Vetmedin for Dogs

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Vetmedin is a pet medication which can open up the main blood vessels to the heart to reduce the pressure. It can also make the heart work more efficiently and clinical studies indicate that this can increase life expectancy. This medication is commonly used to treat heart failure in dogs. Dogs may need to take this medication for the rest of their lives though improvements can usually be seen in a few days. The medication is available in different strengths for different sized animals and is in the form of chewable tablets so it is easy to administer.

Vetmedin is used mostly in dogs with defective heart valves. (Valvular insufficiency or regurgitation, often as a result of nodular endocardiosis.) If the valves in the heart fail to operate properly, blood flows back when the valves is supposed to be closed, making the heart less efficient as a pump. This also makes a whooshing sound in the heart, called a heart murmur, which vets can hear using a stethoscope. Vetmedin acts on the muscle of the heart and of blood vessel walls, helping the heart to beat more efficiently.

Vetmedin is also used to treat heart problems where the muscle has become stretched and weak (dilated cardiomyopathy). The heart muscle can contract more powerfully, improving circulation to the body tissues. Vetmedin can be used on its own, but usually one or more other drugs are used to add edto increase the beneficial effects.

Vetmedin is not suitable for dogs under the age of six months and should not be given to pregnant or nursing dogs. Care should also be taken with animals suffering from conditions such as diabetes and who are already taking other medications. Your vet will be able to determine if there is a risk of interactions with any other pet medication.

Vetmedin can only be obtained with a prescription from the vet. Buying prescription pet meds online still requires a written prescription, which must be sent with the order before the drugs can be supplied.

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Vetmedin Flavour Tablets

Presentation

Vetmedin Flavour Tablets, containing 1.25 mg or 5.0 mg pimobendan per tablet.

Uses

For the treatment of canine congestive heart failure originating from dilated cardiomyopathy or valvular insufficiency (mitral and/or tricuspid regurgitation). When used in cases of valvular insufficiency in conjunction with frusemide the product has been shown to improve the quality of life and extend life expectancy in treated dogs. When used in a limited number of cases of dilated cardiomyopathy in conjunction with frusemide, enalapril and digoxin, the product has been shown to improve the quality of life and to extend life expectancy in treated dogs.

Dosage and administration

See dosing table below.

Vetmedin 1.25 mg and 5.0 mg Tablets Dosage Guide

Bodyweight

Daily Dosage

Morning

Evening

(kg)

(mg)

1.25 mg

5.0 mg

1.25 mg

5.0 mg

< 5

1.25

½

-

½

-

5-10

2.5

1

-

1

-

11-20

5

-

½

-

½

21-40

10

-

1

-

1

41-60

20

-

2

-

2

> 60

30

-

3

-

3

Vetmedin Flavour Tablets should be administered orally at a dose of 0.2 mg to 0.6 mg pimobendan/kg body weight per day. The preferable daily dose is 0.5 mg pimobendan/kg bodyweight. The daily dose should be divided into two equal administrations, one half of the dose given in the morning and the other half approximately 12 hours later. Each dose should be given approximately one hour before feeding. The tablet is flavoured and may be given as a treat. The large size of 5.0 mg can be readily divided into two halves, using the scored line on the tablet to give a dose that contains 2.5 mg. Do not exceed the recommended dosage.

Determine the bodyweight accurately before prescribing to ensure administration of the correct dosage.

Vetmedin Flavour Tablets may be combined with a diuretic treatment such as furosemide.

Contra-indications, warnings, etc

Vetmedin Tablets should not be used in cases of hypertrophic cardiomyopathies or clinical conditions where an augmentation of cardiac output is not possible for functional or anatomical reasons (e.g. aortic stenosis). The product should only be used in dogs with cardiac insufficiency.

A moderate positive chronotropic effect and vomiting may occur in rare cases. However, these effects are dose-dependent and may be avoided by reducing the dose in these cases. In rare cases transient diarrhoea, anorexia or lethargy have been observed.

