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Clindacyl Tablets

  • 25mg » Priced per Tablet £0.34
  • 75mg » Priced per Tablet £0.53
  • 150mg » Priced per Tablet £0.89
  • 300mg » Priced per Tablet £1.29

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Description

Clindacyl contains the antibiotic clindamycin, which is used in dogs and cats for a variety of types of infection, including abscesses, infected skin wounds and oral and dental infections. The antibiotic is particularly good at penetrating into tissues where other antibiotics are not effective. It can be given once or twice daily.

Presentation

Four tablet strengths are available:

Clindacyl 25mg containing 25mg Clindamycin (as Clindamycin Hydrochloride)

Clindacyl 75mg containing 75mg Clindamycin (as Clindamycin Hydrochloride)

Clindacyl 150mg containing 150mg Clindamycin (as Clindamycin Hydrochloride)

Clindacyl 300mg containing 300mg Clindamycin (as Clindamycin Hydrochloride)

Uses

In dogs. Clindacyl Tablets are indicated for the treatment of infected wounds, abscesses, superficial pyoderma and oral cavity/dental infections caused by or associated with clindamycin-sensitive staphylococci, streptococci, bacteroidaceae, Fusobacterium necrophorum, Clostridium perfringens and osteomyelitis caused by Staphylococcus aureus in dogs. Clindacyl Tablets can also be used to help provide antimicrobial cover during dental procedures.

Dosage and administration

For oral administration.

For treatment of infected wounds, abscesses, oral cavity/dental infections, administer 5.5 mg/kg bodyweight every 12 hours for 7 - 10 days.

Treatment may be extended to a maximum of 28 days based on clinical judgement. If no improvement is seen within 4 days, the sensitivity of the pathogens involved should be redetermined.

For the treatment of superficial pyoderma administer 11 mg/kg every 24 hours. Continue treatment for at least 21 days.

For the treatment of osteomyelitis administer 11mg/kg every 12 hours for at least 28 days. If no improvement is seen within 14 days, the sensitivity of the pathogens involved should be redetermined.

To help provide antimicrobial cover during dental procedures, a 10 day course of 5.5mg/kg every 12 hours is recommended (beginning 5 days before the intended procedure and continuing for 5 days thereafter).

Bodyweight

Dental infections

wounds, abscesses

Superficial

pyoderma

Osteomyelitis

5.5mg/kg every 12h

11mg/kg every 24h

11mg/kg every 12h

4.5kg

1 x 25 mg twice daily

2 x 25 mg once daily

2 x 25 mg twice daily

13.5kg

1 x 75 mg twice daily

1 x 150 mg once daily

1 x 150 mg twice daily

27.0 kg

1 x 150mg twice daily

1 x 300 mg once daily

1 x 300 mg twice daily

54.0 kg

1 x 300 mg twice daily

2 x 300 mg once daily

2 x 300 mg twice daily

Contra-indications, warnings, etc

Do not administer to animals with hypersensitivity to clindamycin and lincomycin preparations.

Do not administer to rabbits, guinea pigs, chinchillas, hamsters, horses or ruminants.

Special warnings

Before use of Clindacyl tablets, the identification of causative pathogenic micro-organisms should be carried out and their susceptibility to clindamycin should be established.

Clindamycin and lincomycin show parallel resistance. There is a partial cross-resistance to erythromycin and other macrolide antibiotics.

Special precautions for use in animals

During prolonged therapy of one month or greater, periodic liver and kidney function tests and blood counts should be performed. Patients with severe renal and/or very severe hepatic disturbances accompanied by severe metabolic aberrations should be dosed with caution and should be monitored by serum examination during high dose clindamycin therapy.

Adverse reactions (frequency and seriousness)

Clindamycin sometimes causes the overgrowth of non sensitive organisms such as resistant clostridia and yeasts. In cases of superinfection, appropriate measures should be taken according to the clinical situation.

Vomiting and diarrhoea are observed occasionally.

Use during pregnancy and lactation

While high dose studies in rats suggests that clindamycin is not a teratogen and does not significantly affect the breeding performance of males and females, safety in gestating bitches or breeding male dogs has not been established.

Interaction with other medicinal products and other forms of interaction

Neuromuscular blocking effects have been observed with clindamycin possibly leading to an increase of efficacy of other neuromuscular blocking agents. The concomitant use of such drugs must be handled with care.

Clindamycin should not be used concomitantly with chloramphenicol or macrolides because they may antagonise each other at the site of action.

Operator warning

None

Overdose

Symptoms of overdose include vomiting, inappetency and diarrhoea. In such cases, treatment should be stopped immediately and the dogs treated symptomatically.

Withdrawal periods

Not applicable

Pharmaceutical precautions

This veterinary product does not require any special storage conditions.

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Legal category

POM-V

Packaging Quantities

Polyethylene bottle with child resistant tamper evident snap-cap closures containing 100 tablets (25mg, 75mg, 150mg, 300mg)

Further information

Clindamycin, a chlorinated analogue of lincomycin, is an antibiotic with bacteriostatic action. Bactericidal actions have also been reported.

Clindamycin is rapidly absorbed; following oral administration up to 90% of the active ingredient is absorbed from the gastro-intestinal tract.

Bioavailability is greater in fasting dogs than fed dogs.

Clindamycin crosses the placental barrier and can be detected in milk.

Marketing authorisation number

Clindacyl 25 mg Vm 08007/4104

Clindacyl 75 mg Vm 08007/4087

Clindacyl 150 mg Vm 08007/4103

Clindacyl 300 mg Vm 08007/4129

GTIN (Global Trade Item No)

Clindacyl 25mg

03605874090606

Clindacyl 75mg

03605874090613

Clindacyl 150mg

03605874090590

Clindacyl 300mg

03605874174405

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