination product, the pyrantel is active against the following ascarids: Toxocara cati, and Toxascaris leonina; the praziquantel is effective against tapeworms, in particular Dipylidium caninum and Taenia taeniaeformis.
The product has been shown to be efficacious in the control of hookworms Ancylostoma tubaeforme and A. braziliense and the tapeworm Joyeuxiella pasqualei, none of which occur naturally in cats in the UK but may occasionally be found in imported animals. Praziquantel is effective against Echinococcus multilocularis. E. multilocularis does not occur in the UK but is becoming more common in some European countries. As a precautionary measure to prevent establishment of E. multilocularis in the UK, it is recommended that all dogs and cats entering the country be treated with praziquantel.
Fleas serve as intermediate hosts for one common type of tapeworm - Dipylidium caninum. Tapeworm infection is certain to re-occur unless control of intermediate hosts such as fleas, mice etc. is undertaken.
| Drontal® Cat Film-coated Tablets | Vm 00010/4094 |
|---|---|
| Drontal® Cat XL Film-coated Tablets | Vm 00010/4135 |
Drontal Plus Flavour Bone Shaped Tablets are pale brown to brown flavoured bone shaped tablets scored on both sides for oral administration to dogs, containing 50 mg praziquantel, 144 mg pyrantel embonate and 150 mg febantel as active constituents and 116.5 mg Artificial beef flavour irradiated.
For the control of the following roundworms and tapeworms in dogs and puppies:
Ascarids
Toxocara canis, Toxascaris leonina (adult and late immature forms)
Hookworms
Uncinaria stenocephala, Ancylostoma caninum (adults)
Whipworms
Trichuris vulpis (adults)
Tapeworms
Echinococcus spp. Taenia spp. and Dipylidium caninum (adult and immature forms).
For oral administration only.
The recommended dose rates are :
15 mg/kg body weight febantel, 14.4 mg/kg pyrantel and 5 mg/kg praziquantel. This is equivalent to 1 tablet per 10 kg body weight
Puppies and Small Dogs:
3-5 kg body weight = ½ tablet
6-10 kg body weight = 1 tablet
Medium Dogs:
11-15 kg body weight = 1 ½ tablets
16-20 kg body weight = 2 tablets
21-25 kg body weight = 2 ½ tablets
26-30 kg body weight = 3 tablets
Large Dogs:
31-35 kg body weight = 3 ½ tablets
36-40 kg body weight = 4 tablets
Oral administration, the tablet(s) can be given directly to the dog or disguised in food. Access to normal diet does not need to be limited before or after treatment.
Puppies should be treated at 2 weeks of age and every 2 weeks until 12 weeks of age. Thereafter they should be treated at 3 month intervals. It is advisable to treat the bitch at the same time as the puppies. Not for use in dogs weighing less than 3 kg.
For the control of Toxocara, nursing bitches should be dosed 2 weeks after giving birth and every 2 weeks until weaning.
For routine control adult dogs should be treated every 3 months. In the event of a heavy roundworm infection, a repeat dose should be given after 14 days.
Consult a veterinary surgeon before treating pregnant animals for roundworms.
The product may be used during lactation.
Do not exceed the stated dosage when treating pregnant bitches.
Do not use simultaneously with piperazine compounds
Do not exceed the stated dosage when treating pregnant bitches.
Any part-used tablets should be discarded.
In very rare cases slight and transient digestive tract disorders such as vomiting and/or diarrhoea may occur. In individual cases these signs can be accompanied by nonspecific signs such as lethargy, anorexia or hyperactivity.
Benzimidazoles possess a wide safety margin. Pyrantel is not absorbed systemically to any extent. Praziquantel has a wide safety margin of up to five times the normal dose
In the interests of good hygiene, persons administering the tablets directly to the dog, or by adding them to the dog's food, should wash their hands afterwards.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.
Do not store above 25ºC.
Shelf-life of the veterinary medicinal product as packaged for sale: 5 years
Container material : Polypropylene-coated aluminium foil
Container colour : White.
Container sizes : Cartons containing 2, 6, 24 or 108 tablets.
