A clear, yellow aqueous solution for injection containing 100 mg per ml of oxytetracycline (as the hydrochloride). Antioxidant sodium formaldehyde sulphoxylate 5mg per ml.

The treatment of infections caused by organisms sensitive to oxytetracycline in horses, cattle, sheep, pigs, dogs and cats.
In vitro, oxytetracycline is active against a range of both Gram-positive and Gram-negative microorganisms including: Streptococcus spp., Staphylococcus spp., Listeria monocytogenes, Mannheimia haemolytica, Haemophilus parahaemolyticus, Bordetella bronchiseptica, and against Chlamydophila abortus (formerly Chlamydia psittaci), the causative organism of enzootic abortion in sheep.

DD=Dual Dosage. Engemycin 10% (DD) can be administered either at a low dose rate for a 24 hour duration of activity or at a high dose rate for prolonged duration of activity.
24 hour dosage regime
The recommended dosage rate is 3–10 mg/kg bodyweight (depending on age and species – see table), by intramuscular or intravenous injection in large animals, subcutaneous or intramuscular injection in small animals.
The treatment may be repeated at 24 hour intervals up to 4 times (5 treatments in all). Intravenous injections must be given slowly over a period of at least one minute.
Prolonged action dosage regime
10 or 20 mg/kg bodyweight depending on age and species (see table) by intramuscular injection only, repeated once after 48–60 hours if required. This dosage regime is not advised for use in horses, dogs or cats.

Engemycin 10% (DD) Dosage table
Animal	Weight	24 hour dosage		Prolonged action dosage
		Dose	Volume	Dose	Volume
	kg	mg/kg	ml	mg/kg	ml
Horse	500	5	25	Not recommended
Foal	100	10	10	Not recommended
Cow	500	3	15	10	50
Calf	100	8	8	20	20
Sow/boar	150	5	7.5	10	15
Pig	25	8	2	20	5
Sheep	50	8	4	20	10
Lamb	25	8	2	20	5
Dog	10	10	1	Not recommended
Cat	5	10	0.5	Not recommended

Prophylactic treatment of enzootic abortion in sheep
20 mg/kg administered about day 95–100 of gestation. A further treatment may be given 2–3 weeks later.
Before administration, clean the area of the injection site and swab with spirit.
Maximum recommended dose at any one site: 20 ml for cattle, 10ml for sheep and pigs.
Repeat doses should be administered at different sites, and the sites massaged well after injection.

Do not administer to horses during concomitant therapy with corticosteroids.
A transient swelling may be observed following intramuscular administration in horses and subcutaneous administration in dogs.
The use of tetracyclines during the period of tooth and bone development, including late pregnancy, may lead to discolouration.
Photodermatitis may occur after treatment if exposure to intense sunlight occurs.
Not for intravenous administration in dogs or cats.
It is not recommended to administer bacteriostatic and bactericidal antimicrobials concurrently.
Withdrawal periods
Animals must not be slaughtered for human consumption during treatment. Animals may be slaughtered for human consumption after the number of days stated below. Milk for human consumption must not be taken during treatment. Milk for human consumption may be taken from cows after the number of days stated below.
24 hour dose

Cattle milk	6 days
Cattle meat	35 days
Sheep	14 days
Pigs	14 days

Prolonged action dose

Cattle milk	6 days
Cattle meat	21 days
Sheep	14 days
Pigs	10 days

Not for use in sheep producing milk for human consumption.
Not for use in horses for human consumption.
Treated horses may never be slaughtered for human consumption.
The horse must have been declared as not intended for human consumption under national horse passport legislation.
For animal treatment only. Keep out of reach and sight of children.

Do not store above 25°C. Protect from light. Do not freeze. Keep container in outer carton.
Dilution with calcium salts is not recommended as this may lead to precipitation of crystals.
When the container is broached for the first time, calculate the discard date and write this in the space provided on the label. (A statement of the in-use shelf life of the product is given on the packaging insert, from which the discard date may be calculated.)
Dispose of any unused product and empty containers in accordance with guidance from your local waste regulation authority.

POM-V

Glass bottles or polyethylene terephthalate (PET) bottles containing 100 ml.

This product has been specifically formulated to reduce pain on injection without the need for addition of a local anaesthetic.
As with other tetracyclines, caution should be exercised in treating horses under stress.
Exercise caution in animals with renal or hepatic impairment.