Summer Essentials

Bravecto Chewable Tablets for Dogs

  • 112.5mg Toy Dog (Single Tablet) £18.49
  • 250mg Small Dog (Single Tablet) £19.49
  • 500mg Medium Dog (Single Tablet) £20.99
  • 1000mg Large Dog (Single Tablet) £22.49
  • 1400mg Extra-Large Dog (Single Tablet) £26.50

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Bravecto Chewable Tablets contain fluranaler and are used in dogs to control fleas and ticks. One dose is effective for 12 weeks against fleas and most types of tick. Bravecto can be given safely to breeding dogs, including pregnant or lactating bitches. It can be given to puppies from 8 weeks of age. The tablets should not be broken prior to dosing and are best given with food.

Bravecto is only effective once the parasite has bitten the dog and taken some blood. Therefore in a heavily infested environment, newly attached parasites might be seen briefly before they die. Newly emerged fleas will be killed before they are mature enough to lay eggs, so the life cycle of the flea is effectively stopped, so contributing to the control of the background environmental flea population.

Bravecto® chewable tablets for dogs

Qualitative & Quantitative Composition

Active substance:

Each chewable tablet contains:

Bravecto chewable tablets

Fluralaner (mg)

for very small dogs (2-4.5 kg)


for small dogs (>4.5-10 kg)


for medium-sized dogs (>10-20 kg)


for large dogs (>20-40 kg)


for very large dogs (>40-56 kg)


For the full list of excipients, see section “Pharmaceutical particulars”.

Pharmaceutical Form

Chewable tablet.

Light to dark brown tablet with a smooth or slightly rough surface and circular shape. Some marbling, speckles or both may be visible.

Clinical Particulars

Target species


Indications for use, specifying the target species

For the treatment of tick and flea infestations in dogs.

This veterinary medicinal product is a systemic insecticide and acaricide that provides:

  • immediate and persistent flea (Ctenocephalides felis) killing activity for 12 weeks,

  • immediate and persistent tick killing activity for 12 weeks for Ixodes ricinus, Dermacentor reticulatus and D. variabilis,

  • immediate and persistent tick killing activity for 8 weeks for Rhipicephalus sanguineus.

Fleas and ticks must attach to the host and commence feeding in order to be exposed to the active substance. The onset of effect is within 8 hours of attachment for fleas (C. felis) and 12 hours of attachment for ticks (I. ricinus).

The product can be used as part of a treatment strategy for the control of flea allergy dermatitis (FAD).


Do not use in case of hypersensitivity to the active substance or to any of the excipients.

Special warnings for each target species

Parasites need to start feeding on the host to become exposed to fluralaner; therefore the risk of the transmission of parasite borne diseases cannot be excluded.

Special precautions for use

Special precautions for use in animals

In the absence of available data, the veterinary medicinal product should not be used on puppies less than 8 weeks old and /or dogs weighing less than 2 kg.

The product should not be administered at intervals shorter than 8 weeks as the safety for shorter intervals has not been tested.

Special precautions to be taken by the person administering the veterinary medicinal product to animals

Keep the product in the original packaging until use, in order to prevent children from getting direct access to the product.

Do not eat, drink or smoke while handling the product.

Wash hands thoroughly with soap and water immediately after use of the product.

Adverse reactions (frequency and seriousness)

Commonly observed adverse reactions in clinical trials (1.6% of treated dogs) were mild and transient gastrointestinal effects such as diarrhoea, vomiting, inappetence, and drooling.

The frequency of adverse reactions is defined using the following convention:

- very common (more than 1 in 10 animals displaying adverse reaction(s) during the course of one treatment)

- common (more than 1 but less than 10 animals in 100 animals)

- uncommon (more than 1 but less than 10 animals in 1,000 animals)

- rare (more than 1 but less than 10 animals in 10,000 animals)

- very rare (less than 1 animal in 10,000 animals, including isolated reports).

Use during pregnancy, lactation or lay

The safety of the veterinary medicinal product in breeding, pregnant and lactating dogs has been demonstrated. Can be used in breeding, pregnant and lactating dogs.

Interaction with other medicinal products and other forms of interaction

None known.

