Tylan Antibiotic

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Tylan contains the antibiotic tylosin, whihch is used in cattle, pigs and poultry. There are formulations for adding to food or drinking water. A veterinary prescription is required for this to be supplied, and the prescription will detail all dosing information. For full datasheet, click on the individual products below.

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Tylan Soluble Powder for Oral Solution

Presentation

Tylan Soluble is tylosin tartrate BP (Vet), a white to medium yellow coloured soluble powder for oral solution. Each bottle contains 100 g of tylosin tartrate activity. Each bag contains 1000 g of tylosin tartrate activity.

Uses

For the prevention and treatment of bovine pneumonia associated with bovine respiratory Mycoplasma or Pasteurella multocida sensitive to tylosin.

For the control of Mycoplasma synoviae airsacculitis in chickens and Mycoplasma gallisepticum S6 in chickens and turkeys. In the field Tylan Soluble has also proved useful in reducing the level of infection following stress association with live vaccination.

As an aid in the control of outbreaks of necrotic enteritis caused by Clostridia perfringens in chickens.

For the prevention and control of enzootic pneumonia, swine dysentery and other scours caused by organisms (e.g. Lawsonia intracellularis) sensitive to tylosin, in pigs.

Dosage and administration

Calves

One gram of Tylan Soluble per young calf administered orally twice daily for seven to fourteen days. The product may be incorporated into the milk or reconstituted milk replacer at the time of feeding.

Chickens and turkeys

Tylan Soluble is administered in the drinking water at a concentration of 0.5 g per litre to provide 50-200 mg/kg bw, depending on the age and the water consumption of the birds. Tylan soluble should be added to the water and not agitated or stirred until it dissolves.

For routine preventative medication in poultry, the following programmes are recommended:

As an aid to mycoplasmosis prevention in chickens (refer to Table 1):

Tylan Soluble: Table 1

Class of Stock

Age

Tylan Soluble at 0.5g per litre

Broiler

0-3 days

35 g per 1000 birds

4th week of life

35 g per 1000 birds

Layers & Replacement pullets

0-3 days

35 g per 1000 birds

4th week of life

35 g per 1000 birds

9th-12 th week

48 hours medication

16th-20th week

48 hours medication

Breeders

0-3 days

50 g per 1000 birds

4th week of life

80 g per 1000 birds

9th, 12th, 16th, 20th, 24th weeks of age

48 hours medication

As an aid to mycoplasmosis prevention in turkeys (refer to Table 2):

Tylan Soluble: Table 2

Class of Stock

Age

Tylan Soluble at 0.5g per litre

Table Turkeys

0-5 days

12.5 g per 100 birds

4th week of life

7.5 g per 100 birds

For treatment of mycoplasmosis (refer to Table 3):

Tylan Soluble: Table 3

Class of Stock

Tylan Soluble at 0.5g per litre

Broilers

24-72 hours medication

Layers & Replacement pullets

48-72 hours medication

Turkeys

48-120 hours medication

As an aid in the control of necrotic enteritis in chickens (refer to Table 4):

As an aid in the control of outbreaks of necrotic enteritis caused by Clostridium perfringens in chickens use Tylan in the drinking water for 5 days at a concentration of 0.15 g per litre water (150ppm), to provide 20-50 mg/kg bw, depending on the age and the water consumption of the birds.

Tylan Soluble: Table 4

Class of Stock

Tylan Soluble at 0.15g per litre

Broilers

5 days

Layers & Replacement pullets

5 days

Pigs

For the prevention and control of swine dysentery and enzootic pneumonia, Tylan soluble is administered in the drinking water to provide 25 mg/kg bodyweight. This may be achieved by adding 0.25g per litre (1.1 g/gal).

Tylan Soluble requirements per tonne of pigs daily:

Disease Treatment

Tylan Soluble required

Water consumption (l) approx.

Swine dysentery and enzootic pneumonia

25g

100 litres

Ileitis

5-10 g

100 litres

A medicated solution of drinking water should be administered until 24 hours after scouring or respiratory symptoms have ceased, normally 3-10 days. The diagnosis should be reviewed if no response after 5 days of medication.

Contra-indications, warnings, etc

Keep out of reach of children.

For animal treatment only.

Do not leave or dispose of water containing tylosin tartrate where it may be accessible to animals not under treatment, or wildlife.

Operator warnings

Tylosin may induce irritation. Macrolides, such as tylosin, may also cause hypersensitivity (allergy) following injection, inhalation, ingestion or contact with skin or eye. Hypersensitivity to tylosin may lead to cross reactions to other macrolides and vice versa. Allergic reactions to these substances may occasionally be serious and therefore direct contact should be avoided.

