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Aludex Concentrate Solution for Dogs

Aludex Concentrate Solution for Dogs
50ml Bottle

  • 50ml Bottle £21.49

Description

Aludex is diluted in water to make a wash. It used to treat the two main types of mange affecting dogs, Demodectic mange and Sarcoptic mange. Where just localised areas are affected it can be applied to these alone, or in generalised cases it is used over the entire animal. Dogs should be washed first with a normal cleansing shampoo, then Aludex solution is applied. It needs to be diluted with water first, at the correct concentration as advised by your vet (or see details below). This process needs to be repeated at weekly intervals for Demodex, or every 2 to 6 weeks for Sarcoptes. Once the skin has been soaked with the resultant solution, the dog should be allowed to stand in a well ventilated area to dry off. The solution should NOT be rinsed off or dried with a towel. Operators using Aludex should wear a protective gown and gloves and should avoid contact with their own skin or eyes.
The active ingredient is called amitraz, which is toxic to horses. It is not recommended for use on cats, pregnant or lactating bitches, or on Chihuahuas. It has been used successfully on Rabbits, Guinea Pigs, Hamsters and Rats, but a more dilute solution is recommended. Some dogs will show side effects due to an alpha-2-adrenoreceptor stimulation effect. This usually shows as sedation or lethargy, but vomiting and salivation can be seen. It is not recommended to use Aludex at the same time as alpha-2-adrenoreceptor sedatives. Dogs showing side effects which last more than 24 hours should be washed in warm, soapy water (not detergent).

Aludex is used to treat the two main types of mange affecting dogs, Demodectic mange and Sarcoptic mange. Where just localised areas are affected it can be applied to these alone, or in generalised cases it is used over the entire animal. Dogs should be washed first with a normal cleansing shampoo, then Aludex solution is applied. Aludex needs to be diluted with water first, at a ration of 1ml Aludex to 50mls water for Demodex treatment, or 25ml Aludex to 50 Litres water for Sarcoptes treatment. This process needs to be repeated at weekly intervals for Demodex, or every 2 to 6 weeks for Sarcoptes. Once the skin has been soaked with the Aludex solution, the dog should be allowed to stand in a well ventilated area to dry off. Aludex should NOT be rinsed off or dried with a towel. Operators applying Aludex should wear a protective gown and gloves and should avoid contact with their own skin or eyes.

The active ingredient in Aludex is amitraz, which istoxic to horses. It is not recommended for use on cats, pregnant or lactating bitches, or on Chihuahuas. It has been used successfully on Rabbits, Guimea Pigs, Hamsters and Rats, but a more dilute solution is recommended. Some dogs will show side effects due to an alpha-2-adrenoreceptor stimulation effect. This usually shows as sedation or lethargy, but vomiting and salivation can be seen. It is not recommended to use Aludex at the same time as alpha-2-adrenoreceptor sedatives. Dogs showing side effects which last more than 24 hours should be washed in warm, soapy water (not detergent).

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Medication Datasheets

50ml Bottle

Aludex 50 g/l concentrate for cutaneous solution

Qualitative and quantitative composition

Amitraz (as Amitrax technical) 50 g/L.

Stabiliser: Tetraisopropyldiphenylcarboiimide (Stabaxol 1) 10.5 g/L.

For full list of excipients, see section "Pharmaceutical Particulars".

Pharmaceutical form

Concentrate for cutaneous solution. Clear pale yellow liquid.

Clinical particulars

Target species

Dogs

Indications for use

For the control of demodectic and sarcoptic mange.

Contra-indications

Do not use on Chihuahuas. Do not use on dogs suffering from heat stress. Do not use on pregnant or lactating bitches, nor puppies less than 3 months old. Do not use on cats.

Special warnings for each target species

None.

Special precautions for use

For use on dogs only. For external use only. For use only under the supervision of a veterinary surgeon. Dogs should be prevented from licking the fur after treatment. For the treatment of demodectic mange in severely debilitated dogs use 25 ml of Aludex in 5 litres of water (half the normal dose rate).

Operator warnings

Flammable. Prepare and use the dilution of the product in a well-ventilated area. Wear waterproof gloves, apron and face shield when handling the product and wash all protective clothing thoroughly after use, including the inside of gloves. May cause sensitisation (allergy) by skin contact. Avoid any contact of the product with the skin or eyes. In case of skin contamination, wash thoroughly with soap and water. In case of eye contamination, rinse with plenty of clean, running water immediately. If irritation persists, seek medical help. Do not eat drink or smoke whilst using the product. When treatment is completed, wash hands thoroughly before eating, drinking or smoking. Do not handle treated animals without use of protective clothing until the treatment has dried thoroughly. Treated animals should not be allowed to sleep or play with people, particularly children, until the animal is dry. If you feel unwell, seek medical advice taking the product leaflet with you.

