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Canigen DHP

Species: Dogs Therapeutic indication: Immunological veterinary medical products: For dogs Active ingredient: Vaccine Antigens Product:Canigen DHP Product index: Canigen DHP

Presentation

Live freeze-dried pellet for suspension for injection. Each single dose vial contains Canine distemper virus, strain Onderstepoort³ 104.0 TCID50, Canine adenovirus 2, strain Manhattan LPV3³ 104.0 TCID50, Canine parvovirus, strain 154³ 107.0 TCID50.

Uses

The vaccine contains attenuated antigens to stimulate active immunity in dogs against canine distemper virus, canine parvovirus, infectious canine hepatitis caused by canine adenovirus 1 and respiratory disease caused by canine adenovirus type 2. For the active immunisation of dogs to reduce clinical signs of disease caused by canine distemper virus infection; to prevent clinical signs and reduce viral excretion caused by canine parvovirus infection; to reduce clinical signs of infectious canine hepatitis and viral excretion due to canine adenovirus 1 infection and to reduce clinical signs of respiratory infection and viral excretion caused by adenovirus type 2 infection.

Specific claims

Onset of immunity: one week. Duration of immunity: three years.

Dosage and administration

The contents of one vial of reconstituted vaccine should be injected subcutaneously. Reconstitute immediately prior to use by the addition of the contents of one vial (1.0 ml) of Canigen Lepto 4, Canigen Lepto 2 or Canigen Rabies. Sterile equipment should be used for administration. Avoid contamination of vaccine with traces of chemical sterilising agents. Do not use chemicals such as disinfectant or spirit to disinfect the skin prior to inoculation.

Primary course vaccination

A single injection should establish active immunity in dogs of 10 weeks of age or older. Where earlier protection is required a first dose may be given to puppies from 6 weeks of age, but because maternally derived passive antibody can interfere with the response to vaccination a final dose should be given 2-4 weeks later i.e. at 10 weeks of age or older.

Booster vaccination

To maintain protection a single booster dose is recommended every three years. The product can be used in pregnant bitches which have previously been vaccinated with Canigen DHPPi, Canigen DHP, Canigen Parvo-C or Canigen Pi

Contra-indications, warnings, etc

A common reaction after subcutaneous administration with the diluent provided is a diffuse swelling up to 5 mm in diameter at the site of injection. Occasionally this swelling may be hard and painful and last for up to 3 days post injection. In rare cases a transient rise in body temperature and/or a transient acute hypersensitivity reaction (anaphylaxis) - with signs that may include lethargy, facial oedema, pruritus, dyspnoea, vomiting, diarrhoea or collapse - may occur shortly after vaccination. Can be used in pregnant bitches which have previously been vaccinated with the Canigen DHPPi, DHP, Parvo-C or Pi. Safety and efficacy data are available which demonstrate that this vaccine can be mixed and administered with the inactivated vaccines of the Canigen series against canine leptospirosis caused by all or some of the following serovars: L. interrogans serogroup Canicola serovar Canicola, L. interrogans serogroup Icterohaemorrhagiae serovar Copenhageni, L. interrogans serogroup Australis serovar Bratislava, and L. kirschneri serogroup Grippotyphosa serovar Bananal/Liangguang. After administration with one of the leptospirosis vaccines, a mild and transient increase in body temperature (≤ 1 °C) may occur for a few days after vaccination, with some pups showing less activity and/or a reduced appetite. A small transient swelling (≤ 4 cm), which can occasionally be firm and painful on palpation, may be observed at the site of injection. Any such swelling will either have disappeared or be clearly diminished by 14 days post-vaccination. After mixed administration of an overdose of Canigen DHP and an overdose of the leptospirosis vaccines of the Canigen series, transient local reactions such as diffuse to firm swellings from 1 to 5 cm in diameter may be observed, usually these will persist no longer than 5 weeks, however some may take a little longer to completely disappear. Safety and efficacy data are available which demonstrate that this vaccine can be mixed and administered with the inactivated vaccine of the Canigen series against rabies. After administration with the rabies vaccine, where this product is authorised, transient local reactions such as diffuse to firm swellings from 1 to 4 cm in diameter may be observed for up to 3 weeks after vaccination. The swellings may be painful for up to 3 days post dosing. Safety and efficacy data are available which demonstrate that this vaccine can be administered on the same day, but not mixed, with the live vaccine for intranasal administration of the Canigen series against infectious tracheobronchitis caused by Bordetella bronchiseptica and/or canine parainfluenza virus. When Canigen DHP is used with any of the other Canigen vaccines referred to above, the minimum vaccination age for each vaccine must be taken into account such that at the time of vaccination, the dogs are at or older than the oldest minimum vaccination age for the individual vaccines. Consult product leaflets before administering products simultaneously. No information is available on the safety and efficacy of this vaccine when used with any other veterinary medicinal product except the products mentioned above. A decision to use this vaccine before or after any other veterinary medicinal product therefore needs to be made on a case by case basis.

Operator warnings

In the case of accidental self-injection, wash the area immediately with water. If symptoms develop, seek medical attention showing a copy of the product literature.

Withdrawal period

Not applicable. For animal treatment only. Keep out of reach and sight of children.

Pharmaceutical precautions

The product should be stored between +2°C and +8°C. Do not freeze. Protect from light.

Reconstituted vaccine

Store in a refrigerator at +2°C to +8°C with care being taken to avoid prolonged or repetitive exposure to high ambient temperature following withdrawal from the refrigerator prior to use. Shelf life after reconstitution: 30 minutes.

Disposal advice

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Legal category

Legal category: POM-V

Packaging quantities

Canigen DHP may be presented in cartons containing 5, 10, 25 or 50 single dose vials. Not all presentations may be marketed.

Further information

Nil

Marketing Authorisation Number

Vm 06376/4052

GTIN

GTIN description:Canigen DHP (50 doses) GTIN:8713184041906

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