In studies with rats and rabbits pimobendan had no effect on fertility and embryotoxic effects only occurred at maternotoxic doses. In rat experiments it has been shown that pimobendan is excreted into milk. Therefore, the product should only be administered to pregnant and lactating bitches if the expected therapeutic benefits overweigh the potential risk.

The pimobendan-induced increase in contractility of the heart is attenuated in the presence of the calcium antagonist verapamil and the β-antagonist propranolol. In pharmacological studies no interaction between the cardiac glycoside ouabain and pimobendan was detected. Do not exceed the recommended dosage.

In the case of overdose, symptomatic treatment should be initiated.

Any unused product or waste material derived from such veterinary medicinal product should be disposed of in accordance with local requirements.

For animal treatment only.

In case of accidental ingestion, seek medical advice immediately and show the package leaflet or the label to the physician. Wash hands after use. Advice to doctors: accidental ingestion, especially by a child, may lead to the occurrence of tachycardia, orthostatic hypotension, flushing of the face and headaches.

Pharmaceutical precautions

Do not store above 25°C.

Store in the original package tightly closed in order to protect from moisture.

Keep out of reach and sight of children.

Legal category

POM-V

Packaging Quantities

50 tablets or 100 tablets of 1.25 mg tablets packed in white child-resistant polypropylene bottles.

50 tablets of 5.0 mg tablets packed in white child-resistant polypropylene bottles.

Not all pack sizes may be marketed

Further information

Pharmacodynamic properties

Pimobendan, a benzimidazole-pyridazinone derivative, is a non-sympathomimetic, non-glycoside inotropic substance with potent vasodilatative properties.

Pimobendan exerts its stimulatory myocardial effect by a dual mechanism of action: increase in calcium sensitivity of cardiac myofilaments and inhibition of phosphodiesterase (type III). It also exhibits a vasodilating action through an inhibitory action on phosphodiesterase III activity. The combined evidence from cell culture, laboratory animal and small studies in the target species suggests that the combination of the specific PD properties of pimobendan may reduce the progression of myocardial damage in dogs with MVD and DCM when used together with other standard therapy.

Pharmacokinetic particulars

Absorption: Following oral administration of pimobendan, the absolute biovailability of the active principle is 60 - 63 %. Since this bioavailability is considerably reduced when pimobendan is administered with food or shortly thereafter, it is recommended to treat animals approximately 1 hour before feeding.

Distribution: The volume of distribution is 2.6 l/kg, indicating that pimobendan is distributed readily into the tissues. The mean plasma protein binding is 93 %.

Metabolism: The compound is oxidatively demethylated to its major active metabolite (UD-CG 212). Further metabolic pathways are phase II conjugates of UD-CG 212, in essence glucuronides and sulfates.

Elimination: The plasma elimination half-life of pimobendan is 0.4 + 0.1 hours, consistent with the high clearance of 90 + 19 ml/min/kg and a short mean residence time of 0.5 + 0.1 hours.

The main active metabolite is eliminated with a plasma elimination half-life of 2.0 + 0.3 hours. Almost the entire dose is eliminated via faeces.

Marketing authorisation number

Vm 00015/4077 Vetmedin 1.25 mg Flavour Tablets.

Vm 00015/4076 Vetmedin 5.0 mg Flavour Tablets.

GTIN (Global Trade Item No)

Vetmedin 1.25mg Flavour Tablets x 50 -

5012917025200

Vetmedin 1.25mg Flavour Tablets x 100 -

5012917025248

Vetmedin 5 mg Flavour Tablets x 50 -

5012917025217

Vetmedin 5 mg hard capsules

Presentation

Hard gelatin capsules white to orange in colour, containing 5 mg pimobendan per capsule.

Excipients: Titanium Dioxide (E171) 1.2320 mg/capsule and Sunset Yellow (E110) 0.3080 mg/capsule.

