Duphamox Antibiotic

Below is the product datasheet. This has been provided by the manufacturer and should always be provided with the medication.

Introduction

Company name: Pfizer Limited
Address: Ramsgate Road
Sandwich
Kent CT13 9NJ
Telephone: 0845 300 8034 (Out of hours: 01304 616161)
Fax: 01737 332521
Email: UKVetLine@pfizer.com
Website: www.pfizerah.co.uk

Presentation

Duphamox Palatable Tablets 40 mg are presented as off-white circular tablets scored on one face. Each tablet contains 40 mg amoxicillin as Amoxicillin Trihydrate in a highly palatable base.
Chemically, amoxicillin is 6-[D(-)-α-amino-p- hydroxyphenylacetamido] penicillanic acid.
The scoreline is intended to facilitate ease of swallowing and not to divide into equal doses.

Uses

Duphamox Palatable Tablets 40 mg are indicated for use only in cats and dogs for the treatment of infections of the alimentary tract, respiratory tract and urogenital tract and in eye, ear, skin and wound infections caused by susceptible organisms.
Duphamox is a broad-spectrum semi-synthetic penicillin, bactericidal in action. In vitro activity has been demonstrated against a wide range of Gram-positive and Gram-negative bacteria found in cats and dogs which include: Bacillus cereus, Bordetella bronchiseptica, Corynebacterium spp, Citrobacter freundii, Chromobacter spp, Escherichia coli, Flavobacter spp, Proteus mirabilis, Pasteurella spp, including P. multocida, Salmonella spp, Staphylococci (penicillin-sensitive strains) and Streptococci.

Dosage and administration

The recommended dosage rate is 10mg Amoxicillin/kg bodyweight (one tablet per 4kg bodyweight) twice daily for seven days. Tablets are given orally by hand or crushed in food. The following is intended as a guide:
Cats 1 × 40 mg tablet per 4 kg bodyweight twice daily for 7 days.
Dogs 2 × 40 mg tablets per 8 kg bodyweight twice daily for 7 days.
As high blood levels are achieved rapidly after oral dosing parenteral antibiotic treatment may not be necessary.
Duphamox Palatable Tablets 40mg are normally accepted from the hand. However for the treatment of fastidious animals the tablets may be crushed and added to a little food. Any remaining medicated feed should be disposed of at the end of the day.

Contra-indications, warnings, etc

FOR ANIMAL TREATMENT ONLY
Duphamox Palatable Tablets 40 mg should not be given to penicillin-sensitive animals.
As with other penicillins, Duphamox Palatable Tablets 40 mg should not be used orally or parenterally in rabbits, guinea pigs, gerbils and hamsters. Caution is advised when used in other very small herbivores.
Operator warning
Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross reactions to cephalosporins and vice versa. Allergic reactions to these substances may occasionally be serious.
1. Do not handle this product if you know you are sensitised, or if you have been advised not to work with such preparations.
2. Handle this product with great care to avoid exposure, taking all recommended precautions.
3. If you develop symptoms following exposure, such as a skin rash, you should seek medical advice and show the doctor this warning. Swelling of the face, lips or eyes or difficulty with breathing, are more serious symptoms and require urgent medical attention.
4. Wash hands after use.

Pharmaceutical precautions

Do not store above 25°C. Store in a dry place. Keep out of the reach of children.

Legal category

POM-V

Packaging Quantities

Duphamox Palatable Tablets 40 mg are supplied in plastic containers of 500 tablets.

Further information

After absorption, high levels of amoxicillin are found throughout the tissues especially in kidney, urine, liver and bile.
Amoxicillin provides rapid bactericidal action and due to its mode of action normally prevents recrudescence of sensitive respiratory infections. In common with other penicillins an absence of toxicity has been demonstrated even at very high dose levels.
It is not recommended to administer concurrently with bacteriostatic antibacterials.
No known contra-indication exists for use during pregnancy.
Disposal:
Dispose of any unused product and empty containers in accordance with guidance from your local waste regulation authority.

Marketing authorisation number

Vm 01596/4114.

Below is the product datasheet. This has been provided by the manufacturer and should always be provided with the medication.

