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Activyl Spot-on is the latest flea treatment for dogs and cats made by MSD. Fleas have shown no resistance to this innovative product which has a totally unique active ingredient, called indoxacarb. Activyl is supplied in pipettes of two different sizes for cats and five different sizes for dogs, so that each animal receives just the right dose for its bodyweight. One pipette is used per month to maintain effective flea control on puppies and kittens from 8 weeks of age..
Activyl is the first product designed to achieve flea control through the use of "metabolic activation, or bioactivation". It is applied once every month to the surface of the skin where fleas take it up and they then convert it into a highly active metabolite. The drug in Activyl has very little effect without the activation until it is taken in by a flea or other insect, so the possibility of toxicity to the base ingredient is very slim. Mammals are not able to activate the compound in this way and so are not exposed to the active insecticide by licking at their coat or swallowing hair - unlike other spot-on treatments.
All prices include VAT where applicable.
Each ml contains 195mg indoxacarb as active ingredient
Excipients: Isopropyl alcohol 354mg/ml
A clear, colourless to yellow spot-on solution
Treatment and prevention of flea infestation (Ctenocephalides felis).Efficacy against new infestations with fleas persists for 4 weeks following a single application.
The veterinary medicinal product can be used as part of a treatment strategy for flea allergy dermatitis (FAD).
Developing stages of fleas in the pet’s immediate surroundings are killed following contact with Activyl treated pets.
The safety of Activyl has not been established in cats younger than 8 weeks of age.
The safety of Activyl has not been established in cats weighing less than 0.6 kg.
Special precautions for use in animals
Ensure that the dosage (pipette) corresponds to the weight of the treated cat.
Apply the product only to the skin surface and on intact skin. Apply the dose to an area where the cat cannot lick it off. Ensure that animals do not groom each other immediately following treatment. Keep treated animals separately until the application site is dry.
This product is for external topical application only. Do not administer orally or via any other route. Care should be taken to avoid the product coming into contact with the eyes of the cat.
The product remains effective following shampoo treatment, water immersion (swimming, bathing) and exposure to sunlight. However, animals should not be allowed to swim or treated with shampoo within 48 hours after treatment.
All cats in a household should be treated with a suitable flea product.
A proper treatment of the pet´s environment by additional chemical or physical measures is recommended.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
Keep pipettes in the original packaging until ready to use.
Do not eat, drink or smoke while handling the veterinary medicinal product.
The sachet is child-resistant. Keep the product in the sachet until use, in order to prevent children from getting direct access to the product. Used pipettes should be disposed of immediately.
People with known hypersensitivity to indoxacarb should avoid contact with this product.
Local and/or systemic reactions have been observed in some people after exposure. To avoid adverse reactions:
• administer the product in a well-ventilated area;
• do not handle recently treated animals until the application site is dry;
• on the day of treatment, children must not handle treated animals and the animals should not be permitted to sleep with their owners, especially children;
• wash hands immediately after use and wash off any product in contact with the skin immediately with soap and water;
• avoid contact with eyes, as the product may cause moderate eye irritation. If it occurs, the eyes should be rinsed slowly and gently with water.
If symptoms occur, seek medical advice and show the package leaflet to the physician.
This product is highly flammable. Keep away from heat, sparks, open flame or other sources of ignition.
In rare cases, neurological signs (e.g. incoordination, tremor, ataxia, convulsions, mydriasis and impaired vision) have been observed. Other signs observed include emesis in rare cases or anorexia, lethargy, hyperactivity and vocalisation in very rare cases. All signs are generally reversible following supportive treatment.
In very rare cases, a brief period of hypersalivation may occur if the animal licks the application site immediately after treatment. This is not a sign of intoxication and disappears within some minutes without treatment. Correct application will minimise licking of the application site. In rare cases, application site reactions such as transitory scratching, erythema, alopecia or dermatitis at the application site may occur. These effects will usually resolve without treatment.
The application of the veterinary medicinal product may produce a local, temporary oily appearance or hair clumping at the application site. A dry white residue may be also observed. This is normal and will generally resolve within a couple of days after administration. These changes do not affect the safety or efficacy of the veterinary product.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals displaying adverse reaction(s) during the course of one treatment)
- common (more than 1 but less than 10 animals in 100 animals)
- uncommon (more than 1 but less than 10 animals in 1,000 animals )
- rare (more than 1 but less than 10 animals in 10,000 animals)
- very rare (less than 1 animal in 10,000 animals, including isolated reports).
