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Dopram-V is available as a liquid drop to place inside the mouth, or as an injection. The oral dropper is often kept by breeders of dogs, cats, lambs and calves to use after a difficult birth to help stimulate breathing. The active ingredient is quickly absorbed through the mucus membranes in the mouth and gets into the blood stream where it travels to the brain. Absorption is quickest if the dose can be placed under the tongue. It is important to ensure the airways are not obstructed before using. It is important not to overdose. Repeat doses can only be given after the previous dose has worn off. Normally one dose only is required in order to stimulate the start of breathing. See datasheet for full instructions.
Dopram-V Drops is a clear colourless, aqueous, oral drops, solution. Each 1 ml contains Doxapram Hydrochloride 20 mg. The product also contains chlorobutanol 5 mg/ml as an antimicrobial preservative.
To initiate or stimulate respiration in neonatal dogs, cats, calves and lambs, following dystocia or caesarean section.
ENSURE AIRWAY IS NOT OBSTRUCTED BEFORE USE.
FOR SUBLINGUAL USE ONLY
Administer on the ventral (underside) surface of the tongue at the following doses:.
80-200 drops (2-5 ml)
The dosage should be adjusted to meet the requirements of the situation, in particular the size of the neonate and degree of respiratory depression. Repeated doses should not be given until the effects of the first dose have passed and the condition of the animal requires it. Do not exceed the recommended dosage. The action of the drops is rapid, usually beginning in a few seconds. The duration and intensity of response depends on the dose and the condition of the animal at the time it is administered.
FOR ANIMAL TREATMENT ONLY
Dopram-V Drops are contra-indicated for use in food producing animals with the exception of neonatal calves and lambs. For neonatal calves and lambs the meat withdrawal period is 28 days from last administration. Not intended for use in animals producing milk for human consumption.
Excessive doses may produce hyperventilation which may be followed by reduced carbon dioxide tension in the blood, cerebral vasoconstriction, hypoxia and possible brain damage.
In trials carried out on conscious cats to determine the total dose required to initiate hyperventilation compared to the total dose required to produce convulsions, the convulsive to respirogenic dose was calculated to be 38:1.
Avoid contact with skin and eyes. In the event of contact, wash with plenty of water. If irritation or other symptoms persist, seek medical advice. Do not smoke, eat or drink when using the product. Wash hands after use.
Following withdrawal of the first dose, use the product within 28 days. Discard unused material. The cap should be replaced on the bottle immediately after use. Store at +2°C - +8°C. Do not freeze. Protect from light.
Keep out of reach and sight of children.
5 ml and 25 ml plastic dropper bottles.
Not all pack sizes may be marketed.
Dopram-V is also available in 20 ml vials for injection.
Unused product or waste material should be disposed of in accordance with current practice for pharmaceutical waste under national waste disposal regulations.
Dopram-V Solution for Injection is a clear colourless solution for injection or sublingual use. Each ml contains Doxapram Hydrochloride 20 mg. It also contains Chlorbutanol 5 mg/ml as an antimicrobial preservative. Dopram-V (doxapram hydrochloride) is a potent respiratory stimulant. It differs from the analeptic agents in having greater specificity of action on the respiratory centre.
The metabolism of doxapram has been studied in the rat, dog and man. Doxapram is extensively metabolised; the metabolites and unchanged doxapram are excreted in the bile and urine. The pharmacokinetic properties of doxapram can be described by a multi-compartmental model. Due to rapid redistribution the pharmacological effects of an intravenous injection of doxapram are terminated within 15-20 minutes following administration.
For dogs, cats and horses:
1.To stimulate respiration during and after general anaesthesia.
2.To speed awakening and return of reflexes after anaesthesia, when this is considered beneficial.
For neonatal dogs, cats, calves and lambs:
1.To initiate respiration following dystocia or Caesarean section.
2.To stimulate respiration following dystocia or Caesarean section.
To ensure adequate dosing an insulin-type syringe must be used for administration to low bodyweight animals.
For intravenous use only.
