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Zylkene Stress Treatment

Zylkene is a unique treatment for stress in Dogs, Cats and Horses. It is a safe and natural remedy, based on a protein extracted from milk. It acts on certain receptors in the brain to have a calming effect during periods of stress or environmental challenge. Ideally it is given once daily for a few days beforehand, then also on the same day as the stressful event. It is safe to give for long periods too, but if this is done, it works best if combined with some form of training or de-sensitising regime.

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There are many reports in the literature of remarkably good responses to Zylkene. In dogs and cats it is particularly good for travel, re-homing, grooming, visiting the vets etc. For horses, Zylkene Equine can easily be given in feed for clipping, travelling, shoeing etc.

Zylkene can help in many situations where animals might be expected to feel anxious or stressed. However do remember that you have a part to play too. Our animals have a phenomenal ability to pick up on signals we give them. Zylkene works best when combined with thoughtful and considerate handling from calm and sensible people!

Suitable for situations such as:

  • Changes in environment

  • Being left alone

  • New person, baby or pet being introduced

  • Travelling

  • Kennel or cattery visits

  • Fireworks

  • Loud noises and thunderstorms

  • Vet visits

  • Celebrations

  • Moving house

  • Lactation

  • Weaning

Dosage Guide

For oral administration.

The recommended daily amount should be given in one intake.

The capsule can be opened and the powder mixed with food or a treat.

Zylkène 75mg for cats and small dogs

Up to 5kg

1 capsule per day

5-10 kg

2 capsules per day

Zylkène 225mg for medium dogs


1 capsule per day


2 capsules per day

Zylkène 450mg for large dogs


1 capsule per day


2 capsules per day

Short Term Use: use for 1-2 days before the predicted event or change in environment. Some animals may need earlier administration (5-7 days).

Longer Term Use: 1-2 months

Horses up to 500kg: 1 sachet daily
Horses over 500kg: 2 sachets daily

Horses are often dosed for 2 days prior to a particular event, as well as on the day itself. Longer periods can be given, up to permanent, daily medication.

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Reviews of Zylkene Stress Treatment

Read our customers' reviews of Zylkene Stress Treatment

Questions & Answers for Zylkene Stress Treatment

Below are some recent questions we've received regarding Zylkene Stress Treatment, including answers from our team.

Ask Your Own Question

How can I help my dog with daily anxiety

29th Oct 2014
Tanya Smith
  • VioVet Customer Since: March 2014
  • From: kent, United Kingdom

I have a 8 year old dog and he panics about most thing and it getting to the point were he dont listen to commands I give him. My agility trainer has told me not to shout at him as it make it worse the worst time is when he go's to the groomers, being separated from me and firework can you help me with how to calm him down

John Cousins
  • Veterinary Surgeon at VioVet

There are lots of products which might help with this, but they are not very potent. Zylkene is a good one to try, but it works best if combined with calm and reassuring contact. I would agree that it is never a good idea to shout at a dog if it is playing up because it is scared. You will find that he will be much better behaved if you can get him over the fear with calm reassurance. It is fine to be firm in what you expect, but you need to appear calm at all times, or you will make him worse. If Zylkene fails to work well enough, especially for causes of fear like fireworks, you might find he would respond well to a drug called Xanax. It is prescription only so your vet needs to prescribe it, but the tablets are cheap and often very effective.

Zylkene and CDS

27th Oct 2014

Could we you Zylkene in cognitive dysfunction dog that has night screeming or separation anxiety?

John Cousins
  • Veterinary Surgeon at VioVet

Certainly Zylkene can be used to help with calming the anxiety associated with these conditions. It will not help cognitive function as such, but along with appropriate changes in management, it can help overall.

Separation anxiety can be helped massively by changes in the owner's "leaving routine" and general behaviour. There is lots of information available about this and this should be the main part of the strategy for helping with this condition. Zylkene can certainly help though.

Can it be used as a calmer for horses at competition?