The product contains anthelmintics active against roundworms and tapeworms. The product contains three active substances:
1) Febantel, 2) Pyrantel embonate (pamoate) and 3) Praziquantel, a partially hydrogenated pyrazinoisoquinoline derivative used widely as an anthelmintic for both human and veterinary use. ATC Vet Code: QP52AC55
In this fixed combination product pyrantel and febantel act synergistically against all relevant nematodes (ascarids, hookworms and whipworms) in dogs. In particular, the activity spectrum covers Toxocara canis, Toxascaris leonina, Uncinaria stenocephala, Ancylostoma caninum and Trichuris vulpis.
The spectrum of activity of praziquantel covers all important cestode species in dogs, in particular all Taenia spp, Dipylidium caninum, Echinococcus granulosus and Echinococcus multilocularis. Praziquantel acts against adult and immature forms of these parasites.
Pyrantel acts as a cholinergic agonist. Its mode of action is to stimulate nicotinic cholinergic receptors of the parasite, induce spastic paralysis and thereby allow removal from the gastro-intestinal (GI) system by peristalsis.
Within the mammalian system febantel undergoes ring closure forming fenbendazole and oxfendazole. It is these chemical entities which exert the anthelmintic effect by inhibition of tubulin polymerization. Formation of microtubules is thereby prevented, resulting in disruption to structures vital to the normal functioning of the helminth. Glucose uptake, in particular, is affected, leading to a depletion in cell ATP. The parasite dies upon exhaustion of its energy reserves, which occurs 2-3 days later.
Praziquantel is very rapidly absorbed and distributed throughout the parasite. Both in vivo and in vitro studies have shown that praziquantel causes severe damage to the parasite integument, resulting in contraction and paralysis. There is an almost instantaneous tetanic contraction of the parasite musculature and a rapid vacuolisation of the syncytial tegument. This rapid contraction has been explained by changes in divalent cation fluxes, especially calcium.
Since it contains praziquantel, the product is effective against Echinococcus multilocularis which does not occur in the UK but is becoming more common in some European countries.
Fleas serve as intermediate hosts for one common type of tapeworm - Dipylidium caninum. Tapeworm infection is certain to re-occur unless control of intermediate hosts such as fleas, mice etc. is undertaken.
Vm 00010/4115
Drontal Plus XL Flavour Tablets are pale brown to brown oval-shaped divisible tablets scored on both sides containing 175 mg praziquantel, 504 mg pyrantel embonate and 525 mg febantel as active constituents and 408.0 mg Artificial beef flavour irradiated.
For the control of the following gastrointestinal roundworms and tapeworms of dogs and puppies.
Ascarids
Toxocara canis, Toxascaris leonina (adult and late immature forms).
Hookworms
Uncinaria stenocephala, Ancylostoma caninum (adults).
Whipworms
Trichuris vulpis (adults).
Tapeworms
Echinococcus species, Taenia species, Dipylidium caninum (adults and immature forms).
For oral administration only.
The recommended dose rate is: 15 mg/kg body weight febantel, 14.4 mg/kg pyrantel and 5 mg/kg praziquantel.
This is equivalent to 1 Drontal Plus XL Flavour Tablet per 35 kg bodyweight as follows:
Drontal Plus XL Flavour Tablets
17.5 kg body weight = ½ tablet
>17.5 - 35 kg body weight = 1 tablet
>35 - 52.5 kg body weight = 1½ tablets
>52.5 - 70 kg body weight = 2 tablets
Drontal Dog Tasty Bone Tablets should be used to achieve accurate dosing in dogs weighing less than 17.5 kg. The dose of Drontal Dog Tasty Bone Tablets is equivalent to 1 tablet per 10 kg.
Oral administration: the tablet(s) can be given directly to the dog or disguised in food. No starvation is needed before or after treatement.
For routine treatment a single dose is recommended.
For the control of Toxocara, nursing bitches should be dosed 2 weeks after giving birth and every two weeks until weaning.
For routine control adult dogs should be treated every 3 months. In the event of heavy roundworm infection a repeat dose should be given after 14 days.
Consult a veterinary surgeon before treating pregnant animals for roundworms.
The product may be used during lactation.
Do not exceed the recommended dose when treating pregnant bitches.
Do not use simultaneously with piperazine compounds.
Concurrent use with other cholinergic compounds is not recommended.
In very rare cases slight and transient digestive tract disorders such as vomiting and/or diarrhoea may occur. In individual cases these signs can be accompanied by nonspecific signs such as lethargy, anorexia or hyperactivity.
Drontal Plus XL Flavour Tablets are well tolerated in dogs. In safety studies doses of 5 x or greater gave rise to occasional vomiting.