To the physician: Amitraz is NOT an organophosphorous compound. Do NOT use atropine as an antidote. Do NOT induce vomiting. Treatment should be symptomatic and supportive, paying particular attention to monitoring of respiratory and cardiac function. Recovery, however, is normally spontaneous.

Adverse reactions

Aludex treatment can lead to known side-effects in a small numbers of dogs. In rare cases neurological disorders (ataxia, lethargy, sedation and CNS depression), skin reactions (erythema, pruritus and dermatitis), digestive tract disorders (diarrhoea and emesis), salivation, anorexia, shallow breathing, dyspnoea, bradypnoea, bradycardia and allergic reactions (oedema) could be observed. Most of these signs are due to alpha-2-adrenoreceptor agonistic effects. Signs are usually transitory and generally resolved without treatment. If symptoms persist, the dogs should be washed in soapy water (not washing-up detergent), dried and warmed. The alpha-2-adrenoreceptor antagonist, atipamezole hydrochloride, may be used at a dose of 0.2 mg/kg body weight by intramuscular injection to reverse these side-effects.

Use during pregnancy, lactation or lay

Contra-indicated in the absence of adequate safety trials data.

Interactions

This product can be used with other dermatological preparations, except those that are water-repellent and with anthelmintics. Concurrent use with other alpha-2-adrenoreceptor agonists is not recommended. Do not use simultaneously with other ectoparasiticide preparations.

Amounts to be administered and administration route

For external use only. Shake the container/bottle before use. Make up wash immediately before use.

Demodectic mange:

Use 50 ml Aludex concentrate per 5 litres of water for small dogs or 100 ml Aludex per 10 litres of water for large dogs. Whatever quantity of wash is required it is essential that the initial concentration is not varied from 1 part Aludex to 100 parts water (0.05 % w/v amitraz). Repeat the treatment at intervals of 5-7 days until neither live mites nor viable eggs can be identified microscopically by skin scrapings. Alternatively, continue treatment for at least 3 weeks after all overt clinical symptoms have subsided.

Sarcoptic mange:

Use 25 ml Aludex per 5 litres of water for small dogs or 50 ml Aludex per 10 litres water for large dogs. Do not vary the concentration from 1 part Aludex to 200 parts water. (0.025 % w/v amitraz). Repeat treatment at weekly intervals for 2 to 6 weeks.

Application method

Overdose

Even after accidental overdose, adverse effects should not exceed those described under section "Interactions". Refer to this section for recommended actions. Clinical signs of toxicity include:

i) Signs of CNS depression eg. drowsiness.

ii) Reduced body temperature.

iii) Reduced heart rate and blood pressure.

iv) Increased blood sugar levels (alpha-2-adrenergic agonists are known to reduce insulin release, eg. clonidine).

v) Delayed gastro-intestinal transit.

Withdrawal periods

Not applicable.

Pharmacological particulars

Pharmacodynamic properties

ATC Vet Code: QP53AD01

Acute toxicity (single dose studies)

A) Tecnical material, amitraz

Species Sex Route LD50 mg/kg
Rat Male Oral 650
Rat Male Dermal > 1600

B) Formulated product - Aludex

Species Sex Route LD50 mg/kg
Rat Male Oral 2259
Rat Male & Female Dermal > 2100

Toxicity with repeat administration

Technical material, amitraz

Species* Route Duration No effect level
Rat Oral 90 days 3 mg/kg/day
Rat Oral 2 years 2 mg/kg/day

*males and females in each case.

Mutagenicity, Teratogenicity and Carcinogenicity

Amitraz was inactive in a wide range of laboratory tests for genotoxicity and mutagenicity and is not teratogenic. There was no evidence of tumourogenesis in the rat carcinogenicity study but in a mouse oncogenicity study there were liver tumours in high dose (dietary level of 400 ppm) animals. This was seen in females only, was species specific and of no relevance for humans.

Mode of action and clinical symptomology Amitraz has a variety of pharmacological activities, which are believed to contribute both to its biological efficacy and to the clinical signs of toxicity.

