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Cortavance Spray for Dogs

  • 76ml Bottle £26.50

Cortavance Spray is used to treat dogs suffering from inflamed and itchy skin. It is effective for conditions where there is an allergic or sensitivity reaction as the underlying cause. It is not advised to cover the entire dog on one occasion, but it is acceptable to treat both flanks, or an equivalent area. Cortavance contains the steroid hydrocortisone, and is formulated to have a pronounced effect on the skin with minimal systemic effects in the body. If steroids are needed to control the symptoms, Cortavance does so with fewer potential side effects than using tablets.

Qualitative and quantitative composition

Hydrocortisone aceponate 0.584 mg/ml

Pharmaceutical form

Cutaneous spray, solution.

Clinical particulars

Target species


Indications for use

For symptomatic treatment of inflammatory and pruritic dermatoses in dogs.


Do not use on cutaneous ulcers.

Special warnings for each target species

Total body surface treated should not exceed a surface corresponding for example to a treatment of two flanks from the spine to the mammary chains including the shoulders and the thighs. Otherwise, use only according to the risk-benefit assessment and subject the dog to regular clinical evaluations.

Special precautions for use in animals

In the case of concurrent microbial disease or parasitic infestation, the dog should receive appropriate treatment for such conditions. In the absence of specific information, the use in animals suffering from Cushing’s syndrome shall be based on the risk-benefit assessment. Since glucocorticosteroids are known to slow growth, use in young animals (under 7 months of age) shall be based on the risk-benefit assessment and subject to regular clinical evaluations.

In 12 dogs suffering from atopic dermatitis, after topical application on the skin at the recommended therapeutic dosage for 28 to 70 consecutive days, no noticeable effect on the systemic cortisol level was observed.

Special precautions to be taken by the person administering the veterinary medicinal product to animals

In case of accidental skin contact, it is recommended to wash thoroughly with water. Wash hands after use.

Avoid contact with eyes. In case of accidental eye contact, rinse with abundant quantities of water. In case of eye irritation, seek medical advice. In case of accidental ingestion, seek medical advice immediately and show the leaflet or the label to the physician.

Spray preferably in a well ventilated area.

Flammable. Do not spray on naked flame or any incandescent material. Do not smoke while handling the veterinary medicinal product.

Use during pregnancy or lactation

The safety of the veterinary medicinal product has not been established during pregnancy and lactation. Systemic absorption of hydrocortisone aceponate being negligible, it is unlikely for teratogenic, foetotoxic, maternotoxic effects to happen at the recommended dosage in dogs.

Use only according to the risk-benefit assessment by the responsible veterinarian.


In the absence of information, it is recommended not to apply other topical preparations simultaneously on the same lesions.

Amounts to be administered and administration route

Cutaneous use.

Before administration, screw the pump spray on the bottle.

The veterinary medicinal product is then applied by activating the pump spray, from a distance of about 10 cm from the area to be treated.

The recommended dosage is 1.52 µg of hydrocortisone aceponate/cm2 of affected skin per day. This dosage can be achieved with two pump spray activations over the surface to be treated equivalent to a square of 10 cm x 10 cm. Repeat the treatment daily for 7 consecutive days.

Care should be taken to avoid spraying into the eyes of the animal.

Presented as a volatile spray, this veterinary medicinal product does not require any massage.

In case of conditions requiring an extended treatment, the responsible veterinarian should subject the use of the veterinary medicinal product to the risk-benefit assessment.

If signs fail to improve within 7 days, treatment should be re-evaluated by the veterinarian.


After topical application on the skin at the recommended therapeutic dosage and twice the recommended duration of treatment and up to a body surface area corresponding to the two flanks, from the spine to the mammary chains including the shoulder and the thighs, no systemic effects are observed.

Tolerance studies using 3 and 5 times the recommended dosage for twice the recommended duration of treatment resulted in a reduced capacity for production of cortisol, that is fully reversible within 7 to 9 weeks after the end of treatment.

Withdrawal periods

Not applicable.

Pharmacological particulars

Pharmacodynamic properties

The veterinary medicinal product contains the active substance hydrocortisone aceponate.

Hydrocortisone aceponate (HCA) is a dermocorticoid with a potent intrinsic glucocorticoid activity which means a relief of both inflammation and pruritus leading to a quick improvement of skin lesions observed in case of inflammatory and pruritic dermatosis.

Pharmacokinetic properties

HCA belongs to the diesters class of the glucocorticosteroids.

The diesters are lipophilic components ensuring an enhanced penetration into the skin associated to a low plasma availability. HCA thus accumulates in the dog’s skin allowing local efficacy at low dosage. The diesters are transformed inside the skin structures. This transformation is responsible for the potency of the therapeutic class. In laboratory animals, hydrocortisone aceponate is eliminated the same way as hydrocortisone (other name for endogenous cortisol) through urine and faeces.

Topical application of diesters results in high therapeutic index: high local activity with reduced systemic secondary effects.

Pharmaceutical particulars


Propylene glycol methyl ether

Major incompatibilities

None known.

Shelf life

Shelf-life of the veterinary medicinal product as packaged for sale: 2 years.

Shelf-life after first opening the immediate packaging: 6 months.

Special precautions for storage


Immediate packaging

Box containing a polyethylene terephtalate (PET) bottle filled with 76 ml of solution, closed with an aluminium screw cap and a pump spray.


Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Marketing authorisation number


Date of the first authorisation or date of renewal


Date of revision of the text


Any other information

Keep treated animals away from fires, other sources of heat and surfaces likely to be affected by the excipient (propylene glycol methyl ether) for at least 30 minutes following spraying or until the fur is totally dry.

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Questions & Answers for Cortavance Spray for Dogs

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2nd Oct 2017
Antoinette Ellis

Hi can this be used on 12 week old puppy.? Thankyou

  • Veterinary Advisor

It is recommended not to use steroids on dogs less than 7 months old. However it is up to your vet to assess the risks against the benefits of using this spray on a puppy- sometimes it is the right thing to do.

Hair Loss

21st Feb 2017

Can this spray cause hair loss ? We have been using this product on an off for a while now and have noticed patches have started to appear. Thanking you once again in advance

  • Veterinary Advisor

This is not a side effect usually associated with Cortavance spray or one that I have seen before. Presumably your dog has itchy/inflammed skin which is why you are using the spray? Is it possible your dog has rubbed the hair out due to itchiness? That said any dog can react differently to anything so it is not impossible that the spray is causing the hair loss. It may be worth your vet having a look to try to determine the cause and prevent any further patches appearing.

My dog got sore paws and her genitals area can I spray on them as well

12th Sep 2015

I have cortavance cutaneous spray for my dog for her paws. her bum and genital area is sore as well can I use the spray for them parts as well.

  • Non-Executive Director

Usually this is acceptable but you should check with your own vet first, just in case the problem there is different in some way.

Can this product be used on cats?

9th Aug 2015

In the absence of anything else, could this product be used on cats?

  • Non-Executive Director

This product is only licensed for dogs. This means that it cannot be used for cats unless there is no suitable licensed product. If your vet considers that this is the best product for your cat then under the "cascade" system your vet can prescribe it. We need the written veterinary prescription before we can supply it.