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Alamycin Oxytetracycline Antibiotic

Alamycin Oxytetracycline Antibiotic
100ml » LA300, Long Acting Injection
140g » Aerosol

  • 100ml » LA300, Long Acting Injection £34.00
  • 100ml » LA Injection £21.49
  • 140g » Aerosol £10.00

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Description

Oxytetracycline is active against a wide range of Gram-positive and Gram-negative pathogenic bacteria, certain rickettsia and the larger viruses. Alamycin 10% Injection is indicated in the treatment of a wide range of common systemic, respiratory and local infections caused by or associated with organisms sensitive to Oxytetracycline in cattle and pigs.

is a bacteriostatic antibiotic that inhibits protein synthesis in susceptible bacteria. Inside the cell it binds irreversibly to receptors on the 30S subunit of the bacterial ribosome where it interferes with the binding of the amino-acyl transfer RNA, to the acceptor site on the messenger RNA ribosome complex. This effectively prevents the addition of the amino acids to the elongating peptide chain, inhibiting protein synthesis.

Oxytetracycline is a bacteriostatic antibiotic that inhibits protein synthesis in susceptible bacteria. Inside the cell it binds irreversibly to receptors on the 30S subunit of the bacterial ribosome where it interferes with the binding of the amino-acyl transfer RNA, to the acceptor site on the messenger RNA ribosome complex. This effectively prevents the addition of the amino acids to the elongating peptide chain, inhibiting protein synthesis. Without the process of protein synthesis taking place, the cell is unable to grow and repair.

Aerosol

Presentation

33 mg/g Oxytetracycline (as the hydrochloride) in 140g aerosol spray can

Uses

An aid in the treatment of foot rot in sheep, digital dermatitis in cattle and superficial skin infections caused by oxytetracycline sensitive organisms in pigs, sheep and cattle.

Dosage & Administration

SHAKE WELL BEFORE USE. Before spraying, the infected area should be cleansed and hooves should be pared. Holding the can upright, spray at a distance of 10 - 15 cm for a minimum of 5 seconds or until the area is covered.
Treated cattle and sheep should be allowed to stand on dry ground for 1 hour before returning to pasture.

Withdrawal Period

MEAT: Nil
MILK: Nil
Avoid milk contamination. Wash thoroughly from teats and udders prior to milking.

Pharmaceutical Precautions

Store below 25°C (Air Conditioning) in a dry place out of direct sunlight.

Disposal

Aerosols should be completely emptied before disposal. Place empty can in household rubbish. DO NOT PUNCTURE OR INCINERATE.

Further Information

GENERAL INSTRUCTIONS
Oxytetracycline is active against a wide range of
gram-positive and gram-negative pathogenic bacteria. In
severe infections, topical treatment should be
supplemented with systemic antibiotic treatment.

TRADE ADVICE
EXPORT SLAUGHTER INTERVAL (ESI): Animals can be
slaughtered for export at zero days after the last
treatment.
SAFETY AND FIRST AID INSTRUCTIONS:
If poisoning occurs, contact a doctor or Poisons
Information Centre (Ph: 131126). Keep away from eyes.
Avoid inhalation. Wash hands after use.

Store below 25°C (Air Conditioning) in a dry place out of
direct sunlight.

Misc

APVMA Approval No.: 47532

Injection

Presentation

A sterile aqueous solution containing:
Oxytetracycline Dihydrate equivalent to 200mg/ml of oxytetracycline base.
Sodium Formaldehyde Sulphoxylate Dihydrate (0.4%w/v).

Uses

Alamycin LA is specifically formulated to provide a prolonged action resulting in sustained antibacterial activity. Blood levels persist for at least 4 days. After administration by the intramuscular route maximum blood levels are achieved after 4 to 8 hours making Alamycin LA suitable for the treatment of acute infections.

Oxytetracycline has been shown to be effective in vitro against the following bacterial species: Bordetella bronchiseptica, Arcanobacterium pyogenes, Erysipelothrix rhusiopathiae, Escherichia coli, Haemophilus somnus, Mannheimia haemolytica, Pasteurella multocida, Salmonella dublin, Staphylococcus aureus, Streptococcus agalactiae, Streptococcus faecalis, Streptococcus pyogenes and Streptococcus uberis.

