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Activyl Tick Plus Spot-On for Dogs

Activyl Tick Plus Spot-On for Dogs

  • 150mg (Small) » Pack of 4 Pipettes £25.00
  • 600mg (Large) » Pack of 4 Pipettes £34.99

Selection of 2 products from

£25.00 to £34.99


This is a new product recently released in the UK. Activyl Tick Plus is a combination of the latest flea treatment, indoxacarb combined with the tried and trusted tick treatment permethrin. It can be used on dogs only and provides effective flea and tick control for 4 weeks after the application of one small pipette.

Activyl Tick Plus kills more than 90 percent of the main tick species, including those which are known to transmit the serious diseases Babesiosis, Ehrlichiosis and Lyme disease.

Qualitative and quantitative composition

Active substance:

Each unit dose pipette delivers:

Activyl Tick Plus spot-on solution

Volume of unit dose (ml)

Indoxacarb (mg)

Permethrin (mg)

Very small dogs ( 1.2 to 5 kg)




Small dogs ( 5 to 10 kg)




Medium dogs ( 10 to 20 kg)




Large dogs ( 20 to 40 kg)




Extra large dogs (40 to 60 kg)




For full list of excipients, see Section "Pharmaceutical Particulars".

Pharmaceutical form

Spot-on solution.

A clear, colourless to yellow or brown-coloured solution .

Clinical particulars

Target species


Indications for use

Treatment of flea infestations (Ctenocephalides felis); the product has persistent insecticidal efficacy for up to 4 weeks against Ctenocephalides felis. The product has persistent acaricidal efficacy for up to 5 weeks against Ixodes ricinus and up to 3 weeks against Rhipicephalus sanguineus. If ticks of these species are present when the product is applied, all the ticks may not be killed within the first 48 hours but they may be killed within a week. The veterinary medicinal product can be used as part of a treatment strategy for flea allergy dermatitis (FAD).

Developing stages of fleas in the pet’s immediate surroundings are killed following contact with Activyl Tick Plus treated pets.


Do not use in cats.

Do not use in case of known hypersensitivity to the active substances or to any of the excipients.

Special warnings for each target species

The safety of Activyl Tick Plus has not been established in dogs younger than 8 weeks of age.

The safety of Activyl Tick Plus has not been established in dogs weighing less than 1.2 kg.

Special precautions for use

Care should be taken to avoid contact of the veterinary medicinal product with the eyes of the dog. Avoid contact with treated areas (application sites) until dry. The veterinary medicinal product remains effective when treated animals are exposed to sunlight or immersed in water (e.g. swimming, bathing). However, dogs should not be allowed to swim or be shampooed within 48 hours after treatment. In case of frequent shampooing, the duration of activity may be reduced. Ticks already attached on the dog may not be killed within two days after treatment and may remain attached and visible. Therefore the removal of ticks already on the dog at the time of treatment is recommended, in order to prevent them from attaching and having a blood meal. The veterinary medicinal product can induce convulsions in cats that could be fatal, due to the unique physiology of this species which is unable to metabolise certain compounds, including permethrin. In case of accidental exposure, if undesirable effects occur, wash the cat with shampoo or soap, and seek veterinary advice rapidly. To prevent cats from being accidentally exposed to the product, keep treated dogs away from cats until the application site is dry. It is important to ensure that cats do not groom the site of application on a dog, which has been treated with this product. In case of exposure of this type seek veterinary advice immediately.

Operator warnings:

Do not eat, drink or smoke while handling the veterinary medicinal product. The sachet is child-resistant. Keep the product in the sachet until use, in order to prevent children from getting direct access to the product. Keep the used pipette out of reach and sight of children. Used pipettes should be disposed of immediately. Wash hands immediately after use. This product contains indoxacarb and permethrin. People with known hypersensitivity to indoxacarb and/or permethrin should avoid contact with this product. As the veterinary medicinal product may cause moderate eye irritation, avoid contact with eyes. If this occurs, rinse slowly and gently with water. This product is highly flammable. Keep away from heat, sparks, open flame or other sources of ignition.

Adverse reactions

Transitory scratching, erythema or hair loss at the application site may occur. These effects will usually resolve without treatment.

The application of the veterinary medicinal product may produce a local, temporary oily appearance or hair clumping at the application site. A dry white residue may be also observed. This is normal and will generally resolve within a couple of days after administration. These changes do not affect the safety or efficacy of the veterinary medicinal product.