To avoid exposure during preparation of the medicated drinking water, wear overalls, safety glasses, impervious gloves and wear either a disposable half mask respirator conforming to European Standard EN149 or a non-disposable respirator to European Standard EN140 with a filter to EN143. Wash hands after use.

In the event of accidental skin contact, wash thoroughly with soap and water. In case of accidental eye contact, flush the eyes with plenty of clean, running water.

Do not handle the product if you are allergic to ingredients in the product.

If you develop symptoms following exposure, such as skin rash, you should seek medical advice and show the physician this warning. Swelling of the face, lips and eyes or difficulty in breathing are more serious symptoms and require urgent medical attention.

Withdrawal Period

Refer to Table 5.

Tylan Soluble Withdrawal Periods: Table 5

Withdrawal Period (days)

Species

Indications

Treatment Duration

Dose

Meat

Eggs

Chickens

For the control of chronic respiratory disease

5

500 mg/litre water (50-200 mg tylosin/kg bw)

1

Zero

Chickens

As an aid in the control of outbreaks of necrotic enteritis caused by Costridium perfringens

5

150 mg/litre water (20-50 mg tylosin/kg bw)

Zero

Zero

Turkeys

For the control of chronic respiratory disease

5

500 mg/litre water

Zero

Pigs

For the prevention and control of enzootic pneumonia, swine dysentery and other scours caused by organisms (eg Lawsonia intracellularis) sensitive to tylosin

3-10

250 mg/litre water (25 mg tylosin/kg bw)

Zero

Calves

For the control of pneumonia associated with mycoplasmata and Pasteurella multocida sensitive to tylosin.

7-14

1000 mg per calf twice daily

14

Pharmaceutical precautions

Store in a dry place below 25°C.

Any medicated water which is not consumed within 24h should be discarded.

Legal category

POM-V

Marketing authorisation number

Vm 00006/4091.

GTIN (Global Trade Item No)

Tylan Soluble

05014602853099

05014602853105

Tylan 200, 200mg/ml Solution for Injection

Presentation

Tylan 200 for injection is a sterile yellow aqueous solution containing tylosin base dissolved in 50% propylene glycol with 4% benzyl alcohol. Each ml contains 200 mg of tylosin base activity.

Uses

Indications. Tylan 200mg/ml injection is indicated in all conditions associated with bacteria sensitive to tylosin which includes organisms in the following genera:

Streptococcus

Campylobacter

Chlamydia

Bacillus

Spirochaetes

Staphylococcus

Mycoplasma

Corynebacterium

Fusiformis

Clostridium

Pasteurella

Erysipelothrix

Tylan 200mg/ml has been successfully used in respiratory and genito-urinary tract infections, otitis, cellulitis and secondary bacterial conditions associated with virus disease or post operative infections. Specific disease entities treated successfully with Tylan include swine dysentery, erysipelas and Enzootic Pneumonia in pigs, foul in the foot, mastitis and calf pneumonia in cattle.

Dosage and administration

Tylan 200 should be given by intramuscular injection at the following dose rates:

Cattle

4–10 mg/kg bodyweight daily

Pigs

2–10 mg/kg bodyweight daily

If there is no response to treatment in 3 days, diagnosis should be reassessed.

The maximum injection volume for cattle is limited to 15ml per injection site.

To ensure accurate dosage, bodyweight should be determined as accurately as possible.

Use of the product should be based on susceptibilty testing of the bacteria isolated from the animal. If this is not possible, therapy should be based on local epidemiological information.

For administration by the intramuscular route only.

Use different injection sites for repeat injections.

Contra-indications, warnings, etc

Precautions and contra-indications

Pigs must not be slaughtered for human consumption during treatment or for at least 9 days after the last treatment. Pigs should not be slaughtered for human consumption for three weeks after the last treatment to avoid blemish at the site of injection.

Cattle must not be slaughtered for human consumption within 28 days of the last treatment.

Milk for human consumption must not be taken from a cow during treatment. Milk for human consumption may be taken only after 108 hours from the last treatment.

Tylan 200 should not be given to chickens or turkeys.

Do not administer to horses or other equines in which injection of tylosin may be fatal

Do not mix with other solutions, since this may cause precipitation of the active ingredient.

For animal treatment only.

Care should be taken to avoid accidental self injection. If accidental self injection occurs, seek medical attention immediately. In the event of accidental skin contact, wash thoroughly with soap and water. In case of accidental eye contact, flush eyes with plenty of clean, running water.

Wash hands after use.

