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Broadline is the latest all-round parasite treatment for cats. It is easily applied to the back of the neck as a simple spot-on and then provides effective treatment against all major internal and external parasites.
It contains a range of ingredients to produce a powerful effect against fleas, ticks, internal roundworms and tapeworms. At the time of introduction, this is the widest range of parasites treated by one simple medication available for cats.
Broadline is applied once a month for complete parasite control in cats.
A new product has taken a leap closer to joining Advocate and Stronghold in the fight to be called the UK's 'top feline anti-parasitic'. Merial have furthered their leading flea and tick treatments 'Frontline' and 'Frontline Combo' and taken things not one, but two steps further . In order to beat products currently seen as 'the best', Merial had to come up with something that does that little bit extra; Broadline is a broad spectrum insecticidal, miticidal, anthelmintic spot on, able to provide total coverage of common feline parasites.
Broadline contains four active ingredients: fipronil, (S)-methoprene, praziquantel and eprinomectin. As an E-SQP reading about this for the first time, I immediately recognised and could relate to three of the active ingredients. Eprinomectin was a new name to me but I was at least able to link it to a group of wormers, the macrocyclic lactones (MLs)- quite exciting as I realised this meant that roundworms, fleas, ticks and tapeworms were all covered in one treatment. Furthermore, MLs are also highly effective against both lice and mites, conveying greater protection as an endectoside.
I am sure SQPs who have studied the Farm Animal Module will be familiar with the Merial's POM-VPS 'Eprinex Pour-On', a topical solution for cattle containing eprinomectin. If like me you hadn't heard of it, it is still clear to see that it only seems natural to try and combine active ingredients from two successful products.
I've never been one to just accept that something does a job- I need an explanation because quite frankly, I would forget its importance otherwise! I started looking into eprinomectin and found that it is a semi-synthetic avermectin, indeed a derivative of MLs. In keeping with a ML mechanism of action, eprinomectin binds to invertebrate ligand-gated ion channels and in particular, has a high affinity for glutamate-gate chloride channels (GluCls) and exerts anti-parasitic properties by causing neurotoxicosis. GluCls play vital roles in feeding, locomotion and other behaviours. When a ML such as eprinomectin binds to and opens these channels, the cell membrane is made more permeable to chloride ions. Subsequent influx of ions produces hyperpolarisation of either the muscle or nerve cell and paralysis which ultimately leads to death of the parasite. Mammals do not have GluCls and eprinomectin has low affinity for other ligand-gated ion channels mammals possess. Additionally, while the chemical is absorbed into the bloodstream, it is unable to cross the blood-brain barrier and along with other MLs well known to E-SQPs such as ivermectin, is very safe.
Alongside eprinomectin's action against the wide range of roundworms, lice and mites, the remaining three active ingredients target fleas, ticks and tapeworms. Fipronil and (S)-methoprene are renowned for their efficacy against fleas, working in different ways to break their life cycle. Fipronil acts through non-competitive inhibition of insect GABA receptors, blocking flow of ions and leaving the central nervous system uncontrolled, resulting in death of the adult fleas. It is effective against ticks in the same way. Females are sterilised by (S)-methoprene, as it mimics an insect hormone to prevent sexual development and further build up of eggs in the environment. Praziquantel delivers the final blow to the yet untouched tapeworm population, leaving them paralysed and unable to resist digestion by the host. They lose hold of their position in the gut and are either fully digested and or passed out in fragments.
Each unit dose applicator delivers:
Broadline Spot-on Solution
Volume of unit dose (ml)
Cats <2.5 kg
Cats 2.5-7.5 kg
Excipient: Butylhydroxytoluene (E321) 1 mg/ml. For a full list of excipients, see below.
Spot-on solution. Clear colourless to yellow solution.
For cats with or at risk from mixed infestations by cestodes, nematodes and ectoparasites. The product is exclusively indicated when all three groups are targeted at the same time.
- Treatment and prevention of infestations by fleas (Ctenocephalides felis). Elimination of fleas within 24 hours. One treatment prevents further infestations for at least one month.