Use during pregnancy, lactation or lay

Laboratory animal studies (rats, mice and rabbits) with indoxacarb and permethrin have not produced any evidence of a teratogenic, foetotoxic or maternotoxic effects. However, a reproductive toxicity study conducted in the dog at three times the recommended therapeutic dose did reveal a significant reduction in the live pup ratio; the clinical significance of this latter finding is unknown as no studies were carried out in dogs using the recommended therapeutic dose. Therefore the use of the product in pregnant and lactating animals or animals intended for breeding should be based on a benefit/risk assessment by a veterinarian.


None known.

Amounts to be administered and administration route

Dosage schedule:

The recommended minimum dose is 15 mg indoxacarb/kg bodyweight, and 48 mg/kg permethrin equivalent to 0.1 ml spot-on solution per kg bodyweight.

The following table defines the size of pipette to be used according to the weight of the dog:

ACTIVYL TICK PLUS: Table defining the size of pipette to be used according to weight of the dog

Weight of dog (kg)


Volume (ml)

Indoxacarb (mg/kg)

Permethrin (mg/kg)

1.2 to 5 kg

Activyl Tick Plus spot-on solution for very small dogs


min. of 15

min. of 48

5 to 10 kg

Activyl Tick Plus spot-on solution for small dogs


15 - 30

48 - 96

10 to 20 kg

Activyl Tick Plus spot-on solution for medium dogs


15 - 30

48 - 96

20 to 40 kg

Activyl Tick Plus spot-on solution for large dogs


15 - 30

48 - 96

40 to 60 kg

Activyl Tick Plus spot-on solution for extra large dogs


15 - 22.5

48 - 72

For dogs weighing more than 60 kg the appropriate combination of pipettes should be used.

Method of administration

For spot-on use. Care should be taken to apply the product to intact skin.

Open one sachet and remove the pipette.

Step 1: With one hand, hold pipette in an upright position away from your face and snap tip open by bending it and folding it back on itself.

Activyl Tick Plus - fig 1

Step 2: The dog should be standing for easy application. Part the hair until the skin is visible and place pipette tip against the skin between the shoulder blades.

Activyl Tick Plus - fig 2

Step 3: Gently squeeze the pipette hence applying the solution on the skin. In order to avoid the product running onto the coat of the animal (especially in larger dogs) do not apply an excessive amount of solution to any one spot. Should this occur, re-application is not necessary; however, contact with treated areas (application sites) should be avoided until dry.

For very small and small dogs, squeeze pipette firmly applying the entire contents directly to the skin in one spot, between the shoulder blades.

For larger dogs, apply the contents of the pipette evenly to two (medium dogs) or three (large dogs) or four (very large dogs) spots, all located at different application sites along the backline from the shoulder to the base of the tail.

Activyl Tick Plus - fig 3


No adverse reactions were observed in dogs aged 8 weeks and older, treated 8 times at 4 week intervals or 6 times at 2 week intervals, with 5 times the recommended dose.

Withdrawal periods

Not applicable.

Pharmacological particulars

ATC Vet Code QP53AC54

Pharmacotherapeutic group Ectoparasiticides for topical use.

Pharmacodynamic properties

Indoxacarb is an ectoparasiticide belonging to the oxadiazine chemical family. Indoxacarb is a pro-drug that requires bioactivation by enzymes in susceptible insects to exert its pharmacodynamic effects. It enters the insect primarily through ingestion but is also absorbed, to a lesser degree, through the insect cuticle. In the mid-gut of susceptible insect species, the insect’s enzymes remove the carbomethoxy group from parent indoxacarb, and convert it into its biologically active form.The bioactivated metabolite acts as a voltage-dependent sodium channel antagonist in insects, by blocking the sodium channels that regulate the flow of sodium ions in the insect’s nervous system. This results in a rapid cessation of feeding within 0 to 4 hours after treatment followed by cessation of egg laying (oviposition), paralysis and death occurring within 4 to 48 hours. In addition to its adulticidal activity against fleas, indoxacarb has activity against the developing stages of fleas in the immediate surroundings of the treated dog. Permethrin belongs to the Type I class of pyrethroids, which are acaricides and insecticides with repellent activity. Pyrethroids affect the voltage-gated sodium channels in vertebrates and non-vertebrates. Pyrethroids are so-called “open channel blockers” affecting the sodium channel by slowing both the activation and the inactivation properties, thus leading to hyper-excitability and death of the parasite. The product provides repellent (anti-feeding) activity against ticks and various insect species, preventing the repelled parasite from taking a blood meal and thus reducing the risk of disease transmission.

