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For the short term relief of moderate to severe abdominal pain such as colic associated with intestinal impaction and hypermotility.
Species: Cats, Dogs, Horses and other equidae Therapeutic indication: Pharmaceuticals: Neurological preparations: General anaesthetics, Analgesics Active ingredient: Butorphanol Tartrate Product:Butador Injection Product index: Butador Injection Withdrawal notes: Horse meat: Zero days
1 ml contains Butorphanol 10mg (as butorphanol tartrate 14.58 mg) Excipient: Benzethonium chloride 0.1 mg Clear, colourless to almost colourless solution
As an analgesic: For the short term relief of pain such as colic of gastrointestinal tract origin. As a sedative and pre-anaesthetic: In combination with α2-adrenoceptor agonists (detomidine, romifidine, xylazine): For therapeutic and diagnostic procedures such as minor standing surgery and sedation of intractable patients.
As an analgesic: For relief of moderate visceral pain e.g. pre- and post-surgical as well as post-traumatic pain. As a sedative: In combination with α2-adrenoceptor agonists (medetomidine). As a pre-anaesthetic: Part of anaesthetic regime (medetomidine, ketamine).
Horse: Intravenous use Dog: Intravenous, subcutaneous and intramuscular use Cat: Intravenous and subcutaneous use HORSE As an analgesic Monotherapy: 0.1 mg/kg (1 ml/100 kg bw) IV. As a sedative and as a pre-anaesthetic With detomidine: Detomidine: 0.012 mg/kg IV, followed within 5 minutes by Butorphanol: 0.025 mg/kg (0.25 ml /100 kg bw) IV. With romifidine: Romifidine: 0.05 mg/kg IV, followed within 5 minutes by Butorphanol: 0.02 mg/kg (0.2 ml/100 kg bw) IV. With xylazine: Xylazine: 0.5 mg/kg IV, followed after 3-5 minutes by Butorphanol: 0.05–0.1 mg/kg (0.5-1 ml/100 kg bw) IV. DOG As an analgesic Monotherapy: 0.1 - 0.4 mg/kg (0.01 – 0.04 ml/kg bw) slowly IV (in the lower to medium dose range) as well as IM, SC. For post-operative pain control the injection should be administered 15 minutes before the end of anaesthesia in order to achieve sufficient pain relief during the recovery phase. As a sedative With medetomidine: Butorphanol: 0.1 mg/kg (0.01 ml/kg bw) IV, IM Medetomidine: 0.01 mg/kg IV, IM. As a pre-anaesthetic With medetomidine and ketamine: Butorphanol: 0.1 mg/kg (0.01 ml/kg bw) IM Medetomidine: 0.025 mg/kg IM, followed after 15 minutes by Ketamine: 5 mg/kg IM. It is only possible to use atipamezole 0.1 mg/kg body weight for medetomidine-antagonisation when ketamine action has ceased. CAT As an analgesic Monotherapy: 15 minutes prior to recovery either: 0.4 mg/kg (0.04 ml/kg bw) SC or: 0.1 mg/kg (0.01 ml/kg bw) IV As a sedative With medetomidine: Butorphanol: 0.4 mg/kg (0.04 ml/kg bw) SC Medetomidine: 0.05 mg/kg SC. For wound debridement an additional local anaesthesia is recommended. Medetomidine-antagonisation is possible with atipamezole 0.125 mg/kg body weight. As a pre-anaesthetic With medetomidine and ketamine: Butorphanol: 0.1 mg/kg (0.01 ml/kg bw) IV Medetomidine: 0.04 mg/kg IV Ketamine: 1.5 mg/kg IV. It is only possible to use atipamezole 0.1 mg/kg body weight for medetomidine–antagonisation when ketamine action has ceased. Butorphanol is intended for use where short (horse and dog) and short to medium (cat) analgesia is required. The dose may be repeated as required. The need for and timing of repeated treatment will be based on clinical response. For information on the duration of analgesia see section “Further information”. Rapid intravenous injection should be avoided. Do not mix the product with other veterinary medicinal products in one syringe.
Do not use in case of hypersensitivity to the active substance or to any of the excipients. Do not use for treatment of animals with severe dysfunction of the liver and kidneys, in case of cerebral injury or organic brain lesions and in animals with obstructive respiratory diseases, heart dysfunctions or spastic conditions. For combination use with α2-agonists in horses: Do not use in horses with a pre-existing cardiac dysrhythmia. The combination will cause a reduction in gastrointestinal motility and consequently should not be used in cases of colic associated with impaction. Do not use combination during pregnancy.
HORSE Undesirable effects are generally related to the known activity of opioids. In published trials with butorphanol, transient ataxia, lasting about 3 to 15 minutes, occurred in about 20 % of horses. Mild sedation occurred in about 10 % of horses. Increased motor activity (running movements) is possible. Gastrointestinal motility may be reduced. For combination use: Any reduction of gastrointestinal motility caused by butorphanol may be enhanced by the concomitant use of α2-agonists. The respiratory depressive effects of α2-agonists may be enhanced by concomitant butorphanol, particularly if respiratory function is already impaired. Other undesirable effects (e.g. cardiovascular) are likely to be related to the α 2-agonist. DOG/CAT Depression of the respiratory and cardiovascular system. Local pain associated with intramuscular administration. Decreased gastrointestinal motility. In rare cases, ataxia, anorexia and diarrhoea. In cats excitation or sedation, anxiety, disorientation, dysphoria and mydriasis are possible. If you notice any serious effects or other effects not mentioned in this leaflet, please inform your veterinary surgeon.
