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Milbemax Worming Tablets for Dogs & Cats

Milbemax Worming Tablets for Dogs & Cats

Milbemax is a safe and effective multi-wormer for dogs and cats, available in three different forms. There are small, easy to swallow tablets available for cats and for dogs. These are designed to be placed directly into the animals mouth. There are also chewable tablets available for dogs, which can be offered as treats or in a meal. Milbemax can be used for the treatment of mixed infections by tapeworms, roundworms, lungworms and eye worm, as well as the prevention of heartworm and angiostrongylosis. There are a number of different dosing schedules used, depending on the type of worm being targeted and the degree of risk of infection.

Description

Milbemax Tablets for Small Cats and Kittens/Milbemax Tablets for Cats

Presentation

MILBEMAX* tablets for Small cats and kittens: Film coated tablet. Oblong shaped, beige to brown, artificial beef flavoured tablet with a score on both sides, containing 4mg of Milbemycin oxime and 10mg Praziquantel per tablet. One side bears the imprint "BC", the other side "NA".

MILBEMAX* tablets for Cats: Film coated. Oblong shaped, reddish to reddish brown, artificial beef flavoured tablets with a score on both sides, containing 16mg of Milbemycin oxime and 40mg Praziquantel. One side bears the imprint "KK", the other side "NA".

Uses

In cats: treatment of mixed infections by immature and adult cestodes and nematodes of the following species:

Cestodes: Dipylidium caninum, Taenia spp., Echinococcus multilocularis

Nematodes: Toxocara cati, Ancylostoma tubaeforme

Prevention of heartworm disease (Dirofilaria immitis) if concomitant treatment against cestodes is indicated.

Dosage and administration

MILBEMAX tablets are administered at a minimum recommended dose rate of 2 mg milbemycin oxime and 5 mg praziquantel per kg body weight, given orally as a single dose.

The product should be administered with or after some food. Doing so ensures optimum protection against heartworm disease.

Depending on the bodyweight of the cat, the practical dosing is as follows:

Weight

MILBEMAX tablets for small cats and kittens

MILBEMAX tablets for cats

0.5 – 1 kg

½ tablet

> 1 – 2 kg

1 tablet

> 2 – 4 kg

½ tablet

> 4 – 8 kg

1 tablet

> 8 – 12 kg

1 ½ tablets

MILBEMAX can be inserted into a programme for prevention of heartworm disease if at the same time treatment against tapeworms is indicated. MILBEMAX has a duration of heartworm prevention of one month. For regular prevention of heartworm disease the use of a monosubstance is preferred.

Contra-indications, warnings, etc

Do not use the ‘tablets for small cats and kittens’ in cats of less than 6 weeks of age and/or weighing less than 0.5 kg

Do not use the ‘tablets for cats’ in cats weighing less than 2 kg.

Pregnancy and lactation

MILBEMAX can be used in breeding cats including pregnant and lactating queens.

Precautions for use

As per good veterinary practice, animals should be weighed to ensure accurate dosing.

Echinococcosis represents a hazard for humans. In case of Echinococcosis, specific guidelines on the treatment and follow up and on the safeguard of persons have to be followed. Experts or institutes of parasitology should be consulted.

No studies have been performed with severely debilitated cats or individuals with seriously compromised kidney or liver function. The product is not recommended for such animals or only according to a benefit/risk assessment by the responsible veterinary surgeon.

In very rare occasions, especially in young cats, systemic signs (such as lethargy), neurological signs (such as ataxia and muscle tremors) and/or gastrointestinal signs (such as emesis and diarrhoea) have been observed after administration of the veterinary medicinal product.

In case of overdose, in addition to signs observed at the recommended dose drooling was observed. This sign will usually disappear spontaneously within a day.

For animal treatment only.

Wash hands after use.

In the event of accidental ingestion of the tablets, particularly by a child, seek medical advice immediately and show the package leaflet or the label to the doctor.

Storage precautions

Do not store above 25°C.

Keep blister in the outer carton to protect from light.

Shelf-life of the veterinary medicinal product as packaged for sale: 3 years.

