Danilon Equidos comes in sachets of yellow, odourless granules to add to the food of horses. It has to be prescribed by your vet and is used to treat pain and inflammation associated with osteoarthritis, degenerative joint disease, musculo-skeletal injuries and conditions such as bursitis and laminitis. One sachet is an adequate starting dose for a 240kg pony. A horse weighing 480kg needs two sachets on the first day. On the following three days a half dose is all that is required, and then afterwards this dose can be given daily or on alternate days, depending on the response. A scoop is provided within the carton to enable half sachets to be measured out for more accurate dosing of different sized equines. Danilon Equidos should not be given to any equine which might go for human consumption in future. It is also a prohibited substance under international equine competition rules. Treatment with Danilon should be stopped for a suitable time before competing to allow the drug to clear.
All prices include VAT where applicable.
Each 10 g sachet contains
Suxibuzone (microencapsulated) 1.5 g
Quinoline yellow (E 104) 0.0025
For a full list of excipients, see Pharmaceutical Particulars.
Granules for top dressing use. Yellow and odourless granules
Indications for use
Treatment of pain and inflammation associated with musculo-skeletal conditions in the horse eg osteoarthritic conditions, bursitis, laminitis and soft tissue inflammation.
Do not administer to animals with renal, hepatic or cardiac disorders; where there is the possibility of gastro-intestinal ulceration or bleeding, or where there is evidence of a blood dyscrasia or hypersensitivity to the product.
Avoid use in dehydrated, hypovolemic or hypotensive animals as there is an increased risk of renal failure.
Special warnings for each target species
Do not administer to horses prior to taking part in a competition.
During treatment of very young animals (less than 12 weeks) where development of their hepatic or renal function may be incomplete, or in aged animals which may have these functions impaired, as well as in ponies, additional risk may be involved. In these cases, doses should be accurately calculated and patients monitored closely.
During treatment, do not restrict the consumption of water. Avoid use in any dehydrated, hypovolaemic or hypotensive animals as there may be an increased risk of renal failure.
NSAIDs can cause inhibition of phagocytosis and hence, in the treatment of inflammatory conditions associated with bacterial infections appropriate antimicrobial therapy should be instigated.
Special precautions for use
Special precautions for use in animals
During treatment do not restrict the consumption of water.
Use in very young or aged animals and ponies may involve additional risk. Adjust the dose to bodyweight and closely monitor clinical response.
Do not exceed the stated dose or duration of treatment. Dosage should be kept to a minimum for alleviation of symptoms.
Special precautions to be taken by the person administering the product to the animals
Wear suitable gloves. Wash hands after use.
Use in a well-ventilated area. Avoid inhaling any dust when opening sachet and mixing with feed. In case of accidental contact with eyes, wash immediately with plenty of clean water. In case of accidental ingestion, seek medical advice immediately and show this label to the physician.
Adverse reactions (frequency and seriousness)
After continued use, or at high doses gastro-intestinal changes may occur. Occasionally blood dyscrasias and renal alterations may be found, especially in animals with restricted access to water.
Use during pregnancy and lactation
Studies have not been carried out in the horse to establish safe use during pregnancy and lactation.
Interaction with other veterinary medicinal products and other forms of interaction
Suxibuzone and its metabolites may be highly bound to plasma proteins and compete with other highly bound drugs eg sulphonamides, warfarin; or it may itself be displaced to produce an increase of non-bound pharmacologically active concentrations which could lead to toxic effects. Drug compatibility must be closely monitored when adjunctive therapy is required.
Do not administer together with other NSAIDs concurrently or within 24 hours of each other.
Concurrent administration of potentially nephrotoxic drugs should be avoided.
Amounts to be administered and administration route
For oral administration.
When added to a portion of feed the product will be accepted by most horses.
The following should be used as a guide, according to individual response:
For a 480 kg bodyweight horse, the contents of 2 sachets should be administered twice daily (equivalent to 12.5 mg of suxibuzone/kg/day) for 2 days, followed by 1 sachet twice daily (6.25 mg of suxibuzone/kg/day) for 3 days.
Thereafter, 1 sachet daily (3.1 mg of suxibuzone/kg/day) or on alternate days, or the minimum dose necessary for a satisfactory clinical response.
Ponies should receive only half the dose rate recommended for horses.
For a 240 kg bodyweight pony, the contents of 1 sachet should be administered daily (equivalent to 6.25 mg of suxibuzone/kg/day) for 2 days, followed by 1/2 sachet daily (3.1 mg of suxibuzone/kg/day) for 3 days or 1 sachet on alternate days.
Thereafter, reduce the dose to the minimum dose necessary for a satisfactory clinical response.
For administration of less than one sachet, use the measuring scoop provided. One full level scoop contains 5 g granules (equivalent to 1/2 sachet) and up to the green line level contains 2,5 g granules (equivalent to 1/4 sachet).
Hay, as part of the diet, may delay the absorption of suxibuzone and so the onset of clinical effect. It is advisable not to feed hay immediately prior to, or with DANILON equidos.
See also special precautions for use.
