Synulox Antibiotic for Dogs & Cats

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Synulox is the most commonly used antibiotic for dogs and cats in the UK. It contains amoxycillin and clavulanic acid which act together to provide a safe and effective antibiotic with activity against a wide range of bacteria. The tablets are flavoured to ease administration to dogs and cats and are given twice daily. They will normally be eaten from the hand, or can be crumbled and added to food. Synulox is safe to use during pregnancy and lactation in dogs and cats. Smaller animals can be given Synulox Drops, but they are not suitable for small herbivores such as rabbits and guinea pigs, which can develop serious enteritis following the use of this type of antibiotic.
Synulox LC is supplied in single-use syringes to treat mastitis in milking cows.

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Synulox Palatable Tablets 50 mg and 250 mg

Presentation

Synulox Palatable Tablets are presented as circular, pink tablets with a break line on one face and `SYNULOX' engraved on the other. Each tablet contains clavulanic acid as potassium clavulanate and amoxicillin as Amoxicillin trihydrate in a palatable base. The composition of the two tablet sizes is as follows:

50 mg

40 mg amoxicillin and 10 mg clavulanic acid.

250 mg

200 mg amoxicillin and 50 mg clavulanic acid.

Uses

Synulox Palatable Tablets have a notably broad spectrum of bactericidal activity against bacteria commonly found in cats and dogs.

In vitro Synulox is active against a wide range of clinically important aerobic and anaerobic bacteria including:

Gram-positive:

Staphylococci (including β-lactamase producing strains); Clostridia; Corynebacteria; Peptostreptococcus spp; Streptococci.

Gram-negative:

Bacteroides spp (including β-lactamase producing strains); Escherichia coli (including most β-lactamase producing strains); Salmonellae (including β-lactamase producing strains); Bordetella bronchiseptica; Campylobacter spp; Fusobacterium necrophorum; Klebsiellae; Pasteurellae; Proteus spp.

Clinically Synulox has been shown to be effective in treating a wide range of diseases of cats and dogs including: Skin disease (including deep and superficial pyodermas); soft tissue infections (abscesses and anal sacculitis); dental infections (eg gingivitis); urinary tract infections; respiratory disease (involving upper and lower respiratory tract); enteritis.

Dosage and administration

Administration

By the oral route. Synulox palatable tablets are often accepted from the hand even by sick cats and dogs. Alternatively, the tablets may be crushed and added to a little food.

Dosage rate

12.5 mg/kg bodyweight.

Dosage frequency

The following table is intended as a guide to dispensing Synulox Palatable Tablets at the standard dose rate of 12.5 mg/kg, twice daily.

For the majority of infections, including those of the skin, urinary tract and gastrointestinal tract, the above dosing regime is effective.

Refractory cases, however, particularly those of the respiratory tract, have shown improved cure rates by doubling the dose to 25 mg/kg bodyweight twice daily. (Note that the smallest animals of 1 kg bodyweight when dosed with ½ tablet will already be receiving the doubled (25 mg/kg) dose rate.)

Duration of therapy

Routine cases involving all indications: The majority of these cases respond to between 5 and 7 days therapy.

Number of tablets per dose,

twice daily

Bodyweight (kg)

50 mg

250 mg

1– 2

½

3– 5

1

6– 9

2

10–13

3

14–18

4

19–25

1

26–35

36–49

2

50

3

Chronic or refractory cases

In these cases, where there is considerable tissue damage, a longer course of therapy may be required in that it allows sufficient time for damaged tissue to repair. Based on clinical trials, the following durations are suggested as guidelines:

Chronic skin disease

10–20 days

Chronic cystitis

10–28 days

Respiratory disease

8–10 days

Contra-indications, warnings, etc

For animal treatment only. Synulox Palatable Tablets should not be given to rabbits, guinea pigs, hamsters or gerbils. Caution is advised in their use in any other very small herbivores.

Operator warning

Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross reaction to cephalosporins and vice-versa. Allergic reaction to these substances may occasionally be serious.

Do not handle this product if you know you are sensitised, or if you have been advised not to work with such preparations. Wash hands after use.

Handle this product with great care to avoid exposure, taking all recommended precautions.