Alamycin LA is indicated for use in cattle, sheep and pigs in the treatment of: atrophic rhinitis caused by Bordetella bronchiseptica, Mannheimia haemolytica and Pasteurella multocida; navel/joint ill caused by Arcanobacterium pyogenes, E. coli, and Staphylococcus aureus; mastitis caused by Arcanobacterium pyogenes, E. coli, Staphylococcus aureus, Streptococcus agalactiae, and Streptococcus uberis;metritis caused by E. coli and Streptococcus pyogenes; pasteurellosis and infections of the respiratory tract caused by Mannheimia haemolytica and Pasteurella multocida; septicaemia caused by Salmonella dublin and Streptococcus pyogenes; erysipelas caused by Erysipelothrix rhusiopathiae.

Alamycin LA can also be used in the control of enzootic abortion in sheep.

Dosage & Administration

The recommended dosage rate is 20mg/kg bodyweight (1ml per 10kg bodyweight) by deep intramuscular injection. The product is recommended for a single administration only.

Withdrawal Period

Milk for human consumption: Milk taken from cows should not be used for human consumption during treatment or for 10 days after treatment. Sheep’s milk may not be used for human consumption during treatment or for 7 days after treatment.

Meat for human consumption: Cattle, Sheep and Pigs must not be slaughtered for human consumption during treatment. Cattle may be slaughtered for human consumption only after 31 days from last treatment and Sheep only after 9 days from last treatment. Pigs may be slaughtered for human consumption after a period of 18 days following last treatment.

Contraindictions, Warnings etc

When the container is broached for the first time, the date on which any product remaining in the container should be discarded should be calculated and recorded.

A statement of the in-use shelf life of the product is given on the package insert. This discard date should be written in the space provided on the primary label.

Do not dilute Alamycin LA. Although Alamycin LA is well tolerated, occasionally a slight reaction of a transient nature has been observed. The use of tetracyclines during the period of tooth and bone development, including late pregnancy, may lead to discolouration. If concurrent treatment is administered, use a separate injection site. Wash hands after use. In case of contact with eyes or skin, wash immediately with water as irritation may occur. Take care to avoid accidental injection.

Pharmaceutical Precautions

Do not store above 25ºC. Protect from light. Following withdrawal of the first dose, use the product within 28 days. Discard unused material. Keep container in outer carton. Dispose of any unused product and empty containers in accordance with guidance from your local waste regulation authority.

Further Information

If stored as directed Alamycin LA can be expected to retain its potency for 2 years from the manufacturing date.

When the vial has been broached and the contents exposed to air, the solution may darken but the potency will be unchanged.

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Medication Datasheets

100ml » LA Injection

Alamycin LA 300 Solution for Injection 300 mg/ml

Qualitative and quantitative composition

Active substance(s):%w/vOxytetracycline30.00(as Oxytetracycline dihydrate )32.40Excipients:Sodium Formaldehyde Sulphoxylate Anhydrous0.40For a full list of excipients, see section Pharmaceutical Particulars

Active substance(s):

%w/v

Oxytetracycline

30.00

(as Oxytetracycline dihydrate )

32.40

Excipients:

Sodium Formaldehyde Sulphoxylate Anhydrous

0.40

For a full list of excipients, see section Pharmaceutical Particulars

Pharmaceutical form

Solution for injection.

Clear dark amber liquid.

Clinical particulars

Target species

Cattle, Sheep, Pigs

Indications for use, specifying the target species

For the treatment of conditions caused by or associated with organisms sensitive to oxytetracycline including:

Certain mycoplasma, rickettsiae, protozoa and chlamydia are also sensitive to oxytetracycline.

The product is indicated for the treatment and control of pasteurellosis, pneumonia, atrophic rhinitis, erysipelas, joint-ill, navel-ill, summer mastitis in cows, ovine keratoconjunctivitis (pink-eye) and enzootic abortion in sheep.

Contraindications

Do not dilute the product.

Special Warnings for each target species

Oxytetracycline therapy does not completely eliminate chlamydial infection in the flock.

Special precautions for use

Use of the product should be based on susceptibility testing of bacteria isolated from the animal. If this is not possiable, therapy should be based on local (regional, farm level) epidemiological information about susceptability of the target bacteria.

Special precautions for use in animals

If concurrent treatment is administered use a separate injection site.