Introduction

Company name: Pfizer Limited
Address: Ramsgate Road
Sandwich
Kent CT13 9NJ
Telephone: 0845 300 8034 (Out of hours: 01304 616161)
Fax: 01737 332521
Email: UKVetLine@pfizer.com
Website: www.pfizerah.co.uk

Presentation

Duphamox Palatable Tablets 200 mg are presented as off-white circular tablets scored on one face. The scoreline is intended to facilitate ease of swallowing and not to divide into equal doses. Each tablet contains 200 mg Amoxicillin as Amoxicillin Trihydrate BP in a highly palatable base.
Chemically, Amoxicillin is 6-[D(-)-α-amino-p- hydroxyphenylacetamido] penicillanic acid.

Uses

Duphamox Palatable Tablets 200 mg are indicated for use only in cats and dogs for the treatment of bacterial infections of the alimentary tract, respiratory tract and urogenital tract, eye, ear, skin and wound infections caused by susceptible organisms.
Duphamox is a broad-spectrum semi-synthetic penicillin, bactericidal in action. In vitro activity has been demonstrated against a wide range of Gram-positive and Gram-negative bacteria found in cats and dogs which include: Bacillus cereus, Bordetella bronchiseptica, Corynebacterium spp, Citrobacter freundii, Chromobacter spp, Escherichia coli, Flavobacter spp, Proteus mirabilis, Pasteurella spp, including P. multocida, Salmonella spp, Staphylococci (penicillin-sensitive strains) and Streptococci.

Dosage and administration

The recommended dosage rate is 10mg. Amoxicillin/kg bodyweight (one tablet per 20kg bodyweight) twice daily for seven days. Tablets are given orally, by hand or crushed in food.
The following is intended as a guide: dogs per 20 kg: 1×200 mg tablet twice daily for 7 days.
As high blood levels are achieved rapidly after oral dosing parenteral antibiotic treatment may not be necessary. However, where parenteral treatment is required, Duphamox injection is indicated and the tablets are valuable for use as follow-up therapy.
Duphamox Palatable Tablets 200 mg are normally accepted from the hand. However for the treatment of fastidious animals the tablets may be crushed and added to a little food.

Contra-indications, warnings, etc

FOR ANIMAL TREATMENT ONLY
Duphamox Palatable Tablets 200 mg should not be given to penicillin-sensitive animals.
As with other penicillins, Amoxicillin should not be used orally or parenterally in rabbits, guinea pigs, hamsters or gerbils. Caution is advised when used in other very small herbivores.
It is not recommended to administer concurrently with bacteriostatic antibacterials.
Operator warning
Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross reactions to cephalosporins and vice versa. Allergic reactions to these substances may occasionally be serious.
1. Do not handle this product if you know you are sensitised, or if you have been advised not to work with such precautions.
2. Handle this product with great care to avoid exposure, taking all recommended precautions.
3. If you develop symptoms following exposure, such as a skin rash, you should seek medical advice and show the doctor this warning. Swelling of the face, lips or eyes or difficulty with breathing, are more serious symptoms and require urgent medical attention.
4. Wash hands after use.

Pharmaceutical precautions

Keep out of the reach of children.
Do not store above 25°C. Store in a dry place.

Legal category

POM-V

Packaging Quantities

Duphamox Palatable Tablets 200 mg are supplied in plastic containers of 250 tablets.

Further information

After absorption, high levels of amoxicillin are found throughout the tissues especially in kidney, urine, liver and bile.
Amoxicillin provides rapid bactericidal action and due to its mode of action normally prevents recrudescence of sensitive respiratory infections.
In common with other penicillins an absence of toxicity has been demonstrated even at very high dose levels.
No known contra-indication exists for the use of Duphamox Palatable Tablets 200mg during pregnancy.
Dispose of any unused product or containers in accordance with guidance from your local waste regulation authority.

Marketing authorisation number

Vm 01596/4118.

Below is the product datasheet. This has been provided by the manufacturer and should always be provided with the medication.

Introduction

Company name: Pfizer Limited
Address: Ramsgate Road
Sandwich
Kent CT13 9NJ
Telephone: 0845 300 8034 (Out of hours: 01304 616161)
Fax: 01737 332521
Email: UKVetLine@pfizer.com
Website: www.pfizerah.co.uk
 

Presentation

Duphamox LA is a stable, injectable, off-white oily suspension containing 150 mg amoxicillin per ml as Amoxicillin Trihydrate Ph.Eur. Each ml also contains Butylated Hydroxyanisole Ph.Eur 0.08mg and Butylated Hydroxytoluene Ph.Eur 0.08mg as antioxidants.
 