If you develop symptoms following exposure such as skin rash, you should seek medical advice and show the doctor this warning. Swelling of the face, lips or eyes or difficulty with breathing are more serious symptoms, and may require urgent medical attention.

Pharmaceutical precautions

Do not store above 25°C. Store in a dry place. Keep out of the reach of children.

Dispose of any unused product and empty containers in accordance with guidance from your local waste regulation authority.

Legal category

POM-V

Packaging Quantities

Both size tablets are packed in foil strips containing 5×2 tablets. 50 mg tablets are supplied in packs of 100 and 500, 250 mg tablets are in packs of 100 and 250.

Further information

Resistance to many antibiotics is caused by beta-lactamase enzymes which destroy the antibiotic before it can act on the bacteria themselves. The clavulanate in Synulox counteracts this defence mechanism by inactivating the beta-lactamases, thus rendering the organisms sensitive to amoxicillin's rapid bactericidal effect, at concentrations readily attainable in the body.

Synulox is effective against Klebsiella infections found in veterinary practice, but it is not indicated for cases involving Pseudomonas species.

Synulox Palatable Tablets are often accepted from the hand, even by sick dogs and cats. Alternatively, the tablets may be crumbled and added to a little food.

Synulox Palatable Tablets can safely be used during pregnancy and lactation.

Synulox Palatable Drops are available as an alternative presentation for treating small individuals.

Marketing authorisation numbers

50 mg

Vm 00057/4164

250 mg

Vm 00057/4163

GTIN (Global Trade Item No)

100 x 50 mg:

05013457076929

500 x 50 mg:

05013457076936

100 x 250 mg:

05013457076943

250 x 250 mg:

05013457076950

Synulox Palatable Tablets 500 mg

Presentation

Synulox Palatable Tablets are presented as circular, pink tablets with a break line on one face and `SYNULOX' engraved on the other. Each tablet contains 100 mg clavulanic acid as potassium clavulanate and 400 mg amoxicillin as Amoxicillin trihydrate in a palatable base.

Uses

Synulox Palatable Tablets have a broad spectrum of activity against bacteria commonly found in dogs.

In vitro Synulox is active against a wide range of clinically important aerobic and anaerobic bacteria, including:

Gram-positive

Staphylococci (including beta-lactamase-producing strains), Clostridia, Actinomyces, Peptostreptococcus spp., Streptococci, Enterococci

Gram-negative

Bacteroides spp. (including β-lactamase-producing strains), Escherichia coli (including beta-lactamase-producing strains), Salmonellae (including β-lactamase-producing strains), Bordetella bronchiseptica, Campylobacter spp., Fusobacterium necrophorum, Klebsiellae, Pasteurellae, Proteus spp.

Clinically, Synulox has been shown to be effective in treating a wide range of diseases of dogs including: Skin disease (including deep and superficial pyoderma); urinary tract infection; respiratory disease involving upper and lower respiratory tract, enteritis, dental infections (e.g. gingivitis), soft tissue infections (e.g. abscesses and anal sacculitis).

Note: Synulox is not indicated for cases involving Pseudomonas spp.

Dosage and administration

Administration

By the oral route.

Dosage Guide

Recommended dose rate is 12.5 mg/kg, twice daily. The table below is intended as a guide only.

Bodyweight (kg)

Number of Tablets per dose

Twice Daily

500 mg

20 kg

½

40 kg

1

60 kg

80 kg

2

For oral administration only. Synulox Palatable Tablets are often accepted from the hand, even by sick dogs. Alternatively, the tablets may be crushed and added to a small quantity of food. The majority of routine cases will respond between 5 and 7 days therapy. Because of the low toxicity profile of Synulox, the dose can be doubled if desired at the discretion of the veterinary surgeon for severe infection. In certain indications, for example canine pyoderma and chronic cystitis, bacterial infection may be secondary to other pathology. For such cases longer courses of antibacterial therapy may be required, in addition to diagnosis and treatment of the underlying condition. In such circumstances overall treatment length must be at the clinician's discretion, but should be long enough to ensure complete resolution of the bacterial disease.