Shelf-life after first opening of the immediate packaging: 6 months.

Keep out of the reach and sight of children.

Disposal

Any unused product or waste material should be disposed of in accordance with national requirements.

The product should not enter water courses as this may be dangerous for fish and other aquatic organisms.

Legal category

POM-V

Packaging Quantities

Milbemax tablets for small cats and kittens: Box of 5 blisters with 10 tablets in each blister AND box of 2 blisters with 2 tablets in each blister.

Milbemax tablets for cats: Box of 5 blisters with 10 tablets in each blister AND box of 2 blisters with 2 tablets in each blister.

Further information

Milbemycin oxime belongs to the group of macrocyclic lactones and is active against mites, against larval and adult stages of nematodes as well as against larvae of Dirofilaria immitis.

The concurrent use of MILBEMAX with selamectin is well tolerated. No interactions were observed when the recommended dose of the macrocyclic lactone selamectin was administered during treatment with MILBEMAX at the recommended dose. In the absence of further studies, caution should be taken in the case of concurrent use of MILBEMAX and other macrocyclic lactones. Also, no such studies have been performed with reproducing animals.

Praziquantel is an acylated pyrazino-isoquinoline derivative active against cestodes and trematodes.

MILBEMAX is effective against Dirofilaria imitis, which is endemic in the USA and some parts of continental Europe. The product is also effective against Echinococcus multilocularis which is endemic in some parts of continental Europe and prophylactic treatment is required in all pets entering the UK under the PETS scheme or under quarantine conditions.

Marketing authorisation numbers

MILBEMAX tablets for small cats and kittens

Vm 12501/4134

MILBEMAX tablets for cats

Vm 12501/4135

Milbemax Tablets for small dogs and puppies/Milbemax Tablets for dogs

Presentation

MILBEMAX Tablets for Small dogs and puppies: Oblong shaped, white, with a score on both sides, containing 2.5mg of Milbemycin oxime and 25mg Praziquantel per tablet. One side bears the imprint ``AA'', the other side ``NA''.

MILBEMAX Tablets for Dogs: Round shaped, white, containing 12.5mg Milbemycin oxime and 125mg Praziquantel per tablet. One side bears the imprint "CCA", the other side "NA".

Uses

In dogs: treatment of mixed infections by adult cestodes and nematodes of the following species:

Cestodes: Dipylidium caninum, Taenia spp., Echinococcus spp., Mesocestoides spp

Nematodes: Toxocara canis, Toxascaris leonina, Ancylostoma caninum, Trichuris vulpis.

Crenosoma vulpis(reduction of the level of infection),

Angiostrongylus vasorum (reduction of the level of infection; see specific treatment schedule under dosage and administration).

The product can also be used in the prevention of heartworm disease (Dirofilaria immitis), if concomitant treatment against cestodes is indicated.

Dosage and administration

Minimum recommended dose rate: 0.5 mg milbemycin oxime and 5 mg praziquantel per kg are given orally as a single dose.

The product should be administered with or after some food.

Depending on the bodyweight of the dog, the practical dosing is as follows:

Weight

MILBEMAX tablets for small dogs and puppies

MILBEMAX

tablets for dogs

0.5 – 1 kg

½ tablet

> 1 - 5 kg

1 tablet

>5 – 10 kg

2 tablets

1 tablet

>5 – 25 kg

1 tablet

> 25 – 50 kg

2 tablets

> 50 – 75 kg

3 tablets

In cases where heartworm disease prevention is used and at the same time treatment against tapeworm is required, MILBEMAX can replace the monovalent product for the prevention of heartworm disease.

For Angiostrongylus vasorum infection, milbemycin oxime should be given four times at weekly intervals. It is recommended, where concomitant treatment against cestodes is indicated, to treat once with MILBEMAX and continue with the monovalent product containing milbemycin oxime alone, for the remaining three weekly treatments.

Contra-indications, warnings, etc

Do not use the ‘tablets for small dogs and puppies’ in dogs of less than 2 weeks of age and/or weighing less than 0.5 kg

Do not use the ‘tablets for dogs’ in dogs weighing less than 5 kg.

