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Previcox Tablets for Dogs

Previcox Tablets for Dogs

Previcox is a medication used to treat inflammation and pain in dogs. The tablet works quickly and is chewable, though can be given with food to make administering the drug much easier. It inhibits the enzyme responsible for generating the chemicals which lead to pain and inflammation. Previcox is generally used to treat the symptoms of osteoarthritis though it may be suitable for other conditions as well. Osteoarthritis can occur through old age and general wear and tear, though the use of a drug such as Previcox can lead to dramatic reductions in the inflammation and pain, so giving the pet a whole new lease of life.

Previcox for dogs is only available with a prescription from your vet. The medication can be purchased directly from the vet but this usually works out to be much more expensive, so an alternative is to buy dog medicine from VioVet. The prescription will have to be obtained from the vet and sent with the order before the drug can be supplied.

As with all pain-relieving drugs, some side effects are possible. Any unusual symptoms should be reported to your vet. However Previcox for dogs is in fact one of the safest drugs in its class and very rarely causes any unwanted side effects. Care should be taken if the animal is suffering from conditions such as liver or kidney problems, heart disease or blood pressure problems. The vet will also take into consideration any other medication being given to the pet.

Description

Presentation

Tan-brown, round, convex, engraved, scored chewable tablets, each containing 57mg or 227 mg firocoxib.

Uses

Firocoxib is a non-steroidal anti-inflammatory drug (NSAID) belonging to the Coxib group, which acts by selective inhibition of cyclooxygenase-2 (COX-2)–mediated prostaglandin synthesis. PREVICOX tablets are for the relief of pain and inflammation associated with osteoarthritis in dogs and for the relief of post-operative pain and inflammation associated with soft-tissue, orthopaedic and dental surgery in dogs.

Dosage and administration

Osteoarthritis:

The recommended oral dose is 5 mg per kg bodyweight once daily, as shown in the table below. Tablets can be administered with or without food. Duration of treatment will be dependent on the response observed. As field studies were limited to 90 days, this should be borne in mind when considering longer-term treatment, with regular monitoring carried out by the veterinarian.

Relief of post-operative pain:

The recommended oral dose is 5 mg per kg bodyweight once daily, as shown in the table below, for up to 3 days as needed, starting approximately 2 hours prior to surgery.

Following orthopaedic surgery and depending on the response observed, treatment using the same daily dosing schedule may be continued after the first 3 days, upon judgement of the attending veterinarian.

Body weight (kg)

Number of chewable tablets

mg/kg range

57mg

227mg

3 - 5.5

0.5

5.2 - 9.5

5.6 - 10

1

5.7 - 10.2

10.1 - 15

1.5

5.7 - 8.5

15.1 - 22

0.5

5.2 - 7.5

22.1 - 45

1

5.0 - 10.3

45.1 - 68

1.5

5.0 - 7.5

68.1 - 90

2

5.0 - 6.7

Contra-indications, warnings, etc

For animal treatment only. Do not exceed the recommended dose. Do not use in pregnant or lactating bitches.

Do not use in animals less than 10 weeks of age or less than 3 kg bodyweight. Do not use in animals suffering from gastrointestinal bleeding, blood dyscrasia or haemorrhagic disorders. Where there is a risk of gastrointestinal bleeding, or if the animal previously displayed intolerance to NSAIDs, use this product under strict veterinary monitoring.

Vomiting and diarrhoea have occasionally been reported. These reactions are generally of a transitory nature and are reversible when the treatment is stopped. Rarely, nervous system disorders have been reported in treated dogs.

Do not use concomitantly with corticosteroids or other non-steroidal anti-inflammatory drugs (NSAIDs). Use in very young animals, or animals with suspected or confirmed impairment of renal, cardiac or hepatic function may involve additional risk. If such use cannot be avoided, those dogs require careful veterinary monitoring.

Avoid use in any dehydrated, hypovolaemic or hypotensive animals, as there is a potential risk of increased renal toxicity. Concurrent administration of potentially nephrotoxic drugs should be avoided.

Renal and/or hepatic disorders have been reported in very rare cases in dogs administered the recommended treatment dose. It is possible that a proportion of such cases had sub-clinical renal or hepatic disease prior to the commencement of therapy. Therefore, appropriate laboratory testing to establish baseline renal or hepatic biochemistry parameters is recommended prior to and periodically during administration.