Special precautions to be taken by the person administering the veterinary medicinal product to animals

Wash hands after use. In case of contact with eyes or skin, wash off immediately with water as irritation may occur. Avoid accidental self-injection.

Adverse reactions (frequency and seriousness)

Although the product is well tolerated, occasionally a slight local reaction of a transient nature may be observed.

Use during pregnancy, lactation or lay

The use of this product during the period of tooth and bone development, including late pregnancy, may lead to discoloration. The product can be safely administered during lactation.

Interaction with other medicinal products and other forms of interaction

None known

Amounts to be administered and administration route

To ensure a correct dosage, bodyweight should be determined as accurately as possible, to avoid under dosing.

Deep intramuscular injection.

Alamycin LA 300 can be administered at the standard dose of 20 mg/kg to obtain 3 to 4 days duration of activity or at a high dose of 30 mg/kg for prolonged duration of activity (i.e. activity maintained for 5 to 6 days).

Cattle, Sheep and Pigs:

Maximum recommended dosage at one site:

Cattle: - 15 ml

Pigs: - 10 ml

Sheep: - 5 ml

Piglets:

This product does not contain an antimicrobial preservative. Swab the septum before removing each dose. Use a sterile needle and syringe.

Overdose (symptoms, emergency procedures, antidotes), if necessary

Excessive dosages can cause nephrotoxicity in cattle. No treatment specified.

Withdrawal period

20 mg/kg dose:

Cattle – Meat & offal 28 days

Pigs – Meat & offal 14 days

Sheep – Meat & offal 28 days

30 mg/kg dose:

Cattle – Meat & offal 35 days

Pigs – Meat & offal 28 days

Sheep – Meat & offal 28 days

Cattle – Milk 8 days

Sheep – Milk 8 days.

Pharmacological particulars

Pharmacotherapeutic group: Antibacterial

ATC Vet Code: QJ01AA06

Pharmacodynamic properties

Oxytetracycline is a bacteriostatic antibiotic that inhibits protein synthesis in susceptible bacteria. Inside the cell it binds irreversibly to receptors on the 30S subunit of the bacterial ribosome where it interferes with the binding of the aminoactyl-transfer RNA to the acceptor site on the messenger RNA ribosome complex. This effectively prevents the addition of the amino acids to the elongating peptide chain, inhibiting protein synthesis.

The product is specifically formulated to provide a prolonged action, resulting in sustained antibacterial activity. Following intramuscular administration, effective blood levels persist for 3-4 days at a dose rate of 20mg/kg and for 5-6 days at a dose rate of 30mg/kg. Maximum blood levels are achieved between 4-6 hours following administration.

Pharmaceutical particulars

List of excipients

Sodium Formaldehyde Sulphoxylate Anhydrous

Magnesium Oxide Light

Dimethylacetamide

Ethanolamine (for pH adjustment)

Water for injections

Incompatibilities

None known.

Shelf life

Shelf life of the veterinary medicinal product as packaged for sale: 2 years.

Shelf life after opening the immediate packaging: 28 days

Special precautions for storage

Do not store above 25°C.

Protect from light.

Following withdrawal of the first dose, use the product within 28 days.

Discard unused material safely

This product does not contain any microbial preservative.

Nature and composition of immediate packaging

100 ml, 250 ml and 500 ml amber glass Type I vial with bromobutyl rubber bung with aluminium seal.

Not all pack sizes may be marketed.

Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products

Any unused product or waste material should be disposed of in accordance with national requirements.

Marketing Authorisation Holder (if different from distributor)

Norbrook Laboratories Limited

Station Works

Newry

Co. Down

BT35 6JP

Northern Ireland

Marketing Authorisation Number

Vm 02000/4113

Date of the first authorisation or date of renewal

13 December 1993

Date of revision of the text

December 2016

Any other information

Nil.

Legal category

140g » Aerosol

Alamycin Aerosol 3.58% w/w Cutaneous Spray, Solution

Qualitative and quantitative composition

Active Substance

Each 140g aerosol can contains 5g Oxytetracycline Hydrochloride (equivalent to 3.58% w/w).

Excipients

Patent Blue V (E 131) 0.33% w/w as a marker dye.

Pharmaceutical form

Cutaneous spray solution.

A blue opaque solution.