Uses

For the treatment of canine congestive heart failure originating from dilated cardiomyopathy or valvular insufficiency (mitral and/or tricuspid regurgitation). When used in cases of valvular insufficiency in conjunction with frusemide the product has been shown to improve the quality of life and extend life expectancy in treated dogs. When used in a limited number of cases of dilated cardiomyopathy in conjunction with frusemide, enalapril and digoxin, the product has been shown to improve the quality of life and to extend life expectancy in treated dogs.

Dosage and administration

See dosing table below.

Vetmedin 5 mg Capsules Dosage Guide

Bodyweight (kg)

Daily Dosage (mg)

Morning

Evening

21-40

10

1

1

41-60

20

2

2

>60

30

3

3

Vetmedin capsules should be administered orally (approximately one hour before feeding) at a dose of 0.2 mg to 0.6 mg pimobendan/kg body weight per day. The daily dose should be divided into two equal administrations, one half of the dose given in the morning and the other half approximately 12 hours later.

Determine the bodyweight accurately before prescribing to ensure administration of the correct dosage.

In cases of mild congestive heart failure, a daily dosage at the lower end of the dose range may be adequate. If, however, a clear response is not observable within one week, the dosage should be raised.

Vetmedin capsules may be combined with a diuretic treatment such as frusemide.

Contra-indications, warnings, etc

Vetmedin capsules should not be used in cases of hypertrophic cardiomyopathies or clinical conditions where an augmentation of cardiac output is not possible for functional or anatomical reasons (e.g. aortic stenosis). The product should only be used in dogs with cardiac insufficiency.

Do not exceed the recommend dosage.

A moderate positive chronotropic effect and vomiting may occur in rare cases. However, these effects are dose-dependent and may be avoided by reducing the dose in these cases. In rare cases transient diarrhoea, anorexia or lethargy have been observed.

In studies with rats and rabbits, pimobendan had no effect on fertility and embryotoxic effects occurred only at maternotoxic doses. In experiments with rats it has been shown that pimobendan is excreted into milk. No information is available on the safety of Vetmedin in pregnant and lactating bitches.

The pimobendan-induced increase in contractility of the heart is attenuated in the presence of the calcium antagonist verapamil and the β-antagonist propranolol. In pharmacological studies no interaction between the cardiac glycoside ouabain and pimobendan was detected.

In the case of overdose, symptomatic treatment should be initiated.

User precautions

In case of accidental ingestion, seek medical advice immediately and show the package leaflet or the label to the physician.

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

For animal treatment only.

Pharmaceutical precautions

Do not store above 25°C.

Store in a dry place.

Store in tightly closed original container.

Keep out of the reach and sight of children.

Legal category

POM-V

Packaging Quantities

100 capsules of 5 mg capsules packed in white child-resistant polypropylene bottles.

Further information

Pharmacodynamic properties

Pimobendan, a benzimidazole-pyridazinone derivative, is a non-sympathomimetic, non-glycoside inotropic substance with potent vasodilatative properties. Pimobendan exerts its stimulatory myocardial effect by a dual mechanism of action: increase in calcium sensitivity of cardiac myofilaments and inhibition of phosphodiesterase (type III). It also exhibits a vasodilating action through an inhibitory action on phosphodiesterase III activity. The combined evidence from cell culture, laboratory animal and small studies in the target species suggests that the combination of the specific PD properties of pimobendan may reduce the progression of myocardial damage in dogs with MVD and DCM when used together with other standard therapy.

Pharmacokinetic particulars

Absorption Following oral administration of Vetmedin capsules the absolute bioavailability of the active principle is 60 – 63%. Since this bioavailability is considerably reduced when pimobendan is administered with food or shortly thereafter, it is recommended to treat animals approximately 1 hour before feeding.