16th Oct 2014

I have a 6 year old thoroughbred and we are just starting to compete with him. I have tried other calmers on him when competing but nothing seems to work. Would this product help and is it competing legal?

John Cousins
  • Veterinary Surgeon at VioVet

Zylkene is safe to use for competition and it is quite different from other calmers, so it might well work when they did not. Some horses respond to it better than others so unfortunately you have to try it before you know if it will work for your horse or not. Pretty much all of the non-prescription products are like that.

Aggression in my young colt

30th Sep 2014
Giselle Summers
  • VioVet Customer Since: November 2013
  • From: North Yorkshire, United Kingdom

Hi there I have a young colt who is not gelded yet as to meny flies. He gets pushy and bites to move you and can kick dose not like his training sessions.what can we do

Danielle Fletcher
  • AMTRA Qualified Product Advisor at VioVet

Zylkene is a good one too use for horses in stressful/tense situations like farrier visits or shows but its better as an instant calmer.

Ideally you'd want something that is high in magnesium, so we would suggest Global Herbs Super Calm or Equimins Magnesium Calmer as these are both especially good for horses with nervous or aggressive attitudes and promote much calmer behaviour, which should make him safer to work with and handle. There is also Global Herbs Rigcalm which is mainly for geldings but could help to calm any excitability and aggression toward you.

Zylkene for aggression

30th Jul 2014

Can this help with aggression in dogs, my male dog has a problem with other dogs if I am in the vicinity, he reacts by barking lunging snapping at the other dog while on lead, he is fine off lead if I'm at a distance and a dog sniffs him but will chase if they run off, but if I'm nearby his response is to bark and snap so I always put him on lead if I see another dog before he does, but now we are getting into a cycle of the walks being stressful, I really want to not have to keep my eyes peeled the whole time and to pass other dogs without trouble

John Cousins
  • Veterinary Surgeon at VioVet

Zylkene might well help to some extent, but on its own you are not going to make much progress I think. Is your dog still quite young? Has he been castrated? Would you consider that?

Most dogs which behave like yours, do get worse as time goes by unless they receive well-planned behaviour training. Putting him on a lead will almost certainly make his aggression worse (it always seems to) though not putting him on a lead will leave you open to other problems.

It is very easy to inadvertantly make your dog worse by the way you respond to the situation. He will be picking up signals from you all the time. He might be noticing your unease when another dog comes near, so is trying to protect you. It might be simply that he is worried for himself, so feels better able to fend off dogs when you are near to help.It might be a mixture of both, along with other conflicts in his mind. Essentially I would strongly recommend you contact an experienced dog behaviour adviser (see and follow their advice, or I fear your dog will get worse despite any medication you provide. With suitable training, especially if he is still young, you could make things far better.

Dog stressed with groomed or clipped...Zylkene?

16th Dec 2013
Bernadette Robson

My dog get's extremely stressed when groomed, he has to be clipped about once every 3 months and inevitably gets a cut somewhere - today on his face. He is quite panicky and vocal throughout the whole process and at 9 is showing no signs of improvement. I am wondering if Zylkene would be suitable, but I cannot establish from the information available how long before the groomer visit it would be best to start the treatment - can you advise please?

John Cousins
  • Veterinary Surgeon at VioVet

I would start the day before and make sure he has a dose on the day of grooming before he goes in. Zylkene is likely to be a slight help, but not a complete answer.

Have you asked your vet about tranquilisers? There is a human medication called Xanax which is quite cheap and usually works marvellously for this sort of problem, as well as for firework phobias etc. It is not a sedative so he will not be sleepy, just much less bothered about stuff. Half or one tablet 30 mins before you take him there would be my recommendation. It is a prescription drug though, so you would need your vet to prescribe them, we cannot. The tablets are so cheap that we do not currently find it worth listing them, but they should not cost much from your vet.

Failing that, Zylkene is worth a try, but is less potent.