Fluralaner is highly bound to plasma proteins and might compete with other highly bound drugs such as non-steroidal anti-inflammatory drugs (NSAIDs) and the cumarin derivative warfarin. Incubation of fluralaner in the presence of carprofen or warfarin in dog plasma at maximum expected plasma concentrations did not reduce the protein binding of fluralaner, carprofen or warfarin.

During clinical field testing, no interactions between Bravecto chewable tablets for dogs and routinely used veterinary medicinal products were observed.

Amounts to be administered and administration route

For oral use.

Bravecto should be administered in accordance with the following table (corresponding to a dose of 25–56 mg fluralaner/kg bodyweight within one weight band):

Bodyweight of dog (kg)

Strength and number of tablets to be administered

Bravecto 112.5 mg

Bravecto 250 mg

Bravecto 500 mg

Bravecto 1000 mg

Bravecto 1400 mg











The chewable tablets should not be broken or divided.

For dogs above 56 kg bodyweight, use a combination of two tablets that most closely matches the bodyweight.

Method of administration:

Administer Bravecto chewable tablets at or around the time of feeding.

Bravecto is a chewable tablet and is well accepted by most dogs. If the tablet is not taken up voluntarily by the dog it can also be given with food or directly into the mouth. The dog should be observed during administration to confirm that the tablet is swallowed.

Treatment schedule:

For optimal control of flea infestation, the veterinary medicinal product should be administered at intervals of 12 weeks. For optimal control of tick infestation, the timing of retreatment depends on the tick species. See section 4.2.

Overdose (symptoms, emergency procedures, antidotes), if necessary

No adverse reactions were observed following oral administration to puppies aged 8–9 weeks and weighing 2.0–3.6 kg treated with overdoses of up to 5 times the maximum recommended dose (56 mg, 168 mg and 280 mg fluralaner/kg bodyweight) on three occasions at shorter intervals than recommended (8-week intervals).

There were no findings on reproductive performance and no findings of concern on offspring viability when fluralaner was administered orally to Beagle dogs at overdoses of up to 3 times the maximum recommended dose (up to 168 mg/kg bodyweight of fluralaner).

The veterinary medicinal product was well tolerated in Collies with a deficient multidrug-resistance-protein 1 (MDR1 -/-) following single oral administration at 3 times the recommended dose (168 mg/kg bodyweight). No treatment-related clinical signs were observed.

Withdrawal period

Not applicable.

Pharmacological Properties

Pharmacotherapeutic group: Ectoparasiticides for systemic use.

ATCvet code: QP53BX05.

Pharmacodynamic properties

Fluralaner is an acaricide and insecticide. It is efficacious against ticks (Ixodes spp., Dermacentor spp. and Rhipicephalus sanguineus) and fleas (Ctenocephalides spp.) on the dog.

Fluralaner has a high potency against ticks and fleas by exposure via feeding, i.e. it is systemically active on target parasites.

Fluralaner is a potent inhibitor of parts of the arthropod nervous system by acting antagonistically on ligand-gated chloride channels (GABA-receptor and glutamate-receptor).

In molecular on-target studies on insect GABA receptors of flea and fly, fluralaner is not affected by dieldrin resistance.

In in vitro bio-assays, fluralaner is not affected by proven field resistances against amidines (tick), organophosphates (tick, mite), cyclodienes (tick, flea, fly), macrocyclic lactones (sea lice), phenylpyrazoles (tick, flea), benzophenyl ureas (tick), pyrethroids (tick, mite) and carbamates (mite).

The product contributes towards the control of the environmental flea populations in areas to which treated dogs have access.

Newly emerged fleas on a dog are killed before viable eggs are produced. An in vitro study also demonstrated that very low concentrations of fluralaner stop the production of viable eggs by fleas.

The flea life cycle is broken due to the rapid onset of action and long lasting efficacy against adult fleas on the animal and the absence of viable egg production.

Pharmacokinetic particulars

Following oral administration, fluralaner is readily absorbed reaching maximum plasma concentrations within 1 day. Food enhances the absorption. Fluralaner is systemically distributed and reaches the highest concentrations in fat, followed by liver, kidney and muscle. The prolonged persistence and slow elimination from plasma (t1/2 = 12 days) and the lack of extensive metabolism provide effective concentrations of fluralaner for the duration of the inter-dosing interval. Individual variation in Cmax and t1/2 was observed. The major route of elimination is the excretion of unchanged fluralaner in faeces (~90% of the dose). Renal clearance is the minor route of elimination.

