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Denagard (tiamulin)

Denagard (tiamulin)
12.5% Solution » 1 litre

  • 12.5% Solution » 1 litre £76.99

Description

Denagard is used to treat Mycoplasma disease in chickens and turkeys and swine dysentery in pigs.

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Medication Datasheets

12.5% Solution » 1 litre

Denagard 12.5% w/v Concentrate for Oral Solution

Presentation

Denagard 12.5% Concentrate for Oral Solution is a pale yellow aqueous concentration solution containing 125 mg tiamulin hydrogen fumarate per ml and which contains methy parahydroxybenzoate and propyl parahydroxybenzoate as preservatives, amongst others.

Uses

Actions

The following organisms show sensitivity to tiamulin hydrogen fumarate in vitro:

Brachyspira: Brachyspira hyodysenteriae, Brachyspira pilosicoli

Mycoplasmas: Mycoplasma hyopneumoniae, M.hyorhinis, M. hyosynoviae, Ureaplasma spp. M. gallisepticum, M. synoviae and M. meleagridis

Gram-positive: Staphylococcus spp., Streptococcus spp., Arcanobacterium pyogenes

Gram-negative: Pasteurella spp., Klebsiella pneumoniae, Actinobacillus (Haemophilus) spp., Fusobacterium necrophorum, Bacteroides spp., Campylobacter coli, Lawsonia intracellularis

Indications

Pigs: For the treatment, prevention and control of swine dysentery caused by Brachyspira hyodysenteriae and complicated by Fusobacterium spp. and Bacteroides spp.

Chickens: For the reduction in the severity of disease caused by mycoplasmas.

Turkeys: For the reduction in the severity of disease caused by mycoplasmas.

Dosage and administration

Pigs: The dosage is 8.8 mg of the active substance per kg bodyweight daily, (equivalent to 10 ml Denagard 12.5% Concentrate for Oral Solution per 142 kg bodyweight) administered in the drinking water of pigs for 3 to 5 days, depending on the severity of the infection and/or the duration of the disease.

The contents of each 1 litre bottle will treat 188 pigs of 25 kg bodyweight for three days or 114 pigs of 25 kg bodyweight for 5 days.

To ensure an intake of 8.8 mg/kg daily, Denagard 12.5% Concentrate for Oral Solution may be administered in one of two ways.

Chickens: The dosage for chickens is 25 mg of active substance per kg bodyweight (equivalent to 100 ml of product per 500 kg bodyweight). Tiamulin should be administered continuously at a level of 0.025% (250 ppm) in drinking water (2 ml product per litre of water) for 3 – 5 days and will provide approximately the following daily dosage of tiamulin depending on the age of the bird:

Day old chick: 125 – 150 mg/kg bodyweight

4 week old broiler: 30 – 50 mg/kg bodyweight

10 week old pullet: 30 – 45 mg/kg bodyweight

Layer: 25 mg/kg bodyweight

Turkeys: The dosage for turkeys is 25 mg of active substance per kg bodyweight (equivalent to 100 ml of product per 500 kg bodyweight). Tiamulin should be administered continuously at a level of 0.025% (250 ppm) tiamulin in the drinking water (2 ml product per litre of water) for 5 days and will provide approximately the following daily dosage of tiamulin depending on the age of the bird:

1 week old poult: 70 mg/kg bodyweight

4 week old poult: 50 mg/kg bodyweight

8 week old poult: 20 – 30 mg/kg bodyweight

20 week old poult: 25 mg/kg bodyweight

Monitor water intake at frequent intervals during medication.

Fresh solutions of tiamulin-medicated drinking water should be made up each day.

Contra-indications, warnings, etc

Withdrawal Periods

Pigs: 2 days

Chickens: 2 days

Eggs: Zero

Turkeys: 5 days

Contra-indications

Do not use in animals hypersensitive to the active ingredient or any of the excipients.

Animals and birds should not receive products containing monensin, narasin or salinomycin during or for at least seven days before or after treatment. Severe growth depression or death may result.

Concomitant use of tiamulin and the ionophore anticoccidial maduramicin may lead to a mild to moderate growth depression in chickens. The situation is transient and recovery normally occurs within 3 – 5 days following withdrawal of tiamulin treatment. This does not seem to occur with the ionophores lasalocid or semduramicin.

In order to avoid interactions between tiamulin and the incompatible ionophores monensin, narasin and salinomycin, the feed mill supplying the feed should be notified that tiamulin will be used and that these products should not be included in the feed or contaminate the feed.