Dogs and cats: Following intravenous anaesthesia 2–5 mg/kg (0.1–0.25 ml/kg) depending on response.
Following inhalation anaesthesia 1–2 mg/kg (0.05–0.1 ml/kg) depending on response.
Dosage should be adjusted for depth of anaesthesia and degree of respiratory depression. Dosage can be repeated in 15 to 20 minutes if necessary.
Horses: Following intravenous or inhalation anaesthesia 0.5–1.0 mg/kg (2.5–5.0 ml/100 kg) depending on response. Dosage should be adjusted for depth of anaesthesia and degree of respiratory depression.
For intravenous or subcutaneous injection and for topical sublingual use.
Puppies: 1–5 mg (0.05–0.25 ml) depending on size of neonate and degree of respiratory depression.
Kittens: 1–2 mg (0.05–0.1 ml) depending on size of neonate and degree of respiratory depression.
Calves: For intravenous, intramuscular, subcutaneous or sublingual use.
40–100 mg (2.0–5.0 ml) depending on size of neonate and degree of respiratory depression.
Lambs: For intravenous, subcutaneous or sublingual use.
5–10 mg (0.25–0.5 ml) depending on size of neonate and degree of respiratory depression.
The action is rapid, usually beginning in a few seconds. The duration and intensity of response depends upon the dose, the condition of the animal at the time the drug is administered, and depth of anaesthesia. Repeated doses should not be given until the effects of the first dose have passed, and the condition of the patient requires it.
However, the therapeutic ratio (convulsive dose: respirogenic dose) is very high. In trials carried out on conscious cats to determine the total dose required to initiate hyperventilation compared to the total dose required to produce convulsions, the convulsive dose to respirogenic dose was calculated to be 38:1.
Dopram-V Injection is contra-indicated for use in food producing animals with the exception of neonatal calves and lambs, and horses.
Not for use in animals producing milk for human consumption. For neonatal calves lambs and horses, the meat withdrawal period is 28 days from last administration.
Dosage should be adjusted to meet the requirements of the situation. Adequate, but not excessive, doses should be used. A patent airway is essential. Reflexes should be checked periodically.
Excessive doses may produce hyperventilation which may be followed by reduced carbon dioxide tension in the blood, cerebral vasoconstriction, hypoxia, and possible brain damage.
Excessive doses administered to animals during, or following anaesthesia with cyclopropane or halogenated hydrocarbon anaesthetics may precipitate cardiac arrhythmias.
The product should be used with extreme caution in dogs which have been sedated with morphine. Administration of Dopram-V Injection at a dose of 10 mg/kg to such animals may be followed by convulsions.
Foetal toxicity studies with doxapram in the rat and rabbit have not revealed any teratogenic effects, nor evidence of any effect on male or female fertility.
Avoid self injection with the product. Avoid direct contact with skin and eyes. In the event of contact, wash with plenty of water. If irritation or other symptoms persist, seek medical advice. Do not smoke, eat or drink when using the product. Wash hands after use.
For animal treatment only. Keep out of the reach and sight of children.
Dispose of any unused product and empty containers in accordance with guidance from your local waste regulation authority.
Keep container in outer carton.
Following withdrawal of the first dose, the product should be used within 28 days.
When the container is broached for the first time, using the in-use shelf-life which is specified on this datasheet, the date on which any product remaining in the container should be discarded should be worked out. The discard date should be written in the space provided on the label. Discard any unused material. Should any apparent growth or discolouration occur the product should be discarded.
Dopram-V Injection is incompatible with alkaline solutions such as aminophylline, frusemide, and thiopentone. Do not store above 25°C. Protect from freezing. Protect from light.
20 ml multi-dose vials.
Dopram-V Injection has been used extensively in the treatment of exotic species. Doses of 1 mg/kg have been used; the dose being adjusted according to response and the overall condition of the animal. It has been found to be of particular use in the treatment of respiratory failure associated with lungworm infestation in pinnipeds, respiratory depression produced by barbiturate poisoning in felines and in the anaesthetic management of the giraffe.
Dopram-V is also available in 5 ml dropper bottles for topical sublingual use.
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