The treatment should be discontinued and the advice of a veterinarian should be sought if any of these signs are observed: repeated diarrhoea, vomiting, faecal occult blood, sudden weight loss, anorexia, lethargy, degradation of renal or hepatic biochemistry parameters. As with other NSAIDs, serious adverse effects can occur and, in very rare cases, may be fatal.

Laboratory studies in rabbits have shown evidence of maternotoxic and foetotoxic effects at dose rates approximating the recommended treatment dose for the dog. Pre-treatment with other anti-inflammatory substances may result in additional or increased adverse effects and accordingly a treatment-free period with such drugs should be observed for at least 24 hours before the commencement of treatment with PREVICOX. The treatment-free period, however, should take into account the pharmacokinetic properties of the products used previously.

PREVICOX must not be administered in conjunction with other NSAIDs or glucocorticosteroids. Gastrointestinal tract ulceration may be exacerbated by corticosteroids in animals given non-steroidal anti-inflammatory drugs.

Concomitant treatment with molecules displaying action on renal flow, e.g. diuretics or Angiotensin Converting Enzyme (ACE) inhibitors, should be subject to clinical monitoring. Concurrent administration of potentially nephrotoxic drugs should be avoided, as there might be an increased risk of renal toxicity. As anaesthetic drugs may affect renal perfusion, the use of parenteral fluid therapy during surgery should be considered to decrease potential renal complications when using NSAIDs peri-operatively.

Concurrent use of other active substances that have a high degree of protein binding may compete with firocoxib for binding and thus lead to toxic effects.

In the event of accidental ingestion, seek medical advice immediately and show the package leaflet or label to the physician. Wash hands after use of the product.

Return halved tablets to the blister and keep out of the reach of children.

Disposal advice

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Pharmaceutical precautions

Do not store above 300C. Store in the original package. Halved tablets may be kept for up to 7 days in the original container.

Legal category

POM-V

Packaging Quantities

PREVICOX tablets are supplied in carton boxes containing blisters (transparent PVC /aluminium foil and paper backing).

The chewable tablets are available in the following pack sizes:

57mg: 1 carton box containing three blisters of 10 tablets

227 mg: 1 carton box containing three blisters of 10 tablets

Further information

Firocoxib is approximately 96% bound to plasma proteins. Following multiple oral administrations, the steady state is reached by the third daily dose.

Firocoxib is metabolised predominantly by dealkylation and glucuronidation in the liver. Elimination is principally in the bile and gastrointestinal tract.

PREVICOX chewable tablets are scored to facilitate accurate dosing and contain caramel and smoke flavours to facilitate administration to dogs.

Mode of action: Firocoxib is a non-steroidal anti-inflammatory drug (NSAID) that acts by selective inhibition of cyclooxygenase-2 (COX-2)–mediated prostaglandin synthesis. COX-2 is the isoform of the enzyme that has been postulated to be primarily responsible for the synthesis of prostanoid mediators of pain, inflammation, and fever. In in-vitro canine whole blood assays, firocoxib exhibited approximately 380-fold selectivity for COX-2 over COX-1.

Marketing authorisation number

EU/2/04/045/001-4.

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Alternative to Previcox

16th Dec 2013
Adrian Mills

Since ordering food from yourselves and receiving a speedy service I also see you can provide prescribed drugs and I have a question.
My 10 year old JRT has been on previcox for 3 years following a trauma injury for her crutiate ligament.
She has been quite well in general and I wonder if you have a similar non prescription drug that would be just as effective?
Your advice would be appreciated.

  • Website Content Developer at VioVet

There is nothing like Previcox which is non-prescription. There are however quite a few joint supplements which help the general health of joints and can reduce or sometime eliminate the need for prescription anti-inflammatory drugs like Previcox. I would suggest trying Yumove or Seraquin and gradually trying to wean your dog off the Previcox after a few weeks. If you can reduce the dose, or even stop it altogether, that is great. You might need to use Previcox periodically if there is a flare-up of stiffness or soreness in the leg. Most people find that both types of treatment have their place, along with sensible but controlled exercise and weight control through sensible diet.

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