The feed should be tested for the ionophores prior to use if there is any suspicion that contamination of the feed might occur. If an interaction does occur, stop tiamulin water medication immediately and replace with fresh water. Remove contaminated feed as soon as possible and replace with feed not containing the tiamulin-incompatible ionophores.

Operator warnings

When mixing, direct contact with the skin and eyes should be avoided by wearing impermeable rubber gloves and safety glasses. In case of accidental eye contact, irrigate the eyes thoroughly with clean running water immediately. Seek medical advice if irritation persists. Contaminated clothing should be removed and any splashes on the skin should be washed off immediately. Wash hands after use.

Pregnancy and lactation

Denagard can be used in pregnant and lactating pigs.

Tiamulin may be used in laying and breeding birds as it has been shown to have no adverse effects on egg production, fertility and hatchability in chickens and turkeys.

Precautions

For use in the drinking water of pigs, chickens and turkeys only.

If there is no response to treatment within five days, the diagnosis should be re-established.

Severely affected pigs that do not drink may be treated with Denagard 200 Solution for Injection.

On rare occasions erythema or mild oedema of the skin may occur in pigs following the use of tiamulin hydrogen fumarate.

Water intake may be depressed during the administration of tiamulin to birds. It appears to be concentration dependent with 0.025% (250 ppm) tiamulin reducing intake by approximately 15%. It does not appear to have any adverse effect on overall performance of the birds or efficacy of the product.

There is a relatively high therapeutic index with tiamulin and the likelihood of an overdosage is considered remote, especially as water intake and hence tiamulin intake is reduced if abnormally high concentrations are given. The LD5 for chickens is 1290 mg/kg bodyweight and for turkeys 840 mg/kg bodyweight.

The clinical signs of toxicity in chickens are: vocalization, clonic cramps and lying in a lateral position. Symptoms in turkeys are: clonic cramps, lateral or dorsal position, salivation and ptosis.

If signs of intoxication do occur, promptly remove the medicated water and replace with fresh water.

For animal treatment only.

Keep out of the reach and sight of children.

Pharmaceutical precautions

Do not store above 25°C. Fresh medicated water must be prepared every 24 hours. Watering equipment should be thoroughly cleaned prior to addition of Denagard 12.5% Concentrate for Oral Solution.

Disposal

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Legal category

Packaging quantities

1 litre high density polyethylene bottles with screw cap.

Further information

Nil.

Marketing Authorisation Holder (if different from distributor)

NA

Marketing Authorisation Number

Vm 00879/4052

Delivery Information

How quickly do you deliver?

Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.

What do you charge for delivery?

For UK delivery, we charge the following:

Order Total Weight Delivery
£0-£28.99 Under 2kg £2.99
2kg+ £4.99
£29-£38.99 Under 2kg Free
2kg+ £4.99
£39+ Under 2kg Free
2kg+ Free

Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.

For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.

We can deliver most items to all around the world, but prices do vary. The majority of light weight orders (less than 1.5kg) can be delivered for a flat rate of £10. For an accurate estimate of the delivery charge, please put the items you require in your basket and use the "Estimate Delivery" system on the shopping basket page (you only need to enter your country and postal/zip code) for a quick quote. For deliveries to the USA you may need to go to the checkout page and enter your full address to get a quote (as some services need your state in order to quote too). For more information on international deliveries, please see our delivery information page.

Delivery of aerosols

Due to air freight restrictions aerosols cannot ever be sent abroad by Royal Mail. We appreciate your understanding.

Delivery of temperature controlled items

Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.

How do I cancel or return an order?

Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.

To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.

*For full details on returns, see our terms and conditions page.

Reviews

Q & A

Below are some recent questions we've received regarding Denagard (tiamulin), including answers from our team.

13 October 2015 at 8:57pm

Purchase product over counter.

Billy Rumney

Can i purchase this product over the counter or is it perscription only thanks.

  • Non-Executive Director

Legally this is classed as POM-V so you need a written prescription from your vet to buy it. We then need to receive a copy (or original) of the prescription before we can post it to you.

16 July 2015 at 7:58pm

Dosage for chickens

Amy

HI! Can you please tell me what the dosage for Denagard 12.5% is per 1 gallon. This dosage is for chickens. Thank you.

  • Non-Executive Director

If you scroll down the product page on our website a little and click on the orange text - "Dosage and administration". You will find full and complete instructions there.