Uses

Duphamox LA is indicated in the treatment and control of infections caused by organisms sensitive to amoxicillin.
Amoxicillin is a broad-spectrum semi-synthetic bactericidal in action for use in cattle, pigs, sheep, dogs and cats. In vitro it is effective against a wide range of Gram-positive and Gram-negative bacteria which include:
Escherichia coli, Klebsiella pneumoniae, Proteus mirablis, some Salmonella spp, Staphylococcus spp and Streptococcus spp (non penicillinase producing).
Not effective against beta-lactamase producing organisms. The product is suitable for the control of infections due to susceptible micro-organisms in cattle, sheep, pigs, dogs and cats where a single injection giving prolonged activity is required. It may also protect from secondary bacterial invasion due to sensitive organisms in cases where bacteria are not the initial cause of the disease. Indications include infections of: Alimentary tract; respiratory tract; skin and soft tissue; urogenital tract and in prevention of post-operative infections (treat before surgery).
 

Dosage and administration

Shake well before use. Administration is by the intramuscular route for cattle, sheep and pigs and by the intramuscular or subcutaneous route in dogs and cats. The recommended dosage rate is 15 mg/kg bodyweight repeatable if necessary after 48 hours. The product is recommended for single administration only. Massage the injection site after injection. If dose volume exceeds 20ml in cattle or 10ml in sheep and pigs, it should be divided and injected into two sites.
The suggested dosage rates are

Cattle	450 kg	45.0 ml
Sheep	65 kg	6.5 ml
Pigs	150 kg	15.0 ml
Dogs	20 kg	2.0 ml
Cats	5 kg	0.5 ml

Dose volume is equivalent to 1ml per 10kg bodyweight.
As with other injectable products, normal aseptic precautions should be observed. Use a dry syringe for extraction of suspension to avoid hydrolysis of amoxicillin.
An appropriately graduated syringe must be used to allow accurate administration of the required dose volume. This is particularly important when injecting small volumes.
 

Contra-indications, warnings, etc

FOR ANIMAL TREATMENT ONLY
Not for use in known cases of hypersensitivity to penicillin or cephalosporins.
Not suitable for intravenous or intrathecal use.
Should not be used in rabbits, hamsters, gerbils and guinea pigs.
Not effective against beta-lactamase producing organisms.
Occasional local tissue reaction may result from use of this product.
Milk for human consumption must not be taken from a cow during treatment. Milk for human consumption may only be taken after 60 hours from the last treatment.
Not for use in sheep producing milk for human consumption.
Animals must not be slaughtered for human consumption during treatment. Cattle, sheep and pigs may be slaughtered for human consumption only after 21 days from the last treatment.
Operator warning
Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross reactions to cephalosporins and vice versa. Allergic reactions to these substances may occasionally be serious.
1. Do not handle this product if you know you are sensitised, or if you have been advised not to work with such preparations.
2. Handle this product with great care to avoid exposure, taking all recommended precautions.
3. If you develop symptoms following exposure, such as a skin rash, you should seek medical advice and show the doctor this warning. Swelling of the face, lips or eyes or difficulty with breathing, are more serious symptoms and require urgent medical attention.
Wash hands after use.
 

Pharmaceutical precautions

Do not store above 25°C. Protect from light. Shake the container before use.
This product does not contain an antimicrobial preservative. Swab the septum before removing each dose. Use a dry, sterile needle and syringe.
Keep out of the reach of children.
Following withdrawal of the first dose, use the product within 28 days. Discard unused material.
When the container is broached (opened) for the first time, the date on which any product remaining in the container should be discarded should be calculated. A statement of the in-use shelf-life of the product is given on the package insert. This discard date should be written in the space provided on the label.
 

Legal category

POM-V
 

Packaging Quantities

Multidose vials of 50ml or 100 ml.
Not all pack sizes may be marketed.
 

Further information

After the administration of Duphamox LA, amoxicillin is absorbed and widely distributed in the body and high levels are found in kidney, urine, liver and bile.
Amoxicillin has a rapid bactericidal action which normally prevents the recrudescence of respiratory infections.
As with other penicillins, absence of toxicity is normally encountered. Animals with functional rumens should only be treated parenterally.
Disposal:
Dispose of any unused product and empty containers in accordance with guidance from your local waste regulation authority.
 