The safety of the veterinary medicinal product has not been established during pregnancy and lactation.
Do not use during pregnancy.
Do not use during lactation.
Do not use in breeding animals.
Amounts to be administered and administration route
Cats: The recommended dose is 25 mg indoxacarb/kg body weight, equivalent to 0.128 ml/kg body weight. The following table defines the size of pipette to be used according to the weight of the cat:
Method of administration:
For spot-on use only. Open one sachet and remove the pipette.
Step 1: The animal should be standing for easy application. With one hand, hold pipette in an upright position away from your face and with the other hand, snap tip open by bending it and folding it back on itself.
Step 2: Part the hair until the skin is visible and place pipette tip against the skin at the base of the skull, where the cat cannot lick it off. Squeeze pipette firmly applying the entire contents directly to the skin
Treatment schedule: Following a single administration, the veterinary medicinal product will prevent further flea infestation for at least 4 weeks.
No adverse effects were observed in cats aged 8 weeks or older when administered 5 times the recommended dose on 8 occasions at 4 weeks intervals or administered 5 times the recommended dose on 6 occasions at 2 weeks intervals.
Indoxacarb is an ectoparasiticide belonging to the oxadiazine chemical family. After being converted into a metabolite, indoxacarb is active against adult, larval and egg stages of insects. In fleas, in addition to its adulticidal activity, indoxacarb activity on the developing larval stages in the immediate surroundings of the treated pet has been demonstrated.
Indoxacarb is a pro-drug that requires bioactivation by the insect enzymes to exert its pharmacodynamic effects. It enters the insect primarily through ingestion but is also absorbed, to a lesser degree, through the insect cuticle. In the mid-gut of susceptible insect species, the insect’s enzymes remove the carbomethoxy group from parent indoxacarb, and convert it into its biologically active form. The bioactivated metabolite acts as a voltage-dependent sodium channel antagonist in insects, by blocking the sodium channels that regulate the flow of sodium ions in the insect’s nervous system. This results in a rapid cessation of feeding within 0 to 4 hours after treatment followed by cessation of egg laying (oviposition), paralysis and death occurring within 4 to 48 hours.
Following a single spot-on application of the product, indoxacarb can still be detected in both skin and hair coat after 4 weeks post-treatment. Absorption through the skin also occurs, but this systemic absorption is partial and not relevant for the clinical efficacy. The absorbed indoxacarb is extensively metabolised by the liver to a variety of metabolites. The major route of excretion is in faeces.
List of excipients: Triacetin, Ethyl acetoacetate, Isopropyl alcohol
As packaged for sale - 4 years
Does not require any special temperature storage conditions.
Store in the original package in order to protect from moisture
Cardboard box with 1, 4 or 6 sachets; each sachet contains one unit-dose pipette. One unit-dose pipette holds 0.51 ml or 1.03 ml spot-on solution. One size of unit-dose pipette only per box. The pipette consists of a blister film (polypropylene/cyclic-olefin-copolymer/polypropylene) and a foil lidstock (aluminium/polypropylene co-extruded) sealed into aluminium sachets.
Not all pack sizes may be marketed
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
Activyl should not be allowed to enter surface waters as indoxacarb may have harmful effects on aquatic organisms.
Intervet International BV
Wim de Körverstraat 35
5831 AN Boxmeer
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Below are some recent questions we've received regarding Activyl Spot-on for Dogs & Cats, including answers from our team.
I was given this on saturday 6th sept put on my cat.
How long does it take to kill all fleas?
In the early autumn of a year like we have had, it can take a long time! This is because new fleas will be hatching out in the environment where your cat (and other animals) have been going for the last few months. Waves of new fleas might well be landing on your cat every day. They will die off quite soon (a day or so usually if you applied the treatment effectively) but more fleas will appear. I would suggest you treat the house with product like Indorex after carefully vacuuming all the carpets and furnishings. You will get rid of all the fleas in time, but it is rarely an instant result. It depends on how effective your treatments have been over the last few months and so what size the background flea population is.