Fleas serve as intermediate hosts for one common type of tapeworm - Dipylidium caninum. Tapeworm infestation is certain to re-occur unless control of intermediate hosts such as fleas, mice etc. is undertaken.
Since it contains praziquantel, the product is effective against Echinococcus multilocularis, which does not occur in the UK or Ireland but is becoming more common in some European countries. As a precautionary measure to prevent establishment of E. multilocularis in the UK and Ireland, it is recommended that all dogs entering the country be treated with praziquantel.
In case of accidental ingestion, seek medical advice and show package leaflet to the physician.
In the interests of good hygiene, persons administering the tablets directly to the dog, or by adding them to the dog's food, should wash their hands afterwards.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.
Do not store above 25°C.
Any part-used tablets should be discarded.
Shelf-life of the veterinary medicinal product as packaged for sale: 3 years.
Carton containing a PCTFE/PVC- aluminium foil strip of 2, 8 or 48 tablets.
Pharmacotherapeutic group: Anthelmintics, tetrahydropyrimidine. ATC VetCode: QP52AF30.
The product contains three active substances active against roundworms and tapeworms: 1. Febantel, a probenzimidazole, 2. Pyrantel embonate (pamoate) a tetrahydropyrimidine derivative, 3. Praziquantel, a partially hydrogenated pyrazinoisoquinoline derivative.
In this fixed combination product pyrantel and febantel act synergistically against relevant nematodes (ascarids, hookworms and whipworms) in dogs. In particular, the activity spectrum covers Toxocara canis, Toxascaris leonina, Uncinaria stenocephala, Ancylostoma caninum and Trichuris vulpis.
The spectrum of activity of praziquantel covers all important cestode species in dogs, in particular all Taenia spp, Dipylidium caninum, Echinococcus granulosus and Echinococcus multilocularis. Praziquantel acts against adult and immature forms of these parasites.
Praziquantel is very rapidly absorbed and distributed throughout the parasite. Both in vivo and in vitro studies have shown that praziquantel causes severe damage to the parasite integument, resulting in contraction and paralysis. There is an almost instantaneous tetanic contraction of the parasite musculature and a rapid vacuolisation of the syncytial tegument. This rapid contraction has been explained by changes in divalent cation fluxes, especially calcium.
Pyrantel acts as a cholinergic agonist. Its mode of action is to stimulate nicotinic cholinergic receptors of the parasite, induce spastic paralysis and thereby allow removal from the gastrointestinal (GI) system by peristalsis.
Within the mammalian system febantel undergoes ring closure forming fenbendazole and oxfendazole. It is these chemical entities which exert the anthelmintic effect by inhibition of tubulin polymerisation. Formation of microtubules is thereby prevented, resulting in disruption to structures vital to the normal functioning of the helminth. Glucose uptake, in particular, is affected, leading to a depletion in cell ATP. The parasite dies upon exhaustion of its energy reserves, which occurs 2-3 days later.
Vm 00010/4153
A pale red suspension for oral administration. Each ml of suspension contains 5.0 mg pyrantel (as pyrantel embonate 14.4 mg) and 15 mg febantel. The product also contains 2.05 mg sodium benzoate (E211), 2.05 mg sodium propionate (E281) and 0.25 mg ponceau 4R (E124).
For the treatment of roundworm infections in puppies and young dogs up to one year of age caused by:
| Ascarids | Toxocara canis, Toxascaris leonina |
|---|---|
| Hookworm | Ancylostoma caninum, Uncinaria stenocephala |
| Whipworm | Trichuris vulpis |
The dose is 1 ml suspension/kg body weight (equivalent to 14.4 mg/kg pyrantel embonate and 15 mg/kg febantel).
Administration is by the oral route. The product may be given directly to the animal or mixed with the feed. No special dietary measures are necessary.
Mix the product by inversion of the container before withdrawing the required dose.
Through intrauterine and transmammary infection, ascarid infestation may occur in dogs at a very early age. For some animals, especially in case of severe infections, elimination of ascarids may be incomplete, and a potential risk of infections to humans can not be excluded. Where epidemiologically appropriate, it is recommended that treatment should be started at 2 weeks of age and should be performed repeatedly at suitable intervals (for example every two weeks) until weaning. Otherwise treatment should be based upon confirmed infection, for example the results of faecal examinations.