See also "Precautions for use".

Studies with milbemycin oxime indicate that the margin of safety in certain dogs of Collie or related breeds is less than in other breeds. In these dogs, the recommended dose should be strictly observed.

The tolerance of MILBEMAX in young puppies from these breeds has not been investigated. Clinical signs in Collies are similar to those seen in the general dog population when overdosed.

Precautions for use

As per good veterinary practice, animals should be weighed to ensure accurate dosing.

Treatment of dogs with a high number of circulating microfilariae can sometimes lead to the appearance of hypersensitivity reactions, such as pale mucous membranes, vomiting, trembling, laboured breathing or excessive salivation. These reactions are associated with the release of proteins from dead or dying microfilariae and are not a direct toxic effect of the product. The use in dogs suffering from microfilaremia is thus not recommended.

In heartworm risk-areas, or in the case it is known that a dog has been travelling to and from heartworm risk regions, before using MILBEMAX, a veterinary consultation is advised to exclude the presence of any concurrent infestation of Dirofilaria immitis. In the case of a positive diagnosis, adulticidal therapy is indicated before administering MILBEMAX.

Echinococcosis represents a hazard for humans. In case of Echinococcosis, specific guidelines on the treatment and follow up and on the safeguard of persons have to be followed. Experts or institutes of parasitology should be consulted.

No studies have been performed with severely debilitated dogs or individuals with seriously compromised kidney or liver function. The product is not recommended for such animals or only according to a benefit/risk assessment by the responsible veterinarian.

In dogs less than 4 weeks old, tapeworm infection is unusual. Treatment of animals less than 4 weeks old with a combination product may therefore not be necessary.

Parasite resistance to any particular class of anthelmintic may develop following frequent, repeated use of an anthelmintic of that class.

In very rare occasions, systemic signs (such as lethargy), neurological signs (such as muscle tremors and ataxia) and/or gastrointestinal signs (such as emesis, diarrhoea, anorexia and drooling) have been observed in dogs after administration of the veterinary medicinal product. No other signs than those observed at the recommended dose have been observed.

For animal treatment only.

Wash hands after use.

In the event of accidental ingestion of the tablets, particularly by a child, seek medical advice and show the package leaflet or the label to the doctor.

Pregnancy and lactation

MILBEMAX can be used in breeding dogs including pregnant and lactating bitches.

Storage precautions

Do not store above 30°C.

Keep blister in the outer carton to protect from light.

Keep out of the reach and sight of children.

Disposal

Any unused product or waste material should be disposed of in accordance with national requirements.

This product should not come into contact with water courses as this may be dangerous for fish and other aquatic organisms.

Legal category

POM-V

Packaging Quantities

Milbemax tablets for small dogs and puppies: Box of 5 blisters with 10 tablets in each blister AND box of 2 blisters with 2 tablets in each blister.

Milbemax tablets for dogs: Box of 5 blisters with 10 tablets in each blister AND box of 2 blisters with 2 tablets in each blister.

Further information

Milbemycin oxime belongs to the group of macrocyclic lactones and is active against mites, against larval and adult stages of nematodes as well as against larvae of Dirofilaria immitis.

The concurrent use of MILBEMAX with selamectin is well tolerated. No interactions were observed when the recommended dose of the macrocyclic lactone selamectin was administered during treatment with MILBEMAX at the recommended dose. In the absence of further studies, caution should be taken in the case of concurrent use of MILBEMAX and other macrocyclic lactones. Also, no such studies have been performed with reproducing animals.

Praziquantel is an acylated pyrazino-isoquinoline derivative active against cestodes and trematodes.

MILBEMAX is effective against Dirofilaria imitis, which is endemic in the USA and some parts of continental Europe. The product is also effective against Echinococcus multilocularis which is endemic in some parts of continental Europe and prophylactic treatment is required in all pets entering the UK under the PETS scheme or under quarantine conditions.