Contra-indications, warnings, etc

In common with other penicillins, Synulox should not be administered orally to rabbits, guinea pigs hamsters or gerbils, and should be used with care in other small herbivores.

Synulox should not be administered concomitantly with bacteriostatic antibiotics, which are incompatible.

Operator warning

Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross-reactions to cephalosporins and vice versa. Allergic reaction to these substances may occasionally be serious.

Do not handle this product if you know you are sensitised, or if you have been advised not to work with such preparations.

Handle this product with great care to avoid exposure, taking all recommended precautions.

If you develop symptoms following exposure, such as a skin rash, you should seek medical advice and show the doctor this warning. Swelling of the face, lips or eyes or difficulty with breathing are more serious symptoms and may require urgent medical attention.

In the event of accidental ingestion, seek medical advice.

Wash hands after handling the tablets.

For animal use only.

Keep out of the reach of children.

Pharmaceutical precautions

Do not store above 25°C. Store in a dry place.

Dispose of any unused product and empty containers in accordance with guidance from your local waste regulation authority.

Legal category

POM-V

Packaging Quantities

Laminated aluminium foil packs with 2 tablets in each blister card. Packed in an outer carton box and marketed as a 100 tablet presentation.

Further information

Amoxicillin is a broad-spectrum antibiotic active against a wide range of Gram-positive and Gram-negative bacteria. However, many clinically important bacteria produce beta-lactamase enzymes which destroy this antibiotic. Clavulanic acid inactivates these enzymes, rendering the organisms susceptible to the amoxicillin.

Synulox Palatable Tablets can safely be used in pregnant and lactating animals

Marketing authorisation number

Vm 00057/4102.

GTIN (Global Trade Item No)

100 x 500 mg:

05013457077827

Synulox Palatable Drops, Powder for Oral Suspension

Presentation

Synulox Palatable Drops are presented in a bottle as an off-white powder, containing 150 mg potassium clavulanate equivalent to clavulanic acid and 600 mg Amoxicillin trihydrate equivalent to amoxicillin. Reconstitution of the powder with 15 ml of water provides a suspension containing 10mg clavulanic acid and 40mg amoxicillin per ml.

Uses

Synulox Palatable Drops have a notably broad spectrum of bactericidal activity against bacteria commonly found in dogs and cats.

In vitro Synulox is active against a wide range of clinically important aerobic and anaerobic bacteria including:

Gram-positive:

Staphylococci (including β-lactamase producing strains); Clostridia; Corynebacteria; Peptostreptococcus spp; Streptococci

Gram-negative:

Bacteroides spp. (including β-lactamase producing strains); Escherichia coli (including most β-lactamase producing strains); Salmonellae (including β-lactamase producing strains); Bordetella bronchiseptica; Campylobacter spp; Fusobacterium necrophorum; Klebsiellae; Pasteurellae; Proteus spp.

Clinically Synulox has been shown to be effective in treating a wide range of diseases of cats and dogs including: Skin disease (including deep and superficial pyodermas); soft tissue infections (abscesses and anal sacculitis); dental infections (eg gingivitis); urinary tract infections; respiratory disease (involving upper and lower respiratory tract); enteritis.

Dosage and administration

Administration

By the oral route.

Reconstitution

Add 15ml water. Shake the bottle before use.

Dosage rate

12.5 mg/kg bodyweight (i.e. 0.25 ml/kg). For the accurate dosing of particularly small patients it is valuable to note that one drop from the pipette provided contains 2.3 mg clavulanate-potentiated amoxicillin. Therefore 5–6 drops/kg twice daily are recommended as a guide.

Dosage frequency

Dogs and cats should be dosed at the rate of 0.25 ml of reconstituted product per kg bodyweight twice daily.

For the majority of infections, including those of the skin, urinary tract and gastrointestinal tract, the above dosing regime is effective.

Refractory cases, however, particularly those of the respiratory tract, have shown improved cure rates by doubling the dose to 25 mg/kg bodyweight twice daily (i.e. 0.5 ml of reconstituted product per kg bodyweight twice daily).

Duration of therapy

Routine cases involving all indications

The majority of these cases respond to between 5 and 7 days therapy.

