Urilin is used to control the leaking of urine which occurs in some bitches after they have been spayed. It helps to increase the tone of the muscles near the exit to the bladder so that inadvertent passage of urine while at rest is prevented. Urilin is given three times daily at first. Once leaking has stopped, it is sometime possible to gradually reduce the quantity or frequency of the Urilin administered. Urilin is provided in a squeezable plastic bottle and the dose is measured by counting the number of drops which are added to food. One drop of Urilin is required per 2.34kg bodyweight three times daily at the full starting dose.
1 ml contains: Active substance:
Phenylpropanolamine 40.29 mg (equivalent to 50.0 mg phenylpropanolamine hydrochloride)
Excipients: Sodium methyl parahydroxybenzoate (E219) 1.5 mg, sodium propyl parahydroxybenzoate (E217) 0.15 mg. Also contains maltitol liquid, saccharin sodium, citric acid monohydrate (E330), purified water.
Syrup. Clear, viscous solution.
For the treatment of urinary incontinence associated with acquired urethral sphincter incompetence in the bitch only. The efficacy of phenylpropanolamine has only been demonstrated in ovariohysterectomised bitches.
For oral administration.
0.8 mg/kg body weight phenylpropanolamine (equivalent to 1 mg/kg phenylpropanolamine HCl) three times daily in the feed, corresponding to 0.1 ml Urilin syrup/5 kg body weight three times daily.
1 drop for every 2.34 kg body weight three times daily in feed.
Please see Use during pregnancy and lactation.
Do not use in animals treated with non-selective monoamine oxidase inhibitors.
Do not use in cases of known hypersensitivity to the active substance or to any of the excipients.
Special warnings for each target species: It is not appropriate to use the product for the behavioural cause of inappropriate urination.
Special precautions for use in animals: Because phenylpropanolamine is a sympathomimetic agent, it may affect the cardiovascular system, especially blood pressure and heart rate, and therefore should be used with caution in animals with cardiovascular diseases.
Care should be exercised in treating animals with severe renal or hepatic insufficiency, diabetes mellitus, hyperadrenocorticism, glaucoma or other metabolic disorders.
In bitches less than 1 year old the possibility of anatomical disorders contributing to incontinence should be considered prior to treatment.
Special precautions to be taken by the person administering the veterinary medicinal product to animals: Phenylpropanolamine hydrochloride is toxic when overdoses are ingested. Adverse effects may include dizziness, headache, nausea, insomnia or restlessness, and increased blood pressure. High overdose may be fatal, especially in children.
In the event of accidental skin contact, wash the contaminated area with soap and water. Wash hands after use of the product.
In the event of accidental eye contact, rinse the eye with clean water for about 15 minutes and seek medical advice.
To avoid accidental ingestion, the product must be used and kept out of the reach and sight of children.
Always replace the cap firmly after use to ensure the child resistant closure operates correctly.
In the event of accidental ingestion, seek immediate medical attention showing the doctor the package leaflet.
Adverse reactions: In some dogs, loose stools, liquid diarrhoea, a decrease in appetite, arrhythmia and collapse have been reported following treatment with phenylpropanolamine. Treatment was continued depending on the severity of the undesirable effect observed.
As phenylpropanolamine is a sympathomimetic agent it is possible to produce a wide range of effects, most of which mimic the results of excess stimulation of the sympathetic nervous system (e.g. effects on the heart rate and blood pressure).
Dizziness and restlessness have been reported in some dogs following treatment.
Hypersensitivity may occur in very rare cases.
Use during pregnancy and lactation: Do not use in pregnant or lactating bitches.
Interactions: Care should be exercised in administering the product with other sympathomimetic drugs, anticholinergic drugs, tricyclic antidepressants or specific type B monoamine oxidase.
Overdose: In healthy dogs, no side effects were observed at up to 5 times the recommended dose. However, an overdose could produce signs of excessive stimulation of the sympathetic nervous system.
Treatment should be symptomatic. Alpha-adrenergic blockers may be appropriate in the case of severe overdose. However, no specific recommendation on drugs or dosages can be given.
Incompatibilities: None known.
Do not store above 25°C. Keep the container in the outer carton. Do not use after the expiry date stated on the label after EXP.
Shelf life of the veterinary medicinal product as packaged for sale: 3 years.
Shelf life after first opening the immediate packaging: 3 months.
Disposal: Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
50 ml or 100 ml amber type III glass bottles containing 45 ml or 100 ml of syrup, with a low density polyethylene dropper and a polypropylene child resistant screw cap. Not all pack sizes may be marketed.
For animal treatment only. To be supplied only on veterinary prescription. Keep out of the reach and sight of children.
Manufacturer for the batch release: Dales Pharmaceuticals, Snaygill Industrial Estate, Keighley Road, Skipton, North Yorkshire, BD23 2RW.
Date of last review: 27.08.2010
Dechra Limited, Dechra House, Jamage Industrial Estate, Talke Pits, Stoke-on-Trent, Staffordshire, ST7 1XW.
Urilin 40 mg/ml Syrup for Dogs 45 ml:
Urilin 40 mg/ml Syrup for Dogs 100 ml:
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