Marketing authorisation numbers

MILBEMAX tablets for small dogs and puppies

Vm 12501/4132

MILBEMAX tablets for dogs

Vm 12501/4133

Milbemax chewable tablets for small dogs and puppies / Milbemax chewable tablets for dogs

Presentation

MILBEMAX chewable tablets for small dogs and puppies: Oval shaped, dark brown, chewable tablet, containing milbemycin oxime 2.5 mg and praziquantel 25.0 mg.

MILBEMAX chewable tablets for dogs: Oval shaped, dark brown, chewable tablet, containing milbemycin oxime 12.5 mg and praziquantel 125.0 mg.

Uses

In dogs: treatment of mixed infections by adult cestodes and nematodes of the following species:

Cestodes: Dipylidium caninum, Taenia spp., Echinococcus spp., Mesocestoides spp

Nematodes: Anclystoma caninum, Toxocara canis, Toxascaris leonina, Trichuris vulpis.

Crenosoma vulpis (reduction of the level of infection), Angiostrongylus vasorum - Prevention & Treatment (Reduction of the level of infection by immature adult (L5) and adult parasite stages - see specific treatment and disease prevention schedules under Dosage and administration)

Thelazia callipaeda (see specific treatment schedule under Dosage and administration) The product can also be used in the prevention of heartworm disease (Dirofilaria immitis), if concomitant treatment against cestodes is indicated.

Dosage and administration

Minimum recommended dose rate: 0.5 mg of milbemycin oxime and 5 mg of praziquantel per kg are given once orally.

The product should be administered with or after some food.

Depending on the bodyweight of the dog, the practical dosing is as follows:

Weight

MILBEMAX chewable tablets

for small dogs and puppies

MILBEMAX chewable

tablets for dogs

1 - 5 kg

1 tablet

5 – 25 kg

1 tablet

> 25 – 50 kg

2 tablets

> 50 – 75 kg

3 tablets

In cases where heartworm disease prevention is used and at the same time treatment against tapeworm is required, the product can replace the monovalent product for the prevention of heartworm disease.

For treatment of Angiostrongylus vasorum infections, milbemycin oxime should be given four times at weekly intervals. It is recommended, where concomitant treatment against cestodes is indicated, to treat once with the product and continue with the monovalent product containing milbemycin oxime alone, for the remaining three weekly treatments.

In endemic areas administration of the product every four weeks will prevent angiostrongylosis by reducing immature adult (L5) and adult parasite burden, where concomitant treatment against cestodes is indicated.

For the treatment of Thelazia callipaeda, milbemcyin oxime should be given in 2 treatments, seven days apart. Where concomitant treatment against cestodes is indicated, MILBEMAX can replace the monovalent product containing milbemycin oxime alone.

Contra-indications, warnings, etc

Do not use either strength of tablet in dogs weighing less than 1 kg. Do not use MILBEMAX Chewable Tablets for Dogs in dogs weighing less than 5 kg.

Do not use in case of hypersensitivity to the active substances or to any of the excipients.

Studies with milbemycin oxime indicate that the margin of safety in certain dogs of Collie, or related breeds, is less than in other breeds. In these dogs, the recommended dose should be strictly observed.

The tolerance of the product in young puppies from these breeds has not been investigated. Clinical signs in Collies are similar to those seen in the general dog population when overdosed.

Precautions for Use

Treatment of dogs with a high number of circulating microfilariae can sometimes lead to the appearance of hypersensitivity reactions, such as pale mucous membranes, vomiting, trembling, laboured breathing or excessive salivation. These reactions are associated with the release of proteins from dead or dying microfilariae and are not a direct toxic effect of the product. The use in dogs suffering from microfilaremia is thus not recommended.

In heartworm risk-areas, or in cases where it is known that a dog has been travelling to and from heartworm risk regions, before using MILBEMAX, a veterinary consultation is advised to exclude the presence of any concurrent infestation of Dirofilaria immitis. In the case of a positive diagnosis, adulticidal therapy is indicated before administering the product.

Echinococcosis represents a hazard for humans. In case of Echinococcosis, specific guidelines on the treatment and follow up and on the safeguard of persons have to be followed. Experts or institutes of parasitology should be consulted.