This product is contra-indicated for pregnant and lactating bitches.
Do not use simultaneously with compounds containing piperazine.
Parasite resistance to any particular class of anthelmintic may develop following frequent repeated use of an anthelmintic of that class.
The safety of the product has not been assessed in puppies younger than 2 weeks and weighing less than 0.6 kg.
In very rare cases mild transient digestive tract signs (e.g., vomiting, diarrhoea) may occur.
The anthelmintic effects of both pyrantel (spastic paralysis) and piperazine (neuromuscular paralysis) may be antagonised when the two drugs are used together.
Doses of up to 5 times the therapeutic level of the product have been administered to puppies and young dogs without clinical signs of intolerance arising. At 10 times the recommended dose the first sign of intolerance – vomiting – was evident.
Wash hands after use.
Avoid direct contact with the skin and eyes.
In case of accidental spillage wash the affected area immediately with clean running water.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
This unopened veterinary medicinal product does not require any special storage conditions.
After opening, store the product at a temperature not exceeding 25 ºC.
Do not use after expiry date.
Shelf-life of the veterinary medicinal product as packaged for sale: 5 years.
Shelf-life after first opening the immediate packaging: 12 weeks.
White high density polyethylene bottles of 50 ml and 100 ml with a white polyethylene screw closure and colourless low density polyethylene adapter insert.
Devices supplied: 5ml transparent polypropylene syringe with rubber plunger.
Fixed combination of two anthelmintics: a tetrahydropyrimidine derivative, pyrantel (as the embonate) and a pro-benzimidazole, febantel. ATCvet code QP52AF02.
In this fixed combination product, the pyrantel and febantel act synergistically against nematodes (ascarids, hookworms and whipworms) of dogs. In particular, the spectrum of activity covers Toxocara canis, Ancylostoma caninum and Trichuris vulpis. Published data are also available to confirm that Toxascaris leonina and Uncinaria stenocephala are also susceptible to this particular combination of actives.
Febantel, N-{2-[2,3-bis,(methoxycarbonyl)-guanidino]-5-(phenylthio) phenyl}-2-methoxyacetamide, is a pro-benzimidazole. Within the mammalian system febantel undergoes ring closure forming fenbendazole and oxfendazole. It is these chemical entities which exert the anthelmintic effect by inhibition of tubulin polymerisation. Formation of microtubules is thereby prevented, resulting in disruption to structures vital to the normal functioning of the helminth. Glucose uptake, in particular, is affected, leading to depletion in cell ATP. The parasite dies upon exhaustion of its energy reserves, which occurs 2-3 days later. Pyrantel, (E)-1,4,5,6-Tetrahydro-1-methyl-2-[2-(2-thienyl) vinyl] pyrimidine pamoate belongs to the tetrahydropyrimidine type. Its mode of action is to stimulate nicotinic cholinergic receptors inducing spastic paralysis and thereby allowing removal from the gastro-intestinal (GI) system by peristalsis.
Literature reports indicate after oral application of the recommended dose of 1 ml/kg bodyweight (corresponding to 14.4mg/kg pyrantel embonate and 15 mg/kg febantel) maximum serum concentrations for febantel were found between 1 and 6 hours with a Cmax of 0.019 mg/l two hours after dosing. As febantel, as a pro-drug, is metabolised to fenbendazole which is further converted to oxfendazole, also these metabolites were measured. Cmax of fenbendazole was 0.130 mg/l after 3 hours and Cmax of oxfendazole was 0.157 mg/l at about 5 hours after application.
The Cmax of pyrantel (measured as pyrantel base) was 0.084 mg/l 2.5 hours after application.
Vm 00010/4102
A pale red suspension for oral administration. Each ml of suspension contains 5.0 mg pyrantel (as pyrantel embonate 14.4 mg) and 15 mg febantel. The product also contains 2.05 mg sodium benzoate (E211), 2.05 mg sodium propionate (E281) and 0.25 mg ponceau 4R (E124).
For the treatment of roundworm infections in puppies and young dogs up to one year of age caused by:
| Ascarids | Toxocara canis, Toxascaris leonina |
|---|---|
| Hookworm | Ancylostoma caninum, Uncinaria stenocephala |
| Whipworm | Trichuris vulpis |
The dose is 1 ml suspension/kg body weight (equivalent to 14.4 mg/kg pyrantel embonate and 15 mg/kg febantel).
