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Compagel is used for the treatment of localised inflammatory lesions on horses. It is supplied in a tube as a gel and can be gently massaged into the affected area. This can be done once daily but is probably best done several times a day, as long as the total amount of gel applied does not exceed 50g in any one day. The main indications are for treating tenosynovitis and bursitis, but Campogel is suitable for any localised, swollen or bruised lesion affecting the muscles, tendons or ligaments with an inflammatory cause (usually injury).
Compogel helps to reduce the inflammation and swelling without the use of systemic medication, though this can be used as well if required. It also helps to reduce any feelings of itchiness at the site and has a mild cooling and pain-relieving effect. In this way the horse is less likely to cause any further damage to the area by rubbing etc.
A clear green gel. 100g gel contains 50 000 IU of Heparin Sodium, 0.5g of Levomenthol and 5.0g of Hydroxyethyl salicylate (Ph. Eur).
For the treatment of local inflammatory swellings and bruising, including tenosynovitis, bursitis and other acute inflammatory conditions of the musculo-skeletal system in the horse.
Compagel also promotes the early reabsorption of haematoma and oedematous swelling resulting from such conditions.
Up to a total daily quantity of 50g gel per day is applied using finger tip pressure onto the affected area according to the veterinary surgeon’s instructions until signs and symptoms resolve.
Meat and Offal : Zero days. Do not use in pregnant and lactating animals which are intended to produce milk for human consumption.
Do not use in case of hypersensitivity to the active substances or to any of the excipients.
Do not apply to broken skin.
For animal treatment only.
Special precautions for use in animals: Avoid contact with the eyes or mucous membranes. Do not apply to open wounds or fresh or encrusted skin lesions. If side effects occur, treatment should be discontinued.
Special precautions to be taken by the person administering the veterinary medicinal product to animals: Avoid contact with open wounds or with the eyes. Impervious gloves should be worn when applying the product.
Do not store above 25°C. Keep out of reach and sight of children. Any unused product or waste materials should be disposed of in accordance with national requirements.
LDPE tube with ethylene vinyl alcohol copolymer middle layer, HDPE top and polypropylene cap, containing 250 g of gel
Heparin inhibits blood coagulation. Owing to its strong anionic charge, it forms a complex with cationic protein bodies. This applies particularly to antithrombin III (AT III), a α2-globulin and endogenous inhibitor of the coagulation system, leading to a significant increase in its inhibitor reaction speed.
The essential action mechanism is the activation of AT III, which for its part inhibits thrombin and other serine proteases. Thus, not only thrombin (IIa), but also the activated factors XIIa, IXa, Xa and kallikrein are inactivated. This inactivation is dose-dependent.
Heparin also possesses a lipolysis-promoting action by activating the clearing factor and catalysing the release of lipoprotein lipase from endothelial cells, whereby large-molecular chylomicrons are solubilised in the plasma.
Heparin is involved in allergic and anaphylactic reactions. Heparin and histamine are released in the degranulation of mast cells. In haemostasis caused by shock, the presence of heparin reduces the coagulability of the blood. In addition, heparin acts as a mediator in the release of the histamine-degrading enzyme diamine oxidase.
Hydroxyethyl salicylate, an ester of salicylic acid, is very readily absorbed.
The salicylic acid released after absorption has an analgesic and anti-inflammatory effect. The action mechanism lies in the inhibition of prostaglandin synthesis and reduced formation of the pain-producing bradykinin from its precursors.
The released salicylic acid supports the antithrombotic effect of heparin by means of inhibition of platelet aggregation.
The keratolytic properties of salicylic acid further loosen the epidermis and facilitate absorption of the other active substances.
Levomenthol dissolved in alcohol has an antipruritic effect when applied to the skin and a mild local anaesthetic effect on the sensitive nerve endings of the skin.
At the same time it stimulates the cold receptors in the epidermis, whereby a cooling effect is felt, which is increased by the evaporation of the alcohol on the skin surface.
Hydroxyethyl salicylate:Anti-inflammatory, analgesic; keratolytic
Levomenthol:Local anaesthetic, antipruritic
After absorption through the skin, heparin develops its complex effects in the superficial subcutaneous tissue. Penetration through healthy skin is dose-dependent and is proven for concentrations of 300 IU/g and above. After application to the skin, no systemically therapeutic concentrations are reached.
The salicylate is readily released from the hydrophilic gel base of Compagel and rapidly absorbed through the skin. In the tissue it is metabolised into salicylic acid and ethylene glycol. Part of the salicylate is degraded by oxidation and the rest is bound to glucuronic acid and excreted renally. Ethylene glycol is oxidised and excreted as oxalate.
Levomenthol is absorbed through the skin. It is metabolised in the liver by hydroxylation and subsequent glucuronidation.
Compagel gel for horses
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