Zylkene with heart medication

16th Dec 2013
Patrick Lewis

Hi I have a approx 5 yrs old rescue JRT with not a good past. I have had him 14 months and he is a stressy little fellow. He is fine in the house but the out side world is a different matter and he reacts to most things, now I am working on this with a behaviourist and he has suggested that I try zylkene for Woody. How does this work along side other meds as he takes medication for a heart murmour. And would this help Woody with his problems?

  • Website Content Developer at VioVet


Zylkene is perfectly OK to use alongside medication for heart or other problems, it does not interact with them at all. Chances are that Zylkene will help to some extent, but it is unlikely to change things dramatically. If you are working with a behaviourist then you are doing the right thing. Zylkene will probably improve things, but you will still need to work on the behaviour training for some while.

Separation Anxiety - Zylkene

16th Dec 2013
Lucinda Greene


Will Zylkene treat separation anxiety?

  • Website Content Developer at VioVet

Zylkene are not massively potent, nor can they sort out every problem. However they are indeed a help with this sort of thing. They probably start having an effect after the first dose, but the overall effect will build up over a few weeks. However all they will do is reduce the tendency, or likelihood, of trouble (destruction or toileting etc)..

The way I would look at it is this: On an imaginary "anxiety scale" of 1 to 10, your dog will cause trouble if its anxiety goes above the 5 mark. Zylkene is able to reduce the "anxiety score" by 1 or 2 points. Lots of other factors can increase or decrease the score, by a similar level. If the other factors combine to give your dog a score of 8, then it will seem to make no difference giving Zylkene. The score will go down to 6 or 7 but he will still cause trouble. If the other factors combine to give a score of 5, then giving Zylkene will be like a magic switch - with it he will be perfectly behaved.

There are lots of behavioural techniques which you can adopt to help as well. If you get it right, you will not need Zylkene at all, though it does help initially. From my experience, the following is the best advice:

1) Whenever you first meet your dog after a period of separation, always greet him and look happy, but not wildly so. The meeting should be calm and relaxed, though happy. Try to make your voice and body language along those lines. Imagine a person who does not know you, watching a film of you meeting your dog. You should appear mildly pleased to the observer. Regardless of what your dog has done and how your dog is reacting at the time.
2) When you leave your dog, there should be a "winding down" period when your dog realises that you are going to leave him and gets used to the idea. Do not look at him or talk to him. Walk past him calmly as if he was not there. Make it look like no big deal, and try to get him to realise it is no big deal.
3) Leave your dog for short, or longer periods, during the day, always following the above routines. Sometimes it should just be going from one room to another, shutting the door between you. Same for going into the garden.
Your dog should be able to recognise that he is going to be left for a while by the way you are with him for a few minutes first. Then you do leave him. Then later (a few minutes or a few hours) you come back and meet him, calmly but happily.
4) Do not allow him to sleep in your bedroom. He needs to get used to being apart from you.

Zylkene for dog being left alone

16th Dec 2013
Susan Thornton

Hi there,
I have a staffy cross that I adopted from the pound, I have had her for a few years now and have taken her to the vet and she has separation anxiety.
I have heard that zylkene may work for her to ease her stress?
I was just wondering what mg dosage I have to buy for her, I was just about to purchase it froim your site but realised there were different mg.

  • Website Content Developer at VioVet

Zylkene is good for this problem. There are a few other things you can do too. It is important not to talk to her when you leave her. You must be calm and also a bit dismissive when you leave. If you seem to ignore her a bit before you go, she has a better chance of adjusting to being alone. Then when you get back, you should camly and quietly greet her, without any great emotion. If you take the "heat" out of hte departures and arrivals, she will get much better. It is partly a training thing. Also you should not let her sleep in the bedroom. She should get used to being alone a bit.