Administration is by the oral route. The product may be given directly to the animal or mixed with the feed. No special dietary measures are necessary.
Mix the product by inversion of the container before withdrawing the required dose.
Through intrauterine and transmammary infection, ascarid infestation may occur in dogs at a very early age. For some animals, especially in case of severe infections, elimination of ascarids may be incomplete, and a potential risk of infections to humans can not be excluded. Where epidemiologically appropriate, it is recommended that treatment should be started at 2 weeks of age and should be performed repeatedly at suitable intervals (for example every two weeks) until weaning. Otherwise treatment should be based upon confirmed infection, for example the results of faecal examinations.
This product is contra-indicated for pregnant and lactating bitches.
Do not use simultaneously with compounds containing piperazine.
Parasite resistance to any particular class of anthelmintic may develop following frequent repeated use of an anthelmintic of that class.
The safety of the product has not been assessed in puppies younger than 2 weeks and weighing less than 0.6 kg.
In very rare cases mild transient digestive tract signs (e.g., vomiting, diarrhoea) may occur.
The anthelmintic effects of both pyrantel (spastic paralysis) and piperazine (neuromuscular paralysis) may be antagonised when the two drugs are used together.
Doses of up to 5 times the therapeutic level of the product have been administered to puppies and young dogs without clinical signs of intolerance arising. At 10 times the recommended dose the first sign of intolerance – vomiting – was evident.
Wash hands after use.
Avoid direct contact with the skin and eyes.
In case of accidental spillage wash the affected area immediately with clean running water.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
This unopened veterinary medicinal product does not require any special storage conditions.
After opening, store the product at a temperature not exceeding 25 ºC.
Do not use after expiry date.
Shelf-life of the veterinary medicinal product as packaged for sale: 5 years.
Shelf-life after first opening the immediate packaging: 12 weeks.
White high density polyethylene bottles of 50 ml and 100 ml with a white polyethylene screw closure and colourless low density polyethylene adapter insert.
Devices supplied: 5ml transparent polypropylene syringe with rubber plunger.
Fixed combination of two anthelmintics: a tetrahydropyrimidine derivative, pyrantel (as the embonate) and a pro-benzimidazole, febantel. ATCvet code QP52AF02.
In this fixed combination product, the pyrantel and febantel act synergistically against nematodes (ascarids, hookworms and whipworms) of dogs. In particular, the spectrum of activity covers Toxocara canis, Ancylostoma caninum and Trichuris vulpis. Published data are also available to confirm that Toxascaris leonina and Uncinaria stenocephala are also susceptible to this particular combination of actives.
Febantel, N-{2-[2,3-bis,(methoxycarbonyl)-guanidino]-5-(phenylthio) phenyl}-2-methoxyacetamide, is a pro-benzimidazole. Within the mammalian system febantel undergoes ring closure forming fenbendazole and oxfendazole. It is these chemical entities which exert the anthelmintic effect by inhibition of tubulin polymerisation. Formation of microtubules is thereby prevented, resulting in disruption to structures vital to the normal functioning of the helminth. Glucose uptake, in particular, is affected, leading to depletion in cell ATP. The parasite dies upon exhaustion of its energy reserves, which occurs 2-3 days later. Pyrantel, (E)-1,4,5,6-Tetrahydro-1-methyl-2-[2-(2-thienyl) vinyl] pyrimidine pamoate belongs to the tetrahydropyrimidine type. Its mode of action is to stimulate nicotinic cholinergic receptors inducing spastic paralysis and thereby allowing removal from the gastro-intestinal (GI) system by peristalsis.
Literature reports indicate after oral application of the recommended dose of 1 ml/kg bodyweight (corresponding to 14.4mg/kg pyrantel embonate and 15 mg/kg febantel) maximum serum concentrations for febantel were found between 1 and 6 hours with a Cmax of 0.019 mg/l two hours after dosing. As febantel, as a pro-drug, is metabolised to fenbendazole which is further converted to oxfendazole, also these metabolites were measured. Cmax of fenbendazole was 0.130 mg/l after 3 hours and Cmax of oxfendazole was 0.157 mg/l at about 5 hours after application.
The Cmax of pyrantel (measured as pyrantel base) was 0.084 mg/l 2.5 hours after application.
