Optimmune Ophthalmic Ointment for Dogs

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Optimmune is an eye ointment containing cyclosporin and is used to treat recurrent conjunctivitis resulting from autoimmune disease of the eye in dogs. These include Dry Eye (keratoconjunctivitis sicca or KCS) and Pannus (chronic superficial keratits). Ointment should be used twice daily and is usually required life-long. Cases of Dry Eye will usually respond with increased tear production after about 10 days, but it can take 6 weeks for the full effect to be achieved. Pannus might not need treatment all year round because it is partly triggered by UV light. Antibiotic or steroid drops are sometimes used with Optimmune. It is important to try and maintain treatment without a pause, to prevent progression of the underlying diseases.

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  • 3.5g Tube
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Qualitative and quantitative composition

Active Ingredient

Ciclosporin 2.0 mg/g

Pharmaceutical form

Eye Ointment

A translucent colourless to light yellow ointment.

Clinical particulars

Target species

Dogs

Indications for use

For the treatment of chronic, recurrent conjunctivitis resulting from autoimmune disease of the eye. Indicated for the therapeutic treatment of Keratoconjunctivitis sicca (KCS, ‘dry eye’) and chronic superficial keratitis (‘pannus’) in the dog.

May be used to augment topical corticosteroids or as a substitute for corticosteroids when these are contraindicated by corneal ulceration.

Contra-indications

Do not use where fungal or viral infection of the eye is suspected.

Special warnings for each target species

Clinical experience has shown than 90% of dogs affected with KCS will require life-long therapy. However, if therapy is maintained, the prognosis is good providing that regular clinical assessment is conducted.

Similarly, chronic superficial keratitis may require continuous therapy although, as the condition is exacerbated by ultraviolet light, requirement for treatment may be suspended or reduced at certain times of the year.

In the treatment of KCS, it is important that continuous treatment is maintained. Studies have shown that stimulation of tear production ceases within 24 hours of withdrawing treatment.

Increase in tear production is expected within 10 days but may not be maximal until 6 weeks from commencement of treatment.

Special precautions for use

For external topical use only.

Care should be taken to avoid contamination of the contents during use.

Replace cap between applications.

User warnings

Avoid contact with skin.

Wear gloves when applying the ointment

Wash hands after use.

Adverse reactions

Mild irritation in the first few days of therapy may occur. If such irritation persists, treatment should be discontinued.

Inflammation and swelling of the skin of the lids has been reported in a very few cases. This seems to be associated with overflow of excess ointment. Reduction of the quantity of ointment has resulted in resolution.

Use during pregnancy or lactation

Do not administer to pregnant bitches.

Studies to demonstrate safety in pregnant bitches have not been conducted.

Interactions

None known.

Amounts to be administered and administration route

For topical administration to the conjunctival sac.

Apply a small amount of ointment (approximately ¼ inch or ½ cm) into the affected eye(s) every 12 hours.

Any excessive discharge in the eye should be removed prior to application of the ointment by gently cleansing or flushing the eye with a suitable non-irritating solution.

Overdose

Inflammation and swelling of the skin of the lids has been reported in a very few cases. This seems to be associated with overflow of excess ointment. Reduction of the quantity of ointment has resulted in resolution.

For animal treatment only. Keep out of the reach and sight of children.

Withdrawal periods

N/A

Pharmacological particulars

ATC Vet Code: QS01XA18

Pharmacotherapeutic group: Ophthalmologicals, other opthalmologicals

Optimmune is a pharmaceutically stable sterile ointment containing 0.2% Ciclosporin A. Administration of the ointment improves chronic diseases of the cornea and conjunctiva resulting from autoimmune disease such as keratoconjunctivitis sicca (KCS, dry eye), chronic superifical keratitis (pannus), and plasmacytic infiltration of the nictitans (‘plasmoma’) in dogs. To be applied topically to each affected eye.