Pharmaceutical Particulars

List of excipients

Pork liver flavour, Sucrose, Maize starch, Sodium lauryl sulphate, Disodium embonate monohydrate, Magnesium stearate, Aspartame, Glycerol, Soya-bean oil and Macrogol 3350.


None known.

Shelf life

Shelf life of the veterinary medicinal product as packaged for sale: 2 years.

Special precautions for storage

This veterinary medicinal product does not require any special storage conditions.

Nature and composition of immediate packaging

Cardboard box with 1 aluminium foil blister sealed with paper/PET aluminium foil lid stock containing 1, 2 or 4 chewable tablets.

Not all pack sizes may be marketed.

Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Marketing Authorisation Number

Intervet International B.V.

Wim de Körverstraat 35

5831 AN Boxmeer

The netherlands


EU/2/13/158/001 Bravecto 112.5 mg chewable tablets for very small dogs

EU/2/13/158/004 Bravecto 250 mg chewable tablets for small dogs

EU/2/13/158/007 Bravecto 500 mg chewable tablets for medium-sized dogs

EU/2/13/158/010 Bravecto 1000 mg chewable tablets for large dogs

EU/2/13/158/013 Bravect0 1400 mg chewable tablets for very large dogs


11 February 2014.

Date of Revision of the Text

February 2014.

Legal Catagory

POM-V To be supplied only on veterinary prescription.

MSD Animal Health

Walton Manor


Milton Keynes


Pre-Lanuch Information

Bravecto is in tablet form and allows fuss-free administration for most dogs. The active ingredient, fluralaner, is absorbed into the blood stream and affects parasites after they take a blood meal from the dog; it takes just 8 hours to kill exposed fleas and 12 hours to kill exposed ticks. Fluralaner belongs to a group of ectoparasiticides called the isoxazolines and kills by causing spastic paralysis. A primary target is the GABA receptor which normally prevents repetitive or uncontrolled firing of action potentials (impulses) by allowing entry of negatively charged ions (anions). When fluralaner binds GABA receptor, anion flow is inhibited, so nerve and muscle cells remain excited. Accumulation of positively charged ions (cations) leaves nerve and muscle cells hyperexcited, and induces loss of regulated muscle contraction and death.

For customers wishing to treat their dogs less regularly, Bravecto seems like it would be the ideal choice, as it lasts three times longer than the majority of flea and tick products on the current market. Its systemic, persistent action will ensure that your pet is fully protected but at the same time, the chemical is not a risk to a dog's health. At present, there is little information available but the product promises to be an effective treatment for fleas and ticks and will be a valuable asset when treating dogs with Flea Allergy Dermatitis (FAD). Bravecto will be classified as a POM-V medication and will therefore require a prescription from your veterinary surgeon, which you can send to us at VioVet to supply.

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Reviews of Bravecto Chewable Tablets for Dogs

Read our customers' reviews of Bravecto Chewable Tablets for Dogs

Questions & Answers for Bravecto Chewable Tablets for Dogs

Below are some recent questions we've received regarding Bravecto Chewable Tablets for Dogs, including answers from our team.

Ask Your Own Question

UK prescription

3rd Nov 2015
American Canine

We are in the US. So we need a UK prescription?

John Cousins
  • Non-Executive Director

If we are posting to a US address then we need a US prescription. If we post to the UK then we need a UK prescription.

Safe for Border Collie/ Austrailan Shepard Mix?

9th Oct 2015

I have a 1 1/2 year old Aussie/Border mix who weighs 60 Bravecto safe for collie mixes?

John Cousins
  • Non-Executive Director

This product has been tested at a three-fold overdose in collies with the known genetic variation and found to be very safe. As long as you give the correct dose it should be perfectly safe for your "collie mix".

Spot on

10th Jul 2015
Julie cottam

How soon after using stronghold spot on can I safely give my dogs bravecto ?

John Cousins
  • Non-Executive Director

The active ingredients in these two products are completely different and there is no reason to expect them to interact adversely at all. Theoretically it should be safe to give Bravecto at the same time as Stronghold, but it would be sensible to discuss this with your own vet first.

