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Trimediazine For Horses

Trimediazine is a combination of trimethoprim and sulfadiazine which together produce a powerful anti-bacterial effect. The broad spectrum of activity and high safety levels of Trimediazine mean that it is used for a wide range of infections in horses. These include respiratory, alimentary and general soft tissue infections. Examples would be pneumonia; pleurisy, strangles, infected wounds and septicaemia.

Contra-indications, warnings, etc

Operator warning
Avoid direct contact with skin and eyes. If contact occurs, wash affected area with copious amounts of water. Seek medical advice if irritation persists.
Gloves should be worn whilst handling this product.
Wash hands after use.
Use during pregnancy or lactation
This product can be safely administered during pregnancy and lactation.
Drug absorption may be greater if food is withheld for a few hours prior to dosing.
Do not use in horses intended for human consumption.
Treated horses may never be slaughtered for human consumption.
The horse must have been declared as not intended for human consumption under national horse passport legislation.

Description

Trimediazine™ Plain Oral Powder

Presentation

Trimediazine Plain is a white broad spectrum antibacterial powder for mixing with animal feed . Each sachet contains Trimethoprim 5% w/w and Sulfadiazine 25% w/w.

Uses

Trimediazine Plain is indicated for use in the treatment of bacterial diseases in horses, including upper and lower respiratory tract infections, alimentary tract infections and infected wounds.

Dosage and administration

For oral administration in the feed, to be given at a rate of 30mg combined active ingredients per kg bodyweight.

Mix with a small quantity of feed. Each 50 g sachet provides a daily dose for a 500 kg horse. The dose may be administered daily, or divided and administered at 12 hourly intervals, for 5 days.

Note

It is recommended that other feed be withdrawn until medicated feed has been consumed.

Contra-indications, warnings, etc

Do not use in horses with severe liver parenchymal damage or kidney damage or known sulphonamide sensitivity or horses with blood dyscrasias.

To avoid the possibility of crystalluria, adequate water intake is essential.

Do not exceed 7 days continuous treatment.

The use of Trimediazine Plain in horses under 1 year old should be avoided.

In the rat and rabbit, trimethoprim/sulfadiazine combinations did not produce any foetal abnormalities at doses of up to 600mg/kg, although minor effects on skeletal development were seen below this level. As no studies have been conducted in horses, use on pregnant mares should be avoided.

When administered to lactating females, small amounts of trimethoprim and sulfadiazine are present in the maternal milk. Since no studies have been reported on the effects of Trimediazine Plain on the development of new born foals, it would be prudent not to feed very young foals with milk obtained from mares being treated.

As there is no specific antidote, in case of overdose, treatment should be symptomatic.

Withdrawal period

Meat: 6 months

In accordance with the Horse Passport legislation (Commission Decision 2000/68/EC as implemented in national legislation) a 6 month withdrawal period applies to the use of this product.

Operator warnings

Persons handling this product should avoid inhalation of any dust and contact with skin. Wear either a disposable half-mask respirator conforming to European Standard to EN149 or a non-disposable respirator to European Standard to EN140 with filter EN143 when mixing or handling this product. Rubber gloves should be worn when mixing or handling this product. Hands should be washed thoroughly after use. Sulphonamides may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to sulphonamides may lead to cross reactions with other antibiotics. Allergic reactions to these substances may occasionally be serious.

1. Do not handle this product if you know you are sensitive to sulphonamides.

2. If you develop symptoms following exposure such as a skin rash, you should seek medical advice and show the doctor this warning.

Pharmaceutical precautions

Do not store above 25°C. Store in a dry place away from animal feeding stuffs. Add to feed immediately before administration. Discard any remaining medicated feed.

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Legal category

POM-V

Packaging Quantities

10×50 g sachets.

Further information

ATC vet code: QJ01EW10

Sulfadiazine is a bacteriostatic antibiotic belonging to the sulphonamide group which acts by interference with the synthesis of nucleic acids. Trimethoprim is a reductase inhibitor which also interferes with the synthesis of bacterial nucleic acids. Sulfadiazine and trimethoprim act on the same metabolic pathway, resulting in potentiation of antibacterial activity.

Marketing authorisation number

Vm 08007/4036.

GTIN (Global Trade Item No)

Trimediazine Plain

03605870009886

Trimediazine™ Paste Oral Paste

Presentation

Oral paste.

Each 45g syringe contains Trimethoprim 2.6g and Sulfadiazine 13.0g and as preservatives: Methyl hydroxybenzoate 81mg and Propyl Hydroxybenzoate 9mg.

Uses

Indicated in the treatment of bacterial infections in horses caused by sensitive micro-organisms including:

Escherichia coli

Rhodococcus (Corynebacterium) equi

Staphylococcus spp.

Streptococcus spp.

The product may be effective in alimentary tract infections including diarrhoea; respiratory tract infections including pneumonia; pleurisy and strangles; wounds, septicaemia and general infections.

Dosage and administration

Adjust screw gauge on dial-a-dose plunger to the bodyweight of the horse. Remove cap from nozzle. Place nozzle in corner of mouth. Depress plunger depositing paste on upper surface of tongue.

The daily dose is 30 mg combined actives per kg bodyweight by oral administration. Treatment should be continued for up to 5 days or until 2 days after symptoms have resolved. Each syringe provides one daily dose for a 500 kg horse. Each division on the dial-a-dose plunger provides sufficient product to treat 50 kg of bodyweight.

Replace cap after use.

Contra-indications, warnings, etc

Do not use the same syringe to treat more than one animal unless horses are running together or in direct contact with each other on the same premises.

Operator warning

Avoid direct contact with skin and eyes. If contact occurs, wash affected area with copious amounts of water. Seek medical advice if irritation persists. Gloves should be worn whilst handling this product. Wash hands after use.

Use during pregnancy or lactation

This product can be safely administered during pregnancy and lactation.

Interaction with other medicinal products and other forms of interaction

Drug absorption may be greater if food is withheld for a few hours prior to dosing.

Overdose (symptoms, emergency procedures, antidotes) if necessary

The combination has a wide margin of safety. No treatment specified.

Withdrawal period(s)

Do not use in horses intended for human consumption. Treated horses may never be slaughtered for human consumption. The horse must have been declared as not intended for human consumption under national horse passport legislation.

Pharmaceutical precautions

Do not store above 25°C. Do not freeze.

Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Legal category

POM-V

Packaging Quantities

Creamy white paste in plastic disposal dial-a-dose syringes containing 45g of product.

Further information

Sulfadiazine (SDZ) inhibits the incorporation of para-aminobenzoic acid into folic acid and trimethoprim (TMP) inhibits the enzyme dihydrofolate reductase (DHFR) which converts dihydrofolic acid into tetrahydrofolic acid. TMP and SDZ act together synergistically with a double-blockage mode of action. The combination is bactericidal, inhibiting sequential steps in the synthesis of purines which are required for DNA synthesis. TMP-SDZ combinations have a broad bactericidal action against many gram-positive and gram-negative aerobic bacteria, and a large proportion of anaerobic bacteria.

Marketing authorisation number

Vm 08007/4046.

GTIN (Global Trade Item No)

Trimediazine Paste

03605874089990

Need help or advice? Contact us:

  • Freephone: 0800 084 2608
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  • Sat: 9:00am - 3:00pm
  • Email: support@viovet.co.uk

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