Chronic or refractory cases

In these cases, where there is considerable tissue damage, a longer course of therapy may be required in that it allows sufficient time for damaged tissue to repair. Based on clinical trials, the following durations are suggested as guidelines:

Chronic skin disease

10–20 days

Chronic cystitis

10–28 days

Respiratory disease

8–10 days

Contra-indications, warnings, etc

Synulox Palatable Drops should not be given to rabbits, guinea pigs, hamsters or gerbils. Caution is advised in their use in any other very small herbivores.

Operator warning

Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross-reactions to cephalosporins and vice-versa. Allergic reaction to these substances may occasionally be serious.

Do not handle this product if you know you are sensitised, or if you have been advised not to work with such preparations.

Handle this product with great care to avoid exposure, taking all recommended precautions.

If you develop symptoms following exposure, such as skin rash, you should seek medical advice and show the doctor this warning. Swelling of the face, lips or eyes or difficulty with breathing are more serious symptoms and may require urgent medical attention.

Wash hands after use.

Pharmaceutical precautions

Powder: Do not store above 25°C.

Reconstituted suspension: Store at 2-8°C. Any reconstituted suspension remaining 7 days after preparation should be discarded.

Dispose of any unused product and empty containers in accordance with guidance from your local waste regulation authority.

Keep out of reach of children.

For animal treatment only.

Legal category

POM-V

Packaging Quantities

Synulox Palatable Drops are supplied in bottles containing 15ml of product following reconstitution (equivalent to 750 mg of clavulanate-potentiated amoxicillin). A dropper with graduations of 0.25 ml, up to 1 ml, is included in each pack to ensure accurate, convenient dosing.

Further information

Resistance to many antibiotics is caused by beta-lactamase enzymes which destroy the antibiotic before it can act on the bacteria themselves. The clavulanate in Synulox counteracts this defence mechanism by inactivating the beta-lactamases, thus rendering the organisms sensitive to amoxicillin's rapid bactericidal effect, at concentrations readily attainable in the body.

Synulox is effective against Klebsiella infections found in veterinary practice, but it is not indicated for cases involving Pseudomonas species.

Synulox Palatable Drops can be safely used in pregnant and lactating animals.

Synulox Palatable Tablets are available as an alternative presentation for treating sick dogs and cats.

Marketing authorisation number

Vm 00057/4112.

GTIN (Global Trade Item No)

1 x 15 ml:

05013457076967

Synulox Lactating Cow Intramammary Suspension

Presentation

Synulox Lactating Cow is an intramammary suspension, each 3 g syringe containing 200 mg amoxicillin (as amoxicillin trihydrate),50 mg clavulanic acid (as potassium clavulanate) and 10 mg prednisolone.

Uses

For use in clinical cases of mastitis in lactating cattle including cases associated with infections with the following pathogens:

Staphylococci (including b-lactamase producing strains),

Streptococci (including S. agalactiae, S. dysgalactiae, and S. uberis),

Escherichia coli (including b-lactamase-producing strains).

Dosage and administration

Before the infusion is made, the teat end should be cleaned and disinfected.

The contents of one syringe should be infused into each affected quarter via the teat canal, immediately after milking, at 12 hour intervals for three consecutive milkings.

In cases of infections caused by Staphylococcus aureus, a longer course of antibacterial therapy may be required. Therefore, overall treatment length must be at the veterinary surgeon’s discretion but should be long enough to ensure complete resolution of the intramammary infection.

Contra-indications, warnings, etc

Do not use in animals which are known to be hypersensitive to β-lactamase antibiotics.

Do not use in cases associated with Pseudomonas.

Synulox Lactating Cow should be used for treatment of clinical mastitis only.

Swab teat end with an appropriate disinfectant before treatment.

Use of the product should be based on local (regional, farm level) epidemiological information about susceptibility of the target bacteria and take into account official and local antimicrobial policies.

The use of the product should preferably be based on susceptibility tests.

Avoid use of the product in herds where no β-lactamase producing Staphylococci strains have been isolated. Veterinarians should strive to use narrow spectrum antibiotics if possible. Inappropriate use of the product may increase the prevalence of bacteria resistant to ß-lactam antibiotics and may decrease the effectiveness of treatment with ß-lactam antibiotics, due to the potential for cross-resistance.