- Prevention of environmental flea contamination by inhibiting the development of flea immature stages (eggs, larvae and pupae) for over one month.
- Can be used as part of a treatment strategy for the control of Flea Allergy Dermatitis (FAD).
- Treatment and prevention of infestations by ticks (Ixodes ricinus). Elimination of ticks within 48 hours. One treatment prevents further infestations for up to 3 weeks.
- Treatment of infestations with tapeworms (Dipylidium caninum, Taenia taeniaeformis, Echinococcus multilocularis).
- Treatment of infestations with gastrointestinal nematodes (L3, L4 larvae and adults of Toxocara cati, L4 larvae and adults of Ancylostoma tubaeforme, and adult forms of Toxascaris leonina and Ancylostoma brazilienze).
- Treatment of infestations with vesical worms (Capillaria plica).
- Prevention of heartworm disease (Dirofilaria immitis larvae) for one month.
Do not use in sick or convalescent cats.
Do not use in rabbits.
Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
When applying the product, special attention should be paid in long hair breeds in order to ensure that it is applied directly to the skin and not on the hair, as this could lead to a lower bioavailability of the active substances and thus, to a reduced efficacy.
It is important to apply the product to an area of skin where the cat cannot lick it off. Avoid animals licking each other following treatment.
No data on the effect of bathing/shampooing on the efficacy of the product in cats is available. However, brief contact of the animal with water on one or two occasions within the month following application is unlikely to significantly reduce its efficacy. As a precaution, it is not recommended to bathe animals within 2 days after treatment.
After treatment, ticks will generally be killed within 48 hours after infestation without having a blood meal. However, since the attachment of single ticks after treatment cannot be excluded, transmission of infectious diseases cannot be completely ruled out.
Tapeworm infestation may reoccur unless control of intermediate hosts such as fleas, mice etc. is undertaken.
Parasite resistance to any particular class of antiparasitic drug may develop following frequent use of a compound of that class. Therefore, epidemiological information about current susceptibility of the target species should be taken into account in order to limit the possibility of a future selection for resistance.
Cats in areas endemic for heartworm, or those which have traveled to endemic areas, may be infected with adult heartworms. Although the product may be safely administered to cats infected with adult heartworms, no therapeutic effect against adult Dirofilaria immitis has been established. It is therefore recommended that all cats 6 months of age or more living in areas endemic for heartworm should be tested for existing adult heartworm infestation before being treated for heartwom prevention with the product.
In animals: Spot-on application only. Do not inject. Do not administer orally or via any other route. Avoid contact with the cat's eyes. The safety of the product has not been tested at intervals of less than 2 weeks or in kittens weighing less than 0.6 kg and/or under 7 weeks of age.
The product is not intended for use in dogs. Some dog breeds may present increased susceptibility to macrocyclic lactones, potentially leading to signs of neurotoxicity. Oral uptake by Collies, Old English Sheepdogs and related breeds or crossbreeds should thus be avoided. Echinococcosis represents a hazard for humans, and is a notifiable disease to the World Organisation for Animal Health (OIE).
Special precautions to be taken by the person administering the product to animals: DO not smoke, drink or eat during application. Wash hands after use. Unused applicators must be stored in the intact blister package.
Avoid contact of the applicator content with the fingers. If this occurs, wash off with soap and water. In case of accidental eye exposure flush the eyes thoroughly with water, as the product can cause slight mucous membrane and eye irritation. If eye irritation persists or if side effects are noted, seek medical advice and show the package leaflet or the label to the physician.
Handling of treated animals should be limited until the application site is dry, and children should not be allowed to play with treated animals during this period. It is therefore recommended that recently treated animals do not sleep with owners, especially children.
People with a known hypersensitivity to any of the active ingredients or excipients should avoid contact with the product.
A temporary clumping or spiking of the hair may be seen at the application site after treatment. Mild and transient skin reactions at the application site (itching, hair loss) may occur.
If the cat licks the application site after treatment, temporary excessive salivation can be observed. Oral ingestion of the product may also result in vomiting and/or in transient neurological signs such as ataxia, disorientation, apathy and pupil dilation.