Marketing authorisation number

Vm 00057/4416.
 

Below is the product datasheet. This has been provided by the manufacturer and should always be provided with the medication.

Introduction

Company name: Pfizer Limited
Address: Ramsgate Road
Sandwich
Kent CT13 9NJ
Telephone: 0845 300 8034 (Out of hours: 01304 616161)
Fax: 01737 332521
Email: UKVetLine@pfizer.com
Website: www.pfizerah.co.uk

Presentation

A pale red powder containing Amoxicillin Trihydrate PhEur equivalent to 750 mg amoxcillin. The powder is contained within a bottle and should be reconstituted with 12 ml water to give 15 ml suspension containing 50 mg amoxicillin per ml. Chemically, amoxicillin is 6[D(-)-α-amino-p-hydroxyphenylacetamido] penicillanic acid.

Uses

Duphamox Palatable Drops are indicated for the treatment of infections in dogs and cats caused by or associated with organisms sensitive to amoxicillin including;
Bacillus cereus
Bordetella bronchiseptica
Corynebacterium spp
Citrobacter freundii
Chromobacter spp
Escherichia coli
Flavobacter spp
Pasteurella spp (including P multocida)
Proteus mirabilis
Salmonella spp
Staphylocci (penicillin sensitive strains)
Streptococci
Amoxicillin is particularly indicated for infections involving the alimentary tract, respiratory tract, urogenital tract, eyes, ears, skin and wounds.

Dosage and administration

To be administered orally using the graduated pipette provided, at a dose rate of 10 mg per kg bodyweight twice daily for up to 7 days. This is achieved by administering 1 ml of reconstituted product per 5 kg bodyweight twice daily for up to 7 days. Shake the bottle before use.
Duphamox Palatable Drops provide a particularly useful means of dosing small dogs and cats and those which are unwilling to accept tablets.
As high blood levels are achieved immediately after oral administration of Duphamox Palatable Drops, parenteral antibiotic treatment may not be necessary, even in the presence of systemic diseases. However, where parenteral treatment is required, Duphamox injection is indicated and Duphamox Palatable Drops are recommended for follow-up therapy.

Contra-indications, warnings, etc

Not to be used in animals known to be hypersensitive to penicillin.
Not to be used orally or parentally in rabbits, guinea pigs, hamsters or gerbils.
Caution is advised when used in any other small herbivores.
Operator warning
Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross reactions to cephalosporins and vice versa. Allergic reactions to these substances may occasionally be serious.
1. Do not handle this product if you know you are sensitised, or if you have been advised not to work with such preparations.
2. Handle this product with great care to avoid exposure, taking all recommended precautions.
3. If you develop symptoms following exposure, such as a skin rash, you should seek medical advice and show the doctor this warning. Swelling of the face, lips or eyes or difficulty with breathing, are more serious symptoms and require urgent medical attention.
Wash hands after use of the product.

Pharmaceutical precautions

FOR ANIMAL TREATMENT ONLY
Do not store the reconstituted product above 25°C. After the product is reconstituted, using the in-use shelf-life which is specified on this package insert, the date on which any reconstituted product remaining in the container should be discarded should be worked out. This discard date should be written in the space provided on the carton. Any reconstituted product remaining after 7 days should be discarded. Shake bottle before use. Keep out of the reach of children.
Disposal Advice
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Legal category

POM-V

Packaging Quantities

Duphamox Palatable Drops are packaged in bottles containing Amoxicillin Trihydrate BP equivalent to 750 mg amoxicillin. To enable convenient and accurate dosing a graduated pipette is provided with each pack.

Further information

After absorption, high levels of amoxicillin are found throughout the body, especially in kidney, urine, liver and bile. Amoxicillin provides rapid bactericidal action and due to its mode of action normally prevents recrudescence of respiratory infections. In common with other penicillins an absence of toxicity has been demonstrated at very high dose levels.

Marketing authorisation number

Vm 01596/4123.

Below is the product datasheet. This has been provided by the manufacturer and should always be provided with the medication.