Ciclosporin A is an immunomodulator nonpolar cyclic oligopeptide with lacrimominetic and anti-inflammatory activities. It is produced by the fungus species Tolypocladium inflatum gans. It is a highly lipophilic drug and is absorbed into the cornea in high concentrations. Ciclosporin A also penetrates the lacrimal gland following administration.

Ciclosporin A exerts its immunosuppressive and anti-inflammatory effects by inhibiting the production of cytokines which up-regulate T-helper cell activity. This restores the function of lacrimal acinar epithelium under autoimmune attack and reduces infiltration of ocular tissues by inflammatory cells. In addition to its immunosuppressive activity, Ciclosporin A exerts a direct lacrimomimetic effect by blocking the inhibition of tear production by prolactin.

Optimmune thus increases the flow of tears identical to natural tear secretions. As well as lubrication and wetting, epithelial growth factors and other components of tears are necessary for maintenance of corneal health. Studies have demonstrated that long term use of Optimmune does not increase susceptibility of the eye to microbial infection.

Pharmaceutical particulars

Excipients

Petrolatum Lanolin Alcohol

Maize Oil

Paraffin, White Soft

Major incompatibilities

None known.

Shelf life

Shelf-life of the veterinary medicinal product as packaged for sale: 2 years.

Shelf-life after first opening the immediate packaging: 1 month.

Special precautions for storage

Do not store above 25°C. Do not freeze.

Any contents remaining one month after the date on which the container was first opened should be discarded.

Care should be taken to avoid contamination of the contents during use.

Replace cap between applications.

Immediate packaging

Pack size: 3.5g tube in a cardboard carton

Container:Epoxy-phenol lacquered aluminium aluminium tube with high density polyethylene nozzle

Closure:Tamper-evident high density polyethylene cap, screw fit.

Disposal

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed in accordance with local requirements.

Marketing authorisation number

Vm 01708/4589.

Date of the first authorisation or date of renewal

9th June 1994

Date of revision of the text

August 2012.

Any other information

Nil

Legal category

POM-V

Need help or advice? Contact us:

  • Freephone: 0800 084 2608
  • Mon - Fri: 8:30am - 7:00pm
  • Sat: 10:00am - 3:00pm
  • Email: support@viovet.co.uk

All prices include VAT where applicable.

Information regarding the safe use of all licensed medication supplied in the UK can be found on the Veterinary Medicine Directorate website. Follow this link and then search for the brand name of the product to find the official Summary of Product Characteristics for that product. Unlicensed medication, such as herbal supplements, will not be found here and there is no such formal recognition of any scientifically proven therapeutic effects from any unlicensed medication.

Summary of Customer Ratings & Reviews for Optimmune Ophthalmic Ointment for Dogs

Overall Rating:
4.8 out of 5
  • Effectiveness
    4.8 out of 5
  • Ease Of Use
    4.4 out of 5
  • Value For Money
    4.8 out of 5
  • Absence Of Side Effects
    4.8 out of 5

5 out of 5 (100%) customers would recommend this product.

5 stars
4 reviews
4 stars
1 reviews
3 stars
0 reviews
2 stars
0 reviews
1 star
0 reviews

Have you tried this product? Write a review and help others!

Write a Review!
5 out of 5

My Dog will not go Blind

17th August 2014
  • VioVet Customer Since: June 2014
  • From: Somerset, United Kingdom

Optimmune is saving her sight. My GSD was about to lose one eye. Now she is seeing clearly . This is very expensive ointment but with VioVet I can buy it at half price. She will need this for the rest of her life. VioVet is friendly and helpful. Ginger does not appear to have any side effects. Thank you so very much. A life saver for both of us.

  • Effectiveness
    5 out of 5
  • Ease Of Use
    4 out of 5
  • Value For Money
    5 out of 5
  • Absence Of Side Effects
    5 out of 5
Miss P Harrison would recommend this to a friend!
Number of people who found this review helpful:
4 out of 5

Hassle free service

16th August 2014
  • VioVet Customer Since: July 2014
  • From: Berkshire, United Kingdom

Product seems to be working for my dog with 'dry eye' though early days for us! Ordered product, faxed prescription, came within 24 hours, more to come on same prescription so if as easy next time, brilliant. Hassle free!