Amitraz is a contact insecticide/acaricide with extended residual activity, functioning as an agonist at octopamine receptors in the nerve synapses. This produces increased nervous activity leading to rapid detachment of parasites and their eventual mortality. This novel mode of action differs from other established insecticides eg. organophosphates, carbamates and pyrethroids.

In mammals, the following activities have been reported:

I) Alpha-2-adrenoreceptor agonist:

This is the main activity responsible for most clinical signs.

II) Weak inhibitor of serotonin receptors

III) Weak H1 receptor agonist.

IV) Mono-amine oxidase inhibitor in vitro but not apparently in vivo.

Pharmacokinetic properties

Dermal absorption of amitraz is relatively slow and achieves peak blood levels 24-72 hours after dosing. Less than 40% of the total applied dose was absorbed in studies on dogs over a period of 10 days following treatment.

Metabolism appears to follow the same route in all mammals observed to date. Initial hydrolysis is to N-(2,4-dimethylphenyl)-N=-methylformamidine (BTS 27271) and 2,4-dimethylformanilide (BTS 27919). The main end products of metabolism are excreted predominantly in the urine and consist of 2-methyl-4-carboxyformanilide (BTS 39098), 4-acetamido- 3-methylbenzoic acid (FBC 31158), their respective conjugates and conjugates of 4-amino-3-methylbenzoic acid (BTS 28369). All these products may be converted to BTS 28369 by acid hydrolysis during extraction and processing. Excretion has been rapid following oral dosing in all species studies, with urine as the major route, accounting for 65-84% of the dose (55-76%) in the first 24 hours.

Pharmaceutical particulars

Excipients

Tetraisopropydiphenylcarboiimide (Stabaxol 1), Nonoxinol 9, Naphtha 21/99.

Major incompatibilities

None known.

Shelf life

Shelf life of the veterinary medicinal product as packaged for sale: 2 years.

Dispose of diluted solution immediately after use.

Special precautions for storage

Do not store above 25°C. Store in tightly closed original container in safe place. Store away from food, drink and animal feeding stuffs. Store in a dry place.

Immediate packaging

50 ml packed in amber coloured glass bottle with a white polypropylene/polyethylene (PP/PE) child-resistant closure with expanded low density PE/aluminium foil/ PE faced wad.

Disposal

Harmful to fish and other aquatic life. Do not contaminate ponds, waterways and ditches with concentrate, the diluted wash or used containers.

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Unused diluted wash can be discarded through the normal waste disposal system.

Marketing Authorisation Number

Vm 01708/4408

Date of the first authorisation or date of renewal

1 April 2009

Date of revision of the text

October 2013.

Any other information

For animal treatment only. Keep out of the sight and reach of children.

Legal category

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Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.

What do you charge for delivery?

For UK delivery, we charge the following:

Order Total Weight Delivery
£0-£28.99 Under 2kg £2.99
2kg+ £4.99
£29-£38.99 Under 2kg Free
2kg+ £4.99
£39+ Under 2kg Free
2kg+ Free

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For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.

We can deliver most items to all around the world, but prices do vary. The majority of light weight orders (less than 1.5kg) can be delivered for a flat rate of £10. For an accurate estimate of the delivery charge, please put the items you require in your basket and use the "Estimate Delivery" system on the shopping basket page (you only need to enter your country and postal/zip code) for a quick quote. For deliveries to the USA you may need to go to the checkout page and enter your full address to get a quote (as some services need your state in order to quote too). For more information on international deliveries, please see our delivery information page.

Delivery of aerosols

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How do I cancel or return an order?

Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.

To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.

*For full details on returns, see our terms and conditions page.

Reviews (1)

Q & A

Below are some recent questions we've received regarding Aludex Concentrate Solution for Dogs, including answers from our team.

10 January 2016 at 7:02pm

Aludex treatment demodex mange

jason

Mu dogs 4 staffy boy had demodex since puppy is aludex ment to all but cure the mange we have used before and are tryin other things this seemed the best advice plz

  • Non-Executive Director

This is probably the best product there is. You need to repeat it once per week for about 10 weeks or more to get rid of all the Demodex. Sometimes it helps to use Advocate as well at the same time.

16 December 2013 at 2:20pm

Where can Aludex be applied?

Percy Thorpe

Please can you advise me, is Aludex solution safe to use around the anus and vaginal area in a border terrier?

  • Non-Executive Director

Aludex is routinely used in these areas. As long as it is just applied to those parts which are visible to the eye, rather than slightly internal, it should be fine. If you think of it getting to the parts which would be wetted if the dog was dipped in a full bath, then that is what you should aim for.