Vm 00010/4102
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For UK delivery, we charge the following:
| Order Total | Weight | Delivery |
| £0-£28.99 | Under 2kg | £2.99 |
| 2kg+ | £4.99 | |
| £29-£38.99 | Under 2kg | Free |
| 2kg+ | £4.99 | |
| £39+ | Under 2kg | Free |
| 2kg+ | Free |
Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.
For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.
We can deliver most items to all around the world, but prices do vary. The majority of light weight orders (less than 1.5kg) can be delivered for a flat rate of £10. For an accurate estimate of the delivery charge, please put the items you require in your basket and use the "Estimate Delivery" system on the shopping basket page (you only need to enter your country and postal/zip code) for a quick quote. For deliveries to the USA you may need to go to the checkout page and enter your full address to get a quote (as some services need your state in order to quote too). For more information on international deliveries, please see our delivery information page.
Due to restrictions aerosols can't be sent by Royal Mail. We appreciate your understanding.
Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.
Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.
To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.
*For full details on returns, see our terms and conditions page.
Below are some recent questions we've received regarding Drontal Wormer for Dogs & Cats, including answers from our team.
Janet Timperley
How long does 1 tablet last?
Hello,
Thank you for your question.
Worming needs to be done every 3 months.
VioVet.
Sharon Andrews
My dog a labrador weighs 25kg how many tablets should l give him?
Hello,
Thank you for your question.
He would need 2.5 tablets.
Hope that helps,
VioVet.
Luchi
My 8 week old kitten has been wormed for the first time and passed dead worms in her faeces. This is the first time she has been wormed. How often should I worm her now? Is it every 2 weeks until 12 weeks and then every 3 months. Just need to make sure all the worms she had are gone. Thanks.
Hello,
Thank you for your question.
Kittens need to be wormed every two weeks until twelve weeks of age, then monthly until six months of age. After six months all cats need to be wormed every three months for effective protection.
Hope this helps.
Kim
What is the difference between drontal and drontal plus please?
Drontal plus is intended for dogs and contains the active ingredients Pyrantel, Febantel and Praziquantel. It can be given to puppies from 2 weeks old and is effective against roundworm and tapeworm. Drontal oral suspension for puppies is intended for puppies up to 1 year old only. It contains Pyrantel and Febantel, is effective against roundworm and can be given from 2 weeks old.
Elizabeth
Can I purchase a years supply of drontal or do they have a short expiry date?
Hi Elizabeth,
Thanks for your question.
We recommend only buying six months' of treatment at a time as we cannot guarantee the expiry dates coming from our suppliers.
Thanks,
Laura
Can i used these tablets on 4 week old kittens
Drontal is not intended for use in kittens less than 6 weeks old so it would be best to wait for another 2 weeks before giving.
John Carlin
Can this product be used for treating lungworm in dogs. If not what other treatments do you have that can treat lungworm and be purchased without a vets prescription
No, Drontal is not effective against lungworm. For the dangerous type of lungworm that we are interested in treating, Angiostrongylus Vasorum, you would need a product such as Advocate or Milbemax which requires a prescription from your vet. Unfortunately there are not any non-prescriptions medications that treat this lungworm.
Janet Harris
Drontal tablets make my cat sick and he brings the tablet back up. He suffers from roundworm picked up I suspect from drinking pond water from local school garden! Would appreciate any helpful suggestions.
If tablets are not agreeing with your cat then you could try a spot on. I would suggest Broadline which is effective against fleas, ticks, roundworms and tapeworms. It is the broadest spectrum product for cats and gives complete parasite control so you do not need to use anything else for flea treatments etc. It is applied once a month to the skin on the back of the neck.
Helen
Hi, I've just purchased the drontal XL as the flavour bone said it only treats up to 10k and our pup is just over 13k. However, looking at the dosage, am I right in thinking I only need to feed half a tablet for up to 17k?
Could I have also purchased the flavour bone (as it's much cheaper!) & increased the dosage to suit a 13k pup? If so, what would I increase the dosage to? Thanks, Helen
If you have the XL tablet then you are right- just feed half a tablet. If you prefer the flavour bone tablet in the future then you can buy these and give 1.5 tablets which will dose for 10-15kg.
Rosemarie Thompson
My dogs weigh 18 KGS and 11 kgs what dosage should I give ? 2 and 1?
Hi Rosemarie,
Your 18kg dog will need 2 tablets and your 11kg dog will need 1.5 tablets to ensure they get enough of the active ingredient to be effective for their weight.