Clinical particulars

Target species:

Cattle, sheep and pigs

Indications for use, specifying the target species:

Alamycin Aerosol is indicated for the treatment of foot rot in sheep and topical infections caused by organisms sensitive to oxytetracycline in cattle, sheep and pigs.

Contraindications:

None.

Special Warnings for Each Target Species:

None.

Special Precautions for Use:

Special Precautions for use in animals:

Keep away from the animal’s eyes.

Special precautions to be taken by the person administering the product to the animals:

Keep away from eyes.

Avoid contact with skin.

Avoid inhaling vapours.

Wash hands after use.

Do not spray on a naked flame or any incandescent material.

Highly flammable.

Must be used in a well ventilated area.

Do not smoke when using this product.

Adverse reactions (frequency and seriousness):

None.

Use during pregnancy, lactation or lay:

The product can be safely administered to pregnant and lactating animals.

Interactions with other medicinal products and other forms of interaction:

None.

Amount to be administered and administration route:

For the treatment of foot rot, the hooves should be cleaned and pared prior to administration. Wounds should be cleaned prior to administration. Shake the can before use. Spray for a few seconds or until the lesion is adequately covered.

Treated sheep should be allowed to stand on dry ground for one hour before returning to pasture.

Overdose (symptoms, emergency procedures, antidotes) (if necessary):

Not applicable.

Withdrawal periods:

Cattle: Meat Zero days; Milk: Zero hours

Sheep: Meat Zero days; Milk: Zero hours

Pig: Meat Zero days

Pharmacological particulars

Pharmacotherapeutic group: Antibiotic

ATCvet Code: QD06AA03

Pharmacodynamic properties:

Oxytetracycline is a bacteriostatic antibiotic that inhibits protein synthesis in susceptible bacteria. Inside the cell it binds irreversibly to receptors on the 30S subunit of the bacterial ribosome where it interferes with the binding of the aminoacyl-transfer RNA to the acceptor site on the messenger RNA ribosome complex. This effectively prevents the addition of amino acids to the elongating peptide chain, inhibiting protein synthesis.

Pharmaceutical particulars

List of excipients:

Patent Blue V (E131)

Magnesium Chloride Hexahydrate

Povidone K17

Propylene Glycol

Ethanolamine

Water Purified

Isopropyl Alcohol

Methyl Alcohol

Incompatibilities:

None Known.

Shelf-life:

Shelf life of the veterinary medicinal product as packaged for sale: 2 years.

Special precautions for storage:

Pressurised container, protect from sunlight and do not expose to temperatures above 50°C.

Do not pierce or burn, even after use.

Do not store above 25ºC.

Nature and composition of immediate packaging:

Aluminium cans with valves caps and actuators (140g pack size).

The propellant is Nitrogen (oxygen-free).

Special precautions for the disposal of unused veterinary medicinal products or waste materials derived from the use of such products, if appropriate:

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Marketing Authorisation Holder (if different from distributor)

Norbrook Laboratories Limited

Station Works

Camlough Road

Newry

Co. Down

BT35 6JP

Northern Ireland

Marketing Authorisation Number

Vm 02000/4053

Date of the first authorisation or date of renewal

5th June 1984/5th June 2004

Date of revision of the text

February 2008

Any other information

Nil.

Legal category

Delivery Information

How quickly do you deliver?

Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.

What do you charge for delivery?

For UK delivery, we charge the following:

Order Total Weight Delivery
£0-£28.99 Under 2kg £2.99
2kg+ £4.99
£29-£38.99 Under 2kg Free
2kg+ £4.99
£39+ Under 2kg Free
2kg+ Free

Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.

For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.

We can deliver most items to all around the world, but prices do vary. The majority of light weight orders (less than 1.5kg) can be delivered for a flat rate of £10. For an accurate estimate of the delivery charge, please put the items you require in your basket and use the "Estimate Delivery" system on the shopping basket page (you only need to enter your country and postal/zip code) for a quick quote. For deliveries to the USA you may need to go to the checkout page and enter your full address to get a quote (as some services need your state in order to quote too). For more information on international deliveries, please see our delivery information page.

Delivery of aerosols

Due to restrictions aerosols can't be sent by Royal Mail. We appreciate your understanding.

Delivery of temperature controlled items

Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.

How do I cancel or return an order?

Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.

To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.

*For full details on returns, see our terms and conditions page.

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