If no clinical response is evident after 4-5 days, discontinue treatment and reconsider the diagnosis.
Overdose (symptoms, emergency procedures, antidotes)
In case of accidental continuous overdose, the following symptoms may be observed:
Thirst, depression, anorexia and weight loss
Gastrointestinal disorders (irritation, ulcers, diarrhoea and blood in the faeces)
Altered blood profiles and haemorrhages
Hypoproteinemia with ventral oedema causing hemoconcentration, hypovolemic shock and circulatory collapse.
Renal failure and fluid retention.
If signs of intolerance appear, discontinue treatment and establish symptomatic therapy.
A slow intravenous perfusion of a solution of sodium bicarbonate, which leads to urine alkalinisation, increases the clearance of the product.
Not to be used in animals intended for human consumption.
Treated horses may never be slaughtered for human consumption.
The horse must have been declared as not intended for human consumption under national horse passport legislation.
Pharmacotherapeutic group: Antiinflamatory and Antirheumatic Products, Non-steroids
ATC vet code: QM01AA90
Suxibuzone is a Non-Steroidal Anti-inflammatory Drug (NSAID) synthetically derived from pyrazolone with anti-inflammatory, antipyretic and analgesic properties with low ulcerogenic potential.
When mixed with concentrate feed, the product was shown to be palatable to horses.
Its mechanism of action is based on the inhibition of the cyclooxygenase (enzyme which catalyzes the synthesis of prostaglandins, prostacyclines and thromboxanes from arachidonic acid). The therapeutic effects are mainly due to the inhibition of the biosynthesis of prostaglandines, which act as peripheral mediators of pain and trigger the synthesis of endogen pyrogens and mediators in the inflammatory process. It also inhibits platelet aggregation.
The therapeutic effect of suxibuzone relies entirely on the activity of its active metabolites. Strong anti-inflammatory activity has been shown for phenylbutazone and oxyphenbutazone. The third metabolite γ-hydroxyphenbutazone is considered to be pharmacologically inactive.
After oral administration suxibuzone is readily absorbed and most of it is metabolised by the hepatic microsomal system producing phenylbutazone, oxyphenbutazone andγ-hydroxyphenylbutazone. No unaltered parent compound can be detected in plasma after oral administration of suxibuzone to horses. These active metabolites have a high degree of affinity for plasma proteins and are eliminated mainly through urine, as glucoronide conjugates, but also, in a small percentage, through faeces. Less than 1% is eliminated through saliva and milk.
After the administration of a single 6.25 mg/kg oral dose of the parent compound phenylbutazone reaches its maximum plasma concentration (10 µg/ml) at 4-5- hours after administration with an elimination half life of 5-6 h. Oxyphenbutazone reaches its maximum (2.1 µg/ml) at 15 hours after administration.
As happens with other NSAID´s the duration of the clinical response is much longer than the plasma half-life. Significant concentrations of both active metabolites are found in synovial fluid for at least 24 hours after administration.
List of excipients
Quinoline yellow (E 104)
Ethyl Cellulose 20
Shelf life of the veterinary medicinal product as packaged for sale: 4 years
Shelf life after first opening of the sachet: 7 days.
Special precautions for storage
After opening a sachet re-seal as well as possible between doses. Once opened, use within 7 days.
This medicinal product does not require any special storage conditions.
Nature and composition of immediate packaging
Carton containing 18 x 10 g or 60 x 10 g laminated opaline/aluminium polyethylene sachets with 5 g scoop (when level) and 2.5 g increment dosing device.
Not all pack sizes may be marketed.
Special precautions for the disposal of unused veterinary medicinal product or waste material, if any
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
Ecuphar Veterinaria S.L.U.
Avenida Río de Janeiro 60-66, planta 13
08016 Barcelona (Spain)
02 August 2001
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Below are some recent questions we've received regarding Danilon Equidos Sachets, including answers from our team.
Can we get regular order for danilon
Yes you can, providing we have a prescription for this. It needs to allow 'repeats' so we can send it out as many times as the prescription allows.
I hope this helps.
My older horse has been described 1-2 sachets of danilon a day for arthritis just wondered if it would be ok to feed some tumeric and seaweed alongside the danilon
Yes, the supplements would have a different mode of action to the Danilon so it is fine to feed them all together.
How to I get prescription for danilon to you
You ask your vet for a written prescription, which will explain all about the medication required. Then you can scan it into your computer and email it to [email protected], or you can upload it to our website at the time you place your order, or you can take a photo of it with your phone and email that to us.
I have trouble getting my horse to eat bute in his feed. Is Danilon more palatable or do people have problems getting there horse's to eat it in feed. My boy is quite fussy when different things added to his feed. Thank you!
These 2 products appear to be similar in how well horses will accept them in feed, though I am sure they do taste different from each other. Possibly your horse would go for Danilon better, but it seems that some horses are just very suspicious about any additions to what they eat. You are usually best to give medication along with a new, very palatable food which the horse is not familiar with and therefore has no expectation of what it will taste like. Combining this with the Danilon might well work. You would have to then only ever give that food item with Danilon, or your horse would learn to be suspicious of when it is "different".