Pharmacokinetic properties

Following a single spot-on application of the product, indoxacarb and permethrin can still be detected in both skin and hair coat after 4 weeks post-treatment. Absorption through the skin also occurs, but this systemic absorption is partial and not relevant for the clinical efficacy. The absorbed indoxacarb and permethrin are extensively metabolised by the liver to a variety of metabolites. The major route of excretion is in faeces for indoxacarb and both in urine and faeces for permethrin.

Environmental properties

Activyl Tick Plus should not be allowed to enter surface waters as indoxacarb and permethrin may have harmful effects on aquatic organisms.

Pharmaceutical particulars


Propyl gallate (E310) and Propylene glycol monomethyl ether (Dowanol PM).

Major incompatibilities

None known.

Shelf life

Shelf-life of the veterinary medicinal product as packaged for sale: 2 years.

Special precautions for storage

Store the pipettes in the original package in order to protect from moisture and light.

Immediate packaging

Cartons of 1, 4 or 6 spot-on pipettes consisting of 0.5 ml, 1 ml 2 ml, 4 ml, and 6 ml pipettes. One size only per box. The pipette consists of a blister film (polypropylene/cyclic-olefin-copolymer/polypropylene) and a foil lidstock (aluminium/polypropylene co-extruded) sealed into aluminium child-resistant sachet. Not all pack sizes may be marketed.


Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements. Activyl Tick Plus should not be allowed to enter surface waters as indoxacarb and permethrin may have harmful effects on aquatic organisms.

Marketing Authorisation Holder (if different from distributor)

Date of the first authorisation or date of renewal

9 January 2012.

Date of revision of the text

January 2012.

Any other information


Legal category


GTIN (Global Trade Item No)

Activyl Tick plus Toy Dog 4x75mg:

08713184117083 & 08713184117540 (8 x 4 pack),

Activyl Tick plus Sm Dog 4x150mg:

08713184117106 & 08713184117557 (8 x 4 pack),

Activyl Tick plus Med Dog 4x300mg:

08713184117113 & 08713184117571 (8 x 4 pack),

Activyl Tick plus Lg Dog 4x600mg:

08713184117120 & 08713184117588 (8 x 4 pack),

Activyl Tick plus XLg Dog 4x900mg:

08713184117144 & 08713184117595 (8x 4 pack)

Need help or advice? Contact us:

  • Landline: 01582 842096
  • Mon - Fri: 8:30am - 5:00pm
  • Sat: 9:00am - 1:00pm (Collections only)
  • Email: [email protected]

All prices include VAT where applicable.

Delivery Information

How quickly do you deliver?

Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.

What do you charge for delivery?

For UK delivery, we charge the following:

Order Total Weight Delivery
£0-£28.99 Under 2kg £2.99
2kg+ £4.99
£29-£38.99 Under 2kg Free
2kg+ £4.99
£39+ Under 2kg Free
2kg+ Free

Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.

For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.

We can deliver most items to all around the world, but prices do vary. The majority of light weight orders (less than 1.5kg) can be delivered for a flat rate of £10. For an accurate estimate of the delivery charge, please put the items you require in your basket and use the "Estimate Delivery" system on the shopping basket page (you only need to enter your country and postal/zip code) for a quick quote. For deliveries to the USA you may need to go to the checkout page and enter your full address to get a quote (as some services need your state in order to quote too). For more information on international deliveries, please see our delivery information page.

Delivery of aerosols

Due to air freight restrictions aerosols cannot ever be sent abroad by Royal Mail. We appreciate your understanding.

Delivery of temperature controlled items

Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.

How do I cancel or return an order?

Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.

To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.

*For full details on returns, see our terms and conditions page.


Q & A

Below are some recent questions we've received regarding Activyl Tick Plus Spot-On for Dogs, including answers from our team.

29 April 2015 at 8:55pm

Tick treatment


I currently use advantage for my dogs, on a 4 weekly basis. Can advantage product be used in conjunction with actively plus spot on or do they both do the same thing?
Thank you

  • Non-Executive Director

Both products control fleas, however Activyl also kills ticks. If using Activyl there would be no point in using Advantage.