All these signs resolve spontaneously within 24 hours. Correct application will minimise the occurrence of such events.
The safety of the product has not been established during pegnancy and lactation. Use only according to the benefit-risk assessment by the prescribing veterinarian.
The use of the product should exclusively be based on the confirmed mixed infestations or significant risk of such mixed infestations with ectoparasites and nematodes (including for heartworm disease prevention), and where concurrent treatment against cestodes is indicated.
In the absence of risk of co-infestation, the use of a narrow spectrum parasiticide should be considered as a first line therapy.
The rationale for prescription should be tailored to the individual needs of the cat, based on clinical assessment, the animal's lifestyle and on the local epidemiological situation 9including zoonotic risks, where relevant) in order to address exclusively situations of mixed infestations/risk of infestation.
Treatment should not be extrapolated from one animal to the other without veterinary opinion.
Dosage: The recommended minimum doses are 10 mg/kg bodyweight for fipronil, 12 mg/kg for (S)-methoprene, 0.5 mg/kg for eprinomectin and 10 mg/kg for praziquantel.
Select the appropriate applicator size for the weight of the cat.
1 x 0.3 ml applicator
2.5 - 7.5 kg
1 x 0.9 ml applicator
Appropriate combination of applicators
Method of administration: Use a pair of scissors to cut the blister along the dotted line, then pull the lid away. Remove the applicator from the package and hold it upright. Pull back the plunger slightly, twist and pull the cap off. Part the hair on the midline of the neck, between the base of the skull and the shoulder blades until the skin is visible. Place the tip of the applicator on the skin and apply the entire content directly onto the skin in one spot.
Prevention of heartworm disease should start within 1 month after the first expected exposure to mosquitoes.
Safety has been demonstrated with up to 5 times the maximum exposure dose (i.e. up to 15 times the recommended dose) in healthy kittens aged 7 weeks and older treated up to 6 times at four-week intervals. It has also been confirmed in healthy adult cats treated 3 times at two-week intervals with up to 5 times the recommended dose. Mild and transient nuerological signs such as ataxia, disorientation, apathy and pupil dilation may be observed, with spontaneous recovery the day after. Transient salivation and/or vomiting could also be observed, in both kittens and adult cats, in isolated cases.
Cats infected with adult heartworms tolerated up to 3 times the maximum exposure dose (i.e. up to 9 times the recommended dose), every 4 weeks for 3 treatments, without any adverse effects.
ATCvet code QP54AA
Disodium edetate (E385)
Propyl gallate (E310)
Shelf life of the product as packaged for sale: 2 years.
Store in the original package in order to protect from light. Stored applicators must be kept in the intact blister package. Opened applicators should be disposed of immediately.
Unit dose syringe-shaped applicator containing 0.3 ml or 0.9 ml of product, closed with a polymer cap and placed in individual plastic blisters. Cardboard box containing applicators of 3 x 0.3 ml, 3 x 0.9 ml or 6 x 0.9 ml.
Any unused product or waste materials derived from this product should be disposed of in accordance with local requirements. Do not contaminate ponds, waterways or ditches with the product or empty containers as this may be dangerous for fish and aquatic organisms.
Broadline spot-on for cats <2.5 kg 3x 0.3 ml
Broadline spot-on for cats 2.5-7.5 kg 3x 0.9 ml
Broadline spot-on for cats 2.5-7.5 kg 6x 0.9 ml
All prices include VAT where applicable.
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Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.
For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.
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Below are some recent questions we've received regarding Broadline for Cats, including answers from our team.
Can repeated (monthly) use of Broadline lead to eradication of flea infestations in the home environment? If so, how long would this process of eradication take? Thanks.
If all pets in the home are treated consistently then any fleas jumping on to them should be killed before they have chance to reproduce. So in theory treating monthly could lead to eradication. However, if the fleas can find any host to feed on and reproduce then the infestation will continue. Fleas can survive up to 5 months in the environment and so it is best to treat with a household spray such as Indorex, wash bedding etc and hoover as well as treating the cats.
What is the soonest you can re treat an average size cat?