The Zylkene doseage is:

Small Cats: 1 x 75mg Capsule daily
Large cats / Small dogs <10kg: 2 x 75mg Capsules Daily
Dogs between 10kg & 20kg: 1 x 225mg Capsule Daily
Dogs between 20kg & 40kg: 1 x 450mg Capsule Daily
Dogs over 40kg: 2 x 450mg Capsules Daily

Your Staffy probably weighs under 20kg but some big Staffies are heavier than that. Can you weigh her?

Zylkene for car journeys

16th Dec 2013
Ben Pearce

Could you please give me some more information on the product ZYLKENE.

I have three dogs – two black Labradors and a Boxer.

I work for Labrador Rescue and in fact rehomed my youngster just under a year ago when he was 12 months old. Lovely natured dog with very good working pedigree. Reason for re-homing from original owners was that he was beginning to develop behavioural problems – NOT SURPRISING since they left him at home all one for up to 10 hours a day!!!

Anyway, he was passed from pillar to post and when I originally bought him home he was a little unsettled when left alone for more than half an hour (used DAP plug-in) which had a reasonably good effect. When travelling in the car (with or without my other dogs) he was always calm and no doubt looking forward to walks/socialisation.

As time went on he became totally over-excited in the car – jumping up and down and screeching his head off. This is not fear but most definitely excitement and a desire to get to destination before we even start. Tried everything to calm him down but to no effect.

This is getting me very stressed as I have a desire to shout at him to pipe down!! No doubt he senses me getting wound up.

My vet suggested Zylkene as his dog had behavioural problems and he was impressed with the results.

Sorry for the long winded email but thought it important that you have full facts.

IS ZYLKENE the right product for him? He has no fear of fireworks, loud bangs, thunder, gun shots etc etc

I had 4 tablets from the vet – all they had at time until they receive delivery on Monday/Tuesday – so gave him one capsule this morning (450mg).

The dog is highly active – does some gundog work very well and this certainly is great for him as it focuses him both mentally and physically. On the way home from a training session he is as quiet as a mouse – drained probably!

In the house he seems to be constantly alert to what is going on and he could be described as an “attention seeking missile” He feels the need to follow me everywhere!!! Possibly anxious and unsettled or plain nosey and needs to be where the action is!!!! He sleeps on his own in the kitchen and loves his bed and quite happy being apart from the other dogs at night.

  • Website Content Developer at VioVet

Zylkene is completely safe, the worst that can happen is that it will fail to work and you will have wasted your money. It might well help, depending on what the actual cause of the behaviour is. If some of it is down to stress/anxiety, then it is likely to be a help, though not the complete answer.

If your dog naturally has a lot of "get-up-and-go", which is needed for working, then he will tend to be excited and keen perhaps, when you might want a more relaxed dog. Training is the answer to this, rather than medication.

As for the car, if you have the time you should be able to get him to be better. Ideally you get in the car and as soon as he gets excited and a pain, you stop and switch off the engine. This might be before you have even left the drive, or maybe you do not even switch the engine on. You just get in, make as if you might be going somewhere, then if he is a pain, you get out again. Each "stop" of progress should be accompanied by a short, sharp rebuke (which he might seem to ignore at first, but will after a while associate with stopping). If he is keen to go somewhere, he will in fact learn that the way to get there is to be quiet! You should look happy and pleased, but in a calm way, every time you are making to set off, but unhappy when you have to stop. No actual punishment though, it will not work. Initially all your journeys might be very slow, so it is best to set off like this when you do not need to get anywhere. Ideally not once from now on should he be in the car, being a pain, and you keep driving. Every journey is a lesson, and you can easily teach him to ignore the training by ignoring it yourself. Absolute consistency is vital. It will work.

By the way the worst thing you can do is talk to him nicely when he is misbehaving. You will accidentally be teaching him to do it. You have to look un-affectionate and almost silent when he is being a pain, then calmly happy with him when he is being good. A harsh, briefly barked "AH!" or something is best when he is a pain, then nothing else.

Zylkene is great for stressed/worried dogs, but that is not the case in the car at least.

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