Distribution The volume of distribution is 2.61/kg, indicating that pimobendan is distributed readily into the tissues. The mean plasma protein binding is 93%

Metabolism The compound is oxidatively demethylated to its major active metabolite (UD-CG12). Further metabolic pathways are phase II conjugates of UD-CG 212, in essence glucuronides and sulphates.

Elimination The plasma elimination half-life of pimobendan is 0.4±0.1 hours which is consistent with a high clearance of 90±19 ml/min/kg and a short mean residence time of 0.5 ± 0.1hours.

The main active metabolite is eliminated with a plasma elimination half-life of 2.0 ± 0.3 hours. Almost the entire dose is eliminated via faeces.

Marketing authorisation number

Vm 00015/4050 Vetmedin 5 mg Capsules.

GTIN (Global Trade Item No)

Vetmedin 5 mg hard capsules

5012917025118

Need help or advice? Contact us:

  • Freephone: 0800 084 2608
  • Mon - Fri: 8:30am - 7:00pm
  • Sat: 10:00am - 3:00pm
  • Email: support@viovet.co.uk

All prices include VAT where applicable.

Information regarding the safe use of all licensed medication supplied in the UK can be found on the Veterinary Medicine Directorate website. Follow this link and then search for the brand name of the product to find the official Summary of Product Characteristics for that product. Unlicensed medication, such as herbal supplements, will not be found here and there is no such formal recognition of any scientifically proven therapeutic effects from any unlicensed medication.

Summary of Customer Ratings & Reviews for Vetmedin for Dogs

Overall Rating:
4.8 out of 5
  • Effectiveness
    5 out of 5
  • Ease Of Use
    4.8 out of 5
  • Value For Money
    4.6 out of 5
  • Absence Of Side Effects
    4.8 out of 5

9 out of 9 (100%) customers would recommend this product.

5 stars
7 reviews
4 stars
2 reviews
3 stars
0 reviews
2 stars
0 reviews
1 star
0 reviews

Have you tried this product? Write a review and help others!

Write a Review!
5 out of 5

Vet medin

31st July 2014
  • VioVet Customer Since: December 2012
  • From: Essex, United Kingdom

this is a wonder drug, pescribed by my vet, it gave my Charlie 19 mths of quality life beyond where my vet thought it would. Sadly he has now gone to Rainbow bridge. Robbie is now on this and I hope it does as well for him as Charlie. Vio Vet have been wonderful throughout all of this , I cannot thank them enough. 1st class

  • Effectiveness
    5 out of 5
  • Ease Of Use
    5 out of 5
  • Value For Money
    5 out of 5
  • Absence Of Side Effects
    5 out of 5
Mrs Rolfe would recommend this to a friend!
Number of people who found this review helpful:
5 out of 5

Doing the job

29th July 2014
  • VioVet Customer Since: September 2009
  • From: Northamptonshire, United Kingdom

Obviously these tablets were prescribed by my dogs vet and they're doing the job. Which is what you'd expect! So I will just add that I think VioVet is one of the best Internet companies in existence and thank them for their continuing excellent service and very easy to use website.

  • Effectiveness
    5 out of 5
  • Ease Of Use
    5 out of 5
  • Value For Money
    5 out of 5
  • Absence Of Side Effects
    5 out of 5
MummyLlama would recommend this to a friend!
Number of people who found this review helpful:
5 out of 5

Vetmedin & Viovet 10/10

29th July 2014
  • VioVet Customer Since: March 2009
  • From: Merseyside, United Kingdom

Glad to have found this tablet, my dog has gone from being breathless and lethargic she is now happy to go on walks with my other dogs and also lost weight which is excellent for her condition. Her cough is still with her, but she copes with this. Happy dog thanks to Vetmedin, Cardalis and Frusicare. She will not take tablets, I grind them up and mix them with a spoonful of her dinner on a saucer, before I give her her proper meals, This is the only way to get her to take the tablets, crafty dog.