  • Effectiveness
    4 out of 5
  • Ease Of Use
    3 out of 5
  • Value For Money
    4 out of 5
  • Absence Of Side Effects
    4 out of 5
Lin would recommend this to a friend!
Number of people who found this review helpful:
5 out of 5

A real life-saver

28th July 2014
  • VioVet Customer Since: September 2012
  • From: Staffordshire, United Kingdom
  • Pet's Name: Gizmo
  • Species: Dog
  • Breed: Pekingese

Gizmo was diagnosed with Dry Eye two years ago, and there are very few treatment options - but left untreated, it can often cause blindness. Optimmune is an excellent agent that has vastly increased Gizmo's tear production, and Viovet sell it at less than half what my vet sells it for - which is good, because it is a life-long treatment

  • Effectiveness
    5 out of 5
  • Ease Of Use
    5 out of 5
  • Value For Money
    5 out of 5
  • Absence Of Side Effects
    5 out of 5
Matthew Webber would recommend this to a friend!
Number of people who found this review helpful:
5 out of 5

A God send

28th July 2014
  • VioVet Customer Since: December 2010
  • From: Suffolk, United Kingdom

My dog is Diabetic and developed eye problems that my vet says she will need this cream twice a day for the rest of her life. It cleared her condition very quickly and maintains her eyes in a trouble free way. The price I would have to buy this ointment from my vet is well over double the price Viovet charges, so even paying for a prescription from my vet to buy this here I save money. The service I get here is second to none.

  • Effectiveness
    5 out of 5
  • Ease Of Use
    5 out of 5
  • Value For Money
    5 out of 5
  • Absence Of Side Effects
    5 out of 5
Doris Walker would recommend this to a friend!
Number of people who found this review helpful:
5 out of 5

Excellent price

6th March 2014
  • VioVet Customer Since: August 2013
  • From: Merseyside, United Kingdom

My dog has needed this eye ointment for about 6 years now due to having an antibiotic that then caused his eye problem!! I have been paying my vet a ridiculous price until now. Viovet offer this at a great reduction in price and the service is excellent. Ordered yesterday mid afternoon and received this morning. Many thanks.

  • Effectiveness
    5 out of 5
  • Ease Of Use
    5 out of 5
  • Value For Money
    5 out of 5
  • Absence Of Side Effects
    5 out of 5
Sharon M would recommend this to a friend!
Number of people who found this review helpful:
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Questions & Answers for Optimmune Ophthalmic Ointment for Dogs

Below are some recent questions we've received regarding Optimmune Ophthalmic Ointment for Dogs, including answers from our team.

Opimmune 15th Jul 2014

Do I need a prescription ?

  • Product Management Team at VioVet

Yes, Optimmune Ophthalmic does require a prescription for supply.

How long will a tube last? 29th Jan 2014

Roughly howlong would a tube of Optimmune last?

John Cousins
  • Veterinary Surgeon at VioVet

The dose you use of Optimmune is supposed to be controlled by the length of the line you squeeze onto the eye. This then governs also how long the tube lasts. On average you will get about 1 month from a tube if you are careful about not wasting any and apply a small amount (a quarter of a cm is the minimum recommended dose, twice daily. Theoretically the shelf life is supposed to be 1 month after opening, due to the potential for contamination etc. You are advised to not use any left over after 1 month, though many people do not stick to this.

Suitable for cats ? 13th Sep 2013

  • VioVet Customer Since: October 2010
  • From: Dorset, United Kingdom

Our vet has given us a prescription for this eye ointment to be used on our elderly cat. Is this OK as it states it is for dogs?

John Cousins
  • Veterinary Surgeon at VioVet

Optimmune is only licensed for use in dogs, however there is no medication of this type which is licensed for use in cats. Therefore if your vet considers that your cat would benefit from this medication, there is no option but to use a dog or human product. You and your vet need to make a judgment about safety and effectiveness. The normal level of certainty is not possible in this case, or in many similar situations.