Introduction

Company name: Pfizer Limited
Address: Ramsgate Road
Sandwich
Kent CT13 9NJ
Telephone: 0845 300 8034 (Out of hours: 01304 616161)
Fax: 01737 332521
Email: UKVetLine@pfizer.com
Website: www.pfizerah.co.uk

Presentation

Duphamox is an off-white suspension for injection containing 150 mg of amoxicillin (as Amoxicillin Trihydrate) per ml. Each ml also contains Butylhydroxyanisole 0.08 mg and Butylhydroxytoluene 0.08 mg as antioxidants.

Uses

Duphamox is indicated in the treatment and control of infections caused by organisms sensitive to amoxicillin.
Amoxicillin is a broad-spectrum semi-synthetic penicillin bactericidal in action. In vitro it is effective against a wide range of Gram-positive and Gram-negative bacteria which include:
Actinomyces bovis, Actinobacillus equuli, Actinobacillus lignieresi, Bacillus anthracis, Bordetella bronchiseptica, Clostridium spp, Corynebacterium spp, Erysipelothrix rhusiopathiae, Escherichia coli, Fusiformis spp, Haemophilus spp, Moraxella spp, Pasteurella spp, Proteus mirabilis, Salmonella spp, Staphylococci and Streptococci (non-penicillinase producing) in cattle, sheep, pigs, dogs and cats.

Dosage and administration

Shake well before use.
Administration is by the intramuscular route for cattle, sheep and pigs and by the intramuscular or subcutaneous route in dogs and cats. The dosage rate is 7mg/kg bodyweight daily for up to 5 days (equivalent to 0.25ml per 5kg daily). Massage the injection site after injection.
The suggested dosage rates are

Cattle	450 kg	20.0 ml
Sheep	65 kg	3.0 ml
Pigs	150 kg	7.0 ml
Dogs	20 kg	1.0 ml
Cats	5 kg	0.25 ml

Normal aseptic precautions should be observed. Use a dry syringe for extraction of suspension to avoid hydrolysis of amoxicillin.
If dose volume exceeds 20 ml in cattle or 10 ml in sheep and pigs, it should be divided and injected into two sites.
A separate injection site should be used for each administration.
An appropriately graduated syringe must be used to allow accurate administration of the required dose volume. This is particularly important when injecting small volumes.

Contra-indications, warnings, etc

FOR ANIMAL TREATMENT ONLY
Do not use in cases of known hypersensitivity.
Not suitable for intravenous or intrathecal administration.
Not to be used in small herbivores such as rabbits, hamsters, gerbils and guinea pigs.
Not effective against beta-lactamase producing organisms.
Occasional local tissue reaction may result from the use of this product.
Milk for human consumption must not be taken from a cow during treatment. Milk for human consumption may only be taken from cows after 24 hours from the last treatment.
Not for use in sheep producing milk for human consumption.
Animals must not be slaughtered for human consumption during treatment.
Cattle may be slaughtered for human consumption only after 18 days from the last treatment.
Sheep may be slaughtered for human consumption only after 10 days from the last treatment.
Pigs may be slaughtered for human consumption only after 16 days from the last treatment.
Operator warning
Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross reactions to cephalosporins and vice versa. Allergic reactions to these substances may occasionally be serious.
1.Do not handle this product if you know you are sensitised, or if you have been advised not to work with such preparations.
2.Handle this product with great care to avoid exposure, taking all recommended precautions.
3.If you develop symptoms following exposure, such as a skin rash, you should seek medical advice and show the doctor this warning. Swelling of the face, lips or eyes or difficulty with breathing, are more serious symptoms and require urgent medical attention.
Wash hands after use.

Pharmaceutical precautions

Do not store above 25°C. Protect from light.
This product does not contain an antimicrobial preservative. Swab the septum before removing each dose. Use a dry, sterile needle and syringe.
Keep out of the reach and sight of children.
Following withdrawal of the first dose, use the product within 28 days. Discard unused material.

Legal category

POM-V

Packaging Quantities

Multidose vials of 100 ml.

Further information

After the administration of Duphamox, amoxicillin is absorbed and widely distributed in the body and high levels are found in kidney, urine, liver and bile. Amoxicillin has a rapid bactericidal action which normally prevents the recrudescence of respiratory infections. As with other penicillins, absence of toxicity is normally encountered. Animals with functional rumens should only be treated parenterally.
Disposal
Dispose of any unused product and empty containers in accordance with guidance from your local waste regulation authority.

Marketing authorisation number

Vm 00057/4370.