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Zylkene Stress Treatment

Zylkene is a unique treatment for stress in Dogs, Cats and Horses. It is a safe and natural remedy, based on a protein extracted from milk. It acts on certain receptors in the brain to have a calming effect during periods of stress or environmental challenge. Ideally it is given once daily for a few days beforehand, then also on the same day as the stressful event. It is safe to give for long periods too, but if this is done, it works best if combined with some form of training or de-sensitising regime.

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There are many reports in the literature of remarkably good responses to Zylkene. In dogs and cats it is particularly good for travel, re-homing, grooming, visiting the vets etc. For horses, Zylkene Equine can easily be given in feed for clipping, travelling, shoeing etc.

Zylkene can help in many situations where animals might be expected to feel anxious or stressed. However do remember that you have a part to play too. Our animals have a phenomenal ability to pick up on signals we give them. Zylkene works best when combined with thoughtful and considerate handling from calm and sensible people!

Suitable for situations such as:

  • Changes in environment

  • Being left alone

  • New person, baby or pet being introduced

  • Travelling

  • Kennel or cattery visits

  • Fireworks

  • Loud noises and thunderstorms

  • Vet visits

  • Celebrations

  • Moving house

  • Lactation

  • Weaning

Dosage Guide

For oral administration.

The recommended daily amount should be given in one intake.

The capsule can be opened and the powder mixed with food or a treat.

Zylkène 75mg for cats and small dogs

Up to 5kg

1 capsule per day

5-10 kg

2 capsules per day

Zylkène 225mg for medium dogs


1 capsule per day


2 capsules per day

Zylkène 450mg for large dogs


1 capsule per day


2 capsules per day

Short Term Use: use for 1-2 days before the predicted event or change in environment. Some animals may need earlier administration (5-7 days).

Longer Term Use: 1-2 months

Horses up to 500kg: 1 sachet daily
Horses over 500kg: 2 sachets daily

Horses are often dosed for 2 days prior to a particular event, as well as on the day itself. Longer periods can be given, up to permanent, daily medication.

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Reviews of Zylkene Stress Treatment

Read our customers' reviews of Zylkene Stress Treatment

Questions & Answers for Zylkene Stress Treatment

Below are some recent questions we've received regarding Zylkene Stress Treatment, including answers from our team.

Ask Your Own Question


21st Apr 2015

I am thinking about starting my Rescue dog on this, as she is scared of life. She is two, weighs around 19 / 20 kilos and is fit and healthy and active. I am just wondering about the dose - what should I start with and can this be used for periods say 6 months or a year.
Thank you

John Cousins
  • Veterinary Surgeon at VioVet

I would suggest one 450mg capsule oncce daily. This can be done for as long as you want.

Stressful events

13th Feb 2015

My horse stress out when in competition would zylkene help, I would only be using it for competitions

John Cousins
  • Veterinary Surgeon at VioVet

Zylkene can be used for this. It causes no sedation and is safe for competition use. For some horses it is effective and people notice a difference, but others are disappointed. It is worth a try.

How can I help my dog with daily anxiety

29th Oct 2014
Tanya Smith
  • VioVet Customer Since: March 2014
  • From: kent, United Kingdom

I have a 8 year old dog and he panics about most thing and it getting to the point were he dont listen to commands I give him. My agility trainer has told me not to shout at him as it make it worse the worst time is when he go's to the groomers, being separated from me and firework can you help me with how to calm him down

John Cousins
  • Veterinary Surgeon at VioVet

There are lots of products which might help with this, but they are not very potent. Zylkene is a good one to try, but it works best if combined with calm and reassuring contact. I would agree that it is never a good idea to shout at a dog if it is playing up because it is scared. You will find that he will be much better behaved if you can get him over the fear with calm reassurance. It is fine to be firm in what you expect, but you need to appear calm at all times, or you will make him worse. If Zylkene fails to work well enough, especially for causes of fear like fireworks, you might find he would respond well to a drug called Xanax. It is prescription only so your vet needs to prescribe it, but the tablets are cheap and often very effective.

Zylkene and CDS

27th Oct 2014

Could we you Zylkene in cognitive dysfunction dog that has night screeming or separation anxiety?

John Cousins
  • Veterinary Surgeon at VioVet

Certainly Zylkene can be used to help with calming the anxiety associated with these conditions. It will not help cognitive function as such, but along with appropriate changes in management, it can help overall.

Separation anxiety can be helped massively by changes in the owner's "leaving routine" and general behaviour. There is lots of information available about this and this should be the main part of the strategy for helping with this condition. Zylkene can certainly help though.

Can it be used as a calmer for horses at competition?

16th Oct 2014

I have a 6 year old thoroughbred and we are just starting to compete with him. I have tried other calmers on him when competing but nothing seems to work. Would this product help and is it competing legal?

John Cousins
  • Veterinary Surgeon at VioVet

Zylkene is safe to use for competition and it is quite different from other calmers, so it might well work when they did not. Some horses respond to it better than others so unfortunately you have to try it before you know if it will work for your horse or not. Pretty much all of the non-prescription products are like that.

Aggression in my young colt

30th Sep 2014
Giselle Summers
  • VioVet Customer Since: November 2013
  • From: North Yorkshire, United Kingdom

Hi there I have a young colt who is not gelded yet as to meny flies. He gets pushy and bites to move you and can kick dose not like his training sessions.what can we do

Danielle Fletcher
  • AMTRA Qualified Product Advisor at VioVet

Zylkene is a good one too use for horses in stressful/tense situations like farrier visits or shows but its better as an instant calmer.

