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Estimated dispatch within 1 working day.
Cephorum antibiotic is used to treat a wide range of infections of soft tissue and bone in dogs and cats.
All prices include VAT where applicable.
White round biconvex film-coated tablets scored on one side with “CX” embossed above the score-line and “250” below the score-line. Each tablet contains cefalexin monohydrate Ph. Eur. The tablets are not divisible.
When susceptible organisms are present, Cephorum® Tablets 250 mg are indicated for the treatment of bacterial skin infections, and urinary-tract infections caused by Klebsiella pneumoniae.
The recommended dose rate is 15 mg/kg bodyweight twice daily by the oral route. In severe or acute conditions the dose may be safely doubled or given at more frequent intervals.
The table below is intended as a guide for the recommended dose of 15 mg cefalexin per kg bodyweight. Any increase in the dose should be calculated case-by-case for the individual animal concerned.
* Two doses per day should be given
Treatment for five days is recommended but this may be extended or shortened at the discretion of the veterinary surgeon.
Any increase in dose or duration of use, and any use in dogs less than 12 kg bodyweight, should be in accordance with a risk/benefit assessment by the responsible veterinarian.
To ensure a correct dosage body weight should be determined as accurately as possible to avoid underdosing.
Do not use in cases of known hypersensitivity to the active substance, to other cephalosporins, to other substances of the β-lactam group or to any of the excipients.
Do not use in rabbits, gerbils, guinea pigs and hamsters.
Use of Cephorum® Tablets 250 mg should be based on susceptibility testing and take in to account official and local antimicrobial policies.
Use of the product deviating from the instructions given in the SPC may increase the prevalence of bacteria resistant to cefalexin and may decrease the effectiveness of treatment with other cephalosporins, or with penicillins, due to potential cross-resistance.
In case of an allergic reaction, treatment should be withdrawn.
Cephorum® Tablets 250 mg should not be administered to animals which are known to be hypersensitive to cefalexin.
As with other antibiotics which are excreted mainly by the kidneys, accumulation may occur in the body when renal function is impaired. In cases of known renal insufficiency the dose should be reduced, antimicrobials known to be nephrotoxic should not be administered concurrently and the product should be used only according to a risk/benefit assessment by the responsible veterinarian.
Adverse reactions: In rare cases vomiting, diarrhoea and hypersensitivity can occur. In cases of hypersensitivity reactions the treatment should be stopped.
The frequency of adverse reactions is defined using the following convention: - very common (more than 1 in 10 animals displaying adverse reaction(s) during the course of one treatment) - common (more than 1 but less than 10 animals in 100 animals) - uncommon (more than 1 but less than 10 animals in 1,000 animals ) - rare (more than 1 but less than 10 animals in 10,000 animals) - very rare (less than 1 animal in 10,000 animals, including isolated reports)
The safety of the veterinary medicinal product has not been established in bitches during pregnancy and lactation. Use only accordingly to the benefit/risk assessment by the responsible veterinarian.
The bactericidal activity of cephalosporins is reduced by concomitant administration of bacteriostatic acting compounds (macrolides, sulphonamides and tetracyclines). Nephrotoxicity can be increased when 1st generation cephalosporins are combined with polypeptide antibiotics, aminoglycosides and some diuretics (furosemide). Concomitant use with such active substances should be avoided.
Symptoms of overdose include nausea, vomiting, epigastric distress, diarrhoea and haematuria. Treatment should be symptomatic.
Keep out of reach of children. For animal treatment only.
User precautions: Cephalosporins may cause sensitisation (allergy) following injection,inhalation, ingestion or skin contact. Sensitivity to penicillin may lead to cross-sensitivity to cephalosporin and vice versa. Allergic reactions to these substances may occasionally be serious.
1. Do not handle this product if you know you are sensitised, or if you have been advised not to work with such preparations.
2. Handle this product with great care to avoid exposure, taking all recommended precautions.
3. If you develop symptoms following exposure such as a skin rash you should seek medical advice and show the doctor this warning. Swelling of the face, lips or eyes or difficulty breathing are more serious symptoms and require urgent medical attention.
Wash hands after use.
Summary of Products Characteristics is available on request from TVM UK Animal Health.
Do not store above 25°C. Protect from light.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
Contains 0.55 mg titanium dioxide (E171) per tablet.
Container of 250 tablets and blister packs of 140 tablets.
Cefalexin, first generation cephalosporin, inhibits bacterial cell wall synthesis in a manner similar to the penicillins, and is widely considered to be bacteriocidal in action. It is thought that cephalexins act by binding to and inactivating a number of different penicillin-binding proteins (PBPs) located on the inner aspects of the bacterial cell membrane. Cephalosporins are essentially time-dependent antibiotics.
Cefalexin is active against a large spectrum of gram-positive and gram-negative bacteria. The breakpoints for cefalexin are usually defined as S≤ 8 μg/ml, R> 32 μg/ml.
The in vitro activity of cefalexin against bacterial isolates from skin infections in dogs is as follows:
The MIC90 value of cefalexin against Klebsiella pneumoniae isolated from urinary tract infections in dogs is 4 µg/ml.
The most prevalent resistance mechanism among gram-negative bacteria to cefalexin is due to the production of various beta-lactamases (cephalosporinase) that cause inactivation. Resistance in gram-positive bacteria often involves a decreased affinity of the PBPs (penicillin-binding proteins) for beta-lactam drugs. Efflux pumps, extruding the antibiotic from the bacterial cell, and structural changes in porins (reducing passive diffusion of the drug through the cell wall), may contribute to bacterial resistance.
Cross-resistance (involving the same resistance mechanism) exists between antibiotics belonging to the beta-lactam group due to their similar structures. This occurs with beta-lactamase enzymes, structural changes in porins or variations in efflux pumps. Co-resistance (involving different resistance mechanisms) has been reported in E. coli due to a plasmid with resistance genes.
After oral administration, 60 to 80% of cefalexin is absorbed from the small intestine. The delay reported between administration and beginning of absorption is approximately 20 minutes and differences in mean AUC, Cmax, and Tmax are not significantly affected by food administration concomitant to treatment with cefalexin.
Protein binding is low at 18%. Cefalexin is widely distributed into a variety of tissue fluids, including bile, synovial and pericardial fluid. The passage into interstitial tissue, as demonstrated in wound fluid concentration, peritoneal fluid and skin blisters is generally good.
Cefalexin is minimally metabolized and primarily excreted via the renal route, around 70% of an oral dose is excreted into the urine in 24 hours in the dog. It is important to note that cefalexin concentrations obtained in urine are well above plasma concentrations, and similarly concentrations in bile may be up to four times higher.
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For UK delivery, we charge the following:
Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products are also not always subject to the standard and/or free delivery options.
For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.
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Some products, such as non-ambient items and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.
Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.
To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.
*For full details on returns, see our terms and conditions page.
Below are some recent questions we've received regarding Cephorum for Dogs & Cats Tablets, including answers from our team.
hi my child eat one of my dog cephorum what will happen
You should talk to your doctor about this, although usually it would not cause any problems unless your child happens to be allergic to the antibiotic. Diarrhoea might be caused, and should be treated in the usual way.