  • Effectiveness
    5 out of 5
  • Ease Of Use
    5 out of 5
  • Value For Money
    4 out of 5
  • Absence Of Side Effects
    5 out of 5
Kathleen Hill would recommend this to a friend!
Number of people who found this review helpful:
5 out of 5

Worked well for best part of a year

28th July 2014
  • VioVet Customer Since: March 2012
  • From: Wiltshire, United Kingdom

My darling little boy was diagnosed with CHF in Oct 2013, and, from that moment, he took Vetmedin and Frusemide every day, I never missed a dose. But, sadly, he collapsed on July 9th, vet said she could probably keep him going a bit longer, but I could see in his dear face that he was no longer enjoying life in the way he used to, he was finding the other dogs overwhelming as he could not keep up with them, so I let him go peacefully.

  • Effectiveness
    5 out of 5
  • Ease Of Use
    5 out of 5
  • Value For Money
    5 out of 5
  • Absence Of Side Effects
    5 out of 5
Mrs D Paris would recommend this to a friend!
Number of people who found this review helpful:
5 out of 5

two dogs doing well with this

8th May 2013
  • VioVet Customer Since: January 2011
  • From: Hertfordshire, United Kingdom

these tablets seem to be easy to give them and have no known side effects

  • Effectiveness
    5 out of 5
  • Ease Of Use
    5 out of 5
  • Value For Money
    5 out of 5
  • Absence Of Side Effects
    5 out of 5
Peter Walton would recommend this to a friend!
Number of people who found this review helpful:
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Ask your own question about Vetmedin for Dogs





Thank you for your question regarding Vetmedin for Dogs, you will receive an email when a member of our team provides an answer.

Questions & Answers for Vetmedin for Dogs

Below are some recent questions we've received regarding Vetmedin for Dogs, including answers from our team.

Using Vetmedin for heart trouble 16th Dec 2013

I'm looking for some advice, my dog is currently on Vetmedin 5mg Flavour Tablets and have noticed that she seems to feel the cold as she sits and shivers just wondered if this was a side effect and also what other side effects could this medication cause? also reading the information leaflet it's advised that the tablet should be given half in the morning then the other half 12 hours later? Both an hr before food? however my vet has said one tablet half an hour before food so I am slightly confused as i don't want to be miss dosing my dog?

John Cousins
  • Veterinary Surgeon at VioVet

Vetmedin is a very safe drug. It is most likely that your dog feels the cold because she is getting a bit older and less robust. I would doubt if the Vetmedin is doing that.

It is usual to give Vetmedin twice daily. In fact most of the drug is passed out of the system in just a few hours, so twice a day makes a lot more sense. It is also not absorbed very well from the stomach if there is food there too. 30-60 minutes before feeding is often recommended, but closer to 60 would seem better if you can manage it. Vetmedin is possibly the most useful drug there is for many heart problems, so it is well worth getting right if you can. The amount given on each occasion is based on the weight of your dog. It is always best to ask your own vet about the precise amount to give, which should be decided after weighing your dog.

Use by date on drugs 19th Oct 2013

  • VioVet Customer Since: October 2013
  • From: VIC, Australia

Hi, with regards to the Fortekor and Vetmedin drugs i wanted to find out how long of a use by date they come with, as i need a minimum 12 month use by date.

Danielle Fletcher
  • AMTRA Qualified Product Advisor at VioVet

We have a high turn over of these products and deliveries are received daily, so you should normally expect to receive a product with a good length expiry date. Our supplier will continue to deliver a particular batch to us until they have all been used up, so occasionally the date may be slightly shorter than you require. If you would like to place an order for a long-term supply, you are welcome to contact our customer service team who will be able to tell you the expiry dates of batches in stock at the time. At present (21/10/13) the shortest expiry date we have for these products is 01/2015.

Alternatively, if it is convenient, you can place a few smaller orders for the prescribed medication, as we keep your prescription details and number of medication on our system. Once a prescription is has been loaded by our staff, you can log in to your VioVet account and check your amount remaining in the "Prescriptions" section.