Ideally you'd want something that is high in magnesium, so we would suggest Global Herbs Super Calm or Equimins Magnesium Calmer as these are both especially good for horses with nervous or aggressive attitudes and promote much calmer behaviour, which should make him safer to work with and handle. There is also Global Herbs Rigcalm which is mainly for geldings but could help to calm any excitability and aggression toward you.

Zylkene for aggression

30th Jul 2014

Can this help with aggression in dogs, my male dog has a problem with other dogs if I am in the vicinity, he reacts by barking lunging snapping at the other dog while on lead, he is fine off lead if I'm at a distance and a dog sniffs him but will chase if they run off, but if I'm nearby his response is to bark and snap so I always put him on lead if I see another dog before he does, but now we are getting into a cycle of the walks being stressful, I really want to not have to keep my eyes peeled the whole time and to pass other dogs without trouble

John Cousins
  • Veterinary Surgeon at VioVet

Zylkene might well help to some extent, but on its own you are not going to make much progress I think. Is your dog still quite young? Has he been castrated? Would you consider that?

Most dogs which behave like yours, do get worse as time goes by unless they receive well-planned behaviour training. Putting him on a lead will almost certainly make his aggression worse (it always seems to) though not putting him on a lead will leave you open to other problems.

It is very easy to inadvertantly make your dog worse by the way you respond to the situation. He will be picking up signals from you all the time. He might be noticing your unease when another dog comes near, so is trying to protect you. It might be simply that he is worried for himself, so feels better able to fend off dogs when you are near to help.It might be a mixture of both, along with other conflicts in his mind. Essentially I would strongly recommend you contact an experienced dog behaviour adviser (see and follow their advice, or I fear your dog will get worse despite any medication you provide. With suitable training, especially if he is still young, you could make things far better.

Dog stressed with groomed or clipped...Zylkene?

16th Dec 2013
Bernadette Robson

My dog get's extremely stressed when groomed, he has to be clipped about once every 3 months and inevitably gets a cut somewhere - today on his face. He is quite panicky and vocal throughout the whole process and at 9 is showing no signs of improvement. I am wondering if Zylkene would be suitable, but I cannot establish from the information available how long before the groomer visit it would be best to start the treatment - can you advise please?

John Cousins
  • Veterinary Surgeon at VioVet

I would start the day before and make sure he has a dose on the day of grooming before he goes in. Zylkene is likely to be a slight help, but not a complete answer.

Have you asked your vet about tranquilisers? There is a human medication called Xanax which is quite cheap and usually works marvellously for this sort of problem, as well as for firework phobias etc. It is not a sedative so he will not be sleepy, just much less bothered about stuff. Half or one tablet 30 mins before you take him there would be my recommendation. It is a prescription drug though, so you would need your vet to prescribe them, we cannot. The tablets are so cheap that we do not currently find it worth listing them, but they should not cost much from your vet.

Failing that, Zylkene is worth a try, but is less potent.

Zylkene with heart medication

16th Dec 2013
Patrick Lewis

Hi I have a approx 5 yrs old rescue JRT with not a good past. I have had him 14 months and he is a stressy little fellow. He is fine in the house but the out side world is a different matter and he reacts to most things, now I am working on this with a behaviourist and he has suggested that I try zylkene for Woody. How does this work along side other meds as he takes medication for a heart murmour. And would this help Woody with his problems?

  • Website Content Developer at VioVet


Zylkene is perfectly OK to use alongside medication for heart or other problems, it does not interact with them at all. Chances are that Zylkene will help to some extent, but it is unlikely to change things dramatically. If you are working with a behaviourist then you are doing the right thing. Zylkene will probably improve things, but you will still need to work on the behaviour training for some while.

Separation Anxiety - Zylkene

16th Dec 2013
Lucinda Greene


Will Zylkene treat separation anxiety?

  • Website Content Developer at VioVet

Zylkene are not massively potent, nor can they sort out every problem. However they are indeed a help with this sort of thing. They probably start having an effect after the first dose, but the overall effect will build up over a few weeks. However all they will do is reduce the tendency, or likelihood, of trouble (destruction or toileting etc)..

The way I would look at it is this: On an imaginary "anxiety scale" of 1 to 10, your dog will cause trouble if its anxiety goes above the 5 mark. Zylkene is able to reduce the "anxiety score" by 1 or 2 points. Lots of other factors can increase or decrease the score, by a similar level. If the other factors combine to give your dog a score of 8, then it will seem to make no difference giving Zylkene. The score will go down to 6 or 7 but he will still cause trouble. If the other factors combine to give a score of 5, then giving Zylkene will be like a magic switch - with it he will be perfectly behaved.

There are lots of behavioural techniques which you can adopt to help as well. If you get it right, you will not need Zylkene at all, though it does help initially. From my experience, the following is the best advice:

1) Whenever you first meet your dog after a period of separation, always greet him and look happy, but not wildly so. The meeting should be calm and relaxed, though happy. Try to make your voice and body language along those lines. Imagine a person who does not know you, watching a film of you meeting your dog. You should appear mildly pleased to the observer. Regardless of what your dog has done and how your dog is reacting at the time.
2) When you leave your dog, there should be a "winding down" period when your dog realises that you are going to leave him and gets used to the idea. Do not look at him or talk to him. Walk past him calmly as if he was not there. Make it look like no big deal, and try to get him to realise it is no big deal.
3) Leave your dog for short, or longer periods, during the day, always following the above routines. Sometimes it should just be going from one room to another, shutting the door between you. Same for going into the garden.
Your dog should be able to recognise that he is going to be left for a while by the way you are with him for a few minutes first. Then you do leave him. Then later (a few minutes or a few hours) you come back and meet him, calmly but happily.
4) Do not allow him to sleep in your bedroom. He needs to get used to being apart from you.

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