Frequent bathing

4th Jul 2015

Will frequent bathing reduce the effectiveness of Bravecto?

John Cousins
  • Non-Executive Director

I would not expect frequent bating to reduce the effectiveness. It is a systemic product and parasites have to bite the dog to be killed off. This is different from the usual spot-on treatments which coat the surface of the dog and can be washed off.

Safe for seizure prone dog?

3rd Jun 2015
Cathy D.

I recently acquired a 6 year old rescue German Shepherd. She is on Atopica for anal furunculosis (100mg capsules) and weighs 27kg. Her vaccinations had lapsed so they were given (including the new lepto-4). She had one seizure a few days after the first vacc, which we did not connect, but she had 3 seizures within 24 hours after the second vacc. Previous owner thought she had some seizures but did not connect them with anything. I am about to flea treat her for the first time and was going to use Stronghold which I use for my other GSD, but the leaflet said it can cause seizures so did not want to risk that. I do not know what has been used on her in the past, so was going to use Frontline, then someone mentioned Bravecta. It is just routine treatment, we don't have a particular flea or tick problem. What would you suggest as the safest course of action for her please. Thank you.

John Cousins
  • Non-Executive Director

It is not possible to predict with certainty when another fit might occur but it is true that some medications might well make another fit more likely. I would recommend Frontline Spot-on for your dog. The active ingredient is virtually not absorbed into the body at all, it just sits on the surface of the skin and coat. It is also very non-toxic to dogs anyway. I think that Frontline would be your safest option rather than a systemic product like Bravecto or Stronghold.

Safety of bravecto

26th Jan 2015
Helen patrick

Is bravecto safe for border collies? Is it palatable and what are the side effects if any?

  • Brand Manager

The safety of Bravecto in collies has been tested (using dogs with the MDR1 deletion mutation) and it has been shown to be safe.

The tablets are palatable and intended to be taken directly. If a dog doesn't wish to take it, it can be disguised in food or administered orally. Tablets should not be split or crushed into food, and it is important to watch that it has been swallowed.

Side effects that may be seen include mild and short-lived gastrointestinal effects such as diarrhoea, vomiting, drooling and lack of appetite.


17th Oct 2014

I have a small dog and am not sure if she has a tick or not. looks like a small skin tag? I was going to use Bravecta flea and tick chew. If it is a tick will the chew work with existing ticks?

John Cousins
  • Non-Executive Director

Bravecto should work fine with an existing tick.

If you look very carefully at the base of the "tick", you will see small legs and they will move about if it really is a tick. Most ticks where the observer is not sure if it is a tick or not, turn out not to be if you look carefully. As long as you have averagely normal eyesight, you should be able to tell the difference quite easily. (You can look on Google for images of ticks.)

Bravecto in lactating bitches

30th Sep 2014

Does Bravecto get incorporated into the bitches milk? In other wrods, does it give any direct protection to the pups she is feeding?

John Cousins
  • Non-Executive Director

Bravecto is safe to use in pregnant and lactating bitches. I am not sure if it transfers directly to the puppies through milk or before birth. However fleas as normally quite well controlled by just treating the bitch anyway so that should be adequately effective. Remember to treat the environment with Indorex or similar if you are aware of a significant flea problem.


29th Aug 2014
Phil Wells

we have just used this product and alot of the ticks have dropped off. but there are some large ones and very small white infant ones still left on the dog. will they drop off on their own or do they have to be removed (larger ones) what about the small white ones?

many thanks


John Cousins
  • Non-Executive Director

The ticks should drop off in time, but it is OK to remove them if you need to. Personally I find that gently rolling large ticks around on the skin will usually work them out, if they are alive or dead. It can take a few minutes with a very persistent large tick, but never leaves the jaws behind.

Dog weight

26th Jun 2014
Geoff Russell

I have a newfoundland dog is the 1400mg tablet of Bravecto enough.

  • Brand Manager

If your dog is over 56kg, your vet will to prescribe the appropriate combination of tablets to dose your dog correctly. You can then ask for a prescription and send it to us by email, fax or post or upload it via your Viovet account and we will be able to supply you. To save a little extra, see if your vet will issue repeats on the prescription, so that we can supply the prescribed amount a specified number of times before you need to see them for a new one.