We have 5 & they are out of synch with each other. We are in the process of treating the house but are finding it difficult with 2 young children. We wonder if them being out of synch with treatments is contributing to us still noticing fleas on the lighter coloured cats.
You can use Broadline again after a month. It is a good idea to get them all in sync- each cat can be treated once a month at the same time then you don't lose track of which cat needs treating when. As you say it is also very important to treat the house thoroughly. Fleas will live in carpets, furniture, curtains, beds, blankets etc and will jump back onto your cats. Even if the cats are treated it will then take around 24hrs before the new fleas are killed. Once you manage to treat the house I expect you will not notice the fleas anymore.
Ann Flanagan Longford
How soon after application can the cat safely mix with other cats bearing in mind cats sometimes lick each other?
As soon as the solvent has evaporated away, it should be completely safe for cats to mix. This takes a few hours usually. The product does not taste very nice to cats and so any companions will usually not lick at it anyway.
How effective is Broadline with regard to giardia?
Broadline has no claimed activity against Giradia and I would not expect it to be useful at all in this way. The benzimidazoles are more likely to be helpful, such as fenbendazole (Panacur and other brands).
I apply Broadline around midday, at ten evening our cat goes out for the night, he gets wet occasionally, would this affect the strength from the broadline or is there a time that we should cat kept in so didn't get wet?
It's advisable to avoid bathing or allowing a cat to get very wet within 2 days following administration, but being out for a short period in light rain should be okay. To be on the safe side, it would be best to keep him inside overnight if it looks like it will rain (although he would probably find somewhere to hide).
It's thought that coming into contact with water one or two times through the month shouldn't significantly decrease efficacy, although this has not yet been tested with Broadline.
i applied broadline onto my cat 2 days ago and treated the house yesterday however this monrning i seen a flea on her. How long does broadline take to kill the fleas and is this normal or ahould i reapply broadline?
You should not re-apply it yet. There is no chance of eliminating every flea from the environment this quickly. It is most likely the the flea you have seen has only recently jumped onto your cat. It will soon be killed by the Broadline anyway. This process can go no for a while, depending how heavy the flea burden within the environment is. The things you have done will gradually prove effective, but are unlikely to be 100% effective from day one. (Flea treatments have to be safe for you and your pets. They are effective against fleas, but will not kill every single one instantly.)
My cat is under the weather and being sick. Giving her broardline is a little over due.by giving her the broardline will it get rid of any parasites or worms she has? Or does it just prevent them?
Broadline should kill most, if not all, of the parasites present at the time of dosing. It then has a protective effect for some while, though this varies a bit with the type of parasite.
is a fresh prescription required for each order of 6 pipettes
Your vet is able to prescribe multiple packs or authorise 'repeats' on a prescription for you if they feel it is suitable, and this will allow you to use the same prescription a specified number of times. This saves time and money going back for a new prescription and for long-term medication like Broadline, it is very useful.
If your vet is happy to give you a repeat prescription, we will have all of the details on your account, and will keep track of the number of packs dispensed and the number of packs remaining on the prescription. You can track your remaining repeats in the 'Prescriptions' section of your VioVet account.
Does Broadline kill earmites on cats?
This remains unclear. One of the active ingredients (eprinomectin) is effective against mites and so I would have expected Broadline to be very effective at treating ear mites. However I cannot see anywhere in the company Data Sheet that Broadline claims to be effective against ear mites. There are some scientific papers to support this effect, but it is odd that it is not reflected in the Data Sheet. Personally I would feel happy to use it on cats for this purpose, but officially I cannot tell you that it works!
I put broadline on my cat 3-4 days ago but I'm still finding ticks on him, how long do it take for the stuff to be effective? Or is this normal?
Ticks are very difficult parasites to treat effectively without using something potentially toxic to your cat. Usually it works better than seems to be the case with your cat now, but in fact it is not always 100% effective. If you look at any ticks present they might be dead in fact, or dying off now. Hopefully no more will be attaching at this stage. Dead ticks will usually fall off soon, but might need removing manually (usually easy enough when they are dead - just gently rub them until they fall off.)