No studies have been performed with severely debilitated dogs or individuals with seriously compromised kidney or liver function. The product is not recommended for such animals or only according to a benefit/risk assessment by the responsible veterinarian.

In dogs less than 4 weeks old, tapeworm infection is unusual. Treatment of animals less than 4 weeks old with a combination product may therefore not be necessary.

Parasite resistance to any particular class of anthelmintic may develop following frequent, repeated use of an anthelmintic of that class.

In very rare occasions, systemic signs (such as lethargy), neurological signs (such as muscle tremors and ataxia) and/or gastrointestinal signs (such as emesis, drooling, diarrhoea and anorexia) have been observed in dogs after administration of MILBEMAX.

The adverse reactions observed following an overdose are the same as those observed at the recommended dose but more pronounced.

Interaction with other medicinal products and other forms of interaction The concurrent use of the product with selamectin is well tolerated. No interactions were observed when the recommended dose of the macrocyclic lactone selamectin was administered during treatment with the product at the recommended dose. In the absence of further studies, caution should be taken in the case of

concurrent use of the product and other macrocyclic lactones. Also, no such studies have been performed with reproducing animals.

User warnings

Wash hands after use.

In the event of accidental ingestion of the tablets, particularly by a child, seek medical advice immediately and

show the package leaflet or the label to the doctor.

Pregnancy and lactation

Milbemax can be used in pregnant and lactating bitches and in breeding animals.

Environmental warnings

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product

should be disposed of in accordance with local requirements.

MILBEMAX chewable tablets should not enter water courses as this may be dangerous for fish and other aquatic organisms.

Pharmaceutical precautions

Do not store above 25°C.

Shelf life of the veterinary medicinal product as packaged for sale: 2 years.

Keep out of the reach and sight of children

Legal category

POM-V

Packaging Quantities

Box with 1 blister or strip of 2 tablets

Box with 1 or 12 blisters of 4 tablets

Not all pack sizes may be marketed.

Further information

Milbemycin oxime belongs to the group of macrocyclic lactones and is active against mites, against larval and adult stages of nematodes as well as against larvae of Dirofilaria immitis. Praziquantel is an acylated pyrazino-isoquinoline derivative active against cestodes and trematodes.

MILBEMAX is effective against Dirofilaria immitis, which is endemic in the USA and some parts of continental Europe. The product is also effective against Echinococcus multilocularis which is endemic in some parts of continental Europe and prophylactic treatment is required in all pets entering the UK under the PETS scheme or under quarantine conditions.

Marketing authorisation numbers

MILBEMAX chewable tablets for Small Dogs and Puppies Vm 12501/4170

MILBEMAX chewable tablets for Dogs Vm 12501/4169

GTIN (Global Trade Item No)

MILBEMAX CHEWY 2.5/25MG TAB PK ST 05037694053239

MILBEMAX CHEWY 12.5/125MG TAB 4 PK ST 05037694053246

MILBEMAX CHEWY 2.5/25MG TAB 4 X 12 ST 05037694053215

MILBEMAX CHEWY 12.5/125MG TAB 4 X 12 ST 05037694053222

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Questions & Answers for Milbemax Worming Tablets for Dogs & Cats

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Shelf-life of Milbemax

9th May 2014
Debi Goodchild
  • VioVet Customer Since: May 2014
  • From: Cambridgeshire, United Kingdom

What is the shelf-life of Milbemax Worming Tablets? If I buy a years supply in one go will the use-by date run out?

John Cousins
  • Veterinary Surgeon at VioVet

These tablets generally have a 2 year date from manufacture I believe. They will be manufactured in batches and released gradually to wholesalers, who then release them over a period. This means that there is rarely 2 years left by the time you get them I have just checked and the stock we now hold has an expiry date in March 2015. (This is clearly written on the blister packaging of every single tablet, so there can be no confusion after supply to the customer.) When you place an order with us you can request long expiry dates, but we will be governed by what we are supplied with. We tend to get through our stocks quickly, so the next batch we get in may have a longer date.

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