An aqueous inactivated vaccine containing antigens of rotavirus (strains 1005/78 and Holland), coronavirus (strain 800) and E. coli K99/F41. The vaccine contains aluminium hydroxide and saponin (Quil A) as adjuvants and thiomersal as a preservative.

For the immunisation of pregnant cows and heifers in order to confer passive protection to their calves (via colostrum) to reduce the severity and duration of neonatal diarrhoea caused by rotavirus, coronavirus and E. coli infections.
Protection is conferred only while the calves are fed colostrum from vaccinated cows.

Dose
5 ml by subcutaneous injection in the side of the neck, observing aseptic precautions.
Vaccination schedule
All cows in a herd should receive two injections of 5 ml during the later stages of pregnancy, with an interval of 4-5 weeks between doses and allowing 2-3 weeks from the time of the second dose until the predicted date of calving.
Booster injection
During each subsequent pregnancy previously vaccinated cows should receive a single injection of 5 ml 2-6 weeks prior to predicted calving date.
Passive immunisation
In order to attain local passive immunisation within the intestine against neonatal diarrhoea, the newborn calves must receive sufficient quality colostrum and milk from the vaccinated dams during the first 10 to 14 days of life. For calves born to beef cows this can be achieved by allowing the calf to suckle naturally. Calves born to dairy cows often do not receive sufficient colostrum if suckled naturally, so artificial feeding of colostrum (e.g. via oesophageal tube feeders) should be used.
The vaccine bottle/vial must be shaken before use.
Multi-dose containers must be used within 1 day after opening so as to avoid contamination of the vaccine and subsequent loss of activity.

Do not use in animals which have intercurrent infection or are in poor nutritional status.
Immunisation may rarely result in temporary swellings at the injection site (ranging from small nodules of approximately 1cm in diameter to swellings of 20 cm diameter in extreme cases). Typically, these swellings completely disappear or reduce to a negligible size within 2-4 weeks after vaccination, though in individual animals very small reactions remain longer. Additionally, a transient slight rise in body temperature normally decreasing to a non-significant level within one day may be expected.
Only vaccinate immuno-competent animals.
The vaccine can be used during pregnancy.
No information is available on the safety and efficacy from the concurrent use of Lactovac with any other product. It is therefore recommended that no other products (including injectable nutritional supplements) should be administered to the cow within 14 days before or after vaccination with the product.
Do not mix with any other vaccine/immunological product.
Withdrawal period
Zero days
For animal treatment only. Keep out of reach and sight of children.

Store at +2°C to +8°C in the dark. Do not freeze.
After broaching the vial, the vaccine should be used within 10 hours.
Partially used containers must be discarded at the end of each day's operations.
Any unused product or waste material should be disposed of in accordance with national requirements.

POM-V

25 ml glass bottle.

Protection of the herd
Neonatal diarrhoea in calves is caused by pathogens which are constantly present in the herd. For this reason proper control measures require that all pregnant cows and heifers in a herd must be included in the programme of immunisation. This is the only way in which the pressure of infection can be reduced.
Herd hygiene
Neonatal diarrhoea in calves is often associated with poor hygiene. Thus, general improvements in hygiene are important to support the effect of vaccination.
Immune protection
Diarrhoeal diseases can have many causes. The vaccine induces high levels of antibody in the colostrum and milk against rotavirus and coronavirus as well as against E. coli, i.e. against the principal pathogens of neonatal diarrhoea in calves. The vaccine cannot be expected to provide protection against diarrhoeal diseases of other origins.
Feeding of colostrum
For optimal protection it has been shown that daily intake of colostrum is essential to the calf from birth to 2 weeks of age. All calves should be fed colostrum derived from the first milking, ideally within the first 6 hours of life. Calves should then either be left to suckle naturally for a minimum of 2 weeks or a colostrum feeding regime must be established. Any remaining quantities from the first milking and all the colostrum from the second milking should be pooled, aliquoted and stored deep frozen (-20ºC for maximal one year). Alternatively, these colostrum pools can be stored at about +4°C for about 2 weeks. Following the first suckling of colostrum from the dam by the calves, where the calves are separated from the dam, their feed must be supplemented with 500ml of pooled colostrum each day.