The precautionary measures required for contact with animals should be followed and stress factors for the animals should be avoided. In cats, individual response to butorphanol may be variable. In the absence of an adequate analgesic response, an alternative analgesic agent should be used. Increasing of the dose may not increase the intensity or duration of analgesia.
The safety of the product in puppies, kitten and foals has not been established. Use of the product in these groups should be on the basis of a risk-benefit analysis by the responsible veterinarian. Due to its antitussive properties, butorphanol may lead to an accumulation of mucous in the respiratory tract. Therefore, in animals with respiratory diseases associated with increased mucous production, butorphaol should only be used after a risk-benefit evaluation by the responsible veterinarian. If respiratory depression occurs, naloxone may be used as an antidote. Sedation may be noted in treated animals. The combination of butorphanol and α2-adrenoceptor agonists should be used with caution in animals with cardiovascular disease. The concurrent use of anticholinergic drugs e.g atropine should be considered. Administration of butorphanol and romifidine in one syringe should be avoided due to increased bradycardia, heart block and ataxia. HORSE The use of the product at the recommended dose may lead to transient ataxia and/or excitement. Therefore, to prevent injuries in patient and people when treating horses, the location for the treatment should be chosen carefully. CAT Cats should be weighed to ensure that the correct dose is calculated. An appropriate graduated syringe must be used to allow accurate administration of the required dose volume (e.g. insulin syringe or 1 ml graduated syringe). If repeated administrations are required, use different injection sites.
The concomitant administration of other drugs which are metabolised in the liver may enhance the effect of butorphanol. Butorphanol used with concurrently administered anaesthetics, centrally sedative or respiratory depressive drugs produces additive effects. Any use of butorphanol in this context requires acute control and a careful adaptation of the dose. Administration of butorphanol may remove the analgesic effect in animals, which have already received pure μ-opioid analgesics.
HORSE Increased dosages could result in respiratory depression as a general opioid effect. Intravenous doses of 1.0 mg/kg (10 x the recommended dose), repeated at 4-hourly intervals for 2 days, led to transient adverse effects, including pyrexia, tachypnoea, CNS signs (hyperexcitability, restlessness, mild ataxia leading to somnolence) and gastrointestinal hypomotility, sometimes with abdominal discomfort. An opioid antagonist (e.g. Naloxone) may be used as an antidote. DOG/CAT Miosis (dog)/Mydriasis (cat), respiratory depression, hypotension, disorders of the cardiovascular system and in severe cases respiratory inhibition, shock and coma. Depending on the clinical situation counter-measures should be taken under intense medical monitoring. Monitoring is required for a minimum of 24 hours.
Butorphanol crosses the placental barrier and penetrates into milk. Studies in laboratory species have not produced any evidence of teratogenic effects. The safety of this veterinary medicinal product has not been established in the target species during pregnancy and lactation. The use of butorphanol during pregnancy and lactation is not recommended.
Butorphanol has opioid-like activity. Precautions should be taken to avoid accidental injection/self-injection with this potent drug. The most frequent adverse effects of butorphanol in humans are drowsiness, sweating, nausea, dizziness and vertigo and may occur following unintended self-injection. If accidental self-injection occurs, seek medical advice immediately and show the package leaflet or the label to the physician. Do not drive. An opioid antagonist (e.g. naloxone) may be used as an antidote. Wash splashes from skin and eyes immediately
Horse (meat & offal): Zero days
Keep out of the sight and reach of children. This veterinary medicinal product does not require any special temperature storage conditions. Keep the vial in the outer carton in order to protect from light. Do not use after the expiry date stated on the label. Shelf-life after first opening the immediate container: 28 days
Legal category: POM-V
1 x 10 ml, 5 x 10 ml, 10 x 10 ml, 1 x 50 ml. Not all pack sizes may be marketed.
Richter Pharma AG, Feldgasse 19, 4600 Wels, Austria
Butorphanol is a centrally acting analgesic from the group of synthetic opioids with an agonistic-antagonistic effect, agonist at the kappa opioid receptor subtype and antagonist at the mu receptor subtype. The kappa receptors control analgesia, sedation without depression of cardiopulmonary system and body temperature, whereas the mu receptors control supraspinal analgesia, sedation and depression of cardiopulmonary system and body temperature. The agonist component of butorphanol activity is ten times more potent than the antagonist component. Analgesia generally occurs within 15 minutes following administration in horse, dog and cat. After a single intravenous dose in the horse analgesia usually lasts up to 2 hours. In the dog it lasts up to 30 minutes after a single intravenous administration. In cats with visceral pain analgesic effects have been demonstrated for up to 6 hours. In cats with somatic pain duration of analgesia has been considerably shorter. Increased doses do not correlate with increased analgesia, a dosage of about 0.4 mg/kg leads to a ceiling effect. Butorphanol has minimal cardiopulmonary depressant activity in the target species. It does not cause histamine release in horses. In combination with α2-agonists it causes additive and synergistic sedation.
Post parenteral administration absorption of the product is rapid and almost complete with serum peak levels occurring after 0.5 - 1.5 hours. It is highly bound to plasma proteins (up to 80%). Volume of distribution is large after IV administration (2.1 l/kg for horses, 4.4 l/kg for dogs and 7.4 l/kg for cats) suggesting wide distribution into tissues. Metabolism is rapid and mainly occurs in the liver. Two inactive metabolites are produced. Terminal half life is short: about 44 minutes in the horse, 1.7 hours for dogs and 4.1 hours for cats. The elimination occurs mainly through urine (to a major extent) and faeces. 97 % of the dose after IV administration in the horse will be eliminated in less than 5 hours.
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