Tylosin may induce irritation. Macrolides such as tylosin, may also cause hypersensitivity (allergy) following injection, inhalation, ingestion or contact with skin or eye. Hypersensitivity to tylosin may lead to cross reactions with other macrolides and vice versa. Allergic reactions to these substances may occasionally be serious and therefore direct contact should be avoided. Do not handle the product if you are allergic to ingredients in the product. If you develop symptoms following exposure, such as a skin rash, you should seek medical advice and show the physician this warning. Swelling of the face, lips and eyes or difficulty in breathing are more serious symptoms and require urgent medical attention.

Pharmaceutical precautions

Do not store above 25°C.

Following withdrawal of the first dose use the product within 28 days. Discard unused material.

Any unused veterinary medicinal product or waste materials derived from such products should be disposed of in accordance with national requirements.

Legal category

POM-V

Packaging Quantities

Multi dose glass vial containing 100 ml.

Further information

Marketing authorisation number

Vm 00006/4098.

GTIN (Global Trade Item No)

Tylan 200, 200mg/ml Solution for Injection

05014602853075

Tylan G50 Premix for medicated feedingstuff

Presentation

Tylan G50 Premix is a light tan free-flowing granular meal for inclusion in animal feeding stuffs.

Each 1 kg of Tylan G50 Premix contains tylosin phosphate equivalent to 50 g tylosin activity.

Uses

Indications

For the prevention and control of swine dysentery and enzootic pneumonia. Treatment and control of Lawsonia intracellularis, the organism associated with Porcine Proliferative Enteropathies such as Porcine Intestinal Adenomatosis (Ileitis) and Porcine Haemorrhagic Enteropathy.

Dosage and administration

The required levels of tylosin are obtained by mixing the appropriate quantity of premix with 20-50 kg of a suitable feed component, prior to incorporation into the bulk of the feed to be prepared.

The product should be thoroughly mixed into the complete feed. To ensure thorough dispersion of the product it should first be mixed with a small quantity of feed ingredients before incorporation into the final mix.

For the prevention and control of swine dysentery and enzootic pneumonia

3–6 mg tylosin activity/kg bodyweight, which normally may be achieved by adding the product at the rate of 2 kg per tonne, giving 100 g tylosin base per tonne of feed. Feed as the only ration for 21 days, followed by feed containing 0.8 kg of the product per tonne of feed (giving 40 g of tylosin activity base equivalent per tonne) until the end of the period of risk.

For the treatment and control of Lawsonia intracellularis

3–6 mg tylosin activity/kg bodyweight, which normally may be achieved by adding the product at the rate of 2 kg per tonne, giving 100 g tylosin base per tonne of feed. Feed as the only ration for 21 days.

Contra-indications, warnings, etc

For animal treatment only.

For use in pig feed only.

Do not use in know cases of hypersensitivity to tylosin.

For incorporation into dry feed at the registered mill.

A manufacturer who is approved to incorporate directly at any concentration, veterinary medicinal products or premixtures containing such products must be responsible for mixing when incorporation is less then 2kg per tonne for final feed.

Tylan G50 should be mixed carefully with the mineral supplement or other feed ingredients prior to feed being manufactured to ensure even distribution in the final feed.

Unused product or waste material should be disposed of in accordance with current practice for pharmaceutical waste under national waste disposal regulations.

Operator warnings

Tylosin may induce irritation. Macrolides, such as tylosin, may also cause hypersensitivity (allergy) following injection, inhalation, ingestion or contact with skin or eye. Hypersensitivity to tylosin may lead to cross reactions to other macrolides and vice versa. Allergic reactions to these substances may occasionally be serious and therefore direct contact should be avoided.

To avoid exposure during preparation of the medicated feed, wear overalls, safety glasses, impervious gloves and wear either a disposable half mask respirator conforming to European Standard EN149 or a non-disposable respirator to European Standard EN140 with a filter to EN143. Wash hands after use.

In the event of accidental skin contact, wash thoroughly with soap and water. In case of accidental eye contact, flush the eyes with plenty of clean, running water.

Do not handle the product if you are allergic to ingredients in the product.

If you develop symptoms following exposure, such as skin rash, you should seek medical advice and show the physician this warning. Swelling of the face, lips and eyes or difficulty in breathing are more serious symptoms and require urgent medical attention.

Withdrawal period

Meat: Zero days.

Pharmaceutical precautions

Tylan G50 should be stored in a cool dry place and is stable for two years when kept under satisfactory conditions. Do not store above 25°C

For shelf life see expiry date on label.

Legal category

POM-V

Packaging Quantities

Tylan G50 Premix is supplied in 2 kg multiwalled paper sacks.

Further information

Nil

Marketing authorisation number

Vm 00006/4109.

GTIN (Global Trade Item No)

Tylan G50 Premix for medicated feedingstuff 1 x 2kg

05014602853082

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