Withdrawal periods

Meat and offal: 7 days.

Milk: 84 hours.

With cows milks twice daily, milk for human consumption may only be taken from the 7th milking after the last treatment. Where any other milking routine is followed, milk may be taken for human consumption only after the same period from the last treatment (eg with 3 times a day milking, milk may be taken at the 11th milking).

Operator warnings

Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross-reactions to cephalosporins and vice versa. Allergic reactions to these substances may occasionally be serious.

Do not handle this product if you know you are sensitised, or if you have been advised not to work with such preparations.

Handle this product with great care to avoid exposure, taking all recommended precautions.

If you develop symptoms following exposure such as a skin rash, you should seek medical advice and show the doctor this warning. Swelling of the face, lips or eyes or difficulty with breathing, are more serious symptoms and require urgent medical attention.

Wash hands after use.

Pharmaceutical precautions

Store in a dry place. Do not store above 25°C.

Keep out of the reach and sight of children. For animal treatment only.

Any unused veterinary medicinal product or waste materials from such veterinary medicinal products should be disposed of in accordance with local requirements.

Legal category

POM-V

Packaging Quantities

Cartons of 12 and 24 syringes. Not all pack sizes may be marketed.

Further information

Amoxicillin is a broad spectrum bactericidal b-lactam antibiotic. Clavulanic acid inactivates b-lactamases. This combination is effective against b-lactamase producing organisms. Prednisolone is an anti-inflammatory corticosteroid.

In vitro, clavulanic acid and amoxicillin in combination are active against a wide range of clinically important bacteria including the following organisms which are commonly associated with bovine mastitis:

Staphylococci (including b-lactamase producing strains)

Streptococci (including S. agalactiae, S. dysgalactiae and S. uberis)

Arcanobacteria (including A. pyogenes)

Escherichia coli (including b-lactamase producing strains)

No adverse reactions are to be expected from an accidental overdose.

Marketing authorisation number

Vm 00057/4147.

GTIN (Global Trade Item No)

12 syringes:

05013457076882

24 syringes:

05013457076899

Need help or advice? Contact us:

  • Freephone: 0800 084 2608
  • Mon - Fri: 8:30am - 7:00pm
  • Sat: 10:00am - 3:00pm
  • Email: support@viovet.co.uk

All prices include VAT where applicable.

Information regarding the safe use of all licensed medication supplied in the UK can be found on the Veterinary Medicine Directorate website. Follow this link and then search for the brand name of the product to find the official Summary of Product Characteristics for that product. Unlicensed medication, such as herbal supplements, will not be found here and there is no such formal recognition of any scientifically proven therapeutic effects from any unlicensed medication.

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Questions & Answers for Synulox Antibiotic for Dogs & Cats

Below are some recent questions we've received regarding Synulox Antibiotic for Dogs & Cats, including answers from our team.

Swollen leg due to a wound 25th Jul 2014

Hi my dog recently cut her leg I've been bathing it but this morning the paw looks a little inflamed it's not a big wound but I'm wondering if synulox would be good for this thank you

John Cousins
  • Veterinary Surgeon at VioVet

Synukox and all other antibiotics are prescription only in the UK so you can only buy some from us if you send us a prescription from your vet. This is because a vet should decide upon examining your dog whether or not antibiotics are appropriate. Very often they are not required, but sometimes they can be very important. Your vet is best able to assess this, much as we would like to help.

My tomcat has been taking prescribed synulox 50 mg twice a day and since the first pill.. 9th Jul 2014

My tomcat is eating scarcely since the first pill.. I am asking if the drug synulox has as a side-effect the lack/diminishing of appetite. Thank you!

John Cousins
  • Veterinary Surgeon at VioVet

Loss of appetite is not normally a side effect of Synulox. I think it is much more likely that an underlying illness is the cause. It would be best to get him checked again with your own vet.

Prescription 8th Oct 2013

do isitsmy dog need a presciption he is prone to anal absesses and has one at present l have a few tablet left from previous vet v

John Cousins
  • Veterinary Surgeon at VioVet

Sorry but we cannot sell this product without a prescription, whatever the situation.