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Live, attenuated, freeze dried vaccine containing Chlamydophila abortus strain 1B (105.0-106.9 IFU per dose).
CEVAC® Chlamydia diluent.NB: IFU= Inclusion-body Forming Units.
For the active immunisation of susceptible breeding female sheep as an aid in the prevention of abortion caused by Chlamydophila abortus infection.
The vaccine is reconstituted with the solvent immediately prior to use, allowing 2 ml of diluent per dose. If using the vented transfer device push one end of the device through the centre of the vaccine vial using a firm, twisting action. Similarly, push the solvent vial onto the opposite end of the device taking care to ensure the spike penetrates the centre of the vial bung. Carefully allow diluent to flow into the vaccine vial without completely filling it. Ensure the powder plug is fully dissolved and then invert until all the vaccine solution drains into the diluent vial. Remove the empty vaccine vial and transfer spike from the diluent vial and place into an appropriate disinfectant solution. Alternatively, remove approximately 5 ml of the solvent from the vial with a syringe and needle, inject into the vaccine vial and shake well until the powder plug is fully dissolved. Remove the vaccine solution from the vial, reinject into the diluent vial and shake well. Great care should be taken not to generate an aerosol.
Dose: 2 ml by intramuscular or subcutaneous injection. Ewe lambs, where it is intended to breed from them, may be vaccinated from 5 months of age. Shearlings and older ewes should be vaccinated during the 4 month period prior to mating.
To minimise the risk of self-injection the vaccine should be administered using disposable automatic syringes fitted with a guarded needle system according to the manufacturer's instructions. It is vital that a vented draw off tube is used with this equipment. Regular checks should be made to ensure the syringes are properly calibrated. Carefully attach the vial of reconstituted vaccine to the injection equipment and avoid creating aerosols during the priming process. It may be advisable to wear a visor while carrying out this operation.
Do not vaccinate animals less than 4 weeks before mating. Do not vaccinate pregnant animals. Do not vaccinate animals which are being treated with antimicrobial agents, particularly tetracyclines.
Chlamydophila abortus is only one of the causes of abortion in sheep. If abortion rates remain unchanged in flocks which have been vaccinated with CEVAC® Chlamydia it is recommended that veterinary advice is sought. The epidemiology of abortion due to Chlamydophila abortus in ewes involves a long incubation period. Ewes that abort in any lambing season have usually been infected at the previous lambing. Field trial data indicate that vaccinating incubating ewes will reduce the incidence of abortion, but a proportion can still go on to abort. Care should be taken in handling such abortions as susceptible humans may be at risk of infection.
A transient temperature rise may be observed after vaccination (average of 1.5°C for a maximum of 3 days). In very rare cases abortions may occur where the vaccine strain can be identified. In very rare cases the vaccine may cause hypersensitivity reactions.
No particular signs at ten times dose other than a transient temperature increase as seen with a single dose.
Safety and efficacy data are available which demonstrate that this vaccine can be administered the same day but not mixed with a commercial Toxoplasma gondii vaccine containing live tachyzoites of the S48 strain. No information is available on the safety and efficacy of this vaccine when used with any other veterinary medicinal product except the products mentioned above. A decision to use this vaccine before or after any other veterinary medicinal product therefore needs to be made on a case by case basis.
Do not mix with any other veterinary medicinal product, except diluent supplied for use with the product.
CEVAC® Chlamydia should not be handled by pregnant women or women of child bearing age as the vaccine may cause abortion. CEVAC® Chlamydia should not be handled by persons who are immune-deficient (e.g. AIDS sufferers, persons undergoing chemotherapy or taking immune-suppressive drugs.) If in any doubt, you should consult your GP.
Operators should wear gloves when handling the vaccine.
Care should be taken to avoid self-injection, but if this occurs, immediate medical advice should be sought and the doctor informed that self injection with a living Chlamydophila vaccine has occurred. Tetracycline therapy is the current recognised treatment for infection with Chlamydophila abortus in humans.
Dispose of waste material by boiling, incineration or immersion in an appropriate disinfectant approved for use by the competent authorities.
Store between +2°C and +8°C. Protect from light. Do not freeze. After dilution the vaccine should be kept cool and used as soon as possible (within 2 hours).
Vials containing a freeze dried plug of vaccine (10, 20, 50 or 100 doses) with the appropriate volume of diluent in separate vials (20, 40, 100 or 200 ml).
Not all pack sizes may be marketed.
Cevac Chlamydia 20D:
Cevac Chlamydia 50 D:
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